int mitkLocalFiberPlausibilityTest(int argc, char* argv[])
{
MITK_TEST_BEGIN("mitkLocalFiberPlausibilityTest");
MITK_TEST_CONDITION_REQUIRED(argc==8,"check for input data")
string fibFile = argv[1];
vector< string > referenceImages;
referenceImages.push_back(argv[2]);
referenceImages.push_back(argv[3]);
string LDFP_ERROR_IMAGE = argv[4];
string LDFP_NUM_DIRECTIONS = argv[5];
string LDFP_VECTOR_FIELD = argv[6];
string LDFP_ERROR_IMAGE_IGNORE = argv[7];
float angularThreshold = 25;
try
{
typedef itk::Image<unsigned char, 3> ItkUcharImgType;
typedef itk::Image< itk::Vector< float, 3>, 3 > ItkDirectionImage3DType;
typedef itk::VectorContainer< unsigned int, ItkDirectionImage3DType::Pointer > ItkDirectionImageContainerType;
typedef itk::EvaluateDirectionImagesFilter< float > EvaluationFilterType;
// load fiber bundle
mitk::FiberBundleX::Pointer inputTractogram = dynamic_cast<mitk::FiberBundleX*>(mitk::IOUtil::LoadDataNode(fibFile)->GetData());
// load reference directions
ItkDirectionImageContainerType::Pointer referenceImageContainer = ItkDirectionImageContainerType::New();
for (unsigned int i=0; i<referenceImages.size(); i++)
{
try
{
mitk::Image::Pointer img = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(referenceImages.at(i))->GetData());
typedef mitk::ImageToItk< ItkDirectionImage3DType > CasterType;
CasterType::Pointer caster = CasterType::New();
caster->SetInput(img);
caster->Update();
ItkDirectionImage3DType::Pointer itkImg = caster->GetOutput();
referenceImageContainer->InsertElement(referenceImageContainer->Size(),itkImg);
}
catch(...) {
MITK_INFO << "could not load: " << referenceImages.at(i);
}
}
ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New();
ItkDirectionImage3DType::Pointer dirImg = referenceImageContainer->GetElement(0);
itkMaskImage->SetSpacing( dirImg->GetSpacing() );
itkMaskImage->SetOrigin( dirImg->GetOrigin() );
itkMaskImage->SetDirection( dirImg->GetDirection() );
itkMaskImage->SetLargestPossibleRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetBufferedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetRequestedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->Allocate();
itkMaskImage->FillBuffer(1);
// extract directions from fiber bundle
itk::TractsToVectorImageFilter<float>::Pointer fOdfFilter = itk::TractsToVectorImageFilter<float>::New();
fOdfFilter->SetFiberBundle(inputTractogram);
fOdfFilter->SetMaskImage(itkMaskImage);
fOdfFilter->SetAngularThreshold(cos(angularThreshold*M_PI/180));
fOdfFilter->SetNormalizeVectors(true);
fOdfFilter->SetUseWorkingCopy(false);
fOdfFilter->SetNumberOfThreads(1);
fOdfFilter->Update();
ItkDirectionImageContainerType::Pointer directionImageContainer = fOdfFilter->GetDirectionImageContainer();
// Get directions and num directions image
ItkUcharImgType::Pointer numDirImage = fOdfFilter->GetNumDirectionsImage();
mitk::Image::Pointer mitkNumDirImage = mitk::Image::New();
mitkNumDirImage->InitializeByItk( numDirImage.GetPointer() );
mitkNumDirImage->SetVolume( numDirImage->GetBufferPointer() );
mitk::FiberBundleX::Pointer testDirections = fOdfFilter->GetOutputFiberBundle();
// evaluate directions with missing directions
EvaluationFilterType::Pointer evaluationFilter = EvaluationFilterType::New();
evaluationFilter->SetImageSet(directionImageContainer);
evaluationFilter->SetReferenceImageSet(referenceImageContainer);
evaluationFilter->SetMaskImage(itkMaskImage);
evaluationFilter->SetIgnoreMissingDirections(false);
evaluationFilter->Update();
EvaluationFilterType::OutputImageType::Pointer angularErrorImage = evaluationFilter->GetOutput(0);
mitk::Image::Pointer mitkAngularErrorImage = mitk::Image::New();
mitkAngularErrorImage->InitializeByItk( angularErrorImage.GetPointer() );
mitkAngularErrorImage->SetVolume( angularErrorImage->GetBufferPointer() );
// evaluate directions without missing directions
evaluationFilter->SetIgnoreMissingDirections(true);
evaluationFilter->Update();
EvaluationFilterType::OutputImageType::Pointer angularErrorImageIgnore = evaluationFilter->GetOutput(0);
mitk::Image::Pointer mitkAngularErrorImageIgnore = mitk::Image::New();
mitkAngularErrorImageIgnore->InitializeByItk( angularErrorImageIgnore.GetPointer() );
mitkAngularErrorImageIgnore->SetVolume( angularErrorImageIgnore->GetBufferPointer() );
mitk::Image::Pointer gtAngularErrorImageIgnore = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(LDFP_ERROR_IMAGE_IGNORE)->GetData());
mitk::Image::Pointer gtAngularErrorImage = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(LDFP_ERROR_IMAGE)->GetData());
mitk::Image::Pointer gtNumTestDirImage = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(LDFP_NUM_DIRECTIONS)->GetData());
mitk::FiberBundleX::Pointer gtTestDirections = dynamic_cast<mitk::FiberBundleX*>(mitk::IOUtil::LoadDataNode(LDFP_VECTOR_FIELD)->GetData());
MITK_TEST_CONDITION_REQUIRED(mitk::Equal(gtAngularErrorImageIgnore, mitkAngularErrorImageIgnore, 0.0001, true), "Check if error images are equal (ignored missing directions).");
MITK_TEST_CONDITION_REQUIRED(mitk::Equal(gtAngularErrorImage, mitkAngularErrorImage, 0.0001, true), "Check if error images are equal.");
MITK_TEST_CONDITION_REQUIRED(testDirections->Equals(gtTestDirections), "Check if vector fields are equal.");
MITK_TEST_CONDITION_REQUIRED(mitk::Equal(gtNumTestDirImage, mitkNumDirImage, 0.0001, true), "Check if num direction images are equal.");
}
catch (itk::ExceptionObject e)
{
MITK_INFO << e;
return EXIT_FAILURE;
}
catch (std::exception e)
{
MITK_INFO << e.what();
return EXIT_FAILURE;
}
catch (...)
{
MITK_INFO << "ERROR!?!";
return EXIT_FAILURE;
}
MITK_TEST_END();
}
int StartPeakExtraction(int argc, char* argv[])
{
mitkCommandLineParser parser;
parser.setArgumentPrefix("--", "-");
parser.addArgument("image", "i", mitkCommandLineParser::InputFile, "Input image", "sh coefficient image", us::Any(), false);
parser.addArgument("outroot", "o", mitkCommandLineParser::OutputDirectory, "Output directory", "output root", us::Any(), false);
parser.addArgument("mask", "m", mitkCommandLineParser::InputFile, "Mask", "mask image");
parser.addArgument("normalization", "n", mitkCommandLineParser::Int, "Normalization", "0=no norm, 1=max norm, 2=single vec norm", 1, true);
parser.addArgument("numpeaks", "p", mitkCommandLineParser::Int, "Max. number of peaks", "maximum number of extracted peaks", 2, true);
parser.addArgument("peakthres", "r", mitkCommandLineParser::Float, "Peak threshold", "peak threshold relative to largest peak", 0.4, true);
parser.addArgument("abspeakthres", "a", mitkCommandLineParser::Float, "Absolute peak threshold", "absolute peak threshold weighted with local GFA value", 0.06, true);
parser.addArgument("shConvention", "s", mitkCommandLineParser::String, "Use specified SH-basis", "use specified SH-basis (MITK, FSL, MRtrix)", string("MITK"), true);
parser.addArgument("noFlip", "f", mitkCommandLineParser::Bool, "No flip", "do not flip input image to match MITK coordinate convention");
parser.addArgument("clusterThres", "c", mitkCommandLineParser::Float, "Clustering threshold", "directions closer together than the specified angular threshold will be clustered (in rad)", 0.9);
parser.addArgument("flipX", "fx", mitkCommandLineParser::Bool, "Flip X", "Flip peaks in x direction");
parser.addArgument("flipY", "fy", mitkCommandLineParser::Bool, "Flip Y", "Flip peaks in y direction");
parser.addArgument("flipZ", "fz", mitkCommandLineParser::Bool, "Flip Z", "Flip peaks in z direction");
parser.setCategory("Preprocessing Tools");
parser.setTitle("Peak Extraction");
parser.setDescription("");
parser.setContributor("MIC");
map<string, us::Any> parsedArgs = parser.parseArguments(argc, argv);
if (parsedArgs.size()==0)
return EXIT_FAILURE;
// mandatory arguments
string imageName = us::any_cast<string>(parsedArgs["image"]);
string outRoot = us::any_cast<string>(parsedArgs["outroot"]);
// optional arguments
string maskImageName("");
if (parsedArgs.count("mask"))
maskImageName = us::any_cast<string>(parsedArgs["mask"]);
int normalization = 1;
if (parsedArgs.count("normalization"))
normalization = us::any_cast<int>(parsedArgs["normalization"]);
int numPeaks = 2;
if (parsedArgs.count("numpeaks"))
numPeaks = us::any_cast<int>(parsedArgs["numpeaks"]);
float peakThres = 0.4;
if (parsedArgs.count("peakthres"))
peakThres = us::any_cast<float>(parsedArgs["peakthres"]);
float absPeakThres = 0.06;
if (parsedArgs.count("abspeakthres"))
absPeakThres = us::any_cast<float>(parsedArgs["abspeakthres"]);
float clusterThres = 0.9;
if (parsedArgs.count("clusterThres"))
clusterThres = us::any_cast<float>(parsedArgs["clusterThres"]);
bool noFlip = false;
if (parsedArgs.count("noFlip"))
noFlip = us::any_cast<bool>(parsedArgs["noFlip"]);
bool flipX = false;
if (parsedArgs.count("flipX"))
flipX = us::any_cast<bool>(parsedArgs["flipX"]);
bool flipY = false;
if (parsedArgs.count("flipY"))
flipY = us::any_cast<bool>(parsedArgs["flipY"]);
bool flipZ = false;
if (parsedArgs.count("flipZ"))
flipZ = us::any_cast<bool>(parsedArgs["flipZ"]);
std::cout << "image: " << imageName;
std::cout << "outroot: " << outRoot;
if (!maskImageName.empty())
std::cout << "mask: " << maskImageName;
else
std::cout << "no mask image selected";
std::cout << "numpeaks: " << numPeaks;
std::cout << "peakthres: " << peakThres;
std::cout << "abspeakthres: " << absPeakThres;
std::cout << "shOrder: " << shOrder;
try
{
mitk::Image::Pointer image = dynamic_cast<mitk::Image*>(mitk::IOUtil::Load(imageName)[0].GetPointer());
mitk::Image::Pointer mask = dynamic_cast<mitk::Image*>(mitk::IOUtil::Load(maskImageName)[0].GetPointer());
typedef itk::Image<unsigned char, 3> ItkUcharImgType;
typedef itk::FiniteDiffOdfMaximaExtractionFilter< float, shOrder, 20242 > MaximaExtractionFilterType;
typename MaximaExtractionFilterType::Pointer filter = MaximaExtractionFilterType::New();
int toolkitConvention = 0;
if (parsedArgs.count("shConvention"))
{
string convention = us::any_cast<string>(parsedArgs["shConvention"]).c_str();
if ( boost::algorithm::equals(convention, "FSL") )
{
toolkitConvention = 1;
std::cout << "Using FSL SH-basis";
}
else if ( boost::algorithm::equals(convention, "MRtrix") )
{
toolkitConvention = 2;
std::cout << "Using MRtrix SH-basis";
}
else
std::cout << "Using MITK SH-basis";
}
else
std::cout << "Using MITK SH-basis";
ItkUcharImgType::Pointer itkMaskImage = nullptr;
if (mask.IsNotNull())
{
try{
itkMaskImage = ItkUcharImgType::New();
mitk::CastToItkImage(mask, itkMaskImage);
filter->SetMaskImage(itkMaskImage);
}
catch(...)
{
}
}
if (toolkitConvention>0)
{
std::cout << "Converting coefficient image to MITK format";
typedef itk::ShCoefficientImageImporter< float, shOrder > ConverterType;
typedef mitk::ImageToItk< itk::Image< float, 4 > > CasterType;
CasterType::Pointer caster = CasterType::New();
caster->SetInput(image);
caster->Update();
itk::Image< float, 4 >::Pointer itkImage = caster->GetOutput();
typename ConverterType::Pointer converter = ConverterType::New();
if (noFlip)
{
converter->SetInputImage(itkImage);
}
else
{
std::cout << "Flipping image";
itk::FixedArray<bool, 4> flipAxes;
flipAxes[0] = true;
flipAxes[1] = true;
flipAxes[2] = false;
flipAxes[3] = false;
itk::FlipImageFilter< itk::Image< float, 4 > >::Pointer flipper = itk::FlipImageFilter< itk::Image< float, 4 > >::New();
flipper->SetInput(itkImage);
flipper->SetFlipAxes(flipAxes);
flipper->Update();
itk::Image< float, 4 >::Pointer flipped = flipper->GetOutput();
itk::Matrix< double,4,4 > m = itkImage->GetDirection(); m[0][0] *= -1; m[1][1] *= -1;
flipped->SetDirection(m);
itk::Point< float, 4 > o = itkImage->GetOrigin();
o[0] -= (flipped->GetLargestPossibleRegion().GetSize(0)-1);
o[1] -= (flipped->GetLargestPossibleRegion().GetSize(1)-1);
flipped->SetOrigin(o);
converter->SetInputImage(flipped);
}
std::cout << "Starting conversion";
switch (toolkitConvention)
{
case 1:
converter->SetToolkit(ConverterType::FSL);
filter->SetToolkit(MaximaExtractionFilterType::FSL);
break;
case 2:
converter->SetToolkit(ConverterType::MRTRIX);
filter->SetToolkit(MaximaExtractionFilterType::MRTRIX);
break;
default:
converter->SetToolkit(ConverterType::FSL);
filter->SetToolkit(MaximaExtractionFilterType::FSL);
break;
}
converter->GenerateData();
filter->SetInput(converter->GetCoefficientImage());
}
else
{
try{
typedef mitk::ImageToItk< typename MaximaExtractionFilterType::CoefficientImageType > CasterType;
typename CasterType::Pointer caster = CasterType::New();
caster->SetInput(image);
caster->Update();
filter->SetInput(caster->GetOutput());
}
catch(...)
{
std::cout << "wrong image type";
return EXIT_FAILURE;
}
}
filter->SetMaxNumPeaks(numPeaks);
filter->SetPeakThreshold(peakThres);
filter->SetAbsolutePeakThreshold(absPeakThres);
filter->SetAngularThreshold(1);
filter->SetClusteringThreshold(clusterThres);
filter->SetFlipX(flipX);
filter->SetFlipY(flipY);
filter->SetFlipZ(flipZ);
switch (normalization)
{
case 0:
filter->SetNormalizationMethod(MaximaExtractionFilterType::NO_NORM);
break;
case 1:
filter->SetNormalizationMethod(MaximaExtractionFilterType::MAX_VEC_NORM);
break;
case 2:
filter->SetNormalizationMethod(MaximaExtractionFilterType::SINGLE_VEC_NORM);
break;
}
std::cout << "Starting extraction";
filter->Update();
// write direction image
{
typename MaximaExtractionFilterType::PeakImageType::Pointer itkImg = filter->GetPeakImage();
string outfilename = outRoot;
outfilename.append("_PEAKS.nrrd");
typedef itk::ImageFileWriter< typename MaximaExtractionFilterType::PeakImageType > WriterType;
typename WriterType::Pointer writer = WriterType::New();
writer->SetFileName(outfilename);
writer->SetInput(itkImg);
writer->Update();
}
// write num directions image
{
ItkUcharImgType::Pointer numDirImage = filter->GetNumDirectionsImage();
if (itkMaskImage.IsNotNull())
{
numDirImage->SetDirection(itkMaskImage->GetDirection());
numDirImage->SetOrigin(itkMaskImage->GetOrigin());
}
string outfilename = outRoot.c_str();
outfilename.append("_NUM_PEAKS.nrrd");
typedef itk::ImageFileWriter< ItkUcharImgType > WriterType;
WriterType::Pointer writer = WriterType::New();
writer->SetFileName(outfilename);
writer->SetInput(numDirImage);
writer->Update();
}
}
catch (itk::ExceptionObject e)
{
std::cout << e;
return EXIT_FAILURE;
}
catch (std::exception e)
{
std::cout << e.what();
return EXIT_FAILURE;
}
catch (...)
{
std::cout << "ERROR!?!";
return EXIT_FAILURE;
}
return EXIT_SUCCESS;
}
int LocalDirectionalFiberPlausibility(int argc, char* argv[])
{
ctkCommandLineParser parser;
parser.setArgumentPrefix("--", "-");
parser.addArgument("input", "i", ctkCommandLineParser::String, "input tractogram (.fib, vtk ascii file format)", us::Any(), false);
parser.addArgument("reference", "r", ctkCommandLineParser::StringList, "reference direction images", us::Any(), false);
parser.addArgument("out", "o", ctkCommandLineParser::String, "output root", us::Any(), false);
parser.addArgument("mask", "m", ctkCommandLineParser::StringList, "mask images");
parser.addArgument("athresh", "a", ctkCommandLineParser::Float, "angular threshold in degrees. closer fiber directions are regarded as one direction and clustered together.", 25, true);
parser.addArgument("verbose", "v", ctkCommandLineParser::Bool, "output optional and intermediate calculation results");
parser.addArgument("ignore", "n", ctkCommandLineParser::Bool, "don't increase error for missing or too many directions");
map<string, us::Any> parsedArgs = parser.parseArguments(argc, argv);
if (parsedArgs.size()==0)
return EXIT_FAILURE;
ctkCommandLineParser::StringContainerType referenceImages = us::any_cast<ctkCommandLineParser::StringContainerType>(parsedArgs["reference"]);
ctkCommandLineParser::StringContainerType maskImages;
if (parsedArgs.count("mask"))
maskImages = us::any_cast<ctkCommandLineParser::StringContainerType>(parsedArgs["mask"]);
string fibFile = us::any_cast<string>(parsedArgs["input"]);
float angularThreshold = 25;
if (parsedArgs.count("athresh"))
angularThreshold = us::any_cast<float>(parsedArgs["athresh"]);
string outRoot = us::any_cast<string>(parsedArgs["out"]);
bool verbose = false;
if (parsedArgs.count("verbose"))
verbose = us::any_cast<bool>(parsedArgs["verbose"]);
bool ignore = false;
if (parsedArgs.count("ignore"))
ignore = us::any_cast<bool>(parsedArgs["ignore"]);
try
{
RegisterDiffusionCoreObjectFactory();
RegisterFiberTrackingObjectFactory();
typedef itk::Image<unsigned char, 3> ItkUcharImgType;
typedef itk::Image< itk::Vector< float, 3>, 3 > ItkDirectionImage3DType;
typedef itk::VectorContainer< int, ItkDirectionImage3DType::Pointer > ItkDirectionImageContainerType;
typedef itk::EvaluateDirectionImagesFilter< float > EvaluationFilterType;
// load fiber bundle
mitk::FiberBundleX::Pointer inputTractogram = dynamic_cast<mitk::FiberBundleX*>(mitk::IOUtil::LoadDataNode(fibFile)->GetData());
// load reference directions
ItkDirectionImageContainerType::Pointer referenceImageContainer = ItkDirectionImageContainerType::New();
for (int i=0; i<referenceImages.size(); i++)
{
try
{
mitk::Image::Pointer img = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(referenceImages.at(i))->GetData());
typedef mitk::ImageToItk< ItkDirectionImage3DType > CasterType;
CasterType::Pointer caster = CasterType::New();
caster->SetInput(img);
caster->Update();
ItkDirectionImage3DType::Pointer itkImg = caster->GetOutput();
referenceImageContainer->InsertElement(referenceImageContainer->Size(),itkImg);
}
catch(...){ MITK_INFO << "could not load: " << referenceImages.at(i); }
}
ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New();
ItkDirectionImage3DType::Pointer dirImg = referenceImageContainer->GetElement(0);
itkMaskImage->SetSpacing( dirImg->GetSpacing() );
itkMaskImage->SetOrigin( dirImg->GetOrigin() );
itkMaskImage->SetDirection( dirImg->GetDirection() );
itkMaskImage->SetLargestPossibleRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetBufferedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetRequestedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->Allocate();
itkMaskImage->FillBuffer(1);
// extract directions from fiber bundle
itk::TractsToVectorImageFilter<float>::Pointer fOdfFilter = itk::TractsToVectorImageFilter<float>::New();
fOdfFilter->SetFiberBundle(inputTractogram);
fOdfFilter->SetMaskImage(itkMaskImage);
fOdfFilter->SetAngularThreshold(cos(angularThreshold*M_PI/180));
fOdfFilter->SetNormalizeVectors(true);
fOdfFilter->SetUseWorkingCopy(false);
fOdfFilter->Update();
ItkDirectionImageContainerType::Pointer directionImageContainer = fOdfFilter->GetDirectionImageContainer();
if (verbose)
{
// write vector field
mitk::FiberBundleX::Pointer directions = fOdfFilter->GetOutputFiberBundle();
mitk::CoreObjectFactory::FileWriterList fileWriters = mitk::CoreObjectFactory::GetInstance()->GetFileWriters();
for (mitk::CoreObjectFactory::FileWriterList::iterator it = fileWriters.begin() ; it != fileWriters.end() ; ++it)
{
if ( (*it)->CanWriteBaseDataType(directions.GetPointer()) ) {
string outfilename = outRoot;
outfilename.append("_VECTOR_FIELD.fib");
(*it)->SetFileName( outfilename.c_str() );
(*it)->DoWrite( directions.GetPointer() );
}
}
// write direction images
for (int i=0; i<directionImageContainer->Size(); i++)
{
itk::TractsToVectorImageFilter<float>::ItkDirectionImageType::Pointer itkImg = directionImageContainer->GetElement(i);
typedef itk::ImageFileWriter< itk::TractsToVectorImageFilter<float>::ItkDirectionImageType > WriterType;
WriterType::Pointer writer = WriterType::New();
string outfilename = outRoot;
outfilename.append("_DIRECTION_");
outfilename.append(boost::lexical_cast<string>(i));
outfilename.append(".nrrd");
MITK_INFO << "writing " << outfilename;
writer->SetFileName(outfilename.c_str());
writer->SetInput(itkImg);
writer->Update();
}
// write num direction image
{
ItkUcharImgType::Pointer numDirImage = fOdfFilter->GetNumDirectionsImage();
typedef itk::ImageFileWriter< ItkUcharImgType > WriterType;
WriterType::Pointer writer = WriterType::New();
string outfilename = outRoot;
outfilename.append("_NUM_DIRECTIONS.nrrd");
MITK_INFO << "writing " << outfilename;
writer->SetFileName(outfilename.c_str());
writer->SetInput(numDirImage);
writer->Update();
}
}
string logFile = outRoot;
logFile.append("_ANGULAR_ERROR.csv");
ofstream file;
file.open (logFile.c_str());
if (maskImages.size()>0)
{
for (int i=0; i<maskImages.size(); i++)
{
mitk::Image::Pointer mitkMaskImage = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(maskImages.at(i))->GetData());
mitk::CastToItkImage<ItkUcharImgType>(mitkMaskImage, itkMaskImage);
// evaluate directions
EvaluationFilterType::Pointer evaluationFilter = EvaluationFilterType::New();
evaluationFilter->SetImageSet(directionImageContainer);
evaluationFilter->SetReferenceImageSet(referenceImageContainer);
evaluationFilter->SetMaskImage(itkMaskImage);
evaluationFilter->SetIgnoreMissingDirections(ignore);
evaluationFilter->Update();
if (verbose)
{
EvaluationFilterType::OutputImageType::Pointer angularErrorImage = evaluationFilter->GetOutput(0);
typedef itk::ImageFileWriter< EvaluationFilterType::OutputImageType > WriterType;
WriterType::Pointer writer = WriterType::New();
string outfilename = outRoot;
outfilename.append("_ERROR_IMAGE.nrrd");
MITK_INFO << "writing " << outfilename;
writer->SetFileName(outfilename.c_str());
writer->SetInput(angularErrorImage);
writer->Update();
}
string sens = itksys::SystemTools::GetFilenameWithoutExtension(itksys::SystemTools::GetFilenameName(fibFile));
sens.append(",");
sens.append(itksys::SystemTools::GetFilenameWithoutExtension(itksys::SystemTools::GetFilenameName(maskImages.at(i))));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMeanAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMedianAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMaxAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMinAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(std::sqrt(evaluationFilter->GetVarAngularError())));
sens.append(";\n");
file << sens;
}
}
else
{
// evaluate directions
EvaluationFilterType::Pointer evaluationFilter = EvaluationFilterType::New();
evaluationFilter->SetImageSet(directionImageContainer);
evaluationFilter->SetReferenceImageSet(referenceImageContainer);
evaluationFilter->SetMaskImage(itkMaskImage);
evaluationFilter->SetIgnoreMissingDirections(ignore);
evaluationFilter->Update();
if (verbose)
{
EvaluationFilterType::OutputImageType::Pointer angularErrorImage = evaluationFilter->GetOutput(0);
typedef itk::ImageFileWriter< EvaluationFilterType::OutputImageType > WriterType;
WriterType::Pointer writer = WriterType::New();
string outfilename = outRoot;
outfilename.append("_ERROR_IMAGE.nrrd");
MITK_INFO << "writing " << outfilename;
writer->SetFileName(outfilename.c_str());
writer->SetInput(angularErrorImage);
writer->Update();
}
string sens = itksys::SystemTools::GetFilenameWithoutExtension(itksys::SystemTools::GetFilenameName(fibFile));
sens.append(",");
sens.append("FULL");
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMeanAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMedianAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMaxAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMinAngularError()));
sens.append(",");
sens.append(boost::lexical_cast<string>(std::sqrt(evaluationFilter->GetVarAngularError())));
sens.append(";\n");
file << sens;
}
file.close();
MITK_INFO << "DONE";
}
catch (itk::ExceptionObject e)
{
MITK_INFO << e;
return EXIT_FAILURE;
}
catch (std::exception e)
{
MITK_INFO << e.what();
return EXIT_FAILURE;
}
catch (...)
{
MITK_INFO << "ERROR!?!";
return EXIT_FAILURE;
}
return EXIT_SUCCESS;
}
int TractogramAngularError(int argc, char* argv[])
{
ctkCommandLineParser parser;
parser.setArgumentPrefix("--", "-");
parser.addArgument("input", "i", ctkCommandLineParser::String, "input tractogram (.fib, vtk ascii file format)", us::Any(), false);
parser.addArgument("reference", "r", ctkCommandLineParser::StringList, "reference direction images", us::Any(), false);
parser.addArgument("out", "o", ctkCommandLineParser::String, "output root", us::Any(), false);
parser.addArgument("mask", "m", ctkCommandLineParser::String, "mask image");
parser.addArgument("verbose", "v", ctkCommandLineParser::Bool, "output optional and intermediate calculation results");
parser.addArgument("ignore", "n", ctkCommandLineParser::Bool, "don't increase error for missing or too many directions");
parser.addArgument("trilinear", "t", ctkCommandLineParser::Bool, "use trilinear instead of nearest neighbor interpolation");
map<string, us::Any> parsedArgs = parser.parseArguments(argc, argv);
if (parsedArgs.size()==0)
return EXIT_FAILURE;
ctkCommandLineParser::StringContainerType referenceImages = us::any_cast<ctkCommandLineParser::StringContainerType>(parsedArgs["reference"]);
string fibFile = us::any_cast<string>(parsedArgs["input"]);
string maskImage("");
if (parsedArgs.count("mask"))
maskImage = us::any_cast<string>(parsedArgs["mask"]);
string outRoot = us::any_cast<string>(parsedArgs["out"]);
bool verbose = false;
if (parsedArgs.count("verbose"))
verbose = us::any_cast<bool>(parsedArgs["verbose"]);
bool ignore = false;
if (parsedArgs.count("ignore"))
ignore = us::any_cast<bool>(parsedArgs["ignore"]);
bool interpolate = false;
if (parsedArgs.count("interpolate"))
interpolate = us::any_cast<bool>(parsedArgs["interpolate"]);
try
{
RegisterDiffusionCoreObjectFactory();
RegisterFiberTrackingObjectFactory();
typedef itk::Image<unsigned char, 3> ItkUcharImgType;
typedef itk::Image< itk::Vector< float, 3>, 3 > ItkDirectionImage3DType;
typedef itk::VectorContainer< int, ItkDirectionImage3DType::Pointer > ItkDirectionImageContainerType;
typedef itk::EvaluateTractogramDirectionsFilter< float > EvaluationFilterType;
// load fiber bundle
mitk::FiberBundleX::Pointer inputTractogram = dynamic_cast<mitk::FiberBundleX*>(mitk::IOUtil::LoadDataNode(fibFile)->GetData());
if (!inputTractogram)
return EXIT_FAILURE;
// load reference directions
ItkDirectionImageContainerType::Pointer referenceImageContainer = ItkDirectionImageContainerType::New();
for (int i=0; i<referenceImages.size(); i++)
{
try
{
mitk::Image::Pointer img = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(referenceImages.at(i))->GetData());
typedef mitk::ImageToItk< ItkDirectionImage3DType > CasterType;
CasterType::Pointer caster = CasterType::New();
caster->SetInput(img);
caster->Update();
ItkDirectionImage3DType::Pointer itkImg = caster->GetOutput();
referenceImageContainer->InsertElement(referenceImageContainer->Size(),itkImg);
}
catch(...) {
MITK_INFO << "could not load: " << referenceImages.at(i);
}
}
// load/create mask image
ItkUcharImgType::Pointer itkMaskImage = ItkUcharImgType::New();
if (maskImage.compare("")==0)
{
ItkDirectionImage3DType::Pointer dirImg = referenceImageContainer->GetElement(0);
itkMaskImage->SetSpacing( dirImg->GetSpacing() );
itkMaskImage->SetOrigin( dirImg->GetOrigin() );
itkMaskImage->SetDirection( dirImg->GetDirection() );
itkMaskImage->SetLargestPossibleRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetBufferedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->SetRequestedRegion( dirImg->GetLargestPossibleRegion() );
itkMaskImage->Allocate();
itkMaskImage->FillBuffer(1);
}
else
{
mitk::Image::Pointer mitkMaskImage = dynamic_cast<mitk::Image*>(mitk::IOUtil::LoadDataNode(maskImage)->GetData());
mitk::CastToItkImage<ItkUcharImgType>(mitkMaskImage, itkMaskImage);
}
// evaluate directions
EvaluationFilterType::Pointer evaluationFilter = EvaluationFilterType::New();
evaluationFilter->SetTractogram(inputTractogram);
evaluationFilter->SetReferenceImageSet(referenceImageContainer);
evaluationFilter->SetMaskImage(itkMaskImage);
evaluationFilter->SetIgnoreMissingDirections(ignore);
evaluationFilter->SetUseInterpolation(interpolate);
evaluationFilter->Update();
if (verbose)
{
EvaluationFilterType::OutputImageType::Pointer angularErrorImage = evaluationFilter->GetOutput(0);
typedef itk::ImageFileWriter< EvaluationFilterType::OutputImageType > WriterType;
WriterType::Pointer writer = WriterType::New();
string outfilename = outRoot;
outfilename.append("_ERROR_IMAGE.nrrd");
MITK_INFO << "writing " << outfilename;
writer->SetFileName(outfilename.c_str());
writer->SetInput(angularErrorImage);
writer->Update();
}
string logFile = outRoot;
logFile.append("_ANGULAR_ERROR.csv");
ofstream file;
file.open (logFile.c_str());
string sens = "Mean:";
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMeanAngularError()));
sens.append(";\n");
sens.append("Median:");
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMedianAngularError()));
sens.append(";\n");
sens.append("Maximum:");
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMaxAngularError()));
sens.append(";\n");
sens.append("Minimum:");
sens.append(",");
sens.append(boost::lexical_cast<string>(evaluationFilter->GetMinAngularError()));
sens.append(";\n");
sens.append("STDEV:");
sens.append(",");
sens.append(boost::lexical_cast<string>(std::sqrt(evaluationFilter->GetVarAngularError())));
sens.append(";\n");
file << sens;
file.close();
MITK_INFO << "DONE";
}
catch (itk::ExceptionObject e)
{
MITK_INFO << e;
return EXIT_FAILURE;
}
catch (std::exception e)
{
MITK_INFO << e.what();
return EXIT_FAILURE;
}
catch (...)
{
MITK_INFO << "ERROR!?!";
return EXIT_FAILURE;
}
return EXIT_SUCCESS;
}
