void FoodDifferentialByLabelAreaModifier<DIM>::UpdateTargetAreaOfCell(
CellPtr pCell) {
// Get target area A of a healthy cell in S, G2 or M phase
double cell_target_area = this->mReferenceTargetArea;
//std::cout<<GetCellularFood()<<std::endl;
if (!pCell->ReadyToDivide()) {
if (pCell->HasCellProperty<ApoptoticCellProperty>()) {
//std::cout<<"apoptotic!!"<<std::endl;
cell_target_area = cell_target_area - 0.001 * cell_target_area;
// Don't allow a negative target area
if (cell_target_area < 0) {
cell_target_area = 0;
}
} else {
if (pCell->template HasCellProperty<CellLabel>()) {
double cell_age = pCell->GetAge();
double growth_start_time = 5;
AbstractCellCycleModel* p_model = pCell->GetCellCycleModel();
if (cell_age > growth_start_time) {
if (GetCellularFood() > 1
&& cell_target_area <= 2 * cAreaIdeal) {
double g2_duration = p_model->GetG2Duration();
cell_target_area *=
(1
+ (cell_age - growth_start_time)
/ (g2_duration * 2));
DecreaseCellularFood();
DecreaseCellularFood();
if (pCell->template HasCellProperty<ApoptoticCellProperty>()) {
pCell->template RemoveCellProperty<ApoptoticCellProperty>();
}
} else {
MAKE_PTR(ApoptoticCellProperty, apoptotic);
pCell->AddCellProperty(apoptotic);
}
}
} else {
double cell_age = pCell->GetAge();
double growth_start_time = 7;
AbstractCellCycleModel* p_model = pCell->GetCellCycleModel();
//std::cout<<"edad: "<< cell_age <<" "<< growth_start_time<<std::endl;
// The target area of a proliferating cell increases linearly from A to 2A over the course of the G2 phase
if (cell_age > growth_start_time
&& cell_target_area <= 2 * cAreaIdeal && pCell->GetCellData()->GetItem("Fitness") > 0) {
double g2_duration = p_model->GetG2Duration();
cell_target_area *= (1
+ ((cell_age-growth_start_time) * pCell->GetCellData()->GetItem("Fitness")
/ (g2_duration * 1)));
}
IncreaseCellularFood();
}
}
}
if (cell_target_area > 2.2){
cell_target_area = 2.2;
}
// Set cell data
pCell->GetCellData()->SetItem("target area", cell_target_area);
}
