static int
CalculateGlSZMatrix(itk::Image<TPixel, VImageDimension>* itkImage,
itk::Image<unsigned short, VImageDimension>* mask,
std::vector<itk::Offset<VImageDimension> > offsets,
bool estimateLargestRegion,
mitk::GreyLevelSizeZoneMatrixHolder &holder)
{
typedef itk::Image<TPixel, VImageDimension> ImageType;
typedef itk::Image<unsigned short, VImageDimension> MaskImageType;
typedef typename ImageType::IndexType IndexType;
typedef itk::ImageRegionIteratorWithIndex<ImageType> ConstIterType;
typedef itk::ImageRegionIteratorWithIndex<MaskImageType> ConstMaskIterType;
auto region = mask->GetLargestPossibleRegion();
typename MaskImageType::RegionType newRegion;
newRegion.SetSize(region.GetSize());
newRegion.SetIndex(region.GetIndex());
ConstIterType imageIter(itkImage, itkImage->GetLargestPossibleRegion());
ConstMaskIterType maskIter(mask, mask->GetLargestPossibleRegion());
typename MaskImageType::Pointer visitedImage = MaskImageType::New();
visitedImage->SetRegions(newRegion);
visitedImage->Allocate();
visitedImage->FillBuffer(0);
int largestRegion = 0;
while (!maskIter.IsAtEnd())
{
if (maskIter.Value() > 0 )
{
auto startIntensityIndex = holder.IntensityToIndex(imageIter.Value());
std::vector<IndexType> indices;
indices.push_back(maskIter.GetIndex());
unsigned int steps = 0;
while (indices.size() > 0)
{
auto currentIndex = indices.back();
indices.pop_back();
if (!region.IsInside(currentIndex))
{
continue;
}
auto wasVisited = visitedImage->GetPixel(currentIndex);
auto newIntensityIndex = holder.IntensityToIndex(itkImage->GetPixel(currentIndex));
auto isInMask = mask->GetPixel(currentIndex);
if ((isInMask > 0) &&
(newIntensityIndex == startIntensityIndex) &&
(wasVisited < 1))
{
++steps;
visitedImage->SetPixel(currentIndex, 1);
for (auto offset : offsets)
{
auto newIndex = currentIndex + offset;
indices.push_back(newIndex);
newIndex = currentIndex - offset;
indices.push_back(newIndex);
}
}
}
if (steps > 0)
{
largestRegion = std::max<int>(steps, largestRegion);
steps = std::min<unsigned int>(steps, holder.m_MaximumSize);
if (!estimateLargestRegion)
{
holder.m_Matrix(startIntensityIndex, steps - 1) += 1;
}
}
}
++imageIter;
++maskIter;
}
return largestRegion;
}
SEXP invariantSimilarityHelper(
typename itk::Image< float , ImageDimension >::Pointer image1,
typename itk::Image< float , ImageDimension >::Pointer image2,
SEXP r_thetas, SEXP r_lsits, SEXP r_WM, SEXP r_scale,
SEXP r_doreflection, SEXP r_txfn )
{
unsigned int mibins = 20;
unsigned int localSearchIterations =
Rcpp::as< unsigned int >( r_lsits ) ;
std::string whichMetric = Rcpp::as< std::string >( r_WM );
std::string txfn = Rcpp::as< std::string >( r_txfn );
bool useprincaxis = true;
typedef typename itk::ImageMaskSpatialObject<ImageDimension>::ImageType
maskimagetype;
typename maskimagetype::Pointer mask = ITK_NULLPTR;
Rcpp::NumericVector thetas( r_thetas );
Rcpp::NumericVector vector_r( r_thetas ) ;
Rcpp::IntegerVector dims( 1 );
Rcpp::IntegerVector doReflection( r_doreflection );
unsigned int vecsize = thetas.size();
dims[0]=0;
typedef float PixelType;
typedef double RealType;
RealType bestscale = Rcpp::as< RealType >( r_scale ) ;
typedef itk::Image< PixelType , ImageDimension > ImageType;
if( image1.IsNotNull() & image2.IsNotNull() )
{
typedef typename itk::ImageMomentsCalculator<ImageType> ImageCalculatorType;
typedef itk::AffineTransform<RealType, ImageDimension> AffineType0;
typedef itk::AffineTransform<RealType, ImageDimension> AffineType;
typedef typename ImageCalculatorType::MatrixType MatrixType;
typedef itk::Vector<float, ImageDimension> VectorType;
VectorType ccg1;
VectorType cpm1;
MatrixType cpa1;
VectorType ccg2;
VectorType cpm2;
MatrixType cpa2;
typename ImageCalculatorType::Pointer calculator1 =
ImageCalculatorType::New();
typename ImageCalculatorType::Pointer calculator2 =
ImageCalculatorType::New();
calculator1->SetImage( image1 );
calculator2->SetImage( image2 );
typename ImageCalculatorType::VectorType fixed_center;
fixed_center.Fill(0);
typename ImageCalculatorType::VectorType moving_center;
moving_center.Fill(0);
try
{
calculator1->Compute();
fixed_center = calculator1->GetCenterOfGravity();
ccg1 = calculator1->GetCenterOfGravity();
cpm1 = calculator1->GetPrincipalMoments();
cpa1 = calculator1->GetPrincipalAxes();
try
{
calculator2->Compute();
moving_center = calculator2->GetCenterOfGravity();
ccg2 = calculator2->GetCenterOfGravity();
cpm2 = calculator2->GetPrincipalMoments();
cpa2 = calculator2->GetPrincipalAxes();
}
catch( ... )
{
fixed_center.Fill(0);
}
}
catch( ... )
{
// Rcpp::Rcerr << " zero image1 error ";
}
if ( vnl_math_abs( bestscale - 1.0 ) < 1.e-6 )
{
RealType volelt1 = 1;
RealType volelt2 = 1;
for ( unsigned int d=0; d<ImageDimension; d++)
{
volelt1 *= image1->GetSpacing()[d];
volelt2 *= image2->GetSpacing()[d];
}
bestscale =
( calculator2->GetTotalMass() * volelt2 )/
( calculator1->GetTotalMass() * volelt1 );
RealType powlev = 1.0 / static_cast<RealType>(ImageDimension);
bestscale = vcl_pow( bestscale , powlev );
}
unsigned int eigind1 = 1;
unsigned int eigind2 = 1;
if( ImageDimension == 3 )
{
eigind1 = 2;
}
typedef vnl_vector<RealType> EVectorType;
typedef vnl_matrix<RealType> EMatrixType;
EVectorType evec1_2ndary = cpa1.GetVnlMatrix().get_row( eigind2 );
EVectorType evec1_primary = cpa1.GetVnlMatrix().get_row( eigind1 );
EVectorType evec2_2ndary = cpa2.GetVnlMatrix().get_row( eigind2 );
EVectorType evec2_primary = cpa2.GetVnlMatrix().get_row( eigind1 );
/** Solve Wahba's problem http://en.wikipedia.org/wiki/Wahba%27s_problem */
EMatrixType B = outer_product( evec2_primary, evec1_primary );
if( ImageDimension == 3 )
{
B = outer_product( evec2_2ndary, evec1_2ndary )
+ outer_product( evec2_primary, evec1_primary );
}
vnl_svd<RealType> wahba( B );
vnl_matrix<RealType> A_solution = wahba.V() * wahba.U().transpose();
A_solution = vnl_inverse( A_solution );
RealType det = vnl_determinant( A_solution );
if( ( det < 0 ) )
{
vnl_matrix<RealType> id( A_solution );
id.set_identity();
for( unsigned int i = 0; i < ImageDimension; i++ )
{
if( A_solution( i, i ) < 0 )
{
id( i, i ) = -1.0;
}
}
A_solution = A_solution * id.transpose();
}
if ( doReflection[0] == 1 || doReflection[0] == 3 )
{
vnl_matrix<RealType> id( A_solution );
id.set_identity();
id = id - 2.0 * outer_product( evec2_primary , evec2_primary );
A_solution = A_solution * id;
}
if ( doReflection[0] > 1 )
{
vnl_matrix<RealType> id( A_solution );
id.set_identity();
id = id - 2.0 * outer_product( evec1_primary , evec1_primary );
A_solution = A_solution * id;
}
typename AffineType::Pointer affine1 = AffineType::New();
typename AffineType::OffsetType trans = affine1->GetOffset();
itk::Point<RealType, ImageDimension> trans2;
for( unsigned int i = 0; i < ImageDimension; i++ )
{
trans[i] = moving_center[i] - fixed_center[i];
trans2[i] = fixed_center[i] * ( 1 );
}
affine1->SetIdentity();
affine1->SetOffset( trans );
if( useprincaxis )
{
affine1->SetMatrix( A_solution );
}
affine1->SetCenter( trans2 );
if( ImageDimension > 3 )
{
return EXIT_SUCCESS;
}
vnl_vector<RealType> evec_tert;
if( ImageDimension == 3 )
{ // try to rotate around tertiary and secondary axis
evec_tert = vnl_cross_3d( evec1_primary, evec1_2ndary );
}
if( ImageDimension == 2 )
{ // try to rotate around tertiary and secondary axis
evec_tert = evec1_2ndary;
evec1_2ndary = evec1_primary;
}
itk::Vector<RealType, ImageDimension> axis2;
itk::Vector<RealType, ImageDimension> axis1;
for( unsigned int d = 0; d < ImageDimension; d++ )
{
axis1[d] = evec_tert[d];
axis2[d] = evec1_2ndary[d];
}
typename AffineType::Pointer simmer = AffineType::New();
simmer->SetIdentity();
simmer->SetCenter( trans2 );
simmer->SetOffset( trans );
typename AffineType0::Pointer affinesearch = AffineType0::New();
affinesearch->SetIdentity();
affinesearch->SetCenter( trans2 );
typedef itk::MultiStartOptimizerv4 OptimizerType;
typename OptimizerType::MetricValuesListType metricvalues;
typename OptimizerType::Pointer mstartOptimizer = OptimizerType::New();
typedef itk::CorrelationImageToImageMetricv4
<ImageType, ImageType, ImageType> GCMetricType;
typedef itk::MattesMutualInformationImageToImageMetricv4
<ImageType, ImageType, ImageType> MetricType;
typename MetricType::ParametersType newparams( affine1->GetParameters() );
typename GCMetricType::Pointer gcmetric = GCMetricType::New();
gcmetric->SetFixedImage( image1 );
gcmetric->SetVirtualDomainFromImage( image1 );
gcmetric->SetMovingImage( image2 );
gcmetric->SetMovingTransform( simmer );
gcmetric->SetParameters( newparams );
typename MetricType::Pointer mimetric = MetricType::New();
mimetric->SetNumberOfHistogramBins( mibins );
mimetric->SetFixedImage( image1 );
mimetric->SetMovingImage( image2 );
mimetric->SetMovingTransform( simmer );
mimetric->SetParameters( newparams );
if( mask.IsNotNull() )
{
typename itk::ImageMaskSpatialObject<ImageDimension>::Pointer so =
itk::ImageMaskSpatialObject<ImageDimension>::New();
so->SetImage( const_cast<maskimagetype *>( mask.GetPointer() ) );
mimetric->SetFixedImageMask( so );
gcmetric->SetFixedImageMask( so );
}
typedef itk::ConjugateGradientLineSearchOptimizerv4 LocalOptimizerType;
typename LocalOptimizerType::Pointer localoptimizer =
LocalOptimizerType::New();
RealType localoptimizerlearningrate = 0.1;
localoptimizer->SetLearningRate( localoptimizerlearningrate );
localoptimizer->SetMaximumStepSizeInPhysicalUnits(
localoptimizerlearningrate );
localoptimizer->SetNumberOfIterations( localSearchIterations );
localoptimizer->SetLowerLimit( 0 );
localoptimizer->SetUpperLimit( 2 );
localoptimizer->SetEpsilon( 0.1 );
localoptimizer->SetMaximumLineSearchIterations( 50 );
localoptimizer->SetDoEstimateLearningRateOnce( true );
localoptimizer->SetMinimumConvergenceValue( 1.e-6 );
localoptimizer->SetConvergenceWindowSize( 5 );
if( true )
{
typedef typename MetricType::FixedSampledPointSetType PointSetType;
typedef typename PointSetType::PointType PointType;
typename PointSetType::Pointer pset(PointSetType::New());
unsigned int ind=0;
unsigned int ct=0;
itk::ImageRegionIteratorWithIndex<ImageType> It(image1,
image1->GetLargestPossibleRegion() );
for( It.GoToBegin(); !It.IsAtEnd(); ++It )
{
// take every N^th point
if ( ct % 10 == 0 )
{
PointType pt;
image1->TransformIndexToPhysicalPoint( It.GetIndex(), pt);
pset->SetPoint(ind, pt);
ind++;
}
ct++;
}
mimetric->SetFixedSampledPointSet( pset );
mimetric->SetUseFixedSampledPointSet( true );
gcmetric->SetFixedSampledPointSet( pset );
gcmetric->SetUseFixedSampledPointSet( true );
}
if ( whichMetric.compare("MI") == 0 ) {
mimetric->Initialize();
typedef itk::RegistrationParameterScalesFromPhysicalShift<MetricType>
RegistrationParameterScalesFromPhysicalShiftType;
typename RegistrationParameterScalesFromPhysicalShiftType::Pointer
shiftScaleEstimator =
RegistrationParameterScalesFromPhysicalShiftType::New();
shiftScaleEstimator->SetMetric( mimetric );
shiftScaleEstimator->SetTransformForward( true );
typename RegistrationParameterScalesFromPhysicalShiftType::ScalesType
movingScales( simmer->GetNumberOfParameters() );
shiftScaleEstimator->EstimateScales( movingScales );
mstartOptimizer->SetScales( movingScales );
mstartOptimizer->SetMetric( mimetric );
localoptimizer->SetMetric( mimetric );
localoptimizer->SetScales( movingScales );
}
if ( whichMetric.compare("MI") != 0 ) {
gcmetric->Initialize();
typedef itk::RegistrationParameterScalesFromPhysicalShift<GCMetricType>
RegistrationParameterScalesFromPhysicalShiftType;
typename RegistrationParameterScalesFromPhysicalShiftType::Pointer
shiftScaleEstimator =
RegistrationParameterScalesFromPhysicalShiftType::New();
shiftScaleEstimator->SetMetric( gcmetric );
shiftScaleEstimator->SetTransformForward( true );
typename RegistrationParameterScalesFromPhysicalShiftType::ScalesType
movingScales( simmer->GetNumberOfParameters() );
shiftScaleEstimator->EstimateScales( movingScales );
mstartOptimizer->SetScales( movingScales );
mstartOptimizer->SetMetric( gcmetric );
localoptimizer->SetMetric( gcmetric );
localoptimizer->SetScales( movingScales );
}
typename OptimizerType::ParametersListType parametersList =
mstartOptimizer->GetParametersList();
affinesearch->SetIdentity();
affinesearch->SetCenter( trans2 );
affinesearch->SetOffset( trans );
for ( unsigned int i = 0; i < vecsize; i++ )
{
RealType ang1 = thetas[i];
RealType ang2 = 0; // FIXME should be psi
vector_r[ i ]=0;
if( ImageDimension == 3 )
{
for ( unsigned int jj = 0; jj < vecsize; jj++ )
{
ang2=thetas[jj];
affinesearch->SetIdentity();
affinesearch->SetCenter( trans2 );
affinesearch->SetOffset( trans );
if( useprincaxis )
{
affinesearch->SetMatrix( A_solution );
}
affinesearch->Rotate3D(axis1, ang1, 1);
affinesearch->Rotate3D(axis2, ang2, 1);
affinesearch->Scale( bestscale );
simmer->SetMatrix( affinesearch->GetMatrix() );
parametersList.push_back( simmer->GetParameters() );
}
}
if( ImageDimension == 2 )
{
affinesearch->SetIdentity();
affinesearch->SetCenter( trans2 );
affinesearch->SetOffset( trans );
if( useprincaxis )
{
affinesearch->SetMatrix( A_solution );
}
affinesearch->Rotate2D( ang1, 1);
affinesearch->Scale( bestscale );
simmer->SetMatrix( affinesearch->GetMatrix() );
typename AffineType::ParametersType pp =
simmer->GetParameters();
//pp[1]=ang1;
//pp[0]=bestscale;
parametersList.push_back( simmer->GetParameters() );
}
}
mstartOptimizer->SetParametersList( parametersList );
if( localSearchIterations > 0 )
{
mstartOptimizer->SetLocalOptimizer( localoptimizer );
}
mstartOptimizer->StartOptimization();
typename AffineType::Pointer bestaffine = AffineType::New();
bestaffine->SetCenter( trans2 );
bestaffine->SetParameters( mstartOptimizer->GetBestParameters() );
if ( txfn.length() > 3 )
{
typename AffineType::Pointer bestaffine = AffineType::New();
bestaffine->SetCenter( trans2 );
bestaffine->SetParameters( mstartOptimizer->GetBestParameters() );
typedef itk::TransformFileWriter TransformWriterType;
typename TransformWriterType::Pointer transformWriter =
TransformWriterType::New();
transformWriter->SetInput( bestaffine );
transformWriter->SetFileName( txfn.c_str() );
transformWriter->Update();
}
metricvalues = mstartOptimizer->GetMetricValuesList();
for ( unsigned int k = 0; k < metricvalues.size(); k++ )
{
vector_r[k] = metricvalues[k];
}
dims[0] = vecsize;
vector_r.attr( "dim" ) = vecsize;
return Rcpp::wrap( vector_r );
}
else
{
return Rcpp::wrap( vector_r );
}
}
void udgPerfusionEstimator<TPerfuImage,TMaskImage, TTransform>::ComputeEstimation()
{
if(m_perfuImage.IsNull()){
std::cout<<"Not Perfusion Image defined"<<std::endl;
return;
}
if(m_ventricleMask.IsNull()){
std::cout<<"Not Ventricle Mask Image defined"<<std::endl;
return;
}
if(m_strokeMask.IsNull()){
std::cout<<"Not Stroke Mask Image defined"<<std::endl;
return;
}
if(m_Transform.IsNull()){
std::cout<<"Not Transform defined"<<std::endl;
return;
}
m_estimatedImage = PerfuImageType::New();
m_estimatedImage->SetRegions( m_perfuImage->GetLargestPossibleRegion() );
m_estimatedImage->SetSpacing( m_perfuImage->GetSpacing() );
m_estimatedImage->SetOrigin( m_perfuImage->GetOrigin() );
m_estimatedImage->Allocate();
//Definim la regi�molt probablement infartada
typename MaskImageType::Pointer m_strokeInfluence = MaskImageType::New();
m_strokeInfluence->SetRegions( m_strokeMask->GetLargestPossibleRegion() );
m_strokeInfluence->SetSpacing( m_strokeMask->GetSpacing() );
m_strokeInfluence->SetOrigin( m_strokeMask->GetOrigin() );
m_strokeInfluence->Allocate();
typename DilateFilterType::Pointer binaryDilate = DilateFilterType::New();
binaryDilate->SetDilateValue( 255 ); //suposem que el valor alt ser�255
StructuringElementType structuringElementDilate;
structuringElementDilate.SetRadius( 2 ); // 3x3 structuring element
structuringElementDilate.CreateStructuringElement();
binaryDilate->SetKernel( structuringElementDilate );
binaryDilate->SetInput( m_strokeMask );
binaryDilate->Update();
m_strokeInfluence = binaryDilate->GetOutput();
//Fi regi�molt probablement infartada
typename ResampleFilterType::Pointer resample = ResampleFilterType::New();
typename TransformType::Pointer inverse = TransformType::New();
if (!m_Transform->GetInverse( inverse ))
{
std::cout<<"ERROR! udgPerfusionEstimator<TPerfuImage,TMaskImage, TTransform>::ComputeEstimation() No hi ha inversa!"<<std::endl;
}
resample->SetTransform( inverse );
resample->SetInput( m_ventricleMask);
resample->SetSize( m_perfuImage->GetLargestPossibleRegion().GetSize() );
resample->SetOutputOrigin( m_perfuImage->GetOrigin() );
resample->SetOutputSpacing( m_perfuImage->GetSpacing() );
resample->SetDefaultPixelValue( 0 );
resample->SetInterpolator( m_InterpolatorVentricle );
resample->Update();
Ventricles = resample->GetOutput();
typename ResampleFilterType::Pointer resample2 = ResampleFilterType::New();
resample2->SetTransform( inverse );
resample2->SetInput( m_strokeInfluence);
resample2->SetSize( m_perfuImage->GetLargestPossibleRegion().GetSize() );
resample2->SetOutputOrigin( m_perfuImage->GetOrigin() );
resample2->SetOutputSpacing( m_perfuImage->GetSpacing() );
resample2->SetDefaultPixelValue( 0 );
resample2->SetInterpolator( m_InterpolatorStroke );
resample2->Update();
//Creem les finestres mostrant les imatges registrades
Stroke = resample2->GetOutput();
PerfuIteratorType estimatedIt(m_estimatedImage, m_estimatedImage->GetBufferedRegion());
PerfuIteratorType perfuIt(m_perfuImage, m_perfuImage->GetBufferedRegion());
PerfuIteratorType VentIt(Ventricles, Ventricles->GetBufferedRegion());
PerfuIteratorType StkIt(Stroke, Stroke->GetBufferedRegion());
RadiusNeighborType radius;
radius.Fill(2);
m_InterpolatorVentricle->SetInputImage( m_ventricleMask );
m_InterpolatorStroke->SetInputImage( m_strokeInfluence );
PerfuPointType inputPoint;
PerfuPixelType perfuValue;
PerfuPixelType VentValue;
PerfuPixelType StkValue;
typename PerfuImageType::IndexType index;
MaskPointType transformedPoint;
perfuIt.GoToBegin();
VentIt.GoToBegin();
StkIt.GoToBegin();
estimatedIt.GoToBegin();
++perfuIt;
++VentIt;
++StkIt;
++estimatedIt;
while (!perfuIt.IsAtEnd())
{
perfuValue = perfuIt.Value();
// if(perfuValue == 0) // ((maskValue == m_insideValue)&&(perfuValue == 0))
if ( perfuValue < 32 ) // ((maskValue == m_insideValue)&&(perfuValue == 0))
{ //és a dir, és un punt negre
index = perfuIt.GetIndex();
m_perfuImage->TransformIndexToPhysicalPoint(index, inputPoint);
transformedPoint = m_Transform->TransformPoint(inputPoint); //transformed point és el punt corresponent en difusió
if (m_InterpolatorVentricle->IsInsideBuffer(transformedPoint))
{
// m_Interpolator->SetInputImage( m_ventricleMask );
//const RealType VentriclemaskValue = m_InterpolatorVentricle->Evaluate(transformedPoint);
VentValue = VentIt.Value();
// if(VentriclemaskValue!=0)
if(VentValue!=0)
{
estimatedIt.Set(0);//estimatedIt.Set(1);
}
else
{
/*
const RealType strokemaskValue = m_InterpolatorStroke->Evaluate(transformedPoint);
if(strokemaskValue!=0){
estimatedIt.Set(1);//estimatedIt.Set(255);
}
*/
StkValue = StkIt.Value();
if(StkValue != 0)
{
estimatedIt.Set(255);
}
else
{
estimatedIt.Set(0);
}
}
}
}
else
{
estimatedIt.Set( perfuValue ); //estimatedIt.Set( perfuValue );
}
++perfuIt;
++VentIt;
++StkIt;
++estimatedIt;
}
//Aqu�determinem els punts que no s� ni infart ni ventricle, fent una mitjana dels valors veins
//La imatge s'actualitza sobre ella mateixa, per�no sembla que aix�hagi de portar problemes
/*
double med, cont;
PerfuNeighborIteratorType perfuNeighborIt(radius, m_estimatedImage, m_estimatedImage->GetBufferedRegion());
perfuNeighborIt.GoToBegin();
perfuIt.GoToBegin();
estimatedIt.GoToBegin();
++perfuNeighborIt;
++estimatedIt;
while (!estimatedIt.IsAtEnd())
{
perfuValue = estimatedIt.Get();
if (perfuValue == 0) //� a dir, � un punt negre
{
med=0;
cont=0;
for (unsigned int i = 0; i < perfuNeighborIt.Size(); i++)
{
if ( perfuNeighborIt.GetPixel(i) != 0 && perfuNeighborIt.GetPixel(i)<1000 )
{
med += perfuNeighborIt.GetPixel(i);
cont ++;
}
}
estimatedIt.Set(static_cast<PerfuPixelType> (med/cont));
}
++perfuNeighborIt;
++estimatedIt;
}
*/
//Suavitzem la sortida --> S'hauria de fer per�d�a errors
/*
typename SmoothingFilterType::Pointer smoothFilter = SmoothingFilterType::New();
// smoothFilter->SetInput(m_estimatedImage);
smoothFilter->SetInput(m_perfuImage);
// smoothFilter->SetNumberOfIterations(5);
// smoothFilter->SetTimeStep(0.0625);
// smoothFilter->SetConductanceParameter(1);
//std::cout<<"hola 1"<<std::endl;
smoothFilter->SetVariance(1);
smoothFilter->SetMaximumKernelWidth(6);
//smoothFilter->Update();
RescaleFilterType::Pointer rescaler = RescaleFilterType::New();
rescaler->SetOutputMinimum( 0 );
rescaler->SetOutputMaximum( 255 );
//std::cout<<"hola 2"<<std::endl;
rescaler->SetInput(smoothFilter->GetOutput());
rescaler->Update();
//std::cout<<"hola 3"<<std::endl;
m_estimatedImage = rescaler->GetOutput();
*/
}
void PartialVolumeAnalysisClusteringCalculator::InternalQuantify(
const itk::Image< TPixel, VImageDimension > *image,
mitk::Image::Pointer clusteredImage, double* retval, mitk::Image::Pointer mask ) const
{
typedef itk::Image< TPixel, VImageDimension > ImageType;
typedef itk::Image< float, VImageDimension > ProbImageType;
typedef itk::Image< unsigned char, VImageDimension > MaskImageType;
typedef mitk::ImageToItk<ProbImageType> CastFilterType;
typename CastFilterType::Pointer castFilter = CastFilterType::New();
castFilter->SetInput( clusteredImage );
castFilter->Update();
typename ProbImageType::Pointer clusterImage = castFilter->GetOutput();
typename MaskImageType::Pointer itkmask = 0;
if(mask.IsNotNull())
{
typedef mitk::ImageToItk<MaskImageType> CastFilterType2;
typename CastFilterType2::Pointer castFilter2 = CastFilterType2::New();
castFilter2->SetInput( mask );
castFilter2->Update();
itkmask = castFilter2->GetOutput();
}
else
{
itkmask = MaskImageType::New();
itkmask->SetSpacing( clusterImage->GetSpacing() ); // Set the image spacing
itkmask->SetOrigin( clusterImage->GetOrigin() ); // Set the image origin
itkmask->SetDirection( clusterImage->GetDirection() ); // Set the image direction
itkmask->SetRegions( clusterImage->GetLargestPossibleRegion() );
itkmask->Allocate();
itkmask->FillBuffer(1);
}
itk::ImageRegionConstIterator<ImageType>
itimage(image, image->GetLargestPossibleRegion());
itk::ImageRegionConstIterator<ProbImageType>
itprob(clusterImage, clusterImage->GetLargestPossibleRegion());
itk::ImageRegionConstIterator<MaskImageType>
itmask(itkmask, itkmask->GetLargestPossibleRegion());
itimage.GoToBegin();
itprob.GoToBegin();
itmask.GoToBegin();
double totalProb = 0;
double measurement = 0;
double error = 0;
while( !itimage.IsAtEnd() && !itprob.IsAtEnd() && !itmask.IsAtEnd() )
{
double valImag = itimage.Get();
double valProb = itprob.Get();
double valMask = itmask.Get();
typename ProbImageType::PixelType prop = valProb * valMask;
totalProb += prop;
measurement += valImag * prop;
error += valImag * valImag * prop;
++itimage;
++itprob;
++itmask;
}
measurement = measurement / totalProb;
error = error / totalProb;
retval[0] = measurement;
retval[1] = sqrt( error - measurement*measurement );
}