Exemple #1
0
// note: takes smart pointer as it maybe added to the results
static hal_size_t mapDown(MappedSegmentPtr mappedSeg, hal_size_t childIndex, list<MappedSegmentPtr> &results,
                          hal_size_t minLength) {
    const Genome *child = mappedSeg->getGenome()->getChild(childIndex);
    assert(child != NULL);
    hal_size_t added = 0;
    if (mappedSeg->isTop() == false) {
        TopSegmentIteratorPtr topSegIt = child->getTopSegmentIterator();
        SegmentIteratorPtr targetSegIt = mappedSeg->getTargetIteratorPtr();
        BottomSegmentIteratorPtr botSegIt = std::dynamic_pointer_cast<BottomSegmentIterator>(targetSegIt);

        if (botSegIt->bseg()->hasChild(childIndex) == true && botSegIt->getLength() >= minLength) {
            topSegIt->toChild(botSegIt, childIndex);
            mappedSeg->setTarget(std::dynamic_pointer_cast<SegmentIterator>(topSegIt));
            results.push_back(MappedSegmentPtr(mappedSeg));
            ++added;
        }
    } else {
        hal_index_t rightCutoff = mappedSeg->getEndPosition();
        TopSegmentIteratorPtr topSegIt = mappedSeg->targetAsTop();
        hal_index_t startOffset = (hal_index_t)topSegIt->getStartOffset();
        hal_index_t endOffset = (hal_index_t)topSegIt->getEndOffset();
        BottomSegmentIteratorPtr botSegIt = mappedSeg->getGenome()->getBottomSegmentIterator();
        botSegIt->toParseDown(topSegIt);
        do {
            BottomSegmentIteratorPtr newBotSegIt = botSegIt->clone();

            // we map the new target back to see how the offsets have
            // changed.  these changes are then applied to the source segment
            // as deltas
            TopSegmentIteratorPtr backTopSegIt = topSegIt->clone();
            backTopSegIt->toParseUp(newBotSegIt);
            hal_index_t startBack = (hal_index_t)backTopSegIt->getStartOffset();
            hal_index_t endBack = (hal_index_t)backTopSegIt->getEndOffset();
            assert(startBack >= startOffset);
            assert(endBack >= endOffset);
            SegmentIteratorPtr newSourceSegIt = mappedSeg->sourceClone();
            hal_index_t startDelta = startBack - startOffset;
            hal_index_t endDelta = endBack - endOffset;
            assert((hal_index_t)newSourceSegIt->getLength() > startDelta + endDelta);
            newSourceSegIt->slice(newSourceSegIt->getStartOffset() + startDelta, newSourceSegIt->getEndOffset() + endDelta);

            MappedSegmentPtr newMappedSeg(new MappedSegment(newSourceSegIt, newBotSegIt));

            assert(newMappedSeg->isTop() == false);
            assert(newMappedSeg->getSource()->getGenome() == mappedSeg->getSource()->getGenome());

            added += mapDown(newMappedSeg, childIndex, results, minLength);

            // stupid that we have to make this check but odn't want to
            // make fundamental api change now
            if (botSegIt->getEndPosition() != rightCutoff) {
                botSegIt->toRight(rightCutoff);
            } else {
                break;
            }
        } while (true);
    }
    return added;
}
Exemple #2
0
// note: takes smart pointer as it maybe added to the results
static hal_size_t mapUp(MappedSegmentPtr mappedSeg, list<MappedSegmentPtr> &results, bool doDupes, hal_size_t minLength) {
    const Genome *parent = mappedSeg->getGenome()->getParent();
    assert(parent != NULL);
    hal_size_t added = 0;
    if (mappedSeg->isTop() == true) {
        BottomSegmentIteratorPtr botSegIt = parent->getBottomSegmentIterator();
        TopSegmentIteratorPtr topSegIt = mappedSeg->targetAsTop();
        if (topSegIt->tseg()->hasParent() == true && topSegIt->getLength() >= minLength &&
            (doDupes == true || topSegIt->tseg()->isCanonicalParalog() == true)) {
            botSegIt->toParent(topSegIt);
            mappedSeg->setTarget(std::dynamic_pointer_cast<SegmentIterator>(botSegIt));
            results.push_back(mappedSeg);
            ++added;
        }
    } else {
        hal_index_t rightCutoff = mappedSeg->getEndPosition();
        BottomSegmentIteratorPtr botSegIt = mappedSeg->targetAsBottom();
        hal_index_t startOffset = (hal_index_t)botSegIt->getStartOffset();
        hal_index_t endOffset = (hal_index_t)botSegIt->getEndOffset();
        TopSegmentIteratorPtr topSegIt = mappedSeg->getGenome()->getTopSegmentIterator();
        topSegIt->toParseUp(botSegIt);
        do {
            TopSegmentIteratorPtr newTopSegIt = topSegIt->clone();

            // we map the new target back to see how the offsets have
            // changed.  these changes are then applied to the source segment
            // as deltas
            BottomSegmentIteratorPtr backBotSegIt = botSegIt->clone();
            backBotSegIt->toParseDown(newTopSegIt);
            hal_index_t startBack = (hal_index_t)backBotSegIt->getStartOffset();
            hal_index_t endBack = (hal_index_t)backBotSegIt->getEndOffset();
            assert(startBack >= startOffset);
            assert(endBack >= endOffset);
            SegmentIteratorPtr newSourceSegIt = mappedSeg->sourceClone();
            hal_index_t startDelta = startBack - startOffset;
            hal_index_t endDelta = endBack - endOffset;
            assert((hal_index_t)newSourceSegIt->getLength() > startDelta + endDelta);
            newSourceSegIt->slice(newSourceSegIt->getStartOffset() + startDelta, newSourceSegIt->getEndOffset() + endDelta);

            MappedSegmentPtr newMappedSeg(new MappedSegment(newSourceSegIt, newTopSegIt));

            assert(newMappedSeg->isTop() == true);
            assert(newMappedSeg->getSource()->getGenome() == mappedSeg->getSource()->getGenome());

            added += mapUp(newMappedSeg, results, doDupes, minLength);
            // stupid that we have to make this check but odn't want to
            // make fundamental api change now
            if (topSegIt->getEndPosition() != rightCutoff) {
                topSegIt->toRight(rightCutoff);
            } else {
                break;
            }
        } while (true);
    }
    return added;
}
void TopSegmentIteratorParseTest::checkCallBack(const Alignment *alignment) {
    BottomSegmentIteratorPtr bi;
    TopSegmentIteratorPtr ti;

    // case 1
    const Genome *case1 = alignment->openGenome("case1");
    ti = case1->getTopSegmentIterator();
    bi = case1->getBottomSegmentIterator();
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
    CuAssertTrue(_testCase, bi->getLength() == ti->getLength());
    bi->slice(3, 1);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getLength() == bi->getBottomSegment()->getLength() - 4);

    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
    CuAssertTrue(_testCase, bi->getLength() == ti->getLength());

    // case 2
    const Genome *case2 = alignment->openGenome("case2");
    ti = case2->getTopSegmentIterator();
    bi = case2->getBottomSegmentIterator(1);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
    bi->slice(1, 1);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());

    // case 3
    const Genome *case3 = alignment->openGenome("case3");
    ti = case3->getTopSegmentIterator();
    bi = case3->getBottomSegmentIterator();
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
    bi->slice(2, 1);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());

    // case 4
    const Genome *case4 = alignment->openGenome("case4");
    ti = case4->getTopSegmentIterator();
    bi = case4->getBottomSegmentIterator(1);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
    bi->slice(2, 2);
    ti->toParseUp(bi);
    CuAssertTrue(_testCase, bi->getStartPosition() == ti->getStartPosition());
}
Exemple #4
0
// note: takes smart pointer as it maybe added to the results
static hal_size_t mapSelf(MappedSegmentPtr mappedSeg, list<MappedSegmentPtr> &results, hal_size_t minLength) {
    hal_size_t added = 0;
    if (mappedSeg->isTop() == true) {
        SegmentIteratorPtr target = mappedSeg->getTargetIteratorPtr();
        SegmentIteratorPtr source = mappedSeg->getSourceIteratorPtr();
        TopSegmentIteratorPtr top = std::dynamic_pointer_cast<TopSegmentIterator>(target);
        TopSegmentIteratorPtr topCopy = top->clone();
        do {
            // FIXME: why isn't clone() polymorphic?
            SegmentIteratorPtr newSource;
            if (source->isTop()) {
                newSource = std::dynamic_pointer_cast<TopSegmentIterator>(source)->clone();
            } else {
                newSource = std::dynamic_pointer_cast<BottomSegmentIterator>(source)->clone();
            }
            TopSegmentIteratorPtr newTop = topCopy->clone();
            MappedSegmentPtr newMappedSeg(new MappedSegment(newSource, newTop));
            assert(newMappedSeg->getGenome() == mappedSeg->getGenome());
            assert(newMappedSeg->getSource()->getGenome() == mappedSeg->getSource()->getGenome());
            results.push_back(newMappedSeg);
            ++added;
            if (topCopy->tseg()->hasNextParalogy()) {
                topCopy->toNextParalogy();
            }
        } while (topCopy->tseg()->hasNextParalogy() == true && topCopy->getLength() >= minLength &&
                 topCopy->getArrayIndex() != top->getArrayIndex());
    } else if (mappedSeg->getGenome()->getParent() != NULL) {
        hal_index_t rightCutoff = mappedSeg->getEndPosition();
        BottomSegmentIteratorPtr bottom = mappedSeg->targetAsBottom();
        hal_index_t startOffset = (hal_index_t)bottom->getStartOffset();
        hal_index_t endOffset = (hal_index_t)bottom->getEndOffset();
        TopSegmentIteratorPtr top = mappedSeg->getGenome()->getTopSegmentIterator();
        top->toParseUp(bottom);
        do {
            TopSegmentIteratorPtr topNew = top->clone();

            // we map the new target back to see how the offsets have
            // changed.  these changes are then applied to the source segment
            // as deltas
            BottomSegmentIteratorPtr bottomBack = bottom->clone();
            bottomBack->toParseDown(topNew);
            hal_index_t startBack = (hal_index_t)bottomBack->getStartOffset();
            hal_index_t endBack = (hal_index_t)bottomBack->getEndOffset();
            assert(startBack >= startOffset);
            assert(endBack >= endOffset);
            SegmentIteratorPtr newSource = mappedSeg->sourceClone();
            hal_index_t startDelta = startBack - startOffset;
            hal_index_t endDelta = endBack - endOffset;
            assert((hal_index_t)newSource->getLength() > startDelta + endDelta);
            newSource->slice(newSource->getStartOffset() + startDelta, newSource->getEndOffset() + endDelta);

            MappedSegmentPtr newMappedSeg(new MappedSegment(newSource, topNew));

            assert(newMappedSeg->isTop() == true);
            assert(newMappedSeg->getSource()->getGenome() == mappedSeg->getSource()->getGenome());

            added += mapSelf(newMappedSeg, results, minLength);
            // stupid that we have to make this check but odn't want to
            // make fundamental api change now
            if (top->getEndPosition() != rightCutoff) {
                top->toRight(rightCutoff);
            } else {
                break;
            }
        } while (true);
    }
    return added;
}