virtual void fire(){
E0 = getVariableReference( "E0" );
Real PO2 = E0.getVariable()->getValue();
// theCurrentTime = getStepper()->getCurrentTime();
Real i = trunc( getStepper()->getCurrentTime() / 5.5 );
theCalcTime = getStepper()->getCurrentTime() - 5.5 * i;
if (0 < theCalcTime <=0.36)
PO2 = 186.1111 * theCalcTime + 30;
else if(theCalcTime <= 2.55)
PO2 = 97;
else if(theCalcTime < 5.5)
PO2 = 60 - 32 * (theCalcTime - 2.57)/(0.15 + (theCalcTime - 2.57));
// else if(theCalcTime == 5.5)
// {
//// theCalcTime = 0;
// i= i+1;
// }
// std::cout << "i: " << i << std::endl;
// std::cout << "theCalcTime: " << theCalcTime << std::endl;
E0.getVariable()->setValue( PO2 );
}
void fire()
{
if( theLastTime < 0.0 )
{
return;
}
Real aCurrentTime( getStepper()->getCurrentTime() );
Real aNextTime( theLastTime + Interval );
if( aNextTime >= Duration )
{
theLastTime = -1;
P0.setValue( 1e-20 * getSuperSystem()->getSizeN_A() );
return;
}
Real aTimeDifference( aCurrentTime - theLastTime );
Real aDecay( aTimeDifference * DecayFactor / Interval );
P0.setValue( Impulse * getSuperSystem()->getSizeN_A()
/ ( aDecay + 1 ) );
if( aTimeDifference >= Interval )
{
theLastTime += Interval;
}
}
void System::preinitialize()
{
// no need to call subsystems' initialize() -- the Model does this
if ( !theStepper )
{
theStepper = theModel->getStepper( theStepperID );
theStepper->registerSystem( this );
}
//
// Set Process::theStepper.
//
for ( ProcessMap::const_iterator i( theProcessMap.begin() );
i != theProcessMap.end() ; ++i )
{
Process* aProcess( i->second );
if( !aProcess->getStepper() )
{
aProcess->setStepper( getStepper() );
}
}
configureSizeVariable();
}
void MoleculePopulateProcess::populateUniformSparse(Species* aSpecies)
{
Comp* aComp(aSpecies->getComp());
if(!aSpecies->getIsPopulated())
{
if(UniformRadiusX == 1 && UniformRadiusY == 1 && UniformRadiusZ == 1 &&
!OriginX && !OriginY && !OriginZ)
{
unsigned int aSize(aSpecies->getPopulateMoleculeSize());
int availableVoxelSize(aComp->coords.size());
for(unsigned int j(0); j != aSize; ++j)
{
Voxel* aVoxel;
do
{
aVoxel = theSpatiocyteStepper->coord2voxel(
aComp->coords[gsl_rng_uniform_int(
getStepper()->getRng(), availableVoxelSize)]);
}
while(aVoxel->id != aComp->vacantID);
aSpecies->addMolecule(aVoxel);
}
}
else
{
populateUniformRanged(aSpecies);
}
aSpecies->setIsPopulated();
}
}
void Process::initialize()
{
if( !getStepper() )
{
THROW_EXCEPTION_INSIDE( InitializationFailed,
"No stepper is connected with [" +
asString() + "]." );
}
}
virtual void fire()
{
int col(gsl_rng_uniform_int(getStepper()->getRng(),
theComp->maxCol-theComp->minCol-4));
col += theComp->minCol;
theSpatiocyteStepper->growCompartment(theComp, Axis, col);
theTime += theStepInterval;
thePriorityQueue->moveTop();
}
void Model::deleteStepper( String const& anID )
{
Stepper* aStepper( getStepper( anID ) );
if ( !aStepper->getProcessVector().empty() )
{
THROW_EXCEPTION( IllegalOperation,
"Stepper [" + anID + "] is relied on by one or more processes" );
}
aStepper->detach();
}
virtual void initialize()
{
if(isInitialized)
{
return;
}
isInitialized = true;
Process::initialize();
theSpatiocyteStepper = dynamic_cast<SpatiocyteStepper*>(getStepper());
theSortedVariableReferences.resize(theVariableReferenceVector.size());
for(VariableReferenceVector::iterator
i(theVariableReferenceVector.begin());
i != theVariableReferenceVector.end(); ++i)
{
theSortedVariableReferences[(*i).getEllipsisNumber()] = *i;
}
for(VariableReferenceVector::iterator
i(theSortedVariableReferences.begin());
i != theSortedVariableReferences.end(); ++i)
{
Variable* aVariable((*i).getVariable());
// if Name is HD, it is a homogeneously distributed species.
// only create Species for immobile or diffusing species
if(aVariable->getName() != "HD")
{
Species* aSpecies(theSpatiocyteStepper->addSpecies(aVariable));
theProcessSpecies.push_back(aSpecies);
}
if((*i).getCoefficient() > 0)
{
thePositiveVariableReferences.push_back(*i);
}
else if((*i).getCoefficient() < 0)
{
theNegativeVariableReferences.push_back(*i);
}
else
{
theZeroVariableReferences.push_back(*i);
}
}
}
void PolymerizationProcess::removeContPoint(Subunit* aSubunit, Point* aPoint)
{
if(aSubunit->contPoints.size() == 1)
{
--aSubunit->contPointSize[0];
if(!aSubunit->contPointSize[0])
{
aSubunit->contPoints.clear();
aSubunit->contPointSize.clear();
}
return;
}
//If the size of contPoints is more than 1:
else
{
for(unsigned int i(0); i != aSubunit->contPoints.size(); ++i)
{
if(getDistance(&aSubunit->contPoints[i], aPoint) < 0.1)
{
--aSubunit->contPointSize[i];
//If the size of the continuous point is zero, we need to remove
//the point from the contPoints, and update the contPointSize
//list size:
if(!aSubunit->contPointSize[i])
{
//Remove the continuous point:
aSubunit->contPoints[i] = aSubunit->contPoints.back();
aSubunit->contPoints.pop_back();
//Update the size:
aSubunit->contPointSize[i] = aSubunit->contPointSize.back();
aSubunit->contPointSize.pop_back();
}
return;
}
}
}
std::cout << "error in remove contPoint at time:" << getStepper()->getCurrentTime() << std::endl;
}
virtual double getInterval()
{
return getPropensity()*
(-log(gsl_rng_uniform_pos(getStepper()->getRng())));
}
virtual void fire()
{
setFlux( gsl_ran_poisson( getStepper()->getRng(), getPropensity() ) );
}
void MoleculePopulateProcess::populateUniformRanged(Species* aSpecies)
{
Comp* aComp(aSpecies->getComp());
double delta(0);
// Increase the compartment dimensions by delta if it is a surface
// compartment:
if(aComp->dimension == 2)
{
delta = 0.1;
}
double maxX(std::min(1.0, OriginX+UniformRadiusX));
double minX(std::max(-1.0, OriginX-UniformRadiusX));
double maxY(std::min(1.0, OriginY+UniformRadiusY));
double minY(std::max(-1.0, OriginY-UniformRadiusY));
double maxZ(std::min(1.0, OriginZ+UniformRadiusZ));
double minZ(std::max(-1.0, OriginZ-UniformRadiusZ));
maxX = aComp->centerPoint.x + maxX*aComp->lengthX/2*(1+delta);
minX = aComp->centerPoint.x + minX*aComp->lengthX/2*(1+delta);
maxY = aComp->centerPoint.y + maxY*aComp->lengthY/2*(1+delta);
minY = aComp->centerPoint.y + minY*aComp->lengthY/2*(1+delta);
maxZ = aComp->centerPoint.z + maxZ*aComp->lengthZ/2*(1+delta);
minZ = aComp->centerPoint.z + minZ*aComp->lengthZ/2*(1+delta);
std::vector<unsigned int> aCoords;
for(std::vector<unsigned int>::iterator i(aComp->coords.begin());
i != aComp->coords.end(); ++i)
{
Voxel* aVoxel(theSpatiocyteStepper->coord2voxel(*i));
Point aPoint(theSpatiocyteStepper->coord2point(aVoxel->coord));
if(aVoxel->id == aSpecies->getVacantID() &&
aPoint.x < maxX && aPoint.x > minX &&
aPoint.y < maxY && aPoint.y > minY &&
aPoint.z < maxZ && aPoint.z > minZ)
{
aCoords.push_back(*i);
}
}
unsigned int aSize(aSpecies->getPopulateMoleculeSize());
if(aCoords.size() < aSize)
{
THROW_EXCEPTION(ValueError, String(
getPropertyInterface().getClassName()) +
"[" + getFullID().asString() + "]: There are " +
int2str(aSize) + " " + getIDString(aSpecies) +
" molecules that must be uniformly populated in a " +
"given range,\n but there are only " +
int2str(aCoords.size()) + " vacant voxels of " +
getIDString(aSpecies->getVacantSpecies()) +
" that can be populated.");
}
unsigned int aCoordsArray[aCoords.size()];
for(unsigned int i(0); i != aCoords.size(); ++i)
{
aCoordsArray[i] = aCoords[i];
}
gsl_ran_shuffle(getStepper()->getRng(), aCoordsArray, aCoords.size(),
sizeof(unsigned int));
for(unsigned int i(0); i != aSize; ++i)
{
aSpecies->addMolecule(theSpatiocyteStepper->coord2voxel(aCoordsArray[i]));
}
}
GET_METHOD_DEF( Real, StepInterval, GillespieProcess )
{
return getPropensity_R() *
( - log( gsl_rng_uniform_pos( getStepper()->getRng() ) ) );
}
