void BSplineRegistration::GenerateData2( itk::Image<TPixel, VImageDimension>* itkImage1)
{
std::cout << "start bspline registration" << std::endl;
// Typedefs
typedef typename itk::Image< TPixel, VImageDimension > InternalImageType;
typedef typename itk::Vector< float, VImageDimension > VectorPixelType;
typedef typename itk::Image< VectorPixelType, VImageDimension > DeformationFieldType;
typedef itk::BSplineDeformableTransform<
double,
VImageDimension,
3 > TransformType;
typedef typename TransformType::ParametersType ParametersType;
//typedef itk::LBFGSOptimizer OptimizerType;
typedef itk::SingleValuedNonLinearOptimizer OptimizerType;
//typedef itk::SingleValuedCostFunction MetricType;
typedef itk::MattesMutualInformationImageToImageMetric<
InternalImageType,
InternalImageType > MetricType;
typedef itk::MeanSquaresImageToImageMetric<
InternalImageType,
InternalImageType > MetricTypeMS;
typedef itk::LinearInterpolateImageFunction<
InternalImageType,
double > InterpolatorType;
typedef itk::ImageRegistrationMethod<
InternalImageType,
InternalImageType > RegistrationType;
typedef typename itk::WarpImageFilter<
InternalImageType,
InternalImageType,
DeformationFieldType > WarperType;
typedef typename TransformType::SpacingType SpacingType;
typedef typename TransformType::OriginType OriginType;
typedef itk::ResampleImageFilter<
InternalImageType,
InternalImageType > ResampleFilterType;
typedef itk::Image< TPixel, VImageDimension > OutputImageType;
// Sample new image with the same image type as the fixed image
typedef itk::CastImageFilter<
InternalImageType,
InternalImageType > CastFilterType;
typedef itk::Vector< float, VImageDimension > VectorType;
typedef itk::Image< VectorType, VImageDimension > DeformationFieldType;
typedef itk::BSplineDeformableTransformInitializer <
TransformType,
InternalImageType > InitializerType;
typename InterpolatorType::Pointer interpolator = InterpolatorType::New();
typename RegistrationType::Pointer registration = RegistrationType::New();
typename InitializerType::Pointer initializer = InitializerType::New();
typename TransformType::Pointer transform = TransformType::New();
if(m_Metric==0 || m_Metric==1)
{
typename MetricType::Pointer metric = MetricType::New();
metric->SetNumberOfHistogramBins( 32);
metric->SetNumberOfSpatialSamples(90000);
registration->SetMetric( metric );
}
else{
typename MetricTypeMS::Pointer metric = MetricTypeMS::New();
registration->SetMetric( metric );
}
typename OptimizerFactory::Pointer optFac = OptimizerFactory::New();
optFac->SetOptimizerParameters(m_OptimizerParameters);
optFac->SetNumberOfTransformParameters(transform->GetNumberOfParameters());
OptimizerType::Pointer optimizer = optFac->GetOptimizer();
optimizer->AddObserver(itk::AnyEvent(), m_Observer);
//typedef mitk::MetricFactory <TPixel, VImageDimension> MetricFactoryType;
//typename MetricFactoryType::Pointer metricFac = MetricFactoryType::New();
//metricFac->SetMetricParameters(m_MetricParameters);
////MetricType::Pointer metric = metricFac->GetMetric();
typename InternalImageType::Pointer fixedImage = InternalImageType::New();
mitk::CastToItkImage(m_ReferenceImage, fixedImage);
typename InternalImageType::Pointer movingImage = itkImage1;
typename InternalImageType::RegionType fixedRegion = fixedImage->GetBufferedRegion();
typename InternalImageType::RegionType movingRegion = movingImage->GetBufferedRegion();
if(m_MatchHistograms)
{
typedef itk::RescaleIntensityImageFilter<InternalImageType,InternalImageType> FilterType;
typedef itk::HistogramMatchingImageFilter<InternalImageType,InternalImageType> HEFilterType;
typename FilterType::Pointer inputRescaleFilter = FilterType::New();
typename FilterType::Pointer referenceRescaleFilter = FilterType::New();
referenceRescaleFilter->SetInput(fixedImage);
inputRescaleFilter->SetInput(movingImage);
TPixel desiredMinimum = 0;
TPixel desiredMaximum = 255;
referenceRescaleFilter->SetOutputMinimum( desiredMinimum );
referenceRescaleFilter->SetOutputMaximum( desiredMaximum );
referenceRescaleFilter->UpdateLargestPossibleRegion();
inputRescaleFilter->SetOutputMinimum( desiredMinimum );
inputRescaleFilter->SetOutputMaximum( desiredMaximum );
inputRescaleFilter->UpdateLargestPossibleRegion();
// Histogram match the images
typename HEFilterType::Pointer intensityEqualizeFilter = HEFilterType::New();
intensityEqualizeFilter->SetReferenceImage( inputRescaleFilter->GetOutput() );
intensityEqualizeFilter->SetInput( referenceRescaleFilter->GetOutput() );
intensityEqualizeFilter->SetNumberOfHistogramLevels( 64 );
intensityEqualizeFilter->SetNumberOfMatchPoints( 12 );
intensityEqualizeFilter->ThresholdAtMeanIntensityOn();
intensityEqualizeFilter->Update();
//fixedImage = referenceRescaleFilter->GetOutput();
//movingImage = IntensityEqualizeFilter->GetOutput();
fixedImage = intensityEqualizeFilter->GetOutput();
movingImage = inputRescaleFilter->GetOutput();
}
//
registration->SetOptimizer( optimizer );
registration->SetInterpolator( interpolator );
registration->SetFixedImage( fixedImage );
registration->SetMovingImage( movingImage );
registration->SetFixedImageRegion(fixedRegion );
initializer->SetTransform(transform);
initializer->SetImage(fixedImage);
initializer->SetNumberOfGridNodesInsideTheImage( m_NumberOfGridPoints );
initializer->InitializeTransform();
registration->SetTransform( transform );
const unsigned int numberOfParameters = transform->GetNumberOfParameters();
typename itk::BSplineDeformableTransform<
double,
VImageDimension,
3 >::ParametersType parameters;
parameters.set_size(numberOfParameters);
parameters.Fill( 0.0 );
transform->SetParameters( parameters );
// We now pass the parameters of the current transform as the initial
// parameters to be used when the registration process starts.
registration->SetInitialTransformParameters( transform->GetParameters() );
std::cout << "Intial Parameters = " << std::endl;
std::cout << transform->GetParameters() << std::endl;
std::cout << std::endl << "Starting Registration" << std::endl;
try
{
double tstart(clock());
registration->StartRegistration();
double time = clock() - tstart;
time = time / CLOCKS_PER_SEC;
MITK_INFO << "Registration time: " << time;
}
catch( itk::ExceptionObject & err )
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
}
typename OptimizerType::ParametersType finalParameters =
registration->GetLastTransformParameters();
std::cout << "Last Transform Parameters" << std::endl;
std::cout << finalParameters << std::endl;
transform->SetParameters( finalParameters );
/*
ResampleFilterType::Pointer resampler = ResampleFilterType::New();
resampler->SetTransform( transform );
resampler->SetInput( movingImage );
resampler->SetSize( fixedImage->GetLargestPossibleRegion().GetSize() );
resampler->SetOutputOrigin( fixedImage->GetOrigin() );
resampler->SetOutputSpacing( fixedImage->GetSpacing() );
resampler->SetOutputDirection( fixedImage->GetDirection() );
resampler->SetDefaultPixelValue( 100 );
resampler->SetInterpolator( interpolator);
resampler->Update();*/
// Generate deformation field
typename DeformationFieldType::Pointer field = DeformationFieldType::New();
field->SetRegions( movingRegion );
field->SetOrigin( movingImage->GetOrigin() );
field->SetSpacing( movingImage->GetSpacing() );
field->SetDirection( movingImage->GetDirection() );
field->Allocate();
typedef itk::ImageRegionIterator< DeformationFieldType > FieldIterator;
FieldIterator fi( field, movingRegion );
fi.GoToBegin();
typename TransformType::InputPointType fixedPoint;
typename TransformType::OutputPointType movingPoint;
typename DeformationFieldType::IndexType index;
VectorType displacement;
while( ! fi.IsAtEnd() )
{
index = fi.GetIndex();
field->TransformIndexToPhysicalPoint( index, fixedPoint );
movingPoint = transform->TransformPoint( fixedPoint );
displacement = movingPoint - fixedPoint;
fi.Set( displacement );
++fi;
}
// Use the deformation field to warp the moving image
typename WarperType::Pointer warper = WarperType::New();
warper->SetInput( movingImage );
warper->SetInterpolator( interpolator );
warper->SetOutputSpacing( movingImage->GetSpacing() );
warper->SetOutputOrigin( movingImage->GetOrigin() );
warper->SetOutputDirection( movingImage->GetDirection() );
warper->SetDeformationField( field );
warper->Update();
typename InternalImageType::Pointer result = warper->GetOutput();
if(m_UpdateInputImage)
{
Image::Pointer outputImage = this->GetOutput();
mitk::CastToMitkImage( result, outputImage );
}
// Save the deformationfield resulting from the registration
if(m_SaveDeformationField)
{
typedef itk::ImageFileWriter< DeformationFieldType > FieldWriterType;
typename FieldWriterType::Pointer fieldWriter = FieldWriterType::New();
fieldWriter->SetInput( field );
fieldWriter->SetFileName( m_DeformationFileName );
try
{
fieldWriter->Update();
}
catch( itk::ExceptionObject & excp )
{
std::cerr << "Exception thrown " << std::endl;
std::cerr << excp << std::endl;
//return EXIT_FAILURE;
}
}
}
void RunRegistration() {
_transform = TransformType::New();
OptiReporter::Pointer optiReporter = OptiReporter::New();
Metric::Pointer metric = Metric::New();
metric->SetFixedImage(_dst);
bool useIndexes = false;
if (useIndexes) {
_centerOfRotation.SetSize(ImageType::ImageDimension);
for (int i = 0; i < ImageType::ImageDimension; i++) {
_centerOfRotation[i] = i;
}
itk::ImageRegionConstIteratorWithIndex<LabelType> labelIter(_dstLabel, _dstLabel->GetBufferedRegion());
int nPixels = 0;
for (labelIter.GoToBegin(); !labelIter.IsAtEnd(); ++labelIter) {
LabelType::PixelType label = labelIter.Get();
if (label > 0) {
_labelIndexes.push_back(labelIter.GetIndex());
for (int i = 0; i < ImageType::ImageDimension; i++) {
_centerOfRotation[i] += labelIter.GetIndex()[i];
}
nPixels ++;
}
}
for (int i = 0; i < ImageType::ImageDimension; i++) {
_centerOfRotation[i] /= nPixels;
}
metric->SetFixedImageIndexes(_labelIndexes);
_transform->SetFixedParameters(_centerOfRotation);
} else {
metric->SetFixedImageRegion(_dst->GetBufferedRegion());
metric->SetUseAllPixels(true);
_centerOfRotation.SetSize(ImageType::ImageDimension);
for (int i = 0; i < 3; i++) {
_centerOfRotation[i] = _dstCenter[i];
}
_transform->SetFixedParameters(_centerOfRotation);
}
cout << "Fixed Parameters: " << _centerOfRotation << endl;
metric->SetMovingImage(_src);
metric->SetInterpolator(Interpolator::New());
metric->SetTransform(_transform);
metric->Initialize();
Optimizer::Pointer opti = Optimizer::New();
opti->SetCostFunction(metric);
Optimizer::ScalesType scales;
scales.SetSize(TransformType::ParametersDimension);
scales.Fill(1);
if (_method == "affine") {
cout << "apply affine scaling ..." << endl;
for (int i = 0; i < 3; i++) {
for (int j = 0; j < 3; j++) {
if (i == j) {
scales[3*i+j] = 160;
} else {
scales[3*i+j] = 30;
}
}
}
scales[9] = scales[10] = scales[11] = 0.1;
} else if (_method == "scale") {
scales[0] = scales[1] = scales[2] = 30;
scales[3] = scales[4] = scales[5] = .5;
scales[6] = scales[7] = scales[8] = 100;
} else if (_method == "similar") {
scales[0] = scales[1] = scales[2] = 10;
scales[3] = scales[4] = scales[5] = 0.5;
scales[6] = 100;
}
opti->SetScales(scales);
const int maxIters = 100;
#ifdef USE_CG_OPTIMIZER
opti->SetMaximumIteration(maxIters);
opti->SetMaximumLineIteration(10);
opti->SetUseUnitLengthGradient(true);
opti->SetStepLength(1);
opti->SetToFletchReeves();
#endif
#ifdef USE_GD_OPTIMIZER
opti->SetNumberOfIterations(maxIters);
opti->SetMinimumStepLength(1e-4);
opti->SetMaximumStepLength(3);
opti->SetRelaxationFactor(.5);
opti->SetGradientMagnitudeTolerance(1e-4);
#endif
opti->SetInitialPosition(_transform->GetParameters());
opti->AddObserver(itk::StartEvent(), optiReporter);
opti->AddObserver(itk::IterationEvent(), optiReporter);
opti->StartOptimization();
cout << "Current Cost: " << opti->GetValue() << endl;
_transformResult = opti->GetCurrentPosition();
_transform->SetParameters(opti->GetCurrentPosition());
}