/*
** concordance mapping
*/
VImage VCCM2(float *A1,float *A2,VImage map,int type)
{
VImage dest=NULL;
size_t b,r,c,i,j,k,kk,nvoxels;
int nslices=0,nrows=0,ncols=0;
double *arr1=NULL,*arr2=NULL,u;
nslices = VPixel(map,0,3,0,VShort);
nrows = VPixel(map,0,3,1,VShort);
ncols = VPixel(map,0,3,2,VShort);
nvoxels = VImageNColumns(map);
dest = VCreateImage(nslices,nrows,ncols,VFloatRepn);
VFillImage(dest,VAllBands,0);
VCopyImageAttrs (map, dest);
VSetAttr(VImageAttrList(dest),"modality",NULL,VStringRepn,"conimg");
arr1 = (double *) VCalloc(nvoxels,sizeof(double));
arr2 = (double *) VCalloc(nvoxels,sizeof(double));
fprintf(stderr," concordance mapping...\n");
for (i=0; i<nvoxels; i++) {
if (i%50 == 0) fprintf(stderr," %6d of %d\r",i,nvoxels);
b = (int)VPixel(map,0,0,i,VShort);
r = (int)VPixel(map,0,1,i,VShort);
c = (int)VPixel(map,0,2,i,VShort);
for (j=0; j<nvoxels; j++) arr1[j] = arr2[j] = 0;
kk = 0;
for (j=0; j<i; j++) {
k=j+i*(i+1)/2;
arr1[kk] = (double)A1[k];
arr2[kk] = (double)A2[k];
kk++;
}
for (j=i+1; j<nvoxels; j++) {
k=i+j*(j+1)/2;
arr1[kk] = (double)A1[k];
arr2[kk] = (double)A2[k];
kk++;
}
u = 0;
switch (type) {
case 0:
u = kendall(arr1,arr2,nvoxels);
break;
case 1:
u = CCC(arr1,arr2,nvoxels);
break;
default:
VError("illegal type");
}
VPixel(dest,b,r,c,VFloat) = (VFloat)u;
}
fprintf(stderr,"\n");
return dest;
}
VGraph VCreateGraph (int size, int nfields, VRepnKind repn, int useW)
{
VGraph graph;
/* Check parameters: */
if (size < 1 || nfields < 1)
VWarning ("VCreateGraph: Invalid number of nodes or fields.");
/* Allocate memory for the VGraph, and the node table: */
graph = VMalloc (sizeof (VGraphRec));
if (graph == NULL) return NULL;
graph->table = VCalloc(size, sizeof(VNode));
if (graph->table == NULL) {
VFree(graph);
return NULL;
};
/* Initialize the VGraph: */
graph->nnodes = 0;
graph->nfields = nfields;
graph->node_repn = repn;
graph->attributes = VCreateAttrList ();
graph->lastUsed = 0;
graph->size = size;
graph->useWeights = useW;
graph->iter = 0;
return graph;
}
/*
** read slice onset times from ASCII file, if not in header
*/
float *
ReadSlicetimes(VString filename) {
FILE *fp;
int i, j, id, n = 256;
float onset;
float *onset_array = NULL;
char buf[LEN];
onset_array = (float *) VCalloc(n, sizeof(float));
fp = fopen(filename, "r");
if(!fp)
VError(" error opening file %s", filename);
/* fprintf(stderr," reading file: %s\n",filename); */
i = 0;
while(!feof(fp)) {
if(i >= n)
VError(" too many lines in file %s, max is %d", filename, n);
for(j = 0; j < LEN; j++)
buf[j] = '\0';
fgets(buf, LEN, fp);
if(buf[0] == '%' || buf[0] == '#')
continue;
if(strlen(buf) < 2)
continue;
if(sscanf(buf, "%f", &onset) != 1)
VError(" line %d: illegal input format", i + 1);
onset_array[i] = onset;
i++;
}
fclose(fp);
return onset_array;
}
static VNode VCopyNodeDeep(VGraph graph, VNode src)
{
VNode dst;
VAdjacency o, n;
int cnt;
if (src == 0) return 0;
/* allocate and copy base part */
dst = VCalloc(1, VNodeSize(graph));
dst->base.hops = src->base.hops;
dst->base.visited = src->base.visited;
dst->base.weight = src->base.weight;
dst->base.head = 0;
/* copy all adjacencies */
for (o = src->base.head; o; o = o->next) {
n = VMalloc(sizeof(VAdjRec));
n->id = o->id; n->weight = o->weight;
n->next = dst->base.head;
dst->base.head = n;
};
/* copy private area */
cnt = (graph->nfields * VRepnPrecision(graph->node_repn)) / 8;
memcpy(dst->data, src->data, cnt);
return dst;
}
static VNode VCopyNodeShallow (VGraph graph, VNode src)
{
VNode dst;
if (src == 0) return 0;
dst = VCalloc(1, VNodeSize(graph));
memcpy(dst, src, VNodeSize(graph));
dst->base.head = 0;
return dst;
}
static int growGraph (VGraph graph)
/* note that we grow just a pointer table */
{
int newsize = (graph->size * 3) / 2;
VNode *t = VCalloc(newsize, sizeof(VNode));
if (t == 0) return 0;
memcpy(t, graph->table, graph->size * sizeof(VNode));
VFree(graph->table); graph->table = t;
graph->size = newsize; graph->nnodes = newsize; return newsize;
}
static int growGraphPos(VGraph graph, int pos)
/* note that we grow just a pointer table */
{
VNode *t;
int newsize = (graph->size * 3) / 2;
if (pos > newsize) newsize = pos+1;
t = (VNode *)VCalloc(newsize, sizeof(VNode));
if (t == 0) return 0;
memcpy(t, graph->table, graph->size * sizeof(VNode));
VFree(graph->table); graph->table = t;
graph->size = newsize; graph->nnodes = newsize; return newsize;
}
int VGraphAddAndGrow(VGraph graph, VNode node, int pos)
{
VNode dst;
if (graph->lastUsed == graph->size || pos > graph->size)
if (growGraphPos(graph, pos) == 0) return 0;
if (node == 0) return 0;
VDestroyNode(graph, pos);
dst = (VNode)VCalloc(1, VNodeSize(graph));
memcpy(dst, node, VNodeSize(graph));
dst->base.head = 0;
VGraphGetNode(graph, pos) = dst;
if (pos > graph->lastUsed) graph->lastUsed = pos;
return pos;
}
int VGraphResizeFields (VGraph graph, int newfields)
{
VNode o, n;
int i;
int nsize = sizeof(VNodeBaseRec) + (newfields * VRepnPrecision(graph->node_repn)) / 8;
int osize = VNodeSize(graph);
if (newfields <= graph->nfields) return TRUE;
for (i = 1; i <= graph->lastUsed; i++) {
if (VGraphNodeIsFree(graph, i)) continue;
o = VGraphGetNode(graph, i);
n = VCalloc(1, nsize);
memcpy(n, o, osize);
VGraphGetNode(graph, i) = n; VFree(o);
};
graph->nfields = newfields;
return TRUE;
}
/*
** check if IDs of ROIs match across masks
*/
int
CheckROI(Volumes *volumes, int m, int nROI) {
int i;
Volume vol;
int *table;
if(m < 2)
return 1; /* no problem if just one mask */
table = (int *) VCalloc(nROI + 1, sizeof(int));
for(i = 0; i < m; i++) {
for(vol = volumes[i]->first; vol != NULL; vol = vol->next) {
table[vol->label]++;
}
}
for(i = 1; i <= nROI; i++) {
if(table[i] != m)
VError(" ROI %d missing in at least one mask", i + 1);
}
return 1;
}
double kendall(double *arr1,double *arr2,int n)
{
static gsl_vector *vec = NULL;
static gsl_permutation *perm=NULL,*rank1=NULL,*rank2=NULL;
static double *r=NULL;
int i;
double S,W,R;
double nx=0;
if (vec == NULL) {
vec = gsl_vector_calloc(n);
perm = gsl_permutation_alloc(n);
rank1 = gsl_permutation_alloc(n);
rank2 = gsl_permutation_alloc(n);
r = (double *) VCalloc(n,sizeof(double));
}
for (i=0; i<n; i++) gsl_vector_set(vec,i,arr1[i]);
gsl_sort_vector_index (perm, vec);
gsl_permutation_inverse (rank1, perm);
for (i=0; i<n; i++) gsl_vector_set(vec,i,arr2[i]);
gsl_sort_vector_index (perm, vec);
gsl_permutation_inverse (rank2, perm);
for (i=0; i<n; i++) r[i] = (double)(rank1->data[i] + rank2->data[i]);
nx = (double)n;
R = 0;
for (i=0; i<n; i++) R += r[i];
R /= nx;
S = 0;
for (i=0; i<n; i++) S += SQR(r[i] - R);
W = 12.0*S/(4.0*(nx*nx-1.0)*nx);
return W;
}
float *
VCorrMatrix(VAttrList list,VImage map,VShort first,VShort length)
{
VAttrListPosn posn;
VImage src[NSLICES];
size_t b,r,c,i,j,i1,n,m,nt,last,ntimesteps,nrows,ncols,nslices;
gsl_matrix_float *mat=NULL;
float *A=NULL;
/*
** get image dimensions
*/
i = ntimesteps = nrows = ncols = 0;
for (VFirstAttr (list, & posn); VAttrExists (& posn); VNextAttr (& posn)) {
if (VGetAttrRepn (& posn) != VImageRepn) continue;
VGetAttrValue (& posn, NULL,VImageRepn, & src[i]);
if (VPixelRepn(src[i]) != VShortRepn) continue;
if (VImageNBands(src[i]) > ntimesteps) ntimesteps = VImageNBands(src[i]);
if (VImageNRows(src[i]) > nrows) nrows = VImageNRows(src[i]);
if (VImageNColumns(src[i]) > ncols) ncols = VImageNColumns(src[i]);
i++;
if (i >= NSLICES) VError(" too many slices");
}
nslices = i;
/* get time steps to include */
if (length < 1) length = ntimesteps-2;
last = first + length -1;
if (last >= ntimesteps) last = ntimesteps-1;
if (first < 0) first = 1;
nt = last - first + 1;
i1 = first+1;
if (nt < 2) VError(" not enough timesteps, nt= %d",nt);
/* number of voxels */
n = VImageNColumns(map);
fprintf(stderr," ntimesteps: %d, first= %d, last= %d, nt= %d, nvoxels: %ld\n",
(int)ntimesteps,(int)first,(int)last,(int)nt,(long)n);
/*
** avoid casting to float, copy data to matrix
*/
mat = gsl_matrix_float_calloc(n,nt);
if (!mat) VError(" err allocating mat");
for (i=0; i<n; i++) {
b = VPixel(map,0,0,i,VShort);
r = VPixel(map,0,1,i,VShort);
c = VPixel(map,0,2,i,VShort);
float *ptr = gsl_matrix_float_ptr(mat,i,0);
int k;
j = 0;
for (k=first; k<=last; k++) {
if (j >= mat->size2) VError(" j= %d %d",j,mat->size2);
if (k >= VImageNBands(src[b])) VError(" k= %d %d",k, VImageNBands(src[b]));
*ptr++ = (float) VPixel(src[b],k,r,c,VShort);
j++;
}
}
/*
** compute similarity matrix
*/
m = (n*(n+1))/2;
fprintf(stderr," compute correlation matrix...\n");
A = (float *) VCalloc(m,sizeof(float));
if (!A) VError(" err allocating correlation matrix");
memset(A,0,m*sizeof(float));
size_t progress=0;
#pragma omp parallel for shared(progress) private(j) schedule(guided) firstprivate(mat,A)
for (i=0; i<n; i++) {
if (i%100 == 0) fprintf(stderr," %d00\r",(int)(++progress));
const float *arr1 = gsl_matrix_float_const_ptr(mat,i,0);
for (j=0; j<i; j++) {
const float *arr2 = gsl_matrix_float_const_ptr(mat,j,0);
const double v = Correlation(arr1,arr2,nt);
const size_t k=j+i*(i+1)/2;
if (k >= m) VError(" illegal addr k= %d, m= %d",k,m);
A[k] = v;
}
}
fprintf(stderr," matrix done.\n");
gsl_matrix_float_free(mat);
return A;
}
VAttrList
VNCM(VAttrList list,VImage mask,VShort minval,VShort first,VShort length,VFloat threshold)
{
VAttrList out_list=NULL;
VAttrListPosn posn;
VImage src[NSLICES],map=NULL;
VImage dest=NULL;
size_t b,r,c,i,j,i1,n,m,nt,last,ntimesteps,nrows,ncols,nslices;
gsl_matrix_float *mat=NULL;
float *A=NULL,*ev=NULL;
/*
** get image dimensions
*/
i = ntimesteps = nrows = ncols = 0;
for (VFirstAttr (list, & posn); VAttrExists (& posn); VNextAttr (& posn)) {
if (VGetAttrRepn (& posn) != VImageRepn) continue;
VGetAttrValue (& posn, NULL,VImageRepn, & src[i]);
if (VPixelRepn(src[i]) != VShortRepn) continue;
if (VImageNBands(src[i]) > ntimesteps) ntimesteps = VImageNBands(src[i]);
if (VImageNRows(src[i]) > nrows) nrows = VImageNRows(src[i]);
if (VImageNColumns(src[i]) > ncols) ncols = VImageNColumns(src[i]);
i++;
if (i >= NSLICES) VError(" too many slices");
}
nslices = i;
/* get time steps to include */
if (length < 1) length = ntimesteps-2;
last = first + length -1;
if (last >= ntimesteps) last = ntimesteps-1;
if (first < 0) first = 1;
nt = last - first + 1;
i1 = first+1;
if (nt < 2) VError(" not enough timesteps, nt= %d",nt);
fprintf(stderr,"# ntimesteps: %d, first= %d, last= %d, nt= %d\n",
(int)ntimesteps,(int)first,(int)last,(int)nt);
/* count number of voxels */
n = 0;
for (b=0; b<nslices; b++) {
if (VImageNRows(src[b]) < 2) continue;
for (r=0; r<nrows; r++) {
for (c=0; c<ncols; c++) {
if (VPixel(src[b],i1,r,c,VShort) < minval) continue;
if (VGetPixel(mask,b,r,c) < 0.5) continue;
n++;
}
}
}
fprintf(stderr," nvoxels: %ld\n",(long)n);
/*
** voxel addresses
*/
map = VCreateImage(1,5,n,VFloatRepn);
if (map == NULL) VError(" error allocating addr map");
VFillImage(map,VAllBands,0);
VPixel(map,0,3,0,VFloat) = nslices;
VPixel(map,0,3,1,VFloat) = nrows;
VPixel(map,0,3,2,VFloat) = ncols;
i = 0;
for (b=0; b<nslices; b++) {
if (VImageNRows(src[b]) < 2) continue;
for (r=0; r<nrows; r++) {
for (c=0; c<ncols; c++) {
if (VPixel(src[b],i1,r,c,VShort) < minval) continue;
if (VGetPixel(mask,b,r,c) < 0.5) continue;
VPixel(map,0,0,i,VFloat) = b;
VPixel(map,0,1,i,VFloat) = r;
VPixel(map,0,2,i,VFloat) = c;
i++;
}
}
}
/*
** avoid casting to float, copy data to matrix
*/
mat = gsl_matrix_float_calloc(n,nt);
for (i=0; i<n; i++) {
b = VPixel(map,0,0,i,VFloat);
r = VPixel(map,0,1,i,VFloat);
c = VPixel(map,0,2,i,VFloat);
float *ptr = gsl_matrix_float_ptr(mat,i,0);
int k;
j = 0;
for (k=first; k<=last; k++) {
if (j >= mat->size2) VError(" j= %d %d",j,mat->size2);
if (k >= VImageNBands(src[b])) VError(" k= %d %d",k, VImageNBands(src[b]));
*ptr++ = (float) VPixel(src[b],k,r,c,VShort);
j++;
}
}
/*
** compute similarity matrix
*/
m = (n*(n+1))/2;
fprintf(stderr," matrix computation, n= %ld...\n",(long)n);
A = (float *) calloc(m,sizeof(float));
if (!A) VError(" err allocating correlation matrix");
memset(A,0,m*sizeof(float));
size_t progress=0;
#pragma omp parallel for shared(progress) private(j) schedule(guided) firstprivate(mat,A)
for (i=0; i<n; i++) {
if (i%100 == 0) fprintf(stderr," %d00\r",(int)(++progress));
const float *arr1 = gsl_matrix_float_const_ptr(mat,i,0);
for (j=0; j<i; j++) {
const float *arr2 = gsl_matrix_float_const_ptr(mat,j,0);
const double v = Correlation(arr1,arr2,nt);
const size_t k=j+i*(i+1)/2;
if (k >= m) VError(" illegal addr k= %d, m= %d",k,m);
A[k] = (float)v;
}
}
fprintf(stderr," matrix done.\n");
gsl_matrix_float_free(mat);
/*
** eigenvector centrality
*/
ev = (float *) VCalloc(n,sizeof(float));
DegreeCentrality(A,ev,n,threshold);
dest = WriteOutput(src[0],map,nslices,nrows,ncols,ev,n);
VSetAttr(VImageAttrList(dest),"name",NULL,VStringRepn,"DegreeCM");
out_list = VCreateAttrList();
VAppendAttr(out_list,"image",NULL,VImageRepn,dest);
return out_list;
}
/*
** slicetime correction for non-constant TR
*/
void
VSlicetime_NC(VAttrList list, VShort minval, VFloat tdel,
VBoolean slicetime_correction, float *onset_array, VString filename) {
FILE *fp = NULL;
VImage src;
VAttrListPosn posn;
VString buf, str;
int b, r, c, i, j, nt = 0, mt = 0, val, del = 0;
double xmin, xmax, sum, nx, estim_tr = 0;
double *xx = NULL, *yy = NULL, xi, yi, slicetime = 0, u = 0;
gsl_interp_accel *acc = NULL;
gsl_spline *spline = NULL;
xmin = (VShort) VRepnMinValue(VShortRepn);
xmax = (VShort) VRepnMaxValue(VShortRepn);
buf = VMalloc(LEN);
/*
** read scan times from file, non-constant TR
*/
if(strlen(filename) > 2) {
fp = fopen(filename, "r");
if(!fp)
VError(" error opening file %s", filename);
i = 0;
while(!feof(fp)) {
for(j = 0; j < LEN; j++)
buf[j] = '\0';
fgets(buf, LEN, fp);
if(buf[0] == '%' || buf[0] == '#')
continue;
if(strlen(buf) < 2)
continue;
i++;
}
rewind(fp);
nt = i;
fprintf(stderr, " num timesteps: %d\n", nt);
xx = (double *) VCalloc(nt, sizeof(double));
yy = (double *) VCalloc(nt, sizeof(double));
i = 0;
sum = 0;
while(!feof(fp)) {
for(j = 0; j < LEN; j++)
buf[j] = '\0';
fgets(buf, LEN, fp);
if(buf[0] == '%' || buf[0] == '#')
continue;
if(strlen(buf) < 2)
continue;
if(sscanf(buf, "%lf", &u) != 1)
VError(" line %d: illegal input format", i + 1);
xx[i] = u * 1000.0; /* convert to millisec */
if(i > 1)
sum += xx[i] - xx[i - 1];
i++;
}
fclose(fp);
estim_tr = sum / (double)(nt - 2);
fprintf(stderr, " average scan interval = %.3f sec\n", estim_tr / 1000.0);
}
/*
** process data
*/
b = -1;
for(VFirstAttr(list, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VShortRepn)
continue;
VSetAttr(VImageAttrList(src), "repetition_time", NULL, VLongRepn, (VLong)estim_tr);
VExtractAttr(VImageAttrList(src), "MPIL_vista_0", NULL, VStringRepn, &str, FALSE);
b++;
if(VImageNRows(src) < 2)
continue;
/*
** get header info
*/
if(VGetAttr(VImageAttrList(src), "slice_time", NULL,
VDoubleRepn, (VPointer) & slicetime) != VAttrFound && slicetime_correction && onset_array == NULL)
VError(" 'slice_time' info missing");
if(onset_array != NULL)
slicetime = onset_array[b];
if(nt != VImageNBands(src))
VError(" inconsistent number of time steps, %d %d",
nt, VImageNBands(src));
if(acc == NULL && slicetime_correction) {
acc = gsl_interp_accel_alloc();
spline = gsl_spline_alloc(gsl_interp_akima, nt);
for(i = 0; i < 5; i++) {
if(xx[i] / 1000.0 > tdel)
break;
}
del = i;
fprintf(stderr, " The first %.2f secs (%d timesteps) will be replaced.\n", tdel, del);
}
/*
** loop through all voxels in current slice
*/
if(slicetime_correction)
fprintf(stderr, " slice: %3d, %10.3f ms\r", b, slicetime);
for(r = 0; r < VImageNRows(src); r++) {
for(c = 0; c < VImageNColumns(src); c++) {
if(VPixel(src, 0, r, c, VShort) < minval)
continue;
/* replace first few time steps by average */
if(del > 0) {
mt = del + 10;
if(mt > nt)
mt = nt;
sum = nx = 0;
for(i = del; i < mt; i++) {
sum += VPixel(src, i, r, c, VShort);
nx++;
}
if(nx < 1)
continue;
val = sum / nx;
for(i = 0; i < del; i++) {
VPixel(src, i, r, c, VShort) = val;
}
}
if(!slicetime_correction)
continue;
/* correct for slicetime offsets using cubic spline interpolation */
for(i = 0; i < nt; i++) {
yy[i] = VPixel(src, i, r, c, VShort);
}
gsl_spline_init(spline, xx, yy, nt);
for(i = 1; i < nt; i++) {
xi = xx[i] - slicetime;
yi = gsl_spline_eval(spline, xi, acc);
val = (int)(yi + 0.49);
if(val > xmax)
val = xmax;
if(val < xmin)
val = xmin;
VPixel(src, i, r, c, VShort) = val;
}
}
}
}
fprintf(stderr, "\n");
}
void
HighPassFilter(double *z,int n,float tr,VFloat high)
{
int i,j,nn,nc,tail;
static double *in=NULL;
static double *highp=NULL;
static fftw_complex *out=NULL;
double sharp=0.8,x,alpha;
fftw_plan p1,p2;
tail = n/10;
if (tail < 50) tail = 50;
if (tail >= n/2) tail = n/2-1;
if (tail >= n-1) tail = n-2;
if (tail < 0) tail = 0;
if(n <= tail) tail = n - 2;
nn = n + 2*tail;
nc = (nn / 2) + 1;
if (out == NULL) {
in = (double *) VCalloc(nn,sizeof(double));
out = fftw_malloc (sizeof (fftw_complex ) * nc);
}
i = 0;
for(j=0; j<tail; j++) in[i++] = z[tail-j];
for(j=0; j<n; j++) in[i++] = z[j];
j = n-2;
while (i < n && j >= 0) in[i++] = z[j];
/*
for (i=0; i<n; i++) in[i] = z[i];
*/
/* make plans */
p1 = fftw_plan_dft_r2c_1d (nn,in,out,FFTW_ESTIMATE);
p2 = fftw_plan_dft_c2r_1d (nn,out,in,FFTW_ESTIMATE);
alpha = (double)n * tr;
if (highp == NULL) highp = (double *) VCalloc(nc,sizeof(double));
sharp = 0.8;
for (i=1; i <nc; i++) {
highp[i] = 1.0 / (1.0 + exp( (alpha/high -(double)i)*sharp ));
}
/* forward fft */
fftw_execute(p1);
/* highpass */
for (i=1; i<nc; i++) {
x = highp[i];
out[i][0] *= x;
out[i][1] *= x;
}
/* inverse fft */
fftw_execute(p2);
for (i=0; i<n; i++) z[i] = in[i+tail]/(double)n;
}
/*
** slicetime correction with constant TR
*/
void
VSlicetime(VAttrList list, VShort minval, VFloat tdel,
VBoolean slicetime_correction, float *onset_array) {
VImage src;
VAttrListPosn posn;
VString str, buf;
int b, r, c, i, nt, mt, val, del = 0;
double xmin, xmax, sum, nx;
double *xx = NULL, *yy = NULL, xi, yi, tr = 0, xtr = 0, slicetime = 0;
gsl_interp_accel *acc = NULL;
gsl_spline *spline = NULL;
xmin = (VShort) VRepnMinValue(VShortRepn);
xmax = (VShort) VRepnMaxValue(VShortRepn);
buf = VMalloc(256);
/*
** process data
*/
b = -1;
for(VFirstAttr(list, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VShortRepn)
continue;
b++;
if(VImageNRows(src) < 2)
continue;
/*
** get header info
*/
if(VGetAttr(VImageAttrList(src), "slice_time", NULL,
VDoubleRepn, (VPointer) & slicetime) != VAttrFound && slicetime_correction && onset_array == NULL)
VError(" 'slice_time' info missing");;
if(onset_array != NULL)
slicetime = onset_array[b];
tr = 0;
if(VGetAttr(VImageAttrList(src), "repetition_time", NULL,
VDoubleRepn, (VPointer) & tr) != VAttrFound) {
tr = 0;
if(VGetAttr(VImageAttrList(src), "MPIL_vista_0", NULL,
VStringRepn, (VPointer) & str) == VAttrFound) {
sscanf(str, " repetition_time=%lf %s", &tr, buf);
}
}
if(tr < 1)
VError(" attribute 'repetition_time' missing");
xtr = tr / 1000.0;
del = (int)(tdel / xtr + 0.5); /* num timesteps to be ignored */
nt = VImageNBands(src);
if(acc == NULL) {
acc = gsl_interp_accel_alloc();
spline = gsl_spline_alloc(gsl_interp_akima, nt);
xx = (double *) VCalloc(nt, sizeof(double));
yy = (double *) VCalloc(nt, sizeof(double));
fprintf(stderr, " The first %.2f secs (%d timesteps) will be replaced.\n", tdel, del);
}
/*
** loop through all voxels in current slice
*/
if(slicetime_correction)
fprintf(stderr, " slice: %3d, %10.3f ms, TR: %.3f\r", b, slicetime, xtr);
for(r = 0; r < VImageNRows(src); r++) {
for(c = 0; c < VImageNColumns(src); c++) {
if(VPixel(src, 0, r, c, VShort) < minval)
continue;
/* replace first few time steps by average */
if(del > 0) {
mt = del + 10;
if(mt > nt)
mt = nt;
sum = nx = 0;
for(i = del; i < mt; i++) {
sum += VPixel(src, i, r, c, VShort);
nx++;
}
if(nx < 1)
continue;
val = sum / nx;
for(i = 0; i < del; i++) {
VPixel(src, i, r, c, VShort) = val;
}
}
if(!slicetime_correction)
continue;
/* correct for slicetime offsets using cubic spline interpolation */
for(i = 0; i < nt; i++) {
xi = i;
xx[i] = xi * tr;
yy[i] = VPixel(src, i, r, c, VShort);
}
gsl_spline_init(spline, xx, yy, nt);
for(i = 1; i < nt; i++) {
xi = xx[i] - slicetime;
yi = gsl_spline_eval(spline, xi, acc);
val = (int)(yi + 0.49);
if(val > xmax)
val = xmax;
if(val < xmin)
val = xmin;
VPixel(src, i, r, c, VShort) = val;
}
}
}
}
fprintf(stderr, "\n");
}
int main(int argc, char *argv[]) {
static VArgVector in_files1;
static VArgVector in_files2;
static VString out_filename;
static VShort type = 1;
static VBoolean gauss = FALSE;
static VOptionDescRec options[] = {
{"in1", VStringRepn, 0, & in_files1, VRequiredOpt, NULL, "Input files 1" },
{"in2", VStringRepn, 0, & in_files2, VRequiredOpt, NULL, "Input files 2" },
{"type", VShortRepn, 1, (VPointer) &type, VOptionalOpt, TypeDict, "output type"},
{"gaussianize", VBooleanRepn, 1, (VPointer) &gauss, VOptionalOpt, NULL, "Whether to Gaussianize"},
{"out", VStringRepn, 1, & out_filename, VRequiredOpt, NULL, "Output file" }
};
FILE *fp = NULL;
VStringConst in_filename, buf1, buf2;
VAttrList list1, list2, out_list;
VAttrListPosn posn;
VString str;
VImage src, *src1, *src2, dest = NULL;
int i, nimages, npix = 0;
char prg_name[100];
char ver[100];
getLipsiaVersion(ver, sizeof(ver));
sprintf(prg_name, "vpaired_ttest V%s", ver);
fprintf(stderr, "%s\n", prg_name);
/*
** parse command line
*/
if(! VParseCommand(VNumber(options), options, & argc, argv)) {
VReportUsage(argv[0], VNumber(options), options, NULL);
exit(EXIT_FAILURE);
}
if(argc > 1) {
VReportBadArgs(argc, argv);
exit(EXIT_FAILURE);
}
if(type < 0 || type > 1)
VError(" illegal type");
/* ini */
nimages = in_files1.number;
if(in_files2.number != nimages)
VError(" inconsistent number of files %d %d", nimages, in_files2.number);
for(i = 0; i < nimages; i++) {
buf1 = ((VStringConst *) in_files1.vector)[i];
buf2 = ((VStringConst *) in_files2.vector)[i];
fprintf(stderr, "%3d: %s %s\n", i, buf1, buf2);
}
fprintf(stderr, "\n");
/* images 1 */
src1 = (VImage *) VCalloc(nimages, sizeof(VImage));
for(i = 0; i < nimages; i++) {
src1[i] = NULL;
in_filename = ((VStringConst *) in_files1.vector)[i];
fp = VOpenInputFile(in_filename, TRUE);
list1 = VReadFile(fp, NULL);
if(! list1)
VError("Error reading image");
fclose(fp);
for(VFirstAttr(list1, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VFloatRepn)
continue;
if(VGetAttr(VImageAttrList(src), "modality", NULL, VStringRepn, &str) == VAttrFound) {
if(strcmp(str, "conimg") != 0)
continue;
}
if(i == 0)
npix = VImageNPixels(src);
else if(npix != VImageNPixels(src))
VError(" inconsistent image dimensions");
src1[i] = src;
break;
}
if(src1[i] == NULL)
VError(" no contrast image found in %s", in_filename);
}
/* images 2 */
src2 = (VImage *) VCalloc(nimages, sizeof(VImage));
for(i = 0; i < nimages; i++) {
src2[i] = NULL;
in_filename = ((VStringConst *) in_files2.vector)[i];
fp = VOpenInputFile(in_filename, TRUE);
list2 = VReadFile(fp, NULL);
if(! list2)
VError("Error reading image");
fclose(fp);
for(VFirstAttr(list2, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VFloatRepn)
continue;
if(VGetAttr(VImageAttrList(src), "modality", NULL, VStringRepn, &str) == VAttrFound) {
if(strcmp(str, "conimg") != 0)
continue;
}
if(npix != VImageNPixels(src))
VError(" inconsistent image dimensions");
src2[i] = src;
break;
}
if(src2[i] == NULL)
VError(" no contrast image found in %s", in_filename);
}
/* make normally distributed */
if(gauss) {
VGaussianize(src1, nimages);
VGaussianize(src2, nimages);
}
/* paired t-test */
dest = PairedTest(src1, src2, dest, nimages, type);
/*
** output
*/
out_list = VCreateAttrList();
VHistory(VNumber(options), options, prg_name, &list1, &out_list);
VAppendAttr(out_list, "image", NULL, VImageRepn, dest);
fp = VOpenOutputFile(out_filename, TRUE);
if(! VWriteFile(fp, out_list))
exit(1);
fclose(fp);
fprintf(stderr, "%s: done.\n", argv[0]);
exit(0);
}
VImage
VContrastAny(VImage src,VImage dest,VFloat low,VFloat high)
{
int nbands,nrows,ncols;
double xmin,xmax,slope,sum,a;
float *histo;
int b,r,c,j,dim;
VUByte *dest_pp;
double smin,smax,u,v,tiny;
nbands = VImageNBands(src);
nrows = VImageNRows(src);
ncols = VImageNColumns(src);
dest = VSelectDestImage("VContrastAny",dest,nbands,nrows,ncols,VUByteRepn);
if (! dest) VError(" err creating dest image");
VFillImage(dest,VAllBands,0);
smin = VPixelMaxValue(src);
smax = VPixelMinValue(src);
for (b=0; b<nbands; b++) {
for (r=0; r<nrows; r++) {
for (c=0; c<ncols; c++) {
u = VGetPixel(src,b,r,c);
if (u < smin) smin = u;
if (u > smax) smax = u;
}
}
}
dim = 10000;
if (VPixelRepn(src) == VUByteRepn) dim = 256;
histo = (float *) VCalloc(dim,sizeof(float));
for (j=0; j<dim; j++) histo[j] = 0;
tiny = 2.0/(double)dim;
a = ((double) dim) / (smax - smin);
for (b=0; b<nbands; b++) {
for (r=0; r<nrows; r++) {
for (c=0; c<ncols; c++) {
u = VGetPixel(src,b,r,c);
if (ABS(u) < tiny) continue;
j = (int) (a * (u - smin) + 0.5);
if (j < 0) j = 0;
if (j >= dim) j = dim-1;
histo[j]++;
}
}
}
sum = 0;
for (j=0; j<dim; j++) sum += histo[j];
for (j=0; j<dim; j++) histo[j] /= sum;
xmin = 0;
sum = 0;
for (j=0; j<dim; j++) {
sum += histo[j];
if (sum > low) break;
}
xmin = ((double)j)/a + smin;
xmax = dim;
sum = 0;
for (j=dim; j>0; j--) {
sum += histo[j];
if (sum > high) break;
}
xmax = ((double)j)/a + smin;
slope = 255.0 / (xmax - xmin);
dest_pp = (VUByte *) VImageData(dest);
for (b=0; b<nbands; b++) {
for (r=0; r<nrows; r++) {
for (c=0; c<ncols; c++) {
u = VGetPixel(src,b,r,c);
v = (int) (slope * (u - xmin) + 0.5);
if (ABS(u) < tiny) v = 0;
if (v < 0) v = 0;
if (v > 255) v = 255;
*dest_pp++ = (VUByte) v;
}
}
}
VCopyImageAttrs (src, dest);
return dest;
}
/* Parse command without license information */
VBoolean VParseCommand_nl (int noptions, VOptionDescRec options[],
int *argc, char **argv)
{
int arg, nvalues, i, j;
char *cp;
VBoolean *opts_seen, result = TRUE;
VOptionDescRec *opt, *opt_t;
/* Note the program's name: */
VSetProgramName (argv[0]);
/* Allocate storage for a set of flags indicating which
arguments have been seen: */
opts_seen = VCalloc (noptions, sizeof (VBoolean));
/* Initialize any "found" flags to false, and the number field of any
VArgVector values to zero: */
for (opt = options + noptions - 1; opt >= options; opt--) {
if (opt->found)
*opt->found = FALSE;
if (opt->number == 0 && opt->value)
((VArgVector *) opt->value)->number = 0;
}
/* For each argument supplied with the command: */
for (arg = 1; arg < *argc; ) {
cp = argv[arg++];
/* If it doesn't start with - it can't be an option: */
if (cp[0] != '-' || cp[1] == 0)
continue;
/* Check for -help: */
if (strcmp (cp + 1, "help") == 0) {
/* If found, return FALSE to force printing of usage info: */
*argc = 1;
return FALSE;
}
/* Look up the argument in the list of options: */
i = strlen (cp + 1);
opt = NULL;
for (opt_t = options + noptions - 1; opt_t >= options; opt_t--) {
if (strncmp (cp + 1, opt_t->keyword, i) != 0)
continue; /* not this one */
if (i == strlen (opt_t->keyword)) {
opt = opt_t;
break; /* an exact match */
}
if (opt)
goto NextArg; /* already matched another prefix */
opt = opt_t; /* note a prefix match */
}
/* If the argument isn't recognized, skip it: */
if (! opt)
goto NextArg; /* not recognized */
/* Remove it from the list of command arguments: */
argv[arg - 1] = 0;
/* Ensure that the option has not already been seen: */
if (opts_seen[opt - options]) {
fprintf (stderr,
"%s: Duplicate -%s option; ignoring all but last.\n",
argv[0], opt->keyword);
/* If it has been seen, delete its previous value: */
if (opt->number == 0) {
VFree (((VArgVector *) opt->value)->vector);
((VArgVector *) opt->value)->number = 0;
}
} else opts_seen[opt - options] = TRUE;
/* Swallow any value(s) that follow: */
switch (opt->repn) {
case VBitRepn:
case VUByteRepn:
case VSByteRepn:
case VShortRepn:
case VLongRepn:
case VFloatRepn:
case VDoubleRepn:
case VBooleanRepn:
case VStringRepn:
nvalues = ParseArgValues (& arg, *argc, argv, opt);
break;
default:
VError ("Parsing of command options with %s values "
"is not implemented", VRepnName (opt->repn));
nvalues = 0; /* to quiet lint */
}
/* Ensure that the expected number of arguments was found: */
if (opt->number && nvalues != opt->number) {
/* Either we encountered an argument we couldn't parse, or
we used up all arguments before finding the expected number
of them: */
fprintf (stderr, "%s: Option -%s ", argv[0], opt->keyword);
if (arg < *argc)
fprintf (stderr, "has incorrect value %s.\n", argv[arg]);
else if (opt->number > 1)
fprintf (stderr, "requires %d values; found only %d.\n",
opt->number, nvalues);
else fprintf (stderr, "requires a value.\n");
result = FALSE;
break;
}
if (opt->number == 0)
((VArgVector *) opt->value)->number = nvalues;
/* Note that a value was successfully obtained for this option: */
if (opt->found)
*(opt->found) = TRUE;
NextArg: ;
}
/* Ensure that each mandatory option was seen: */
for (i = 0; i < noptions; i++)
if (options[i].found == VRequiredOpt && ! opts_seen[i]) {
fprintf (stderr, "%s: Option -%s must be specified.\n",
argv[0], options[i].keyword);
result = FALSE;
}
VFree ((VPointer) opts_seen);
/* Squeeze together the remaining arguments in argv: */
for (i = j = 1; i < *argc; i++)
if (argv[i])
argv[j++] = argv[i];
*argc = j;
return result;
}
VBoolean VParseCommand (int noptions, VOptionDescRec options[],
int *argc, char **argv)
{
int arg, nvalues, i, j;
char *cp;
VBoolean *opts_seen, result = TRUE;
VOptionDescRec *opt, *opt_t;
/* Note the program's name: */
VSetProgramName (argv[0]);
/* Allocate storage for a set of flags indicating which
arguments have been seen: */
opts_seen = VCalloc (noptions, sizeof (VBoolean));
/* Initialize any "found" flags to false, and the number field of any
VArgVector values to zero: */
for (opt = options + noptions - 1; opt >= options; opt--) {
if (opt->found)
*opt->found = FALSE;
if (opt->number == 0 && opt->value)
((VArgVector *) opt->value)->number = 0;
}
/* For each argument supplied with the command: */
for (arg = 1; arg < *argc; ) {
cp = argv[arg++];
/* If it doesn't start with - it can't be an option: */
if (cp[0] != '-' || cp[1] == 0)
continue;
/* Check for -help: */
if (strcmp (cp + 1, "license") == 0) {
char* license="This program is free software; you can redistribute it and/or\n modify it under the terms of the GNU General Public License\n as published by the Free Software Foundation; either version 2\n of the License, or (at your option) any later version.\n This program is distributed in the hope that it will be useful,\n but WITHOUT ANY WARRANTY; without even the implied warranty of\n MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the\n GNU General Public License for more details.\n\n You should have received a copy of the GNU General Public License\n along with this program; if not, write to the Free Software\n Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA.\n";
fprintf(stderr,"%s\n",license);
exit(0);
}
}
/* For each argument supplied with the command: */
for (arg = 1; arg < *argc; ) {
cp = argv[arg++];
/* If it doesn't start with - it can't be an option: */
if (cp[0] != '-' || cp[1] == 0)
continue;
/* Check for -help: */
if (strcmp (cp + 1, "help") == 0) {
/* If found, return FALSE to force printing of usage info: */
*argc = 1;
return FALSE;
}
/* Look up the argument in the list of options: */
i = strlen (cp + 1);
opt = NULL;
for (opt_t = options + noptions - 1; opt_t >= options; opt_t--) {
if (strncmp (cp + 1, opt_t->keyword, i) != 0)
continue; /* not this one */
if (i == strlen (opt_t->keyword)) {
opt = opt_t;
break; /* an exact match */
}
if (opt)
goto NextArg; /* already matched another prefix */
opt = opt_t; /* note a prefix match */
}
/* If the argument isn't recognized, skip it: */
if (! opt)
goto NextArg; /* not recognized */
/* Remove it from the list of command arguments: */
argv[arg - 1] = 0;
/* Ensure that the option has not already been seen: */
if (opts_seen[opt - options]) {
fprintf (stderr,
"%s: Duplicate -%s option; ignoring all but last.\n",
argv[0], opt->keyword);
/* If it has been seen, delete its previous value: */
if (opt->number == 0) {
VFree (((VArgVector *) opt->value)->vector);
((VArgVector *) opt->value)->number = 0;
}
} else opts_seen[opt - options] = TRUE;
/* Swallow any value(s) that follow: */
switch (opt->repn) {
case VBitRepn:
case VUByteRepn:
case VSByteRepn:
case VShortRepn:
case VLongRepn:
case VFloatRepn:
case VDoubleRepn:
case VBooleanRepn:
case VStringRepn:
nvalues = ParseArgValues (& arg, *argc, argv, opt);
break;
default:
VError ("Parsing of command options with %s values "
"is not implemented", VRepnName (opt->repn));
nvalues = 0; /* to quiet lint */
}
/* Ensure that the expected number of arguments was found: */
if (opt->number && nvalues != opt->number) {
/* Either we encountered an argument we couldn't parse, or
we used up all arguments before finding the expected number
of them: */
fprintf (stderr, "%s: Option -%s ", argv[0], opt->keyword);
if (arg < *argc)
fprintf (stderr, "has incorrect value %s.\n", argv[arg]);
else if (opt->number > 1)
fprintf (stderr, "requires %d values; found only %d.\n",
opt->number, nvalues);
else fprintf (stderr, "requires a value.\n");
result = FALSE;
break;
}
if (opt->number == 0)
((VArgVector *) opt->value)->number = nvalues;
/* Note that a value was successfully obtained for this option: */
if (opt->found)
*(opt->found) = TRUE;
NextArg: ;
}
/* Ensure that each mandatory option was seen: */
for (i = 0; i < noptions; i++)
if (options[i].found == VRequiredOpt && ! opts_seen[i]) {
fprintf (stderr, "%s: Option -%s must be specified.\n",
argv[0], options[i].keyword);
result = FALSE;
}
VFree ((VPointer) opts_seen);
/* Squeeze together the remaining arguments in argv: */
for (i = j = 1; i < *argc; i++)
if (argv[i])
argv[j++] = argv[i];
*argc = j;
return result;
}
int main(int argc, char *argv[]) {
static VArgVector in_files1;
static VArgVector in_files2;
static VString out_filename;
static VOptionDescRec options[] = {
{ "in1", VStringRepn, 0, & in_files1, VRequiredOpt, NULL, "Input files 1" },
{ "in2", VStringRepn, 0, & in_files2, VRequiredOpt, NULL, "Input files 2" },
{ "out", VStringRepn, 1, & out_filename, VRequiredOpt, NULL, "Output file" }
};
FILE *fp = NULL;
VStringConst in_filename, buf1, buf2;
VAttrList list1, list2, out_list;
VAttrListPosn posn;
VImage src, *src1, *src2, dest = NULL;
int i, nimages, npix = 0;
char prg_name[100];
char ver[100];
getLipsiaVersion(ver, sizeof(ver));
sprintf(prg_name, "vpaired_wilcoxtest V%s", ver);
fprintf(stderr, "%s\n", prg_name);
/*
** parse command line
*/
if(! VParseCommand(VNumber(options), options, & argc, argv)) {
VReportUsage(argv[0], VNumber(options), options, NULL);
exit(EXIT_FAILURE);
}
if(argc > 1) {
VReportBadArgs(argc, argv);
exit(EXIT_FAILURE);
}
/* number of images */
nimages = in_files1.number;
if(in_files2.number != nimages)
VError(" inconsistent number of files ");
for(i = 0; i < nimages; i++) {
buf1 = ((VStringConst *) in_files1.vector)[i];
buf2 = ((VStringConst *) in_files2.vector)[i];
fprintf(stderr, "%3d: %s %s\n", i, buf1, buf2);
}
fprintf(stderr, "\n");
/*
** read images 1
*/
src1 = (VImage *) VCalloc(nimages, sizeof(VImage));
for(i = 0; i < nimages; i++) {
src1[i] = NULL;
in_filename = ((VStringConst *) in_files1.vector)[i];
fp = VOpenInputFile(in_filename, TRUE);
list1 = VReadFile(fp, NULL);
if(! list1)
VError("Error reading image");
fclose(fp);
for(VFirstAttr(list1, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VFloatRepn)
continue;
src1[i] = src;
break;
}
if(i == 0)
npix = VImageNPixels(src1[i]);
else if(npix != VImageNPixels(src1[i]))
VError(" inconsistent image dimensions");
if(src1[i] == NULL)
VError(" no image found in %s", in_filename);
}
/*
** read images 2
*/
src2 = (VImage *) VCalloc(nimages, sizeof(VImage));
for(i = 0; i < nimages; i++) {
src2[i] = NULL;
in_filename = ((VStringConst *) in_files2.vector)[i];
fp = VOpenInputFile(in_filename, TRUE);
list2 = VReadFile(fp, NULL);
if(! list2)
VError("Error reading image");
fclose(fp);
for(VFirstAttr(list2, & posn); VAttrExists(& posn); VNextAttr(& posn)) {
if(VGetAttrRepn(& posn) != VImageRepn)
continue;
VGetAttrValue(& posn, NULL, VImageRepn, & src);
if(VPixelRepn(src) != VFloatRepn)
continue;
src2[i] = src;
break;
}
if(npix != VImageNPixels(src2[i]))
VError(" inconsistent image dimensions");
if(src2[i] == NULL)
VError(" no image found in %s", in_filename);
}
/*
** paired wilcoxon test
*/
dest = PairedWilcoxTest(src1, src2, dest, nimages);
/*
** output
*/
out_list = VCreateAttrList();
VHistory(VNumber(options), options, prg_name, &list1, &out_list);
VAppendAttr(out_list, "image", NULL, VImageRepn, dest);
fp = VOpenOutputFile(out_filename, TRUE);
if(! VWriteFile(fp, out_list))
exit(1);
fclose(fp);
fprintf(stderr, "%s: done.\n", argv[0]);
exit(0);
}
/*!
\fn VImage VContrastShort(VImage src,VImage dest,VFloat percent,VFloat background)
\param src input image (short repn)
\param dest output image (ubyte repn)
*/
VImage
VContrastShort(VImage src,VImage dest,VFloat low,VFloat high)
{
int nbands,nrows,ncols,npixels;
float u,v,xmin,xmax,slope,sum;
float *histo;
int i,j,dim;
VShort *src_pp;
VUByte *dest_pp;
double smin,smax;
double percent1,percent2;
if (VPixelRepn(src) != VShortRepn) VError(" input pixel repn must be short");
nbands = VImageNBands(src);
nrows = VImageNRows(src);
ncols = VImageNColumns(src);
npixels = nbands * nrows * ncols;
dest = VSelectDestImage("VContrastShort",dest,nbands,nrows,ncols,VUByteRepn);
if (! dest) VError(" err creating dest image");
VFillImage(dest,VAllBands,0);
smin = VRepnMinValue(VShortRepn);
smax = VRepnMaxValue(VShortRepn);
percent1 = low; /* unten */
percent2 = high; /* oben */
dim = 2.0 * smax + 1.0;
histo = (float *) VCalloc(dim,sizeof(float));
for (j=0; j<dim; j++) histo[j] = 0;
src_pp = (VShort *) VImageData(src);
for (i=0; i<npixels; i++) {
j = *src_pp++;
j -= smin;
histo[j]++;
}
sum = 0;
for (j=0; j<dim; j++) sum += histo[j];
for (j=0; j<dim; j++) histo[j] /= sum;
xmin = 0;
sum = 0;
for (j=0; j<dim; j++) {
sum += histo[j];
if (sum > percent1) break;
}
xmin = j+smin;
xmax = dim;
sum = 0;
for (j=dim; j>0; j--) {
sum += histo[j];
if (sum > percent2) break;
}
xmax = j+smin;
slope = 255.0f / (xmax - xmin);
src_pp = (VShort *) VImageData(src);
dest_pp = (VUByte *) VImageData(dest);
for (i=0; i<npixels; i++) {
u = *src_pp++;
v = (int) (slope * (u - xmin) + 0.5);
if (v < 0) v = 0;
if (v > 255) v = 255;
*dest_pp++ = (VUByte) v;
}
VFree(histo);
VCopyImageAttrs (src, dest);
return dest;
}
void
VROIpaired_ttest(VImage *src1, VImage *src2, VImage *mask, int n, int nmask, FILE *fp) {
VString str;
int i, j, id, b, r, c, c0, c1, nROI = 0;
float ave1 = 0, ave2 = 0, var1 = 0, var2 = 0;
float sum1 = 0, sum2 = 0, u, mx;
float t, z, p, df, sd, cov, *data1 = NULL, *data2 = NULL;
float tiny = 1.0e-8;
float xa, ya, za, xx, yy, zz, voxelsize = 1;
double mean[3];
Volumes *volumes;
Volume vol;
VTrack tc;
VBoolean found = FALSE;
gsl_set_error_handler_off();
/*
** get ROIs from mask
*/
fprintf(stderr, "\n List of ROIs:\n");
fprintf(fp, "\n List of ROIs:\n");
volumes = (Volumes *) VCalloc(nmask, sizeof(Volumes));
nROI = 0;
for(i = 0; i < nmask; i++) {
fprintf(stderr, "\n Mask %2d:\n", i + 1);
fprintf(fp, "\n Mask %2d:\n", i + 1);
volumes[i] = VImage2Volumes(mask[i]);
voxelsize = 1;
if(VGetAttr(VImageAttrList(mask[i]), "voxel", NULL,
VStringRepn, (VPointer) & str) == VAttrFound) {
sscanf(str, "%f %f %f", &xa, &ya, &za);
voxelsize = xa * ya * za;
}
fprintf(stderr, " ROI addr size(mm^3)\n");
fprintf(stderr, "-----------------------------------------------\n");
fprintf(fp, " ROI addr size(mm^3)\n");
fprintf(fp, "-----------------------------------------------\n");
for(vol = volumes[i]->first; vol != NULL; vol = vol->next) {
VolumeCentroid(vol, mean);
if(nROI < vol->label)
nROI = vol->label;
b = mean[0];
r = mean[1];
c = mean[2];
xx = mean[2];
yy = mean[1];
zz = mean[0];
VGetTalCoord(src1[0], zz, yy, xx, &xa, &ya, &za);
id = vol->label;
fprintf(stderr, " %2d %7.2f %7.2f %7.2f %7.0f\n",
id, xa, ya, za, voxelsize *(double)VolumeSize(vol));
fprintf(fp, " %2d %7.2f %7.2f %7.2f %7.0f\n",
id, xa, ya, za, voxelsize *(double)VolumeSize(vol));
}
}
fprintf(stderr, "\n\n");
fprintf(fp, "\n\n");
/* check consistency */
if(nROI < 1)
VError(" no ROIs found");
CheckROI(volumes, nmask, nROI);
/*
** process each ROI
*/
fprintf(stderr, "\n");
fprintf(stderr, " ROI mean t z p \n");
fprintf(stderr, " --------------------------------------------------\n");
if(fp) {
fprintf(fp, "\n");
fprintf(fp, " ROI mean t z p \n");
fprintf(fp, " --------------------------------------------------\n");
}
df = n - 1;
data1 = (float *) VCalloc(n, sizeof(float));
data2 = (float *) VCalloc(n, sizeof(float));
for(id = 1; id <= nROI; id++) {
for(i = 0; i < n; i++) {
j = 0;
if(nmask > 1)
j = i;
found = FALSE;
for(vol = volumes[j]->first; vol != NULL; vol = vol->next) {
if(vol->label != id)
continue;
found = TRUE;
sum1 = sum2 = mx = 0;
for(j = 0; j < VolumeNBuckets(vol); j++) {
for(tc = VFirstTrack(vol, j); VTrackExists(tc); tc = VNextTrack(tc)) {
b = tc->band;
r = tc->row;
c0 = tc->col;
c1 = c0 + tc->length;
for(c = c0; c < c1; c++) {
u = VPixel(src1[i], b, r, c, VFloat);
if(ABS(u) < tiny)
continue;
sum1 += u;
u = VPixel(src2[i], b, r, c, VFloat);
if(ABS(u) < tiny)
continue;
sum2 += u;
mx++;
}
}
}
if(mx < 1) {
VWarning(" no voxels in ROI %d of mask %d", id, i);
data1[i] = data2[i] = 0;
continue;
}
data1[i] = sum1 / mx;
data2[i] = sum2 / mx;
}
if(!found)
goto next;
}
avevar(data1, n, &ave1, &var1);
avevar(data2, n, &ave2, &var2);
if(var1 < tiny || var2 < tiny) {
VWarning(" no variance in ROI %d", id);
continue;
}
z = t = p = 0;
cov = 0;
for(j = 0; j < n; j++)
cov += (data1[j] - ave1) * (data2[j] - ave2);
cov /= df;
sd = sqrt((var1 + var2 - 2.0 * cov) / (df + 1.0));
if(sd < tiny)
continue;
t = (ave1 - ave2) / sd;
if(ABS(t) < tiny)
p = z = 0;
else {
p = t2p((double)t, (double)df);
z = t2z((double)t, (double)df);
if(t < 0)
z = -z;
}
fprintf(stderr, " %3d %8.4f (%.3f) %7.3f %7.3f %7.4f\n",
id, (ave1 - ave2), sd, t, z, p);
if(fp)
fprintf(fp, " %3d %8.4f (%.3f) %7.3f %7.3f %7.4f\n",
id, (ave1 - ave2), sd, t, z, p);
next:
;
}
fprintf(stderr, "\n");
if(fp) {
fprintf(fp, "\n");
fclose(fp);
}
}
VImage
VHistoEqualize(VImage src,VImage dest,VFloat exponent)
{
int nbands,nrows,ncols,npixels;
float u,v,sum;
float *histo,*p;
int i,j,dim;
VShort *src_pp;
VUByte *dest_pp;
double smin,smax,x,y;
if (VPixelRepn(src) != VShortRepn) VError(" input pixel repn must be short");
if (exponent < 0.5) VError("parameter '-exponent' should be >= 0.5");
if (exponent > 10) VWarning("parameter '-exponent' should be < 10");
nbands = VImageNBands(src);
nrows = VImageNRows(src);
ncols = VImageNColumns(src);
npixels = nbands * nrows * ncols;
dest = VSelectDestImage("VContrastShort",dest,nbands,nrows,ncols,VUByteRepn);
if (! dest) VError(" err creating dest image");
VFillImage(dest,VAllBands,0);
y = (double) exponent;
smin = VRepnMinValue(VShortRepn);
smax = VRepnMaxValue(VShortRepn);
dim = 2.0 * smax + 1.0;
histo = (float *) VCalloc(dim,sizeof(float));
for (j=0; j<dim; j++) histo[j] = 0;
p = (float *) VCalloc(dim,sizeof(float));
src_pp = (VShort *) VImageData(src);
for (i=0; i<npixels; i++) {
j = *src_pp++;
j -= smin;
if (j == 0) continue;
histo[j]++;
}
sum = 0;
for (j=0; j<dim; j++) sum += histo[j];
for (j=0; j<dim; j++) histo[j] /= sum;
/* cumulative hist */
for (i=0; i<dim; i++) {
sum = 0;
for (j=0; j<=i; j++) sum += histo[j];
p[i] = sum;
}
/* make lut */
for (i=0; i<dim; i++) {
x = (double)p[i];
if (x > 0)
p[i] = (float)(pow(x,y) * 255.0);
}
/* apply lut */
src_pp = (VShort *) VImageData(src);
dest_pp = (VUByte *) VImageData(dest);
for (i=0; i<npixels; i++) {
u = *src_pp++;
j = (int) (u-smin);
v = (double)p[j];
if (v < 0) v = 0;
if (v > 255) v = 255;
*dest_pp++ = (VUByte) v;
}
VFree(p);
VFree(histo);
VCopyImageAttrs (src, dest);
return dest;
}
VImage VScaleIntensity(VImage src, double white, double black)
/* scale any input image to VUByte,
mapping white (black) percent of the voxel to white (black) */
{
int x, y, z, nx, ny, nz, i, range, maxshort;
unsigned int lb, ub, limit, sum, *histo;
double m, b, max, min, mean, var, v;
VImage dst;
maxshort = (int)(VRepnMaxValue(VShortRepn));
histo = (unsigned int *)VCalloc(maxshort, sizeof(unsigned int));
nx = VImageNColumns(src);
ny = VImageNRows(src);
nz = VImageNBands(src);
if (white < 0 || white > 100 || black < 0 || black > 100 || white+black >= 100) {
fprintf(stderr, "VScaleIntensity: illegal percentage given.\n");
return 0;
};
/* first pass: find maximum and minimum values */
VImageStats(src, VAllBands, &min, &max, &mean, &var);
if (max == min) {
fprintf(stderr, "VScaleIntensity: illegal data in image.\n");
return 0;
};
b = min;
m = (max-min) / (double)maxshort;
/* second pass: build a histogram*/
for (z = 0; z < nz; z++) {
for (y = 0; y < ny; y++) {
for (x = 0; x < nx; x++) {
v = VGetPixel(src, z, y, x);
i = (int)((v-b)/m+0.5);
histo[i]++;
};
};
};
/* throw away pc percent of the voxel below lb and pc percent above ub */
limit = (black * nx * ny * nz) / 100;
lb = 0; sum = 0;
for (i = 0; i < maxshort; i++) {
sum += histo[i];
if (sum >= limit) { lb = i; break; };
};
limit = (white * nx * ny * nz) / 100;
ub = maxshort-1; sum = 0;
for (i = maxshort-1; i >= 0; i--) {
sum += histo[i];
if (sum >= limit) { ub = i; break; };
};
min = lb*m+b;
max = ub*m+b;
/* third pass: create and convert image */
dst = VCreateImage(nz, ny, nx, VUByteRepn);
if (dst == 0) return 0;
range = 256;
m = range / (max - min);
b = range - (m * max);
for (z = 0; z < nz; z++) {
for (y = 0; y < ny; y++) {
for (x = 0; x < nx; x++) {
v = VGetPixel(src, z, y, x);
i = (int)(v * m + b + 0.5);
if (i < 0) i = 0;
else if (i >= range) i = range-1;
VPixel(dst, z, y, x, VUByte) = i;
};
};
};
VFree(histo);
VCopyImageAttrs(src, dst);
return dst;
}
int *
KMeans(gsl_matrix *mat, int nclusters, double *bic, double *aic) {
int *labels = NULL, *bestlabels = NULL, *list = NULL;
int i, j, s, dim, iter, nvectors, maxiter = 1000;
double xmax, dmin, d, nx, mx, best, xbic = 0;
double rss = 0;
gsl_vector *kmean[N], *kmean_sav[N];
gsl_vector *vec = NULL, *tmp = NULL;
unsigned long int seed;
gsl_rng *rx = NULL;
const gsl_rng_type *T = NULL;
/* random */
seed = 35521738;
gsl_rng_env_setup();
T = gsl_rng_default;
rx = gsl_rng_alloc(T);
gsl_rng_set(rx, (unsigned long int)seed);
/* alloc */
xmax = VRepnMaxValue(VDoubleRepn);
dim = mat->size1; /* vector length */
nvectors = mat->size2; /* num vectors (matrix columns) */
vec = gsl_vector_calloc(dim);
tmp = gsl_vector_calloc(dim);
labels = (int *) VCalloc(nvectors, sizeof(int));
bestlabels = (int *) VCalloc(nvectors, sizeof(int));
list = (int *) VCalloc(nclusters, sizeof(int));
for(i = 0; i < nclusters; i++) {
kmean[i] = gsl_vector_calloc(dim);
kmean_sav[i] = gsl_vector_calloc(dim);
}
/* ini */
best = VRepnMaxValue(VDoubleRepn);
/* best = 1.0e+999 !!!!!!!!!!!!!! */
for(s = 0; s < 50; s++) { /* try several starting values */
Centers(nvectors, nclusters, list, rx);
for(i = 0; i < nclusters; i++)
gsl_matrix_get_col(kmean[i], mat, list[i]);
/* iterations */
for(iter = 0; iter < maxiter; iter++) {
/* get nearest neighbour */
for(j = 0; j < nvectors; j++) {
gsl_matrix_get_col(vec, mat, j);
dmin = xmax;
for(i = 0; i < nclusters; i++) {
d = dist(kmean[i], vec);
if(d < dmin) {
dmin = d;
labels[j] = i;
}
}
}
/* update cluster means */
for(i = 0; i < nclusters; i++) {
gsl_vector_memcpy(kmean_sav[i], kmean[i]);
gsl_vector_set_zero(kmean[i]);
nx = 0;
for(j = 0; j < nvectors; j++) {
if(labels[j] != i)
continue;
gsl_matrix_get_col(vec, mat, j);
gsl_vector_add(kmean[i], vec);
nx++;
}
gsl_vector_scale(kmean[i], 1.0 / nx);
}
/* stop iterations if no significant changes occurr */
d = 0;
for(i = 0; i < nclusters; i++)
d += dist(kmean[i], kmean_sav[i]);
if(d < 1.0e-10)
break;
}
/* residual sum of squares, RSS */
rss = 0;
for(i = 0; i < nclusters; i++) {
for(j = 0; j < nvectors; j++) {
if(labels[j] != i)
continue;
gsl_matrix_get_col(vec, mat, j);
rss += dist(kmean[i], vec);
}
}
if(rss < best) {
best = rss;
for(j = 0; j < nvectors; j++)
bestlabels[j] = labels[j];
}
}
/* Bayesian information criterion (not very useful) */
nx = (double)nvectors;
mx = (double)nclusters;
xbic = nx * log(best) + mx * log(nx);
(*bic) = log(best) + log(nx) * mx / nx;
(*aic) = log(best) + 2.0 * mx / nx;
(*bic) = xbic;
return bestlabels;
}
static VPointer VGraphDecodeMethod (VStringConst name, VBundle b)
{
VGraph graph;
VLong size, nfields, node_repn, useWeights;
VAttrList list;
VLong idx, nadj;
int length;
size_t len;
VNode n;
VPointer p, ptr;
VAdjacency adj;
#define Extract(name, dict, locn, required) \
VExtractAttr (b->list, name, dict, VLongRepn, & locn, required)
/* Extract the required attribute values for Graph. */
if (!Extract (VRepnAttr, VNumericRepnDict, node_repn, TRUE) ||
!Extract (VNNodeFieldsAttr, NULL, nfields, TRUE) ||
!Extract (VNNodeWeightsAttr, NULL, useWeights, TRUE))
return NULL;
/* Look for size attribute, if not present, look for nnodes (for backward compatibility */
if (Extract (VNGraphSizeAttr, NULL, size, TRUE) == FALSE &&
Extract (VNGraphNodesAttr, NULL, size, TRUE) == FALSE)
return NULL;
if (size <= 0 || nfields <= 0) {
VWarning ("VGraphReadDataMethod: Bad Graph file attributes");
return NULL;
}
/* Create the Graph data structure. */
graph = VCreateGraph ((int)size, (int) nfields,
(VRepnKind) node_repn, (int) useWeights);
if (! graph)
return NULL;
/* Give it whatever attributes remain: */
list = VGraphAttrList (graph);
VGraphAttrList (graph) = b->list;
b->list = list;
length = b->length;
if (length == 0) return graph;
p = b->data;
#define unpack(repn, cnt, dest) \
ptr = dest; \
if (VUnpackData(repn, cnt, p, VMsbFirst, & len, & ptr, 0) == 0) return 0; \
p = (char *) p + len; length -= len; len = length; \
if (length < 0) goto Fail;
len = length;
while (length > 0) {
/* Get the index : */
unpack(VLongRepn, 1, &idx);
graph->table[idx-1] = n = VCalloc(1, VNodeSize(graph));
if (idx > graph->lastUsed) graph->lastUsed = idx;
graph->nnodes++;
/* Get the number of adjacencies : */
unpack(VLongRepn, 1, &nadj);
/* Unpack the adjacencies : */
while (nadj--) {
adj = VMalloc(sizeof(VAdjRec));
unpack(VLongRepn, 1, &adj->id);
if (graph->useWeights) {
unpack(VFloatRepn, 1, &adj->weight);
} else
adj->weight = 0.0;
adj->next = n->base.head; n->base.head = adj;
};
/* Unpack the node itself: */
if (graph->useWeights) {
unpack(VFloatRepn, 1, &(n->base.weight));
} else
n->base.weight = 0.0;
unpack(graph->node_repn, graph->nfields, n->data);
}
return graph;
Fail:
VWarning ("VGraphDecodeMethod: %s graph has wrong data length", name);
VDestroyGraph (graph);
return NULL;
#undef Extract
}