Esempi in C++ (Cpp) per indel_key::open_pos_range

Esempio n. 1

File: indel_util.cpp Progetto: DBHi-BiC/isaac_variant_caller

bool
is_indel_conflict(const indel_key& ik1,
                  const indel_key& ik2) {

    // add one to the end_pos of all indels to prevent immediately
    // adjacent indels in the final alignments:
    pos_range pr1(ik1.open_pos_range());
    pr1.end_pos++;
    pos_range pr2(ik2.open_pos_range());
    pr2.end_pos++;

    return pr1.is_range_intersect(pr2);
}

Esempio n. 2

File: starling_pos_processor_htype_util.cpp Progetto: BadSeby/isaac_variant_caller

// 99% of this task is taking care of indel normalization
static
bool
convert_indel_to_htype(const indel_key& ik,
                       const indel_data& /*id*/,
                       const read_segment& rseg,
                       const reference_contig_segment& ref,
                       htype_element& he) {

    he.clear();

    // get best alignment:
    const alignment* alptr(rseg.get_best_alignment());

    assert(alptr);
    const alignment& al(*alptr);

    // Check that alignment is compatible with indel. Many
    // cases where this fails will be for 'private'
    // indels. The posterior above is over all candidate
    // indels, so one candidate may be the best for this read,
    // *but* the best alignment contains a private indel
    // instead.
    //
    pos_range read_indel_pr;
    if (! is_indel_in_alignment(al,ik,read_indel_pr)) return false;

    const bam_seq read_seq(rseg.get_bam_read());

    const rc_segment_bam_seq ref_bseq(ref);
    pos_range ref_indel_pr(ik.open_pos_range());

    assert(! read_indel_pr.is_empty());
    assert(! ref_indel_pr.is_empty());

    // normalization function adjusts ranges:
    //    normalize_indel(read_indel_pr,ref_indel_pr,read_seq,ref_bseq,read_indel_pr,ref_indel_pr);

    assert(! read_indel_pr.is_empty());
    assert(! ref_indel_pr.is_empty());

    // build he:
    if (ref_indel_pr.is_complete()) {
        he.delete_length=ref_indel_pr.end_pos-ref_indel_pr.begin_pos;
    }

    if (!  read_indel_pr.is_begin_pos) {
        he.pos=read_indel_pr.end_pos;
    } else {
        he.pos=read_indel_pr.begin_pos;
    }

    if       (! read_indel_pr.is_end_pos) {
        he.open_end=OPEN::RIGHT;
    } else if (! read_indel_pr.is_begin_pos) {
        he.open_end=OPEN::LEFT;
    }

    {   // copy into htype element seq (don't worry about efficiency for now)
        pos_range pr(read_indel_pr);
        if (! pr.is_complete()) {
            const pos_range nonclip_pr(get_nonclip_range(al.path));
            assert(nonclip_pr.is_complete());
            if       (! pr.is_begin_pos) {
                pr.set_begin_pos(nonclip_pr.begin_pos);
            } else {
                pr.set_end_pos(nonclip_pr.end_pos);
            }
        }

        assert(pr.begin_pos<=pr.end_pos && pr.begin_pos>=0);
        for (pos_t i(pr.begin_pos); i<pr.end_pos; ++i) {
            he.seq.push_back(read_seq.get_char(i));
        }
    }

    if ((he.delete_length==0) &&
        (he.insert_length()==0)) {
        he.clear();
        return false;
    }

    return true;
}