static MRI *
create_distance_transforms(MRI *mri_source, MRI *mri_target, MRI *mri_all_dtrans, float max_dist, GCA_MORPH *gcam)
{
MRI *mri_dtrans, *mri_atlas_dtrans ;
int frame ;
char fname[STRLEN] ;
mri_all_dtrans = MRIallocSequence(mri_source->width, mri_source->height, mri_source->depth,
MRI_FLOAT, NDTRANS_LABELS) ;
MRIcopyHeader(mri_target, mri_all_dtrans) ;
for (frame = 0 ; frame < NDTRANS_LABELS ; frame++)
{
printf("creating distance transform for %s, frame %d...\n",
cma_label_to_name(dtrans_labels[frame]), frame) ;
mri_dtrans =
MRIdistanceTransform(mri_source, NULL, dtrans_labels[frame], max_dist,
DTRANS_MODE_SIGNED, NULL) ;
sprintf(fname, "%s.mgz", cma_label_to_name(dtrans_labels[frame])) ;
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
MRIwrite(mri_dtrans, fname) ;
MRIcopyFrame(mri_dtrans, mri_all_dtrans, 0, frame) ;
mri_atlas_dtrans =
MRIdistanceTransform(mri_target, NULL, dtrans_labels[frame], max_dist,
DTRANS_MODE_SIGNED, NULL) ;
MRInormalizeInteriorDistanceTransform(mri_atlas_dtrans, mri_dtrans, mri_atlas_dtrans) ;
GCAMsetTargetDistancesForLabel(gcam, mri_target, mri_atlas_dtrans, dtrans_labels[frame]);
MRIfree(&mri_dtrans) ;
MRIfree(&mri_atlas_dtrans) ;
}
return(mri_all_dtrans) ;
}
static MRI *
MRIcomputeSurfaceDistanceIntensities(MRI_SURFACE *mris, MRI *mri_ribbon, MRI *mri_aparc, MRI *mri, MRI *mri_aseg, int whalf)
{
MRI *mri_features, *mri_binary, *mri_white_dist, *mri_pial_dist ;
int vno, ngm, outside_of_ribbon, label0, label, ohemi_label, xi, yi, zi, xk, yk, zk, x0, y0, z0, hemi_label, assignable ;
double xv, yv, zv, step_size, dist, thickness, wdist, pdist, snx, sny, snz, nx, ny, nz, xl, yl, zl, x, y, z, dot, angle ;
VERTEX *v ;
mri_features = MRIallocSequence(mris->nvertices, 1, 1, MRI_FLOAT, 1) ; // one samples inwards, one in ribbon, and one outside
MRIcopyHeader(mri, mri_features) ;
mri_binary = MRIcopy(mri_ribbon, NULL) ;
mri_binary = MRIbinarize(mri_ribbon, NULL, 1, 0, 1) ;
mri_pial_dist = MRIdistanceTransform(mri_binary, NULL, 1, max_pial_dist+1, DTRANS_MODE_SIGNED,NULL);
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
MRIwrite(mri_pial_dist, "pd.mgz") ;
MRIclear(mri_binary) ;
MRIcopyLabel(mri_ribbon, mri_binary, Left_Cerebral_White_Matter) ;
MRIcopyLabel(mri_ribbon, mri_binary, Right_Cerebral_White_Matter) ;
MRIbinarize(mri_binary, mri_binary, 1, 0, 1) ;
mri_white_dist = MRIdistanceTransform(mri_binary, NULL, 1, max_white_dist+1, DTRANS_MODE_SIGNED,NULL);
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
MRIwrite(mri_white_dist, "wd.mgz") ;
if (mris->hemisphere == LEFT_HEMISPHERE)
{
ohemi_label = Right_Cerebral_Cortex ;
hemi_label = Left_Cerebral_Cortex ;
}
else
{
hemi_label = Right_Cerebral_Cortex ;
ohemi_label = Left_Cerebral_Cortex ;
}
step_size = mri->xsize/2 ;
for (vno = 0 ; vno < mris->nvertices ; vno++)
{
v = &mris->vertices[vno] ;
if (vno == Gdiag_no)
DiagBreak() ;
if (v->ripflag)
continue ; // not cortex
nx = v->pialx - v->whitex ; ny = v->pialy - v->whitey ; nz = v->pialz - v->whitez ;
thickness = sqrt(nx*nx + ny*ny + nz*nz) ;
if (FZERO(thickness))
continue ; // no cortex here
x = (v->pialx + v->whitex)/2 ; y = (v->pialy + v->whitey)/2 ; z = (v->pialz + v->whitez)/2 ; // halfway between white and pial is x0
MRISsurfaceRASToVoxelCached(mris, mri_aseg, x, y, z, &xl, &yl, &zl) ;
x0 = nint(xl); y0 = nint(yl) ; z0 = nint(zl) ;
label0 = MRIgetVoxVal(mri_aparc, x0, y0, z0,0) ;
// compute surface normal in voxel coords
MRISsurfaceRASToVoxelCached(mris, mri_aseg, x+v->nx, y+v->ny, z+v->nz, &snx, &sny, &snz) ;
snx -= xl ; sny -= yl ; snz -= zl ;
for (ngm = 0, xk = -whalf ; xk <= whalf ; xk++)
{
xi = mri_aseg->xi[x0+xk] ;
for (yk = -whalf ; yk <= whalf ; yk++)
{
yi = mri_aseg->yi[y0+yk] ;
for (zk = -whalf ; zk <= whalf ; zk++)
{
zi = mri_aseg->zi[z0+zk] ;
label = MRIgetVoxVal(mri_aseg, xi, yi, zi,0) ;
if (xi == Gx && yi == Gy && zi == Gz)
DiagBreak() ;
if (label != hemi_label)
continue ;
label = MRIgetVoxVal(mri_aparc, xi, yi, zi,0) ;
if (label && label != label0) // if outside the ribbon it won't be assigned to a parcel
continue ; // constrain it to be in the same cortical parcel
// search along vector connecting x0 to this point to make sure it is we don't perforate wm or leave and re-enter cortex
nx = xi-x0 ; ny = yi-y0 ; nz = zi-z0 ;
thickness = sqrt(nx*nx + ny*ny + nz*nz) ;
assignable = 1 ; // assume this point should be counted
if (thickness > 0)
{
nx /= thickness ; ny /= thickness ; nz /= thickness ;
dot = nx*snx + ny*sny + nz*snz ; angle = acos(dot) ;
if (FABS(angle) > angle_threshold)
assignable = 0 ;
outside_of_ribbon = 0 ;
for (dist = 0 ; assignable && dist <= thickness ; dist += step_size)
{
xv = x0+nx*dist ; yv = y0+ny*dist ; zv = z0+nz*dist ;
if (nint(xv) == Gx && nint(yv) == Gy && nint(zv) == Gz)
DiagBreak() ;
MRIsampleVolume(mri_pial_dist, xv, yv, zv, &pdist) ;
MRIsampleVolume(mri_white_dist, xv, yv, zv, &wdist) ;
label = MRIgetVoxVal(mri_aseg, xi, yi, zi,0) ;
if (SKIP_LABEL(label) || label == ohemi_label)
assignable = 0 ;
if (wdist < 0) // entered wm - not assignable
assignable = 0 ;
else
{
if (pdist > 0) // outside pial surface
outside_of_ribbon = 1 ;
else
{
if (outside_of_ribbon) // left ribbon and reentered
assignable = 0 ;
}
}
}
} // close of thickness > 0
if (assignable)
ngm++ ;
else
DiagBreak() ;
}
}
}
MRIsetVoxVal(mri_features, vno, 0, 0, 0, ngm) ;
}
MRIfree(&mri_white_dist) ; MRIfree(&mri_pial_dist) ; MRIfree(&mri_binary) ;
return(mri_features) ;
}
static MRI *
MRIcomputeSurfaceDistanceProbabilities(MRI_SURFACE *mris, MRI *mri_ribbon, MRI *mri, MRI *mri_aseg)
{
MRI *mri_features, *mri_binary, *mri_white_dist, *mri_pial_dist, *mri_mask ;
int nwhite_bins, npial_bins, x, y, z, label, i ;
HISTOGRAM2D *hw, *hp ;
float pdist, wdist, val ;
double wval, pval ;
mri_features = MRIallocSequence(mri->width, mri->height, mri->depth, MRI_FLOAT, 2) ;
MRIcopyHeader(mri, mri_features) ;
mri_binary = MRIcopy(mri_ribbon, NULL) ;
mri_binary = MRIbinarize(mri_ribbon, NULL, 1, 0, 1) ;
mri_pial_dist = MRIdistanceTransform(mri_binary, NULL, 1, max_pial_dist+1, DTRANS_MODE_SIGNED,NULL);
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
MRIwrite(mri_pial_dist, "pd.mgz") ;
MRIclear(mri_binary) ;
MRIcopyLabel(mri_ribbon, mri_binary, Left_Cerebral_White_Matter) ;
MRIcopyLabel(mri_ribbon, mri_binary, Right_Cerebral_White_Matter) ;
MRIbinarize(mri_binary, mri_binary, 1, 0, 1) ;
mri_white_dist = MRIdistanceTransform(mri_binary, NULL, 1, max_white_dist+1, DTRANS_MODE_SIGNED,NULL);
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
MRIwrite(mri_white_dist, "wd.mgz") ;
nwhite_bins = ceil((max_white_dist - min_white_dist) / white_bin_size)+1 ;
npial_bins = ceil((max_pial_dist - min_pial_dist) / pial_bin_size)+1 ;
hw = HISTO2Dalloc(NBINS, nwhite_bins) ;
hp = HISTO2Dalloc(NBINS, npial_bins) ;
HISTO2Dinit(hw, NBINS, nwhite_bins, 0, NBINS-1, min_white_dist, max_white_dist) ;
HISTO2Dinit(hp, NBINS, npial_bins, 0, NBINS-1, min_pial_dist, max_pial_dist) ;
for (x = 0 ; x < mri->width ; x++)
for (y = 0 ; y < mri->height ; y++)
for (z = 0 ; z < mri->depth ; z++)
{
label = MRIgetVoxVal(mri_aseg, x, y, z, 0) ;
if (IS_CEREBELLUM(label) || IS_VENTRICLE(label) || label == Brain_Stem || IS_CC(label))
continue ;
pdist = MRIgetVoxVal(mri_pial_dist, x, y, z, 0) ;
wdist = MRIgetVoxVal(mri_pial_dist, x, y, z, 0) ;
val = MRIgetVoxVal(mri, x, y, z, 0) ;
if (pdist >= min_pial_dist && pdist <= max_pial_dist)
HISTO2DaddSample(hp, val, pdist, 0, 0, 0, 0) ;
if (wdist >= min_white_dist && wdist <= max_white_dist)
HISTO2DaddSample(hw, val, wdist, 0, 0, 0, 0) ;
}
HISTO2DmakePDF(hp, hp) ;
HISTO2DmakePDF(hw, hw) ;
for (x = 0 ; x < mri->width ; x++)
for (y = 0 ; y < mri->height ; y++)
for (z = 0 ; z < mri->depth ; z++)
{
label = MRIgetVoxVal(mri_aseg, x, y, z, 0) ;
if (IS_CEREBELLUM(label) || IS_VENTRICLE(label) || label == Brain_Stem || IS_CC(label))
continue ;
pdist = MRIgetVoxVal(mri_pial_dist, x, y, z, 0) ;
wdist = MRIgetVoxVal(mri_pial_dist, x, y, z, 0) ;
val = MRIgetVoxVal(mri, x, y, z, 0) ;
wval = HISTO2DgetCount(hw, val, wdist);
if (DZERO(wval) == 0)
MRIsetVoxVal(mri_features, x, y, z, 1, -log10(wval)) ;
pval = HISTO2DgetCount(hp, val, pdist);
if (DZERO(pval) == 0)
MRIsetVoxVal(mri_features, x, y, z, 0, -log10(pval)) ;
}
MRIclear(mri_binary) ;
MRIbinarize(mri_ribbon, mri_binary, 1, 0, 1) ;
mri_mask = MRIcopy(mri_binary, NULL) ;
for (i = 0 ; i < close_order ; i++)
{
MRIdilate(mri_binary, mri_mask) ;
MRIcopy(mri_mask, mri_binary) ;
}
for (i = 0 ; i < close_order ; i++)
{
MRIerode(mri_binary, mri_mask) ;
MRIcopy(mri_mask, mri_binary) ;
}
MRIwrite(mri_mask, "m.mgz") ;
MRImask(mri_features, mri_mask, mri_features, 0, 0) ;
HISTO2Dfree(&hw) ;
HISTO2Dfree(&hp) ;
MRIfree(&mri_white_dist) ; MRIfree(&mri_pial_dist) ; MRIfree(&mri_binary) ;
return(mri_features) ;
}
static MRI *
MRIremoveWMOutliersAndRetainMedialSurface(MRI *mri_src,
MRI *mri_src_ctrl,
MRI *mri_dst_ctrl,
int intensity_below)
{
MRI *mri_bin, *mri_dist, *mri_dist_sup, *mri_outliers = NULL ;
float max, thresh, val;
HISTOGRAM *histo, *hsmooth ;
int wm_peak, x, y, z, nremoved = 0, whalf = 5 ;
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
{
MRIwrite(mri_src_ctrl, "sc.mgz") ;
}
mri_bin = MRIbinarize(mri_dst_ctrl, NULL, 1, 0, 1) ;
mri_dist = MRIdistanceTransform(mri_bin, NULL, 1, -1,
DTRANS_MODE_SIGNED, NULL);
MRIscalarMul(mri_dist, mri_dist, -1) ;
mri_dist_sup = MRInonMaxSuppress(mri_dist, NULL, 0, 1) ;
mri_dst_ctrl = MRIbinarize(mri_dist_sup, mri_dst_ctrl, 1, 0, 1) ;
histo = MRIhistogramLabel(mri_src, mri_src_ctrl, 1, 256) ;
hsmooth = HISTOcopy(histo, NULL) ;
HISTOsmooth(histo, hsmooth, 2) ;
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
{
HISTOplot(histo, "h.plt") ;
HISTOplot(hsmooth, "hs.plt") ;
}
wm_peak = HISTOfindHighestPeakInRegion(hsmooth, 1, hsmooth->nbins-1) ;
wm_peak = hsmooth->bins[wm_peak] ;
thresh = wm_peak-intensity_below ;
HISTOfree(&histo) ;
HISTOfree(&hsmooth) ;
if (Gdiag & DIAG_WRITE)
{
mri_outliers = MRIclone(mri_dst_ctrl, NULL) ;
}
for (x = 0 ; x < mri_src->width ; x++)
{
for (y = 0 ; y < mri_src->height ; y++)
{
for (z = 0 ; z < mri_src->depth ; z++)
{
if (x == Gx && y == Gy && z == Gz)
{
DiagBreak() ;
}
if (nint(MRIgetVoxVal(mri_dst_ctrl, x, y, z, 0)) == 0)
{
continue ;
}
max = MRImaxInLabelInRegion(mri_src, mri_dst_ctrl, 1, x, y, z, whalf);
val = MRIgetVoxVal(mri_src, x, y, z, 0) ;
if (val+intensity_below < max && val < thresh)
{
MRIsetVoxVal(mri_dst_ctrl, x, y, z, 0, 0) ;
if (mri_outliers)
{
MRIsetVoxVal(mri_outliers, x, y, z, 0, 128) ;
}
nremoved++ ;
}
}
}
}
printf( "%d control points removed\n", nremoved) ;
if (mri_outliers)
{
printf( "writing out.mgz outlier volume\n") ;
MRIwrite(mri_outliers, "out.mgz") ;
MRIfree(&mri_outliers) ;
}
if (Gdiag & DIAG_WRITE && DIAG_VERBOSE_ON)
{
MRIwrite(mri_dst_ctrl, "dc.mgz") ;
}
MRIfree(&mri_bin) ;
MRIfree(&mri_dist);
MRIfree(&mri_dist_sup);
return(mri_dst_ctrl);
}
static int
MRISrepositionToInnerSkull(MRI_SURFACE *mris, MRI *mri_smooth, INTEGRATION_PARMS *parms) {
MRI *mri_dist, *mri_bin, *mri_kernel, *mri_bin_smooth, *mri_dist_smooth ;
float l_spring, sigma ;
int i, ic_order, avgs ;
parms->niterations = 1000 ;
if (parms->momentum < 0.0)
parms->momentum = 0.0 /*0.75*/ ;
mri_bin = MRIbinarize(mri_smooth, NULL, 15, 0, TARGET_VAL) ;
mri_dist = MRIdistanceTransform(mri_bin, NULL, TARGET_VAL, 10*mri_bin->width, DTRANS_MODE_SIGNED, NULL) ;
MRIwrite(mri_bin, "bin.mgz") ;
MRIwrite(mri_dist, "dist.mgz") ;
MRISscaleBrain(mris, mris, 0.5) ; // start inside
mri_kernel = MRIgaussian1d(2, 0) ;
mri_bin_smooth = MRIconvolveGaussian(mri_bin, NULL, mri_kernel) ;
MRIwrite(mri_bin_smooth, "bin_smooth.mgz") ;
MRISfindOptimalRigidPosition(mris, mri_bin_smooth, parms) ;
MRIfree(&mri_kernel) ;
MRIfree(&mri_bin_smooth) ;
avgs = parms->n_averages = 32 ;
l_spring = parms->l_spring_norm ;
for (ic_order = 3 ; ic_order <= 3 ; ic_order++) {
if (ic_order != ic_init) {
MRI_SURFACE *mris_new ;
char fname[STRLEN], *mdir ;
mdir = getenv("FREESURFER_HOME") ;
if (!mdir)
ErrorExit(ERROR_BADPARM, "FREESURFER_HOME not defined in environment") ;
sprintf(fname, "%s/lib/bem/ic%d.tri", mdir, ic_order) ;
mris_new = MRISread(fname) ;
MRISupsampleIco(mris, mris_new) ;
MRISfree(&mris) ;
mris = mris_new ;
}
printf("********************** using ICO order %d *********************\n", ic_order) ;
parms->n_averages = avgs ;
parms->l_spring_norm = l_spring ;
for (sigma = 16.0, i = 0 ; i < 7 ; i++, sigma /= 2) {
printf("******************** pass %d, sigma = %2.2f, avgs = %d ******************\n",
i+1, sigma, parms->n_averages) ;
parms->sigma = sigma ;
MRISsetVals(mris,parms->sigma) ;
MRIScopyValToVal2(mris) ;
MRISsetVals(mris, 0) ; // 0 mm from fat
parms->mri_brain = mri_dist ;
mri_kernel = MRIgaussian1d(sigma, 0) ;
mri_dist_smooth = MRIconvolveGaussian(mri_dist, NULL, mri_kernel) ;
MRIfree(&mri_kernel) ;
if (i == 0) {
MRIwrite(mri_dist_smooth, "dist_smooth.mgz") ;
MRISwrite(mris, "lh.0000") ;
}
MRISsetVals(mris, 0) ;
MRISpositionSurface(mris, mri_dist, mri_dist_smooth, parms) ;
parms->l_spring_norm /= 2;
parms->n_averages /= 2 ;
}
}
MRIfree(&mri_bin) ;
MRIfree(&mri_dist) ;
return(NO_ERROR) ;
}
int
main(int argc, char *argv[]) {
char **av, fname[STRLEN], *T1_fname, *PD_fname, *output_dir, *mdir ;
int ac, nargs, msec, s ;
MRI_SURFACE *mris ;
MRI *mri_flash1, *mri_flash2, *mri_masked, *mri_masked_smooth, *mri_kernel,
*mri_mean, *mri_dif, *mri_binary, *mri_distance ;
MRI *mri_smooth, *mri_grad, *mri_inner ;
struct timeb then ;
double l_spring ;
MRI_SEGMENTATION *mriseg ;
/* rkt: check for and handle version tag */
nargs = handle_version_option (argc, argv, "$Id: mris_AA_shrinkwrap.c,v 1.5 2011/03/02 00:04:34 nicks Exp $", "$Name: stable5 $");
if (nargs && argc - nargs == 1)
exit (0);
argc -= nargs;
Gdiag |= DIAG_SHOW ;
Progname = argv[0] ;
ErrorInit(NULL, NULL, NULL) ;
DiagInit(NULL, NULL, NULL) ;
memset(&parms, 0, sizeof(parms)) ;
parms.projection = NO_PROJECTION ;
parms.tol = 0.05 ;
parms.check_tol = 1 ;
parms.ignore_energy = 1 ;
parms.dt = 0.5f ;
parms.base_dt = BASE_DT_SCALE*parms.dt ;
parms.l_spring_norm = 1 ;
parms.l_shrinkwrap = 0 ;
parms.l_intensity = 1 ;
parms.niterations = 0 ;
parms.write_iterations = 0 /*WRITE_ITERATIONS */;
parms.integration_type = INTEGRATE_MOMENTUM ;
parms.momentum = 0.0 /*0.8*/ ;
parms.l_intensity = 1 ;
parms.dt_increase = 1.0 /* DT_INCREASE */;
parms.dt_decrease = 0.50 /* DT_DECREASE*/ ;
parms.error_ratio = 50.0 /*ERROR_RATIO */;
/* parms.integration_type = INTEGRATE_LINE_MINIMIZE ;*/
parms.l_surf_repulse = 0.0 ;
parms.l_repulse = 0 /*1*/ ;
ac = argc ;
av = argv ;
for ( ; argc > 1 && ISOPTION(*argv[1]) ; argc--, argv++) {
nargs = get_option(argc, argv) ;
argc -= nargs ;
argv += nargs ;
}
mdir = getenv("FREESURFER_HOME") ;
if (!mdir)
ErrorExit(ERROR_BADPARM, "FREESURFER_HOME not defined in environment") ;
if (argc < 4)
usage_exit() ;
/* set default parameters for white and gray matter surfaces */
parms.niterations = 1000 ;
if (parms.momentum < 0.0)
parms.momentum = 0.0 /*0.75*/ ;
TimerStart(&then) ;
T1_fname = argv[1] ;
PD_fname = argv[2] ;
output_dir = argv[3] ;
fprintf(stderr, "reading volume %s...\n", T1_fname) ;
mri_flash1 = MRIread(T1_fname) ;
if (!mri_flash1)
ErrorExit(ERROR_NOFILE, "%s: could not read input volume %s", Progname, T1_fname) ;
mri_flash2 = MRIread(PD_fname) ;
if (!mri_flash2)
ErrorExit(ERROR_NOFILE, "%s: could not read input volume %s", Progname, T1_fname) ;
// setMRIforSurface(mri_flash1);
sprintf(fname, "%s/lib/bem/ic%d.tri", mdir, ic_init) ;
mris = MRISread(fname) ;
if (!mris)
ErrorExit(ERROR_NOFILE, "%s: could not read icosahedron %s", Progname, fname) ;
mri_mean = MRImean(mri_flash1, NULL, 5) ;
MRIwrite(mri_mean, "mean.mgz") ;
mri_dif = MRIabsdiff(mri_flash1, mri_flash2, NULL) ;
MRIwrite(mri_dif, "dif.mgz") ;
mriseg = MRIsegment(mri_mean, 30, 100000) ;
s = MRIsegmentMax(mriseg) ;
mri_masked = MRIsegmentToImage(mri_flash1, NULL, mriseg, s) ;
MRIwrite(mri_masked, "mask.mgz") ;
MRIsegmentFree(&mriseg) ;
// MRIthresholdMask(mri_dif, mri_masked, mri_dif, 1, 0) ;
// MRIwrite(mri_dif, "dif_masked.mgz") ;
mri_kernel = MRIgaussian1d(2, 0) ;
mri_smooth = MRIconvolveGaussian(mri_dif, NULL, mri_kernel) ;
MRIwrite(mri_smooth, "smooth.mgz") ;
MRIScopyVolGeomFromMRI(mris, mri_smooth) ;
mris->useRealRAS = 1 ;
initialize_surface_position(mris, mri_dif, 1, &parms) ;
MRISwrite(mris, "init") ;
MRISrepositionToInnerSkull(mris, mri_smooth, &parms) ;
exit(0) ;
mri_grad = MRIsobel(mri_smooth, NULL, NULL) ;
MRIwrite(mri_grad, "grad.mgz") ;
mri_inner = MRIfindInnerBoundary(mri_dif, mri_grad, NULL, 5.0) ;
MRIwrite(mri_inner, "inner.mgz") ;
MRIbinarize(mri_inner, mri_inner, 10, 0, 128) ;
MRISpositionOptimalSphere(mris, mri_inner, 6) ;
MRISwrite(mris, "optimal") ;
exit(0) ;
parms.sigma = 4 / mri_flash1->xsize ;
// mri_dist = create_distance_map(mri_masked, NULL, BORDER_VAL, OUTSIDE_BORDER_STEP) ;
MRISsetVals(mris,parms.sigma) ;
MRIScopyValToVal2(mris) ;
MRISsetVals(mris, 0) ;
sprintf(parms.base_name, "%s_inner_skull%s%s", "test", output_suffix, suffix) ;
parms.mri_brain = mri_masked ;
l_spring = parms.l_spring_norm ;
mri_kernel = MRIgaussian1d(parms.sigma, 0) ;
mri_binary = MRIbinarize(mri_dif, mri_binary, 40, 0, 128) ;
MRIwrite(mri_binary, "bin.mgz") ;
mri_distance = MRIdistanceTransform(mri_binary, NULL, 128, 100, DTRANS_MODE_SIGNED, NULL) ;
MRIwrite(mri_distance, "dist.mgz") ;
mri_masked_smooth = MRIconvolveGaussian(mri_distance, NULL, mri_kernel) ;
MRIfree(&mri_kernel) ;
MRIwrite(mri_masked_smooth, "dif_smooth.mgz") ;
MRISwrite(mris, "inner_skull.tri") ;
msec = TimerStop(&then) ;
fprintf(stderr,"positioning took %2.1f minutes\n", (float)msec/(60*1000.0f));
exit(0) ;
return(0) ; /* for ansi */
}
FCD_DATA *
FCDloadData(char *sdir, char *subject)
{
FCD_DATA *fcd ;
char fname[STRLEN] ;
MRI *mri_interior, *mri_dist, *mri_int_lh, *mri_int_rh, *mri_pvals ;
fcd = (FCD_DATA *)calloc(1, sizeof(FCD_DATA)) ;
sprintf(fname, "%s/%s/surf/lh.white", sdir, subject) ;
fcd->mris_lh = MRISread(fname) ;
if (fcd->mris_lh == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
MRISsaveVertexPositions(fcd->mris_lh, WHITE_VERTICES) ;
if (MRISreadPialCoordinates(fcd->mris_lh, "pial") != NO_ERROR)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load lh pial vertices") ;
}
sprintf(fname, "%s/%s/surf/lh.pial", sdir, subject) ;
fcd->mris_lh_pial = MRISread(fname) ;
if (fcd->mris_lh_pial == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
sprintf(fname, "%s/%s/surf/lh.sphere.d1.left_right", sdir, subject) ;
fcd->mris_lh_sphere_d1 = MRISread(fname) ;
if (fcd->mris_lh_sphere_d1 == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(1, 12, 0, 1) ;
sprintf(fname, "%s/%s/surf/rh.white", sdir, subject) ;
fcd->mris_rh = MRISread(fname) ;
if (fcd->mris_rh == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
MRISsaveVertexPositions(fcd->mris_rh, WHITE_VERTICES) ;
if (MRISreadPialCoordinates(fcd->mris_rh, "pial") != NO_ERROR)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load rh pial vertices") ;
}
sprintf(fname, "%s/%s/surf/rh.pial", sdir, subject) ;
fcd->mris_rh_pial = MRISread(fname) ;
if (fcd->mris_rh_pial == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
sprintf(fname, "%s/%s/surf/rh.sphere.d1.left_right", sdir, subject) ;
fcd->mris_rh_sphere_d1 = MRISread(fname) ;
if (fcd->mris_rh_sphere_d1 == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(2, 12, 0, 1) ;
sprintf(fname, "%s/%s/mri/aseg.mgz", sdir, subject) ;
fcd->mri_aseg = MRIread(fname) ;
if (fcd->mri_aseg == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(3, 12, 0, 1) ;
sprintf(fname, "%s/%s/mri/aparc+aseg.mgz", sdir, subject) ;
fcd->mri_aparc = MRIread(fname) ;
if (fcd->mri_aparc == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(4, 12, 0, 1) ;
fcd->mri_flair = NULL;
sprintf(fname, "%s/%s/mri/flair.reg.norm.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/mri/FLAIR.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/mri/FLAIRax.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/mri/FLAIRcor.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, " ");
}
}
}
}
if (strlen(fname) > 1)
{
fcd->mri_flair = MRIread(fname) ;
if (fcd->mri_flair == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load $s", fname) ;
}
}
fcd->mri_t2 = NULL;
sprintf(fname, "%s/%s/mri/T2.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/mri/T2ax.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/mri/T2cor.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, " ");
}
}
}
if (strlen(fname) > 1)
{
fcd->mri_t2 = MRIread(fname) ;
if (fcd->mri_t2 == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load $s", fname) ;
}
}
exec_progress_callback(5, 12, 0, 1) ;
sprintf(fname, "%s/%s/mri/norm.mgz", sdir, subject) ;
fcd->mri_norm = MRIread(fname) ;
if (fcd->mri_norm == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
fcd->mri_thickness_increase =
MRIcloneDifferentType(fcd->mri_aseg, MRI_FLOAT) ;
fcd->mri_thickness_decrease =
MRIcloneDifferentType(fcd->mri_aseg, MRI_FLOAT) ;
fcd->mri_thickness_difference = MRIadd(fcd->mri_thickness_increase, fcd->mri_thickness_decrease, NULL);
exec_progress_callback(6, 12, 0, 1) ;
sprintf(fname, "%s/%s/surf/lh.rh.thickness.smooth0.mgz", sdir, subject) ;
fcd->rh_thickness_on_lh = MRIread(fname) ;
if (fcd->mri_aseg == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(7, 12, 0, 1) ;
sprintf(fname, "%s/%s/surf/rh.thickness.mgz", sdir, subject) ;
fcd->rh_thickness_on_rh = MRIread(fname) ;
if (fcd->rh_thickness_on_rh == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(8, 12, 0, 1) ;
sprintf(fname, "%s/%s/surf/lh.thickness.mgz", sdir, subject) ;
fcd->lh_thickness_on_lh = MRIread(fname) ;
if (fcd->lh_thickness_on_lh == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
exec_progress_callback(9, 12, 0, 1) ;
sprintf(fname, "%s/%s/surf/rh.lh.thickness.smooth0.mgz", sdir, subject) ;
if ( ! FileExists(fname))
{
sprintf(fname, "%s/%s/surf/rh.lh.thickness.mgz", sdir, subject) ;
if (fcd->lh_thickness_on_rh == NULL)
{
ErrorExit(ERROR_NOFILE, "FCDloadData: couldn't load %s", fname) ;
}
}
fcd->lh_thickness_on_rh = MRIread(fname) ;
exec_progress_callback(10, 12, 0, 1) ;
mri_int_lh = MRIclone(fcd->mri_norm, NULL) ;
mri_int_rh = MRIclone(fcd->mri_norm, NULL) ;
mri_interior = MRIclone(fcd->mri_norm, NULL) ;
mri_dist = MRIcloneDifferentType(mri_interior, MRI_FLOAT) ;
MRISrestoreVertexPositions(fcd->mris_lh, PIAL_VERTICES) ;
MRISrestoreVertexPositions(fcd->mris_rh, PIAL_VERTICES) ;
MRISfillInterior(fcd->mris_lh, mri_interior->xsize, mri_int_lh) ;
MRISfillInterior(fcd->mris_rh, mri_interior->xsize, mri_int_rh) ;
exec_progress_callback(11, 12, 0, 1) ;
MRIor(mri_int_lh, mri_int_rh, mri_interior, 0) ;
MRIfree(&mri_int_lh) ;
MRIfree(&mri_int_rh) ;
MRIbinarize(mri_interior, mri_interior, 1, 0, 1) ;
if (Gdiag & DIAG_WRITE)
{
MRIwrite(mri_interior, "int.mgz") ;
}
MRIdistanceTransform(mri_interior,
mri_dist,
1,
2*MAX_DIST,
DTRANS_MODE_SIGNED,
NULL);
if (Gdiag & DIAG_WRITE)
{
MRIwrite(mri_dist, "dist.mgz") ;
}
mri_pvals = build_distance_by_intensity_histo(fcd->mri_norm,
mri_dist,
fcd->mri_aseg,
DIST_SPACING,
MAX_DIST) ;
exec_progress_callback(12, 12, 0, 1) ;
augment_thicknesses(fcd, mri_pvals, 1.5, 5, 1) ;
MRISrestoreVertexPositions(fcd->mris_lh, WHITE_VERTICES) ;
MRISrestoreVertexPositions(fcd->mris_rh, WHITE_VERTICES) ;
MRIfree(&mri_dist) ;
MRIfree(&mri_interior) ;
MRIfree(&mri_pvals) ;
return(fcd) ;
}
