DwiPhantomGenerationFilter< TOutputScalarType >
::DwiPhantomGenerationFilter()
: m_BValue(1000)
, m_SignalScale(1000)
, m_BaselineImages(0)
, m_MaxBaseline(0)
, m_MeanBaseline(0)
, m_NoiseVariance(0.004)
, m_GreyMatterAdc(0.01)
, m_SimulateBaseline(true)
, m_DefaultBaseline(1000)
{
this->SetNumberOfRequiredOutputs (1);
m_Spacing.Fill(2.5); m_Origin.Fill(0.0);
m_DirectionMatrix.SetIdentity();
m_ImageRegion.SetSize(0, 10);
m_ImageRegion.SetSize(1, 10);
m_ImageRegion.SetSize(2, 10);
typename OutputImageType::Pointer outImage = OutputImageType::New();
outImage->SetSpacing( m_Spacing ); // Set the image spacing
outImage->SetOrigin( m_Origin ); // Set the image origin
outImage->SetDirection( m_DirectionMatrix ); // Set the image direction
outImage->SetLargestPossibleRegion( m_ImageRegion );
outImage->SetBufferedRegion( m_ImageRegion );
outImage->SetRequestedRegion( m_ImageRegion );
outImage->SetVectorLength(QBALL_ODFSIZE);
outImage->Allocate();
outImage->FillBuffer(0);
this->SetNthOutput (0, outImage);
}
void
DicomDiffusionImageReader<TPixelType, TDimension>
::EnlargeOutputRequestedRegion(itk::DataObject *output)
{
typename OutputImageType::Pointer out = dynamic_cast<OutputImageType*>(output);
out->SetRequestedRegion( out->GetLargestPossibleRegion() );
}
void FieldmapGeneratorFilter< OutputImageType >::ThreadedGenerateData( const OutputImageRegionType &outputRegionForThread, ThreadIdType threadId)
{
typename OutputImageType::Pointer outImage = static_cast< OutputImageType * >(this->ProcessObject::GetOutput(0));
ImageRegionIterator< OutputImageType > oit(outImage, outputRegionForThread);
while( !oit.IsAtEnd() )
{
double value = 0;
IndexType idx = oit.GetIndex();
for (int i=0; i<3; i++)
value += idx[i]*m_Gradient[i] + m_Offset[i];
for (int i=0; i<m_WorldPositions.size(); i++)
{
mitk::Point3D c = m_WorldPositions.at(i);
itk::Point<double, 3> vertex;
outImage->TransformIndexToPhysicalPoint(idx, vertex);
double dist = c.EuclideanDistanceTo(vertex);
value += m_Heights.at(i)*exp(-dist*dist/(2*m_Variances.at(i)));
}
oit.Set(value);
++oit;
}
MITK_INFO << "Thread " << threadId << "finished processing";
}
void FieldmapGeneratorFilter< OutputImageType >::BeforeThreadedGenerateData()
{
typename OutputImageType::Pointer outImage = OutputImageType::New();
outImage->SetSpacing( m_Spacing );
outImage->SetOrigin( m_Origin );
outImage->SetDirection( m_DirectionMatrix );
outImage->SetLargestPossibleRegion( m_ImageRegion );
outImage->SetBufferedRegion( m_ImageRegion );
outImage->SetRequestedRegion( m_ImageRegion );
outImage->Allocate();
outImage->FillBuffer(0);
this->SetNthOutput(0, outImage);
}
void DicomDiffusionImageReader<TPixelType, TDimension>
::GenerateOutputInformation(void)
{
typename OutputImageType::Pointer output = this->GetOutput();
typedef itk::ImageSeriesReader<InputImageType> ReaderType;
// Read the first (or last) volume and use its size.
if (m_Headers.size() > 0)
{
typename ReaderType::Pointer reader = ReaderType::New();
try
{
// Read the image
reader->SetFileNames (m_Headers[0]->m_DicomFilenames);
reader->UpdateOutputInformation();
output->SetSpacing( reader->GetOutput()->GetSpacing() ); // Set the image spacing
output->SetOrigin( reader->GetOutput()->GetOrigin() ); // Set the image origin
output->SetDirection( reader->GetOutput()->GetDirection() ); // Set the image direction
output->SetLargestPossibleRegion( reader->GetOutput()->GetLargestPossibleRegion() );
output->SetVectorLength( m_Headers.size() );
}
catch (itk::ExceptionObject &e)
{
throw e;
}
}
else
{
itkExceptionMacro(<< "At least one filename is required." );
}
}
void TractsToFiberEndingsImageFilter< TInputImage, TOutputPixelType >
::GenerateData()
{
MITK_INFO << "Generating 2D fiber endings image";
if(&typeid(TOutputPixelType) != &typeid(unsigned char))
{
MITK_INFO << "Only 'unsigned char' and 'itk::RGBAPixel<unsigned char> supported as OutputPixelType";
return;
}
mitk::Geometry3D::Pointer geometry = m_FiberBundle->GetGeometry();
typename OutputImageType::Pointer outImage =
static_cast< OutputImageType * >(this->ProcessObject::GetOutput(0));
outImage->SetSpacing( geometry->GetSpacing()/m_UpsamplingFactor ); // Set the image spacing
mitk::Point3D origin = geometry->GetOrigin();
mitk::Point3D indexOrigin;
geometry->WorldToIndex(origin, indexOrigin);
indexOrigin[0] = indexOrigin[0] - .5 * (1.0-1.0/m_UpsamplingFactor);
indexOrigin[1] = indexOrigin[1] - .5 * (1.0-1.0/m_UpsamplingFactor);
indexOrigin[2] = indexOrigin[2] - .5 * (1.0-1.0/m_UpsamplingFactor);
mitk::Point3D newOrigin;
geometry->IndexToWorld(indexOrigin, newOrigin);
outImage->SetOrigin( newOrigin ); // Set the image origin
itk::Matrix<double, 3, 3> matrix;
for (int i=0; i<3; i++)
for (int j=0; j<3; j++)
matrix[j][i] = geometry->GetMatrixColumn(i)[j]/geometry->GetSpacing().GetElement(i);
outImage->SetDirection( matrix ); // Set the image direction
float* bounds = m_FiberBundle->GetBounds();
ImageRegion<3> upsampledRegion;
upsampledRegion.SetSize(0, bounds[0]);
upsampledRegion.SetSize(1, bounds[1]);
upsampledRegion.SetSize(2, bounds[2]);
typename InputImageType::RegionType::SizeType upsampledSize = upsampledRegion.GetSize();
for (unsigned int n = 0; n < 3; n++)
{
upsampledSize[n] = upsampledSize[n] * m_UpsamplingFactor;
}
upsampledRegion.SetSize( upsampledSize );
outImage->SetRegions( upsampledRegion );
outImage->Allocate();
int w = upsampledSize[0];
int h = upsampledSize[1];
int d = upsampledSize[2];
unsigned char* accuout;
accuout = reinterpret_cast<unsigned char*>(outImage->GetBufferPointer());
for (int i=0; i<w*h*d; i++) accuout[i] = 0;
typedef mitk::FiberBundle::ContainerTractType ContainerTractType;
typedef mitk::FiberBundle::ContainerType ContainerType;
typedef mitk::FiberBundle::ContainerPointType ContainerPointType;
ContainerType::Pointer tractContainer = m_FiberBundle->GetTractContainer();
for (int i=0; i<tractContainer->Size(); i++)
{
ContainerTractType::Pointer tract = tractContainer->GetElement(i);
int tractsize = tract->Size();
if (tractsize>1)
{
ContainerPointType start = tract->GetElement(0);
ContainerPointType end = tract->GetElement(tractsize-1);
start[0] = (start[0]+0.5) * m_UpsamplingFactor;
start[1] = (start[1]+0.5) * m_UpsamplingFactor;
start[2] = (start[2]+0.5) * m_UpsamplingFactor;
// int coordinates inside image?
int px = (int) (start[0]);
if (px < 0 || px >= w)
continue;
int py = (int) (start[1]);
if (py < 0 || py >= h)
continue;
int pz = (int) (start[2]);
if (pz < 0 || pz >= d)
continue;
accuout[( px + w*(py + h*pz ))] += 1;
end[0] = (end[0]+0.5) * m_UpsamplingFactor;
end[1] = (end[1]+0.5) * m_UpsamplingFactor;
end[2] = (end[2]+0.5) * m_UpsamplingFactor;
// int coordinates inside image?
px = (int) (end[0]);
if (px < 0 || px >= w)
continue;
py = (int) (end[1]);
if (py < 0 || py >= h)
continue;
pz = (int) (end[2]);
if (pz < 0 || pz >= d)
continue;
accuout[( px + w*(py + h*pz ))] += 1;
}
}
MITK_INFO << "2D fiber endings image generated";
}
void TractDensityImageFilter< OutputImageType >::GenerateData()
{
// generate upsampled image
mitk::Geometry3D::Pointer geometry = m_FiberBundle->GetGeometry();
typename OutputImageType::Pointer outImage = this->GetOutput();
// calculate new image parameters
mitk::Vector3D newSpacing;
mitk::Point3D newOrigin;
itk::Matrix<double, 3, 3> newDirection;
ImageRegion<3> upsampledRegion;
if (m_UseImageGeometry && !m_InputImage.IsNull())
{
MITK_INFO << "TractDensityImageFilter: using image geometry";
newSpacing = m_InputImage->GetSpacing()/m_UpsamplingFactor;
upsampledRegion = m_InputImage->GetLargestPossibleRegion();
newOrigin = m_InputImage->GetOrigin();
typename OutputImageType::RegionType::SizeType size = upsampledRegion.GetSize();
size[0] *= m_UpsamplingFactor;
size[1] *= m_UpsamplingFactor;
size[2] *= m_UpsamplingFactor;
upsampledRegion.SetSize(size);
newDirection = m_InputImage->GetDirection();
}
else
{
MITK_INFO << "TractDensityImageFilter: using fiber bundle geometry";
newSpacing = geometry->GetSpacing()/m_UpsamplingFactor;
newOrigin = geometry->GetOrigin();
mitk::Geometry3D::BoundsArrayType bounds = geometry->GetBounds();
newOrigin[0] += bounds.GetElement(0);
newOrigin[1] += bounds.GetElement(2);
newOrigin[2] += bounds.GetElement(4);
for (int i=0; i<3; i++)
for (int j=0; j<3; j++)
newDirection[j][i] = geometry->GetMatrixColumn(i)[j];
upsampledRegion.SetSize(0, geometry->GetExtent(0)*m_UpsamplingFactor);
upsampledRegion.SetSize(1, geometry->GetExtent(1)*m_UpsamplingFactor);
upsampledRegion.SetSize(2, geometry->GetExtent(2)*m_UpsamplingFactor);
}
typename OutputImageType::RegionType::SizeType upsampledSize = upsampledRegion.GetSize();
// apply new image parameters
outImage->SetSpacing( newSpacing );
outImage->SetOrigin( newOrigin );
outImage->SetDirection( newDirection );
outImage->SetRegions( upsampledRegion );
outImage->Allocate();
outImage->FillBuffer(0.0);
int w = upsampledSize[0];
int h = upsampledSize[1];
int d = upsampledSize[2];
// set/initialize output
OutPixelType* outImageBufferPointer = (OutPixelType*)outImage->GetBufferPointer();
// resample fiber bundle
float minSpacing = 1;
if(newSpacing[0]<newSpacing[1] && newSpacing[0]<newSpacing[2])
minSpacing = newSpacing[0];
else if (newSpacing[1] < newSpacing[2])
minSpacing = newSpacing[1];
else
minSpacing = newSpacing[2];
MITK_INFO << "TractDensityImageFilter: resampling fibers to ensure sufficient voxel coverage";
m_FiberBundle = m_FiberBundle->GetDeepCopy();
m_FiberBundle->ResampleFibers(minSpacing);
MITK_INFO << "TractDensityImageFilter: starting image generation";
vtkSmartPointer<vtkPolyData> fiberPolyData = m_FiberBundle->GetFiberPolyData();
vtkSmartPointer<vtkCellArray> vLines = fiberPolyData->GetLines();
vLines->InitTraversal();
int numFibers = m_FiberBundle->GetNumFibers();
boost::progress_display disp(numFibers);
for( int i=0; i<numFibers; i++ )
{
++disp;
vtkIdType numPoints(0);
vtkIdType* points(NULL);
vLines->GetNextCell ( numPoints, points );
// fill output image
for( int j=0; j<numPoints; j++)
{
itk::Point<float, 3> vertex = GetItkPoint(fiberPolyData->GetPoint(points[j]));
itk::Index<3> index;
itk::ContinuousIndex<float, 3> contIndex;
outImage->TransformPhysicalPointToIndex(vertex, index);
outImage->TransformPhysicalPointToContinuousIndex(vertex, contIndex);
float frac_x = contIndex[0] - index[0];
float frac_y = contIndex[1] - index[1];
float frac_z = contIndex[2] - index[2];
if (frac_x<0)
{
index[0] -= 1;
frac_x += 1;
}
if (frac_y<0)
{
index[1] -= 1;
frac_y += 1;
}
if (frac_z<0)
{
index[2] -= 1;
frac_z += 1;
}
frac_x = 1-frac_x;
frac_y = 1-frac_y;
frac_z = 1-frac_z;
// int coordinates inside image?
if (index[0] < 0 || index[0] >= w-1)
continue;
if (index[1] < 0 || index[1] >= h-1)
continue;
if (index[2] < 0 || index[2] >= d-1)
continue;
if (m_BinaryOutput)
{
outImageBufferPointer[( index[0] + w*(index[1] + h*index[2] ))] = 1;
outImageBufferPointer[( index[0] + w*(index[1]+1+ h*index[2] ))] = 1;
outImageBufferPointer[( index[0] + w*(index[1] + h*index[2]+h))] = 1;
outImageBufferPointer[( index[0] + w*(index[1]+1+ h*index[2]+h))] = 1;
outImageBufferPointer[( index[0]+1 + w*(index[1] + h*index[2] ))] = 1;
outImageBufferPointer[( index[0]+1 + w*(index[1] + h*index[2]+h))] = 1;
outImageBufferPointer[( index[0]+1 + w*(index[1]+1+ h*index[2] ))] = 1;
outImageBufferPointer[( index[0]+1 + w*(index[1]+1+ h*index[2]+h))] = 1;
}
else
{
outImageBufferPointer[( index[0] + w*(index[1] + h*index[2] ))] += ( frac_x)*( frac_y)*( frac_z);
outImageBufferPointer[( index[0] + w*(index[1]+1+ h*index[2] ))] += ( frac_x)*(1-frac_y)*( frac_z);
outImageBufferPointer[( index[0] + w*(index[1] + h*index[2]+h))] += ( frac_x)*( frac_y)*(1-frac_z);
outImageBufferPointer[( index[0] + w*(index[1]+1+ h*index[2]+h))] += ( frac_x)*(1-frac_y)*(1-frac_z);
outImageBufferPointer[( index[0]+1 + w*(index[1] + h*index[2] ))] += (1-frac_x)*( frac_y)*( frac_z);
outImageBufferPointer[( index[0]+1 + w*(index[1] + h*index[2]+h))] += (1-frac_x)*( frac_y)*(1-frac_z);
outImageBufferPointer[( index[0]+1 + w*(index[1]+1+ h*index[2] ))] += (1-frac_x)*(1-frac_y)*( frac_z);
outImageBufferPointer[( index[0]+1 + w*(index[1]+1+ h*index[2]+h))] += (1-frac_x)*(1-frac_y)*(1-frac_z);
}
}
}
if (!m_OutputAbsoluteValues && !m_BinaryOutput)
{
MITK_INFO << "TractDensityImageFilter: max-normalizing output image";
OutPixelType max = 0;
for (int i=0; i<w*h*d; i++)
if (max < outImageBufferPointer[i])
max = outImageBufferPointer[i];
if (max>0)
for (int i=0; i<w*h*d; i++)
outImageBufferPointer[i] /= max;
}
if (m_InvertImage)
{
MITK_INFO << "TractDensityImageFilter: inverting image";
for (int i=0; i<w*h*d; i++)
outImageBufferPointer[i] = 1-outImageBufferPointer[i];
}
MITK_INFO << "TractDensityImageFilter: finished processing";
}
void TractsToProbabilityImageFilter< TInputImage, TOutputPixelType >
::GenerateData()
{
bool isRgba = false;
if(&typeid(TOutputPixelType) == &typeid(itk::RGBAPixel<unsigned char>))
{
isRgba = true;
}
else if(&typeid(TOutputPixelType) != &typeid(unsigned char))
{
MITK_INFO << "Only 'unsigned char' and 'itk::RGBAPixel<unsigned char> supported as OutputPixelType";
return;
}
mitk::Geometry3D::Pointer geometry = m_FiberBundle->GetGeometry();
typename OutputImageType::Pointer outImage =
static_cast< OutputImageType * >(this->ProcessObject::GetOutput(0));
outImage->SetSpacing( geometry->GetSpacing()/m_UpsamplingFactor ); // Set the image spacing
mitk::Point3D origin = geometry->GetOrigin();
mitk::Point3D indexOrigin;
geometry->WorldToIndex(origin, indexOrigin);
indexOrigin[0] = indexOrigin[0] - .5 * (1.0-1.0/m_UpsamplingFactor);
indexOrigin[1] = indexOrigin[1] - .5 * (1.0-1.0/m_UpsamplingFactor);
indexOrigin[2] = indexOrigin[2] - .5 * (1.0-1.0/m_UpsamplingFactor);
mitk::Point3D newOrigin;
geometry->IndexToWorld(indexOrigin, newOrigin);
outImage->SetOrigin( newOrigin ); // Set the image origin
itk::Matrix<double, 3, 3> matrix;
for (int i=0; i<3; i++)
for (int j=0; j<3; j++)
matrix[j][i] = geometry->GetMatrixColumn(i)[j]/geometry->GetSpacing().GetElement(i);
outImage->SetDirection( matrix ); // Set the image direction
float* bounds = m_FiberBundle->GetBounds();
ImageRegion<3> upsampledRegion;
upsampledRegion.SetSize(0, bounds[0]);
upsampledRegion.SetSize(1, bounds[1]);
upsampledRegion.SetSize(2, bounds[2]);
typename InputImageType::RegionType::SizeType upsampledSize = upsampledRegion.GetSize();
for (unsigned int n = 0; n < 3; n++)
{
upsampledSize[n] = upsampledSize[n] * m_UpsamplingFactor;
}
upsampledRegion.SetSize( upsampledSize );
outImage->SetRegions( upsampledRegion );
outImage->Allocate();
// itk::RGBAPixel<unsigned char> pix;
// pix.Set(0,0,0,0);
// outImage->FillBuffer(pix);
int w = upsampledSize[0];
int h = upsampledSize[1];
int d = upsampledSize[2];
unsigned char* accuout;
float* accu;
accuout = reinterpret_cast<unsigned char*>(outImage->GetBufferPointer());
if(isRgba)
{
// accuout = static_cast<unsigned char*>( outImage->GetBufferPointer()[0].GetDataPointer());
accu = new float[w*h*d*4];
for (int i=0; i<w*h*d*4; i++) accu[i] = 0;
}
else
{
accu = new float[w*h*d];
for (int i=0; i<w*h*d; i++) accu[i] = 0;
}
// for each tract
int numTracts = m_FiberBundle->GetNumTracts();
for( int i=0; i<numTracts; i++ )
{
////////////////////
// upsampling
std::vector< itk::Point<float, 3> > vertices;
// for each vertex
int numVertices = m_FiberBundle->GetNumPoints(i);
for( int j=0; j<numVertices-1; j++)
{
itk::Point<float, 3> point = m_FiberBundle->GetPoint(i,j);
itk::Point<float, 3> nextPoint = m_FiberBundle->GetPoint(i,j+1);
point[0] += 0.5 - 0.5/m_UpsamplingFactor;
point[1] += 0.5 - 0.5/m_UpsamplingFactor;
point[2] += 0.5 - 0.5/m_UpsamplingFactor;
nextPoint[0] += 0.5 - 0.5/m_UpsamplingFactor;
nextPoint[1] += 0.5 - 0.5/m_UpsamplingFactor;
nextPoint[2] += 0.5 - 0.5/m_UpsamplingFactor;
for(int k=1; k<=m_UpsamplingFactor; k++)
{
itk::Point<float, 3> newPoint;
newPoint[0] = point[0] + ((double)k/(double)m_UpsamplingFactor)*(nextPoint[0]-point[0]);
newPoint[1] = point[1] + ((double)k/(double)m_UpsamplingFactor)*(nextPoint[1]-point[1]);
newPoint[2] = point[2] + ((double)k/(double)m_UpsamplingFactor)*(nextPoint[2]-point[2]);
vertices.push_back(newPoint);
}
}
////////////////////
// calc directions (which are used as weights)
std::list< itk::Point<float, 3> > rgbweights;
std::list<float> intensities;
// for each vertex
numVertices = vertices.size();
for( int j=0; j<numVertices-1; j++)
{
itk::Point<float, 3> vertex = vertices.at(j);
itk::Point<float, 3> vertexPost = vertices.at(j+1);
itk::Point<float, 3> dir;
dir[0] = fabs((vertexPost[0] - vertex[0]) * outImage->GetSpacing()[0]);
dir[1] = fabs((vertexPost[1] - vertex[1]) * outImage->GetSpacing()[1]);
dir[2] = fabs((vertexPost[2] - vertex[2]) * outImage->GetSpacing()[2]);
if(isRgba)
{
rgbweights.push_back(dir);
}
float intensity = sqrt(dir[0]*dir[0]+dir[1]*dir[1]+dir[2]*dir[2]);
intensities.push_back(intensity);
// last point gets same as previous one
if(j==numVertices-2)
{
if(isRgba)
{
rgbweights.push_back(dir);
}
intensities.push_back(intensity);
}
}
////////////////////
// fill output image
// for each vertex
for( int j=0; j<numVertices; j++)
{
itk::Point<float, 3> vertex = vertices.at(j);
itk::Point<float, 3> rgbweight;
if(isRgba)
{
rgbweight = rgbweights.front();
rgbweights.pop_front();
}
float intweight = intensities.front();
intensities.pop_front();
// scaling coordinates (index coords scale with upsampling)
vertex[0] = vertex[0] * m_UpsamplingFactor;
vertex[1] = vertex[1] * m_UpsamplingFactor;
vertex[2] = vertex[2] * m_UpsamplingFactor;
// int coordinates inside image?
int px = (int) (vertex[0]);
if (px < 0 || px >= w-1)
continue;
int py = (int) (vertex[1]);
if (py < 0 || py >= h-1)
continue;
int pz = (int) (vertex[2]);
if (pz < 0 || pz >= d-1)
continue;
// float fraction of coordinates
float frac_x = vertex[0] - px;
float frac_y = vertex[1] - py;
float frac_z = vertex[2] - pz;
float scale = 100 * pow((float)m_UpsamplingFactor,3);
if(isRgba)
{
// add to r-channel in output image
accu[0+4*( px + w*(py + h*pz ))] += (1-frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[0] * scale;
accu[0+4*( px + w*(py+1+ h*pz ))] += (1-frac_x)*( frac_y)*(1-frac_z) * rgbweight[0] * scale;
accu[0+4*( px + w*(py + h*pz+h))] += (1-frac_x)*(1-frac_y)*( frac_z) * rgbweight[0] * scale;
accu[0+4*( px + w*(py+1+ h*pz+h))] += (1-frac_x)*( frac_y)*( frac_z) * rgbweight[0] * scale;
accu[0+4*( px+1 + w*(py + h*pz ))] += ( frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[0] * scale;
accu[0+4*( px+1 + w*(py + h*pz+h))] += ( frac_x)*(1-frac_y)*( frac_z) * rgbweight[0] * scale;
accu[0+4*( px+1 + w*(py+1+ h*pz ))] += ( frac_x)*( frac_y)*(1-frac_z) * rgbweight[0] * scale;
accu[0+4*( px+1 + w*(py+1+ h*pz+h))] += ( frac_x)*( frac_y)*( frac_z) * rgbweight[0] * scale;
// add to g-channel in output image
accu[1+4*( px + w*(py + h*pz ))] += (1-frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[1] * scale;
accu[1+4*( px + w*(py+1+ h*pz ))] += (1-frac_x)*( frac_y)*(1-frac_z) * rgbweight[1] * scale;
accu[1+4*( px + w*(py + h*pz+h))] += (1-frac_x)*(1-frac_y)*( frac_z) * rgbweight[1] * scale;
accu[1+4*( px + w*(py+1+ h*pz+h))] += (1-frac_x)*( frac_y)*( frac_z) * rgbweight[1] * scale;
accu[1+4*( px+1 + w*(py + h*pz ))] += ( frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[1] * scale;
accu[1+4*( px+1 + w*(py + h*pz+h))] += ( frac_x)*(1-frac_y)*( frac_z) * rgbweight[1] * scale;
accu[1+4*( px+1 + w*(py+1+ h*pz ))] += ( frac_x)*( frac_y)*(1-frac_z) * rgbweight[1] * scale;
accu[1+4*( px+1 + w*(py+1+ h*pz+h))] += ( frac_x)*( frac_y)*( frac_z) * rgbweight[1] * scale;
// add to b-channel in output image
accu[2+4*( px + w*(py + h*pz ))] += (1-frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[2] * scale;
accu[2+4*( px + w*(py+1+ h*pz ))] += (1-frac_x)*( frac_y)*(1-frac_z) * rgbweight[2] * scale;
accu[2+4*( px + w*(py + h*pz+h))] += (1-frac_x)*(1-frac_y)*( frac_z) * rgbweight[2] * scale;
accu[2+4*( px + w*(py+1+ h*pz+h))] += (1-frac_x)*( frac_y)*( frac_z) * rgbweight[2] * scale;
accu[2+4*( px+1 + w*(py + h*pz ))] += ( frac_x)*(1-frac_y)*(1-frac_z) * rgbweight[2] * scale;
accu[2+4*( px+1 + w*(py + h*pz+h))] += ( frac_x)*(1-frac_y)*( frac_z) * rgbweight[2] * scale;
accu[2+4*( px+1 + w*(py+1+ h*pz ))] += ( frac_x)*( frac_y)*(1-frac_z) * rgbweight[2] * scale;
accu[2+4*( px+1 + w*(py+1+ h*pz+h))] += ( frac_x)*( frac_y)*( frac_z) * rgbweight[2] * scale;
// add to a-channel in output image
accu[3+4*( px + w*(py + h*pz ))] += (1-frac_x)*(1-frac_y)*(1-frac_z) * intweight * scale;
accu[3+4*( px + w*(py+1+ h*pz ))] += (1-frac_x)*( frac_y)*(1-frac_z) * intweight * scale;
accu[3+4*( px + w*(py + h*pz+h))] += (1-frac_x)*(1-frac_y)*( frac_z) * intweight * scale;
accu[3+4*( px + w*(py+1+ h*pz+h))] += (1-frac_x)*( frac_y)*( frac_z) * intweight * scale;
accu[3+4*( px+1 + w*(py + h*pz ))] += ( frac_x)*(1-frac_y)*(1-frac_z) * intweight * scale;
accu[3+4*( px+1 + w*(py + h*pz+h))] += ( frac_x)*(1-frac_y)*( frac_z) * intweight * scale;
accu[3+4*( px+1 + w*(py+1+ h*pz ))] += ( frac_x)*( frac_y)*(1-frac_z) * intweight * scale;
accu[3+4*( px+1 + w*(py+1+ h*pz+h))] += ( frac_x)*( frac_y)*( frac_z) * intweight * scale;
}
else if (m_BinaryEnvelope)
{
accu[( px + w*(py + h*pz ))] = 1;
accu[( px + w*(py+1+ h*pz ))] = 1;
accu[( px + w*(py + h*pz+h))] = 1;
accu[( px + w*(py+1+ h*pz+h))] = 1;
accu[( px+1 + w*(py + h*pz ))] = 1;
accu[( px+1 + w*(py + h*pz+h))] = 1;
accu[( px+1 + w*(py+1+ h*pz ))] = 1;
accu[( px+1 + w*(py+1+ h*pz+h))] = 1;
}
else
{
accu[( px + w*(py + h*pz ))] += (1-frac_x)*(1-frac_y)*(1-frac_z) * intweight * scale;
accu[( px + w*(py+1+ h*pz ))] += (1-frac_x)*( frac_y)*(1-frac_z) * intweight * scale;
accu[( px + w*(py + h*pz+h))] += (1-frac_x)*(1-frac_y)*( frac_z) * intweight * scale;
accu[( px + w*(py+1+ h*pz+h))] += (1-frac_x)*( frac_y)*( frac_z) * intweight * scale;
accu[( px+1 + w*(py + h*pz ))] += ( frac_x)*(1-frac_y)*(1-frac_z) * intweight * scale;
accu[( px+1 + w*(py + h*pz+h))] += ( frac_x)*(1-frac_y)*( frac_z) * intweight * scale;
accu[( px+1 + w*(py+1+ h*pz ))] += ( frac_x)*( frac_y)*(1-frac_z) * intweight * scale;
accu[( px+1 + w*(py+1+ h*pz+h))] += ( frac_x)*( frac_y)*( frac_z) * intweight * scale;
}
}
}
float maxRgb = 0.000000001;
float maxInt = 0.000000001;
int numPix;
if(isRgba)
{
numPix = w*h*d*4;
// calc maxima
for(int i=0; i<numPix; i++)
{
if((i-3)%4 != 0)
{
if(accu[i] > maxRgb)
{
maxRgb = accu[i];
}
}
else
{
if(accu[i] > maxInt)
{
maxInt = accu[i];
}
}
}
// write output, normalized uchar 0..255
for(int i=0; i<numPix; i++)
{
if((i-3)%4 != 0)
{
accuout[i] = (unsigned char) (255.0 * accu[i] / maxRgb);
}
else
{
accuout[i] = (unsigned char) (255.0 * accu[i] / maxInt);
}
}
}
else if (m_BinaryEnvelope)
{
numPix = w*h*d;
// write output, normalized uchar 0..255
for(int i=0; i<numPix; i++)
{
if(m_InvertImage)
{
accuout[i] = (unsigned char) ((int)(accu[i]+1)%2);
}
else
{
accuout[i] = (unsigned char) accu[i];
}
}
}
else
{
numPix = w*h*d;
// calc maxima
for(int i=0; i<numPix; i++)
{
if(accu[i] > maxInt)
{
maxInt = accu[i];
}
}
// write output, normalized uchar 0..255
for(int i=0; i<numPix; i++)
{
accuout[i] = (unsigned char) (255.0 * accu[i] / maxInt);
}
}
delete[] accu;
}
void DicomDiffusionImageReader<TPixelType, TDimension>
::GenerateData()
{
typedef itk::ImageSeriesReader<InputImageType> ReaderType;
typename OutputImageType::Pointer output = this->GetOutput();
typedef typename OutputImageType::RegionType RegionType;
RegionType requestedRegion = output->GetRequestedRegion();
// Each file must have the same size.
SizeType validSize = requestedRegion.GetSize();
int numberOfVolumes = static_cast<int>(m_Headers.size());
// Allocate the output buffer
output->SetBufferedRegion( requestedRegion );
output->Allocate();
itk::ProgressReporter progress(this, 0,
m_Headers.size(),
m_Headers.size());
itk::ImageRegionIterator<OutputImageType> ot (output, requestedRegion );
// Clear the eventual previous content of the MetaDictionary array
//if( m_MetaDataDictionaryArray.size() )
// {
// for(unsigned int i=0; i<m_MetaDataDictionaryArray.size(); i++)
// {
// // each element is a raw pointer, delete them.
// delete m_MetaDataDictionaryArray[i];
// }
// }
//m_MetaDataDictionaryArray.clear();
typename OutputImageType::PixelType vec;
for (int i = 0; i < numberOfVolumes; i ++)
{
MITK_INFO << "Loading volume " << i+1 << "/" << numberOfVolumes;
typename ReaderType::Pointer reader = ReaderType::New();
reader->SetFileNames(m_Headers[i]->m_DicomFilenames);
reader->UpdateLargestPossibleRegion();
if (reader->GetOutput()->GetRequestedRegion().GetSize() != validSize)
{
itkExceptionMacro(<< "Size mismatch!");
}
itk::ImageRegionConstIterator<InputImageType> it (reader->GetOutput(),
reader->GetOutput()->GetLargestPossibleRegion());
while (!it.IsAtEnd())
{
vec = ot.Get();
vec.SetElement(i, it.Get());
ot.Set(vec);
++it;
++ot;
}
ot = ot.Begin();
progress.CompletedPixel();
}
void mitk::RegionGrowingTool::StartRegionGrowing(itk::Image<TPixel, imageDimension>* inputImage, itk::Index<imageDimension> seedIndex, std::array<ScalarType, 2> thresholds, mitk::Image::Pointer& outputImage)
{
MITK_DEBUG << "Starting region growing at index " << seedIndex << " with lower threshold " << thresholds[0] << " and upper threshold " << thresholds[1];
typedef itk::Image<TPixel, imageDimension> InputImageType;
typedef itk::Image<DefaultSegmentationDataType, imageDimension> OutputImageType;
typedef itk::ConnectedThresholdImageFilter<InputImageType, OutputImageType> RegionGrowingFilterType;
typename RegionGrowingFilterType::Pointer regionGrower = RegionGrowingFilterType::New();
// perform region growing in desired segmented region
regionGrower->SetInput(inputImage);
regionGrower->AddSeed(seedIndex);
regionGrower->SetLower(thresholds[0]);
regionGrower->SetUpper(thresholds[1]);
try
{
regionGrower->Update();
}
catch(...)
{
return; // Should we do something?
}
typename OutputImageType::Pointer resultImage = regionGrower->GetOutput();
// Smooth result: Every pixel is replaced by the majority of the neighborhood
typedef itk::NeighborhoodIterator<OutputImageType> NeighborhoodIteratorType;
typedef itk::ImageRegionIterator<OutputImageType> ImageIteratorType;
typename NeighborhoodIteratorType::RadiusType radius;
radius.Fill(2); // for now, maybe make this something the user can adjust in the preferences?
NeighborhoodIteratorType neighborhoodIterator(radius, resultImage, resultImage->GetRequestedRegion());
ImageIteratorType imageIterator(resultImage, resultImage->GetRequestedRegion());
for (neighborhoodIterator.GoToBegin(), imageIterator.GoToBegin(); !neighborhoodIterator.IsAtEnd(); ++neighborhoodIterator, ++imageIterator)
{
DefaultSegmentationDataType voteYes(0);
DefaultSegmentationDataType voteNo(0);
for (unsigned int i = 0; i < neighborhoodIterator.Size(); ++i)
{
if (neighborhoodIterator.GetPixel(i) > 0)
{
voteYes += 1;
}
else
{
voteNo += 1;
}
}
if (voteYes > voteNo)
{
imageIterator.Set(1);
}
else
{
imageIterator.Set(0);
}
}
if (resultImage.IsNull())
{
MITK_DEBUG << "Region growing result is empty.";
}
// Can potentially have multiple regions, use connected component image filter to label disjunct regions
typedef itk::ConnectedComponentImageFilter<OutputImageType, OutputImageType> ConnectedComponentImageFilterType;
typename ConnectedComponentImageFilterType::Pointer connectedComponentFilter = ConnectedComponentImageFilterType::New();
connectedComponentFilter->SetInput(resultImage);
connectedComponentFilter->Update();
typename OutputImageType::Pointer resultImageCC = connectedComponentFilter->GetOutput();
m_ConnectedComponentValue = resultImageCC->GetPixel(seedIndex);
outputImage = mitk::GrabItkImageMemory(resultImageCC);
}
void ExtractChannelFromRgbaImageFilter< ReferenceImageType, OutputImageType >::GenerateData()
{
typename InputImageType::Pointer rgbaImage = static_cast< InputImageType * >( this->ProcessObject::GetInput(0) );
typename OutputImageType::Pointer outputImage =
static_cast< OutputImageType * >(this->ProcessObject::GetOutput(0));
typename InputImageType::RegionType region = rgbaImage->GetLargestPossibleRegion();
outputImage->SetSpacing( m_ReferenceImage->GetSpacing() ); // Set the image spacing
outputImage->SetOrigin( m_ReferenceImage->GetOrigin() ); // Set the image origin
outputImage->SetDirection( m_ReferenceImage->GetDirection() ); // Set the image direction
outputImage->SetRegions( m_ReferenceImage->GetLargestPossibleRegion());
outputImage->Allocate();
outputImage->FillBuffer(0);
float* outImageBufferPointer = outputImage->GetBufferPointer();
itk::Image< short, 3 >::Pointer counterImage = itk::Image< short, 3 >::New();
counterImage->SetSpacing( m_ReferenceImage->GetSpacing() ); // Set the image spacing
counterImage->SetOrigin( m_ReferenceImage->GetOrigin() ); // Set the image origin
counterImage->SetDirection( m_ReferenceImage->GetDirection() ); // Set the image direction
counterImage->SetRegions( m_ReferenceImage->GetLargestPossibleRegion());
counterImage->Allocate();
counterImage->FillBuffer(0);
short* counterImageBufferPointer = counterImage->GetBufferPointer();
int w = m_ReferenceImage->GetLargestPossibleRegion().GetSize().GetElement(0);
int h = m_ReferenceImage->GetLargestPossibleRegion().GetSize().GetElement(1);
int d = m_ReferenceImage->GetLargestPossibleRegion().GetSize().GetElement(2);
typedef ImageRegionConstIterator< InputImageType > InImageIteratorType;
InImageIteratorType rgbaIt(rgbaImage, region);
rgbaIt.GoToBegin();
while(!rgbaIt.IsAtEnd()){
InPixelType x = rgbaIt.Get();
++rgbaIt;
itk::Point<float, 3> vertex;
itk::Index<3> index = rgbaIt.GetIndex();
rgbaImage->TransformIndexToPhysicalPoint(index, vertex);
outputImage->TransformPhysicalPointToIndex(vertex, index);
itk::ContinuousIndex<float, 3> contIndex;
outputImage->TransformPhysicalPointToContinuousIndex(vertex, contIndex);
float frac_x = contIndex[0] - index[0];
float frac_y = contIndex[1] - index[1];
float frac_z = contIndex[2] - index[2];
int px = index[0];
if (frac_x<0)
{
px -= 1;
frac_x += 1;
}
int py = index[1];
if (frac_y<0)
{
py -= 1;
frac_y += 1;
}
int pz = index[2];
if (frac_z<0)
{
pz -= 1;
frac_z += 1;
}
frac_x = 1-frac_x;
frac_y = 1-frac_y;
frac_z = 1-frac_z;
// int coordinates inside image?
if (px < 0 || px >= w-1)
continue;
if (py < 0 || py >= h-1)
continue;
if (pz < 0 || pz >= d-1)
continue;
OutPixelType out;
switch (m_Channel)
{
case RED:
out = (float)x.GetRed()/255;
break;
case GREEN:
out = (float)x.GetGreen()/255;
break;
case BLUE:
out = (float)x.GetBlue()/255;
break;
case ALPHA:
out = (float)x.GetAlpha()/255;
}
outImageBufferPointer[( px + w*(py + h*pz ))] += out*( frac_x)*( frac_y)*( frac_z);
outImageBufferPointer[( px + w*(py+1+ h*pz ))] += out*( frac_x)*(1-frac_y)*( frac_z);
outImageBufferPointer[( px + w*(py + h*pz+h))] += out*( frac_x)*( frac_y)*(1-frac_z);
outImageBufferPointer[( px + w*(py+1+ h*pz+h))] += out*( frac_x)*(1-frac_y)*(1-frac_z);
outImageBufferPointer[( px+1 + w*(py + h*pz ))] += out*(1-frac_x)*( frac_y)*( frac_z);
outImageBufferPointer[( px+1 + w*(py + h*pz+h))] += out*(1-frac_x)*( frac_y)*(1-frac_z);
outImageBufferPointer[( px+1 + w*(py+1+ h*pz ))] += out*(1-frac_x)*(1-frac_y)*( frac_z);
outImageBufferPointer[( px+1 + w*(py+1+ h*pz+h))] += out*(1-frac_x)*(1-frac_y)*(1-frac_z);
counterImageBufferPointer[( px + w*(py + h*pz ))] += 1;
counterImageBufferPointer[( px + w*(py+1+ h*pz ))] += 1;
counterImageBufferPointer[( px + w*(py + h*pz+h))] += 1;
counterImageBufferPointer[( px + w*(py+1+ h*pz+h))] += 1;
counterImageBufferPointer[( px+1 + w*(py + h*pz ))] += 1;
counterImageBufferPointer[( px+1 + w*(py + h*pz+h))] += 1;
counterImageBufferPointer[( px+1 + w*(py+1+ h*pz ))] += 1;
counterImageBufferPointer[( px+1 + w*(py+1+ h*pz+h))] += 1;
}
typedef ImageRegionIterator< OutputImageType > OutImageIteratorType;
OutImageIteratorType outIt(outputImage, outputImage->GetLargestPossibleRegion());
outIt.GoToBegin();
typedef ImageRegionConstIterator< itk::Image< short, 3 > > CountImageIteratorType;
CountImageIteratorType counterIt(counterImage, counterImage->GetLargestPossibleRegion());
counterIt.GoToBegin();
while(!outIt.IsAtEnd() && !counterIt.IsAtEnd()){
if (counterIt.Value()>0)
outIt.Set(outIt.Value()/counterIt.Value());
++outIt;
++counterIt;
}
}
void DwiPhantomGenerationFilter< TOutputScalarType >
::GenerateData()
{
if (m_NoiseVariance < 0)
m_NoiseVariance = 0.001;
if (!m_SimulateBaseline)
{
MITK_INFO << "Baseline image values are set to default. Noise variance value is treated as SNR!";
if (m_NoiseVariance <= 0)
m_NoiseVariance = 0.0001;
if (m_NoiseVariance>99)
m_NoiseVariance = 0;
else
{
m_NoiseVariance = m_DefaultBaseline/(m_NoiseVariance*m_SignalScale);
m_NoiseVariance *= m_NoiseVariance;
}
}
m_RandGen = Statistics::MersenneTwisterRandomVariateGenerator::New();
m_RandGen->SetSeed();
typename OutputImageType::Pointer outImage = OutputImageType::New();
outImage->SetSpacing( m_Spacing );
outImage->SetOrigin( m_Origin );
outImage->SetDirection( m_DirectionMatrix );
outImage->SetLargestPossibleRegion( m_ImageRegion );
outImage->SetBufferedRegion( m_ImageRegion );
outImage->SetRequestedRegion( m_ImageRegion );
outImage->SetVectorLength(m_GradientList.size());
outImage->Allocate();
typename OutputImageType::PixelType pix;
pix.SetSize(m_GradientList.size());
pix.Fill(0.0);
outImage->FillBuffer(pix);
this->SetNthOutput (0, outImage);
double minSpacing = m_Spacing[0];
if (m_Spacing[1]<minSpacing)
minSpacing = m_Spacing[1];
if (m_Spacing[2]<minSpacing)
minSpacing = m_Spacing[2];
m_DirectionImageContainer = ItkDirectionImageContainer::New();
for (int i=0; i<m_SignalRegions.size(); i++)
{
itk::Vector< float, 3 > nullVec; nullVec.Fill(0.0);
ItkDirectionImage::Pointer img = ItkDirectionImage::New();
img->SetSpacing( m_Spacing );
img->SetOrigin( m_Origin );
img->SetDirection( m_DirectionMatrix );
img->SetRegions( m_ImageRegion );
img->Allocate();
img->FillBuffer(nullVec);
m_DirectionImageContainer->InsertElement(m_DirectionImageContainer->Size(), img);
}
m_NumDirectionsImage = ItkUcharImgType::New();
m_NumDirectionsImage->SetSpacing( m_Spacing );
m_NumDirectionsImage->SetOrigin( m_Origin );
m_NumDirectionsImage->SetDirection( m_DirectionMatrix );
m_NumDirectionsImage->SetRegions( m_ImageRegion );
m_NumDirectionsImage->Allocate();
m_NumDirectionsImage->FillBuffer(0);
m_SNRImage = ItkFloatImgType::New();
m_SNRImage->SetSpacing( m_Spacing );
m_SNRImage->SetOrigin( m_Origin );
m_SNRImage->SetDirection( m_DirectionMatrix );
m_SNRImage->SetRegions( m_ImageRegion );
m_SNRImage->Allocate();
m_SNRImage->FillBuffer(0);
vtkSmartPointer<vtkCellArray> m_VtkCellArray = vtkSmartPointer<vtkCellArray>::New();
vtkSmartPointer<vtkPoints> m_VtkPoints = vtkSmartPointer<vtkPoints>::New();
m_BaselineImages = 0;
for( unsigned int i=0; i<m_GradientList.size(); i++)
if (m_GradientList[i].GetNorm()<=0.0001)
m_BaselineImages++;
typedef ImageRegionIterator<OutputImageType> IteratorOutputType;
IteratorOutputType it (outImage, m_ImageRegion);
// isotropic tensor
itk::DiffusionTensor3D<float> isoTensor;
isoTensor.Fill(0);
float e1 = m_GreyMatterAdc;
float e2 = m_GreyMatterAdc;
float e3 = m_GreyMatterAdc;
isoTensor.SetElement(0,e1);
isoTensor.SetElement(3,e2);
isoTensor.SetElement(5,e3);
m_MaxBaseline = GetTensorL2Norm(isoTensor);
GenerateTensors();
// simulate measurement
m_MeanBaseline = 0;
double noiseStdev = sqrt(m_NoiseVariance);
while(!it.IsAtEnd())
{
pix = it.Get();
typename OutputImageType::IndexType index = it.GetIndex();
int numDirs = 0;
for (int i=0; i<m_SignalRegions.size(); i++)
{
ItkUcharImgType::Pointer region = m_SignalRegions.at(i);
if (region->GetPixel(index)!=0)
{
numDirs++;
pix += SimulateMeasurement(m_TensorList[i], m_TensorWeight[i]);
// set direction image pixel
ItkDirectionImage::Pointer img = m_DirectionImageContainer->GetElement(i);
itk::Vector< float, 3 > pixel = img->GetPixel(index);
vnl_vector_fixed<double, 3> dir = m_TensorDirection.at(i);
dir.normalize();
dir *= m_TensorWeight.at(i);
pixel.SetElement(0, dir[0]);
pixel.SetElement(1, dir[1]);
pixel.SetElement(2, dir[2]);
img->SetPixel(index, pixel);
vtkSmartPointer<vtkPolyLine> container = vtkSmartPointer<vtkPolyLine>::New();
itk::ContinuousIndex<double, 3> center;
center[0] = index[0];
center[1] = index[1];
center[2] = index[2];
itk::Point<double> worldCenter;
outImage->TransformContinuousIndexToPhysicalPoint( center, worldCenter );
itk::Point<double> worldStart;
worldStart[0] = worldCenter[0]-dir[0]/2 * minSpacing;
worldStart[1] = worldCenter[1]-dir[1]/2 * minSpacing;
worldStart[2] = worldCenter[2]-dir[2]/2 * minSpacing;
vtkIdType id = m_VtkPoints->InsertNextPoint(worldStart.GetDataPointer());
container->GetPointIds()->InsertNextId(id);
itk::Point<double> worldEnd;
worldEnd[0] = worldCenter[0]+dir[0]/2 * minSpacing;
worldEnd[1] = worldCenter[1]+dir[1]/2 * minSpacing;
worldEnd[2] = worldCenter[2]+dir[2]/2 * minSpacing;
id = m_VtkPoints->InsertNextPoint(worldEnd.GetDataPointer());
container->GetPointIds()->InsertNextId(id);
m_VtkCellArray->InsertNextCell(container);
}
}
if (numDirs>1)
{
for (int i=0; i<m_GradientList.size(); i++)
pix[i] /= numDirs;
}
else if (numDirs==0)
{
if (m_SimulateBaseline)
pix = SimulateMeasurement(isoTensor, 1.0);
else
pix.Fill(0.0);
}
m_MeanBaseline += pix[0];
it.Set(pix);
m_NumDirectionsImage->SetPixel(index, numDirs);
if (m_NoiseVariance>0)
m_SNRImage->SetPixel(index, pix[0]/(noiseStdev*m_SignalScale));
++it;
}
m_MeanBaseline /= m_ImageRegion.GetNumberOfPixels();
if (m_NoiseVariance>0)
MITK_INFO << "Mean SNR: " << m_MeanBaseline/(noiseStdev*m_SignalScale);
else
MITK_INFO << "No noise added";
// add rician noise
it.GoToBegin();
while(!it.IsAtEnd())
{
pix = it.Get();
AddNoise(pix);
it.Set(pix);
++it;
}
// generate fiber bundle
vtkSmartPointer<vtkPolyData> directionsPolyData = vtkSmartPointer<vtkPolyData>::New();
directionsPolyData->SetPoints(m_VtkPoints);
directionsPolyData->SetLines(m_VtkCellArray);
m_OutputFiberBundle = mitk::FiberBundleX::New(directionsPolyData);
}
template <class inputType, unsigned int Dimension> medAbstractJob::medJobExitStatus medItkBiasCorrectionProcess::N4BiasCorrectionCore()
{
medJobExitStatus eRes = medAbstractJob::MED_JOB_EXIT_SUCCESS;
typedef itk::Image<inputType, Dimension > ImageType;
typedef itk::Image <float, Dimension> OutputImageType;
typedef itk::Image<unsigned char, Dimension> MaskImageType;
typedef itk::N4BiasFieldCorrectionImageFilter<OutputImageType, MaskImageType, OutputImageType> BiasFilter;
typedef itk::ConstantPadImageFilter<OutputImageType, OutputImageType> PadderType;
typedef itk::ConstantPadImageFilter<MaskImageType, MaskImageType> MaskPadderType;
typedef itk::ShrinkImageFilter<OutputImageType, OutputImageType> ShrinkerType;
typedef itk::ShrinkImageFilter<MaskImageType, MaskImageType> MaskShrinkerType;
typedef itk::BSplineControlPointImageFilter<typename BiasFilter::BiasFieldControlPointLatticeType, typename BiasFilter::ScalarImageType> BSplinerType;
typedef itk::ExpImageFilter<OutputImageType, OutputImageType> ExpFilterType;
typedef itk::DivideImageFilter<OutputImageType, OutputImageType, OutputImageType> DividerType;
typedef itk::ExtractImageFilter<OutputImageType, OutputImageType> CropperType;
unsigned int uiThreadNb = static_cast<unsigned int>(m_poUIThreadNb->value());
unsigned int uiShrinkFactors = static_cast<unsigned int>(m_poUIShrinkFactors->value());
unsigned int uiSplineOrder = static_cast<unsigned int>(m_poUISplineOrder->value());
float fWienerFilterNoise = static_cast<float>(m_poFWienerFilterNoise->value());
float fbfFWHM = static_cast<float>(m_poFbfFWHM->value());
float fConvergenceThreshold = static_cast<float>(m_poFConvergenceThreshold->value());
float fSplineDistance = static_cast<float>(m_poFSplineDistance->value());
float fProgression = 0;
QStringList oListValue = m_poSMaxIterations->value().split("x");
std::vector<unsigned int> oMaxNumbersIterationsVector(oListValue.size());
std::vector<float> oInitialMeshResolutionVect(Dimension);
for (int i=0; i<oMaxNumbersIterationsVector.size(); ++i)
{
oMaxNumbersIterationsVector[i] = (unsigned int)oListValue[i].toInt();
}
oInitialMeshResolutionVect[0] = static_cast<float>(m_poFInitialMeshResolutionVect1->value());
oInitialMeshResolutionVect[1] = static_cast<float>(m_poFInitialMeshResolutionVect2->value());
oInitialMeshResolutionVect[2] = static_cast<float>(m_poFInitialMeshResolutionVect3->value());
typename ImageType::Pointer image = dynamic_cast<ImageType *>((itk::Object*)(this->input()->data()));
typedef itk::CastImageFilter <ImageType, OutputImageType> CastFilterType;
typename CastFilterType::Pointer castFilter = CastFilterType::New();
castFilter->SetInput(image);
/********************************************************************************/
/***************************** PREPARING STARTING *******************************/
/********************************************************************************/
/*** 0 ******************* Create filter and accessories ******************/
ABORT_CHECKING(m_bAborting);
typename BiasFilter::Pointer filter = BiasFilter::New();
typename BiasFilter::ArrayType oNumberOfControlPointsArray;
m_filter = filter;
/*** 1 ******************* Read input image *******************************/
ABORT_CHECKING(m_bAborting);
fProgression = 1;
updateProgression(fProgression);
/*** 2 ******************* Creating Otsu mask *****************************/
ABORT_CHECKING(m_bAborting);
itk::TimeProbe timer;
timer.Start();
typename MaskImageType::Pointer maskImage = ITK_NULLPTR;
typedef itk::OtsuThresholdImageFilter<OutputImageType, MaskImageType> ThresholderType;
typename ThresholderType::Pointer otsu = ThresholderType::New();
m_filter = otsu;
otsu->SetInput(castFilter->GetOutput());
otsu->SetNumberOfHistogramBins(200);
otsu->SetInsideValue(0);
otsu->SetOutsideValue(1);
otsu->SetNumberOfThreads(uiThreadNb);
otsu->Update();
updateProgression(fProgression);
maskImage = otsu->GetOutput();
/*** 3A *************** Set Maximum number of Iterations for the filter ***/
ABORT_CHECKING(m_bAborting);
typename BiasFilter::VariableSizeArrayType itkTabMaximumIterations;
itkTabMaximumIterations.SetSize(oMaxNumbersIterationsVector.size());
for (int i = 0; i < oMaxNumbersIterationsVector.size(); ++i)
{
itkTabMaximumIterations[i] = oMaxNumbersIterationsVector[i];
}
filter->SetMaximumNumberOfIterations(itkTabMaximumIterations);
/*** 3B *************** Set Fitting Levels for the filter *****************/
typename BiasFilter::ArrayType oFittingLevelsTab;
oFittingLevelsTab.Fill(oMaxNumbersIterationsVector.size());
filter->SetNumberOfFittingLevels(oFittingLevelsTab);
updateProgression(fProgression);
/*** 4 ******************* Save image's index, size, origine **************/
ABORT_CHECKING(m_bAborting);
typename ImageType::IndexType oImageIndex = image->GetLargestPossibleRegion().GetIndex();
typename ImageType::SizeType oImageSize = image->GetLargestPossibleRegion().GetSize();
typename ImageType::PointType newOrigin = image->GetOrigin();
typename OutputImageType::Pointer outImage = castFilter->GetOutput();
if (fSplineDistance > 0)
{
/*** 5 ******************* Compute number of control points **************/
ABORT_CHECKING(m_bAborting);
itk::SizeValueType lowerBound[3];
itk::SizeValueType upperBound[3];
for (unsigned int i = 0; i < 3; i++)
{
float domain = static_cast<float>(image->GetLargestPossibleRegion().GetSize()[i] - 1) * image->GetSpacing()[i];
unsigned int numberOfSpans = static_cast<unsigned int>(std::ceil(domain / fSplineDistance));
unsigned long extraPadding = static_cast<unsigned long>((numberOfSpans * fSplineDistance - domain) / image->GetSpacing()[i] + 0.5);
lowerBound[i] = static_cast<unsigned long>(0.5 * extraPadding);
upperBound[i] = extraPadding - lowerBound[i];
newOrigin[i] -= (static_cast<float>(lowerBound[i]) * image->GetSpacing()[i]);
oNumberOfControlPointsArray[i] = numberOfSpans + filter->GetSplineOrder();
}
updateProgression(fProgression);
/*** 6 ******************* Padder ****************************************/
ABORT_CHECKING(m_bAborting);
typename PadderType::Pointer imagePadder = PadderType::New();
m_filter = imagePadder;
imagePadder->SetInput(castFilter->GetOutput());
imagePadder->SetPadLowerBound(lowerBound);
imagePadder->SetPadUpperBound(upperBound);
imagePadder->SetConstant(0);
imagePadder->SetNumberOfThreads(uiThreadNb);
imagePadder->Update();
updateProgression(fProgression);
outImage = imagePadder->GetOutput();
/*** 7 ******************** Handle the mask image *************************/
ABORT_CHECKING(m_bAborting);
typename MaskPadderType::Pointer maskPadder = MaskPadderType::New();
m_filter = maskPadder;
maskPadder->SetInput(maskImage);
maskPadder->SetPadLowerBound(lowerBound);
maskPadder->SetPadUpperBound(upperBound);
maskPadder->SetConstant(0);
maskPadder->SetNumberOfThreads(uiThreadNb);
maskPadder->Update();
updateProgression(fProgression);
maskImage = maskPadder->GetOutput();
/*** 8 ******************** SetNumber Of Control Points *******************/
ABORT_CHECKING(m_bAborting);
filter->SetNumberOfControlPoints(oNumberOfControlPointsArray);
}
else if (oInitialMeshResolutionVect.size() == 3)
{
/*** 9 ******************** SetNumber Of Control Points alternative *******/
ABORT_CHECKING(m_bAborting);
for (unsigned i = 0; i < 3; i++)
{
oNumberOfControlPointsArray[i] = static_cast<unsigned int>(oInitialMeshResolutionVect[i]) + filter->GetSplineOrder();
}
filter->SetNumberOfControlPoints(oNumberOfControlPointsArray);
updateProgression(fProgression, 3);
}
else
{
fProgression = 0;
updateProgression(fProgression);
std::cout << "No BSpline distance and Mesh Resolution is ignored because not 3 dimensions" << std::endl;
}
/*** 10 ******************* Shrinker image ********************************/
ABORT_CHECKING(m_bAborting);
typename ShrinkerType::Pointer imageShrinker = ShrinkerType::New();
m_filter = imageShrinker;
imageShrinker->SetInput(outImage);
/*** 11 ******************* Shrinker mask *********************************/
ABORT_CHECKING(m_bAborting);
typename MaskShrinkerType::Pointer maskShrinker = MaskShrinkerType::New();
m_filter = maskShrinker;
maskShrinker->SetInput(maskImage);
/*** 12 ******************* Shrink mask and image *************************/
ABORT_CHECKING(m_bAborting);
imageShrinker->SetShrinkFactors(uiShrinkFactors);
maskShrinker->SetShrinkFactors(uiShrinkFactors);
imageShrinker->SetNumberOfThreads(uiThreadNb);
maskShrinker->SetNumberOfThreads(uiThreadNb);
imageShrinker->Update();
updateProgression(fProgression);
maskShrinker->Update();
updateProgression(fProgression);
/*** 13 ******************* Filter setings ********************************/
ABORT_CHECKING(m_bAborting);
filter->SetSplineOrder(uiSplineOrder);
filter->SetWienerFilterNoise(fWienerFilterNoise);
filter->SetBiasFieldFullWidthAtHalfMaximum(fbfFWHM);
filter->SetConvergenceThreshold(fConvergenceThreshold);
filter->SetInput(imageShrinker->GetOutput());
filter->SetMaskImage(maskShrinker->GetOutput());
/*** 14 ******************* Apply filter **********************************/
ABORT_CHECKING(m_bAborting);
try
{
filter->SetNumberOfThreads(uiThreadNb);
filter->Update();
updateProgression(fProgression, 5);
}
catch (itk::ExceptionObject & err)
{
std::cerr << "ExceptionObject caught !" << std::endl;
std::cerr << err << std::endl;
eRes = medAbstractJob::MED_JOB_EXIT_FAILURE;
return eRes;
}
/**
* Reconstruct the bias field at full image resolution. Divide
* the original input image by the bias field to get the final
* corrected image.
*/
ABORT_CHECKING(m_bAborting);
typename BSplinerType::Pointer bspliner = BSplinerType::New();
m_filter = bspliner;
bspliner->SetInput(filter->GetLogBiasFieldControlPointLattice());
bspliner->SetSplineOrder(filter->GetSplineOrder());
bspliner->SetSize(image->GetLargestPossibleRegion().GetSize());
bspliner->SetOrigin(newOrigin);
bspliner->SetDirection(image->GetDirection());
bspliner->SetSpacing(image->GetSpacing());
bspliner->SetNumberOfThreads(uiThreadNb);
bspliner->Update();
updateProgression(fProgression);
/*********************** Logarithm phase ***************************/
ABORT_CHECKING(m_bAborting);
typename OutputImageType::Pointer logField = OutputImageType::New();
logField->SetOrigin(image->GetOrigin());
logField->SetSpacing(image->GetSpacing());
logField->SetRegions(image->GetLargestPossibleRegion());
logField->SetDirection(image->GetDirection());
logField->Allocate();
itk::ImageRegionIterator<typename BiasFilter::ScalarImageType> IB(bspliner->GetOutput(), bspliner->GetOutput()->GetLargestPossibleRegion());
itk::ImageRegionIterator<OutputImageType> IF(logField, logField->GetLargestPossibleRegion());
for (IB.GoToBegin(), IF.GoToBegin(); !IB.IsAtEnd(); ++IB, ++IF)
{
IF.Set(IB.Get()[0]);
}
/*********************** Exponential phase *************************/
ABORT_CHECKING(m_bAborting);
typename ExpFilterType::Pointer expFilter = ExpFilterType::New();
m_filter = expFilter;
expFilter->SetInput(logField);
expFilter->SetNumberOfThreads(uiThreadNb);
expFilter->Update();
updateProgression(fProgression);
/************************ Dividing phase ***************************/
ABORT_CHECKING(m_bAborting);
typename DividerType::Pointer divider = DividerType::New();
m_filter = divider;
divider->SetInput1(castFilter->GetOutput());
divider->SetInput2(expFilter->GetOutput());
divider->SetNumberOfThreads(uiThreadNb);
divider->Update();
updateProgression(fProgression);
/******************** Prepare cropping phase ***********************/
ABORT_CHECKING(m_bAborting);
typename ImageType::RegionType inputRegion;
inputRegion.SetIndex(oImageIndex);
inputRegion.SetSize(oImageSize);
/************************ Cropping phase ***************************/
ABORT_CHECKING(m_bAborting);
typename CropperType::Pointer cropper = CropperType::New();
m_filter = cropper;
cropper->SetInput(divider->GetOutput());
cropper->SetExtractionRegion(inputRegion);
cropper->SetDirectionCollapseToSubmatrix();
cropper->SetNumberOfThreads(uiThreadNb);
cropper->Update();
updateProgression(fProgression);
/********************** Write output image *************************/
ABORT_CHECKING(m_bAborting);
medAbstractImageData *out = qobject_cast<medAbstractImageData *>(medAbstractDataFactory::instance()->create("itkDataImageFloat3"));
out->setData(cropper->GetOutput());
this->setOutput(out);
m_filter = 0;
return eRes;
}
void TractsToFiberEndingsImageFilter< OutputImageType >::GenerateData()
{
// generate upsampled image
mitk::Geometry3D::Pointer geometry = m_FiberBundle->GetGeometry();
typename OutputImageType::Pointer outImage = this->GetOutput();
// calculate new image parameters
mitk::Vector3D newSpacing;
mitk::Point3D newOrigin;
itk::Matrix<double, 3, 3> newDirection;
ImageRegion<3> upsampledRegion;
if (m_UseImageGeometry && !m_InputImage.IsNull())
{
newSpacing = m_InputImage->GetSpacing()/m_UpsamplingFactor;
upsampledRegion = m_InputImage->GetLargestPossibleRegion();
newOrigin = m_InputImage->GetOrigin();
typename OutputImageType::RegionType::SizeType size = upsampledRegion.GetSize();
size[0] *= m_UpsamplingFactor;
size[1] *= m_UpsamplingFactor;
size[2] *= m_UpsamplingFactor;
upsampledRegion.SetSize(size);
newDirection = m_InputImage->GetDirection();
}
else
{
newSpacing = geometry->GetSpacing()/m_UpsamplingFactor;
newOrigin = geometry->GetOrigin();
mitk::Geometry3D::BoundsArrayType bounds = geometry->GetBounds();
newOrigin[0] += bounds.GetElement(0);
newOrigin[1] += bounds.GetElement(2);
newOrigin[2] += bounds.GetElement(4);
for (int i=0; i<3; i++)
for (int j=0; j<3; j++)
newDirection[j][i] = geometry->GetMatrixColumn(i)[j];
upsampledRegion.SetSize(0, geometry->GetExtent(0)*m_UpsamplingFactor);
upsampledRegion.SetSize(1, geometry->GetExtent(1)*m_UpsamplingFactor);
upsampledRegion.SetSize(2, geometry->GetExtent(2)*m_UpsamplingFactor);
}
typename OutputImageType::RegionType::SizeType upsampledSize = upsampledRegion.GetSize();
// apply new image parameters
outImage->SetSpacing( newSpacing );
outImage->SetOrigin( newOrigin );
outImage->SetDirection( newDirection );
outImage->SetRegions( upsampledRegion );
outImage->Allocate();
int w = upsampledSize[0];
int h = upsampledSize[1];
int d = upsampledSize[2];
// set/initialize output
OutPixelType* outImageBufferPointer = (OutPixelType*)outImage->GetBufferPointer();
for (int i=0; i<w*h*d; i++)
outImageBufferPointer[i] = 0;
// resample fiber bundle
float minSpacing = 1;
if(newSpacing[0]<newSpacing[1] && newSpacing[0]<newSpacing[2])
minSpacing = newSpacing[0];
else if (newSpacing[1] < newSpacing[2])
minSpacing = newSpacing[1];
else
minSpacing = newSpacing[2];
vtkSmartPointer<vtkPolyData> fiberPolyData = m_FiberBundle->GetFiberPolyData();
vtkSmartPointer<vtkCellArray> vLines = fiberPolyData->GetLines();
vLines->InitTraversal();
int numFibers = m_FiberBundle->GetNumFibers();
boost::progress_display disp(numFibers);
for( int i=0; i<numFibers; i++ )
{
++disp;
vtkIdType numPoints(0);
vtkIdType* points(NULL);
vLines->GetNextCell ( numPoints, points );
// fill output image
if (numPoints>0)
{
itk::Point<float, 3> vertex = GetItkPoint(fiberPolyData->GetPoint(points[0]));
itk::Index<3> index;
outImage->TransformPhysicalPointToIndex(vertex, index);
if (m_BinaryOutput)
outImage->SetPixel(index, 1);
else
outImage->SetPixel(index, outImage->GetPixel(index)+1);
}
if (numPoints>2)
{
itk::Point<float, 3> vertex = GetItkPoint(fiberPolyData->GetPoint(points[numPoints-1]));
itk::Index<3> index;
outImage->TransformPhysicalPointToIndex(vertex, index);
if (m_BinaryOutput)
outImage->SetPixel(index, 1);
else
outImage->SetPixel(index, outImage->GetPixel(index)+1);
}
}
if (m_InvertImage)
for (int i=0; i<w*h*d; i++)
outImageBufferPointer[i] = 1-outImageBufferPointer[i];
}
