void Tgam::fasLigandKilling(GrGrid& grid, Stats& stats)
{
Pos coord;
if (returnRandMacFromMoore(grid, coord)) {
Mac* pMac = dynamic_cast<Mac*>(grid.agent(coord, 0));
if (!pMac) pMac = dynamic_cast<Mac*>(grid.agent(coord, 1));
assert(pMac);
// If the mac died on this time step ignore it.
if (pMac->getNextState() == Mac::MAC_DEAD) {
return;
}
// Fas/FasL induced apoptosis with probability
if (pMac->getState() == Mac::MAC_INFECTED || pMac->getState() == Mac::MAC_CINFECTED) {
++stats.getApoptosisFasFasL();
pMac->apoptosis(grid);
pMac->kill();
grid.incKillings(coord);
}
}
}
void Tgam::checkMacTgamInduced(GrGrid& grid)
{
Pos coord;
if (returnRandMacFromMoore(grid, coord))
{
Mac* pMac = dynamic_cast<Mac*>(grid.agent(coord, 0));
if (!pMac) pMac = dynamic_cast<Mac*>(grid.agent(coord, 1));
assert(pMac);
// If the mac died on this time step ignore it.
if (pMac->getNextState() == Mac::MAC_DEAD)
return;
// If mac does not die then check for induction conditions - Macs
bool ProbAntigenPres = g_Rand.getReal() < _PARAM(Tcell_Tgam_probAntigenPresentation);
if(pMac && pMac->getICOS())
_nICOS ++;
switch(pMac->getState())
{
case Mac::MAC_INFECTED:
case Mac::MAC_CINFECTED:
case Mac::MAC_ACTIVE:
if (ProbAntigenPres)
_nAntigenStim ++;
break;
case Mac::MAC_RESTING:
if ((pMac->getNFkB() || pMac->getStat1()) && ProbAntigenPres)
_nAntigenStim ++;
break;
throw std::runtime_error("Unknown Mac State in Tgam Induction Switch");
}
}
}