pulsesequence() { /* Internal variable declarations *************************/ double freq90[MAXNSLICE],freq180[MAXNSLICE],freqIR[MAXNSLICE]; int shape90=0, shape180=0, shapeIR=0; double te_delay1, te_delay2, tr_delay, ti_delay = 0; double del1=0, del2=0, del3=0, del4=0; double tau1=0, tau2=0, difftime=0, tetime=0; int table=0; /* Diffusion parameters */ #define MAXDIR 1024 /* Will anybody do more than 1024 directions or b-values? */ double roarr[MAXDIR], pearr[MAXDIR], slarr[MAXDIR]; int nbval, /* Total number of bvalues*directions */ nbro, nbpe, nbsl, i; double bro[MAXDIR], bpe[MAXDIR], bsl[MAXDIR], /* b-values along RO, PE, SL */ brs[MAXDIR], brp[MAXDIR], bsp[MAXDIR], /* and the cross-terms */ btrace[MAXDIR], /* and the trace */ max_bval=0, dcrush, dgss2, /* "delta" for crusher and gss2 gradients */ Dro, Dcrush, Dgss2; /* "DELTA" for readout, crusher and gss2 gradients */ /* Real-time variables ************************************/ int vpe_steps = v1; int vpe_ctr = v2; int vms_slices = v3; int vms_ctr = v4; int vpe_offset = v5; int vpe_index = v6; int vph180 = v7; // Phase of 180 pulse int vph2 = v8; // alternate phase of 180 on odd transients /* Initialize paramaters *********************************/ init_mri(); /* Check for external PE table ***************************/ if (strcmp(petable,"n") && strcmp(petable,"N") && strcmp(petable,"")) { loadtable(petable); table = 1; } if ((diff[0] == 'y') && (gcrush < 4)) warn_message("Advisory: set gcrush to higher value to avoid image artifacts"); /* Initialize gradient structures *************************/ init_rf(&p1_rf,p1pat,p1,flip1,rof1,rof2); init_rf(&p2_rf,p2pat,p2,flip2,rof2,rof2); init_slice(&ss_grad,"ss",thk); init_slice_butterfly(&ss2_grad,"ss2",thk*1.1,gcrush,tcrush); init_slice_refocus(&ssr_grad,"ssr"); init_readout_butterfly(&ro_grad,"ro",lro,np,sw,gcrushro,tcrushro); init_readout_refocus(&ror_grad,"ror"); init_phase(&pe_grad,"pe",lpe,nv); /* RF Calculations ****************************************/ calc_rf(&p1_rf,"tpwr1","tpwr1f"); calc_rf(&p2_rf,"tpwr2","tpwr2f"); if (p2_rf.header.rfFraction != 0.5) abort_message("RF pulse for refocusing (%s) must be symmetric",p2pat); /* Gradient calculations **********************************/ calc_slice(&ss_grad,&p1_rf,WRITE,"gss"); calc_slice(&ss2_grad,&p2_rf,WRITE,"gss2"); calc_slice_refocus(&ssr_grad, &ss_grad, NOWRITE,"gssr"); calc_readout(&ro_grad, WRITE, "gro","sw","at"); ro_grad.m0ref *= grof; calc_readout_refocus(&ror_grad, &ro_grad, NOWRITE, "gror"); calc_phase(&pe_grad, NOWRITE, "gpe","tpe"); /* Equalize refocus and PE gradient durations *************/ calc_sim_gradient(&ror_grad, &pe_grad, &ssr_grad,0,WRITE); /* Set up diffusion gradient */ if (diff[0] == 'y') { init_generic(&diff_grad,"diff",gdiff,tdelta); calc_generic(&diff_grad,NOWRITE,"",""); /* adjust duration, so tdelta is from start ramp up to start ramp down */ if (ix == 1) diff_grad.duration += diff_grad.tramp; calc_generic(&diff_grad,WRITE,"",""); } /* Min TE *************************************************/ tau1 = ss_grad.rfCenterBack + pe_grad.duration + 4e-6 + ss2_grad.rfCenterFront; tau2 = ss2_grad.rfCenterBack + ror_grad.duration + ro_grad.timeToEcho + alfa; temin = 2*(MAX(tau1,tau2) + 2*4e-6); /* have at least 4us between gradient events */ /* Calculate te_delays with the current TE, then later see how diffusion fits */ if ((minte[0] == 'y') || (te < temin)) { te_delay1 = temin/2 - tau1; te_delay2 = temin/2 - tau2; } else { te_delay1 = te/2 - tau1; te_delay2 = te/2 - tau2; } if (diff[0] =='y') { /* Is tDELTA long enough for RF refocusing gradient? */ if (tDELTA < diff_grad.duration + ss2_grad.duration) abort_message("DELTA too short, increase to %.2fms", (diff_grad.duration + ss2_grad.duration)*1000+0.005); /* Is tDELTA too long for TE dead time? */ difftime = tDELTA + diff_grad.duration; // tDELTA + front & back half diff_grad tetime = ss2_grad.duration + te_delay1 + te_delay2; if (difftime > tetime) { temin += (difftime - tetime); } } /* We now know the minimum TE incl. diffusion */ if (minte[0] == 'y') { te = temin; putvalue("te",ceil(te*1e6)*1e-6); /* round up to nearest us */ } if (te < temin) { if (diff[0] == 'n') { abort_message("TE too short. Minimum TE = %.2fms\n",temin*1000); } else { abort_message("TE too short, increase to %.2fms or reduce DELTA to %.2fms", temin*1000,(tetime-diff_grad.duration)*1000); } } te_delay1 = te/2 - tau1; te_delay2 = te/2 - tau2; /* Set up delays around diffusion gradients */ /* RF1 - del1 - diff - del2 - RF2 - del3 - diff - del4 - ACQ */ if (diff[0] == 'y') { del1 = (tetime - difftime)/2; del4 = del1; del2 = te_delay1 - diff_grad.duration; del3 = te_delay2 - diff_grad.duration; if (del3 < 0.0) { // shift diff block to right del1 += del3; del2 -= del3; del4 -= del3; del3 = 0; } else if (del2 < 0.0) { // shift diff block to left del1 -= del2; del3 -= del2; del4 += del2; del2 = 0; } } else { /* No diffusion */ del1 = 0; del3 = 0; del2 = te_delay1; del4 = te_delay2; } /* Min TR *************************************************/ trmin = (ss_grad.duration - ss_grad.rfCenterBack) + te + ro_grad.timeFromEcho; if (navigator[0] == 'y') trmin += (pe_grad.duration + ro_grad.duration); /* Optional prepulse calculations *************************/ if (sat[0] == 'y') { create_satbands(); trmin += satTime; } if (fsat[0] == 'y') { create_fatsat(); trmin += fsatTime; } if (mt[0] == 'y') { create_mtc(); trmin += mtTime; } if (ir[0] == 'y') { init_rf(&ir_rf,pipat,pi,flipir,rof2,rof2); calc_rf(&ir_rf,"tpwri","tpwrif"); init_slice_butterfly(&ssi_grad,"ssi",thk,gcrushir,tcrushir); calc_slice(&ssi_grad,&ir_rf,WRITE,"gssi"); tau1 = ss_grad.duration - ss_grad.rfCenterBack; /* duration of ss_grad before RF center */ ti_delay = ti - (ssi_grad.rfCenterBack + tau1); if (ti_delay < 0) { abort_message("TI too short, Minimum TI = %.2fms\n",(ti-ti_delay)*1000); } irTime = ti + ssi_grad.duration - ssi_grad.rfCenterBack; /* time to add to TR */ trmin += irTime; trmin -= tau1; /* but subtract out ss_grad which was already included in TR */ } trmin *= ns; if (mintr[0] == 'y'){ tr = trmin + ns*4e-6; putvalue("tr",tr); } if (tr < trmin) { abort_message("TR too short. Minimum TR= %.2fms\n",trmin*1000); } tr_delay = (tr - trmin)/ns > 4e-6 ? (tr - trmin)/ns : 4e-6; /***************************************************/ /* CALCULATE B VALUES ******************************/ if (diff[0] == 'y') { /* Get multiplication factors and make sure they have same # elements */ /* All this is only necessary because putCmd only work for ix==1 */ nbro = (int) getarray("dro",roarr); nbval = nbro; nbpe = (int) getarray("dpe",pearr); if (nbpe > nbval) nbval = nbpe; nbsl = (int) getarray("dsl",slarr); if (nbsl > nbval) nbval = nbsl; if ((nbro != nbval) && (nbro != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (readout)",seqfil); if ((nbpe != nbval) && (nbpe != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (phase)",seqfil); if ((nbsl != nbval) && (nbsl != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (slice)",seqfil); if (nbro == 1) for (i = 1; i < nbval; i++) roarr[i] = roarr[0]; if (nbpe == 1) for (i = 1; i < nbval; i++) pearr[i] = pearr[0]; if (nbsl == 1) for (i = 1; i < nbval; i++) slarr[i] = slarr[0]; } else { nbval = 1; roarr[0] = 0; pearr[0] = 0; slarr[0] = 0; } for (i = 0; i < nbval; i++) { /* Readout */ Dro = ror_grad.duration; bro[i] = bval(gdiff*roarr[i],tdelta,tDELTA); bro[i] += bval(ro_grad.amp,ro_grad.timeToEcho,Dro); /* Slice */ dgss2 = Dgss2 = ss_grad.rfCenterFront; dcrush = tcrush; //"delta" for crusher part of butterfly Dcrush = dcrush + ss_grad.rfDuration; //"DELTA" for crusher bsl[i] = bval(gdiff*slarr[i],tdelta,tDELTA); bsl[i] += bval(gcrush,dcrush,Dcrush); bsl[i] += bval(ss2_grad.ssamp,dgss2,Dgss2); bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); bsl[i] += bval_nested(gcrush,dcrush,Dcrush,ss2_grad.ssamp,dgss2,Dgss2); /* Phase */ bpe[i] = bval(gdiff*pearr[i],tdelta,tDELTA); /* Readout/Slice Cross-terms */ brs[i] = bval2(gdiff*roarr[i],gdiff*slarr[i],tdelta,tDELTA); brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); /* Readout/Phase Cross-terms */ brp[i] = bval2(gdiff*roarr[i],gdiff*pearr[i],tdelta,tDELTA); /* Slice/Phase Cross-terms */ bsp[i] = bval2(gdiff*slarr[i],gdiff*pearr[i],tdelta,tDELTA); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); btrace[i] = (bro[i]+bsl[i]+bpe[i]); if (max_bval < btrace[i]) { max_bval = (bro[i]+bsl[i]+bpe[i]); } } /* End for-all-directions */ putarray("bvalrr",bro,nbval); putarray("bvalpp",bpe,nbval); putarray("bvalss",bsl,nbval); putarray("bvalrp",brp,nbval); putarray("bvalrs",brs,nbval); putarray("bvalsp",bsp,nbval); putarray("bvalue",btrace,nbval); putvalue("max_bval",max_bval); /* Generate phase-ramped pulses: 90, 180, and IR */ offsetlist(pss,ss_grad.ssamp,0,freq90,ns,seqcon[1]); shape90 = shapelist(p1pat,ss_grad.rfDuration,freq90,ns,0,seqcon[1]); offsetlist(pss,ss2_grad.ssamp,0,freq180,ns,seqcon[1]); shape180 = shapelist(p2pat,ss2_grad.rfDuration,freq180,ns,0,seqcon[1]); if (ir[0] == 'y') { offsetlist(pss,ssi_grad.ssamp,0,freqIR,ns,seqcon[1]); shapeIR = shapelist(pipat,ssi_grad.rfDuration,freqIR,ns,0,seqcon[1]); } /* Set pe_steps for profile or full image **********/ pe_steps = prep_profile(profile[0],nv,&pe_grad,&null_grad); initval(pe_steps/2.0,vpe_offset); sgl_error_check(sglerror); /* Return parameters to VnmrJ */ putvalue("rgss",ss_grad.tramp); //90 slice ramp if (ss2_grad.enableButterfly) { //180 slice ramps putvalue("rcrush",ss2_grad.crusher1RampToCrusherDuration); putvalue("rgss2",ss2_grad.crusher1RampToSsDuration); } else { putvalue("rgss2",ss2_grad.tramp); } if (ro_grad.enableButterfly) { putvalue("rgro",ro_grad.crusher1RampToSsDuration); } else { putvalue("rgro",ro_grad.tramp); //RO ramp } putvalue("tror",ror_grad.duration); //ROR duration putvalue("rgror",ror_grad.tramp); //ROR ramp putvalue("gpe",pe_grad.peamp); //PE max amp putvalue("gss",ss_grad.ssamp); putvalue("gro",ro_grad.roamp); g_setExpTime(tr*(nt*pe_steps*arraydim + ssc)); /* PULSE SEQUENCE *************************************/ rotate(); obsoffset(resto); roff = -poffset(pro,ro_grad.roamp); delay(4e-6); /* Begin phase-encode loop ****************************/ peloop(seqcon[2],pe_steps,vpe_steps,vpe_ctr); /* Read external kspace table if set ******************/ if (table) getelem(t1,vpe_ctr,vpe_index); else sub(vpe_ctr,vpe_offset,vpe_index); settable(t2,2,ph180); // initialize phase tables and variables getelem(t2,vpe_ctr,vph180); add(oph,vph180,vph180); // 180 deg pulse phase alternates +/- 90 from receiver mod2(ct,vph2); dbl(vph2,vph2); add(vph180,vph2,vph180); // Alternate phase for 180 on odd transients /* Begin multislice loop ******************************/ msloop(seqcon[1],ns,vms_slices,vms_ctr); if (ticks) { xgate(ticks); grad_advance(gpropdelay); } /* TTL scope trigger **********************************/ sp1on(); delay(5e-6); sp1off(); /* Prepulses ******************************************/ if (sat[0] == 'y') satbands(); if (fsat[0] == 'y') fatsat(); if (mt[0] == 'y') mtc(); /* Optional IR pulse **********************************/ if (ir[0] == 'y') { obspower(ir_rf.powerCoarse); obspwrf(ir_rf.powerFine); delay(4e-6); obl_shapedgradient(ssi_grad.name,ssi_grad.duration,0,0,ssi_grad.amp,NOWAIT); delay(ssi_grad.rfDelayFront); shapedpulselist(shapeIR,ssi_grad.rfDuration,oph,rof1,rof2,seqcon[1],vms_ctr); delay(ssi_grad.rfDelayBack); delay(ti_delay); } /* Slice select RF pulse ******************************/ obspower(p1_rf.powerCoarse); obspwrf(p1_rf.powerFine); delay(4e-6); obl_shapedgradient(ss_grad.name,ss_grad.duration,0,0,ss_grad.amp,NOWAIT); delay(ss_grad.rfDelayFront); shapedpulselist(shape90,ss_grad.rfDuration,oph,rof1,rof2,seqcon[1],vms_ctr); delay(ss_grad.rfDelayBack); /* Phase encode, refocus, and dephase gradient ********/ pe_shapedgradient(pe_grad.name,pe_grad.duration,0,0,-ssr_grad.amp, pe_grad.increment,vpe_index,WAIT); delay(del1); // delay to start of first diffusion gradient if (diff[0] == 'y') { obl_shapedgradient(diff_grad.name,diff_grad.duration, diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); } delay(del2); // delay from end of diffusion to slice refocusing /* Refocusing RF pulse ********************************/ obspower(p2_rf.powerCoarse); obspwrf(p2_rf.powerFine); delay(4e-6); obl_shapedgradient(ss2_grad.name,ss2_grad.duration,0,0,ss2_grad.amp,NOWAIT); delay(ss2_grad.rfDelayFront); shapedpulselist(shape180,ss2_grad.rfDuration,vph180,rof2,rof2,seqcon[1],vms_ctr); delay(ss2_grad.rfDelayBack); delay(del3); // delay from slice refocusing to second diffusion gradient if (diff[0] == 'y') { obl_shapedgradient(diff_grad.name,diff_grad.duration, diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); } delay(del4); // delay from end of diffusion gradient to readout event /* Readout gradient and acquisition ********************/ roff = -poffset(pro,ro_grad.roamp); obl_shapedgradient(ror_grad.name,ror_grad.duration,-ror_grad.amp,0,0,WAIT); obl_shapedgradient(ro_grad.name,ro_grad.duration,ro_grad.amp,0,0,NOWAIT); delay(ro_grad.atDelayFront); startacq(alfa); acquire(np,1.0/sw); delay(ro_grad.atDelayBack); endacq(); /* Rewind Phase encoding ******************************/ pe_shapedgradient(pe_grad.name,pe_grad.duration,0,0,0, pe_grad.increment,vpe_index,WAIT); if (navigator[0] == 'y') { roff = -poffset(pro,-ro_grad.roamp); obl_shapedgradient(ro_grad.name,ro_grad.duration,-ro_grad.amp,0,0,NOWAIT); delay(ro_grad.atDelayFront); startacq(alfa); acquire(np,1.0/sw); delay(ro_grad.atDelayBack); endacq(); } /* Relaxation delay ***********************************/ delay(tr_delay); endmsloop(seqcon[1],vms_ctr); endpeloop(seqcon[2],vpe_ctr); }
pulsesequence() { /* Acquisition variables */ double dw; /* nominal dwell time, = 1/sw */ double aqtm = getval("aqtm"); /* Delay variables */ double tref, te_delay1, te_delay2, tr_delay, ti_delay, del1, del2, del3, del4, del5, /* before and after diffusion gradients */ busy1, busy2, /* time spent on rf pulses etc. in TE periods */ seqtime, invTime; int use_minte; /* RF and receiver frequency variables */ double freq90[MAXNSLICE],freq180[MAXNSLICE],freqIR[MAXNSLICE]; /* frequencies for multi-slice */ int shape90=0, shape180=0, shapeIR=0; /* List ID for RF shapes */ double roff1, roff2, roffn; /* Receiver offsets when FOV is offset along readout */ /* Gradient amplitudes, may vary depending on "image" parameter */ double peramp, perinc, peamp, roamp, roramp; /* diffusion variables */ #define MAXDIR 1024 /* Will anybody do more than 1024 directions or b-values? */ int diff_in_one = 0; double tmp, tmp_ss2; double roarr[MAXDIR], pearr[MAXDIR], slarr[MAXDIR]; int nbval, /* Total number of bvalues*directions */ nbro, nbpe, nbsl; /* bvalues*directions along RO, PE, and SL */ double bro[MAXDIR], bpe[MAXDIR], bsl[MAXDIR], /* b-values along RO, PE, SL */ brs[MAXDIR], brp[MAXDIR], bsp[MAXDIR], /* the cross-terms */ btrace[MAXDIR], /* and the trace */ max_bval=0, dcrush, dgss2, /* "delta" for crusher and gss2 gradients */ Dro, Dcrush, Dgss2; /* "DELTA" for readout, crusher and gss2 gradients */ /* loop variable */ int i; /* Real-time variables used in this sequence **************/ int vms_slices = v3; // Number of slices int vms_ctr = v4; // Slice loop counter int vnseg = v5; // Number of segments int vnseg_ctr = v6; // Segment loop counter int vetl = v7; // Number of choes in readout train int vetl_ctr = v8; // etl loop counter int vblip = v9; // Sign on blips in multi-shot experiment int vssepi = v10; // Number of Gradient Steady States lobes int vssepi_ctr = v11; // Steady State counter int vacquire = v12; // Argument for setacqvar, to skip steady states /******************************************************/ /* VARIABLE INITIALIZATIONS ***************************/ /******************************************************/ get_parameters(); euler_test(); if (tep < 0) { // adjust by reducing gpropdelay by that amount gpropdelay += tep; tep = 0; } setacqmode(WACQ|NZ); // Necessary for variable rate sampling use_minte = (minte[0] == 'y'); /******************************************************/ /* CALCULATIONS ***************************************/ /******************************************************/ if (ix == 1) { /* Calculate RF pulse */ init_rf(&p1_rf,p1pat,p1,flip1,rof1,rof2); calc_rf(&p1_rf,"tpwr1","tpwr1f"); /* Calculate gradients: */ init_slice(&ss_grad,"ss",thk); calc_slice(&ss_grad, &p1_rf,WRITE,"gss"); init_slice_refocus(&ssr_grad,"ssr"); calc_slice_refocus(&ssr_grad, &ss_grad, WRITE,"gssr"); if (spinecho[0] == 'y') { init_rf(&p2_rf,p2pat,p2,flip2,rof1,rof1); calc_rf(&p2_rf,"tpwr2","tpwr2f"); init_slice_butterfly(&ss2_grad,"ss2",thk,gcrush,tcrush); calc_slice(&ss2_grad,&p2_rf,WRITE,"gss2"); } else ss2_grad.duration = 0; /* used for diffusion calculations */ init_readout(&epiro_grad,"epiro",lro,np,sw); init_readout_refocus(&ror_grad,"ror"); init_phase(&epipe_grad, "epipe",lpe,nv); init_phase(&per_grad,"per",lpe,nv); init_readout(&nav_grad,"nav",lro,np,sw); init_epi(&epi_grad); if (!strcmp(orient,"oblique")) { if ((phi != 90) || (psi != 90) || (theta != 90)) { /* oblique slice - this should take care of most cases */ epiro_grad.slewRate /= 3; /* = gmax/trise */ epipe_grad.slewRate /= 3; } } calc_epi(&epi_grad,&epiro_grad,&epipe_grad,&ror_grad,&per_grad,&nav_grad,NOWRITE); /* Make sure the slice refocus, readout refocus, and phase dephaser fit in the same duration */ tref = calc_sim_gradient(&ror_grad, &per_grad, &null_grad, getval("tpe"), WRITE); if (sgldisplay) displayEPI(&epi_grad); /* calc_sim_gradient recalculates per_grad, so reset its base amplitude for centric ordering or fractional k-space*/ switch(ky_order[0]) { case 'l': per_grad.amp *= (fract_ky/(epipe_grad.steps/2)); break; case 'c': per_grad.amp = (nseg/2-1)*per_grad.increment; break; } if (ir[0] == 'y') { init_rf(&ir_rf,pipat,pi,flipir,rof1,rof1); calc_rf(&ir_rf,"tpwri","tpwrif"); init_slice_butterfly(&ssi_grad,"ssi",thk,gcrush,tcrush); calc_slice(&ssi_grad,&ir_rf,WRITE,"gssi"); } if (fsat[0] == 'y') { create_fatsat(); } if (diff[0] == 'y') { init_generic(&diff_grad,"diff",gdiff,tdelta); diff_grad.maxGrad = gmax; calc_generic(&diff_grad,NOWRITE,"",""); /* adjust duration, so tdelta is from start ramp up to start ramp down */ if (ix == 1) { diff_grad.duration += diff_grad.tramp; calc_generic(&diff_grad,WRITE,"",""); } } /* Acquire top-down or bottom-up ? */ if (ky_order[1] == 'r') { epipe_grad.amp *= -1; per_grad.amp *= -1; per_grad.increment *= -1; } } /* end gradient setup if ix == 1 */ /* Load table used to determine multi-shot direction */ settable(t2,(int) nseg,epi_grad.table2); /* What is happening in the 2 TE/2 periods (except for diffusion)? */ busy1 = ss_grad.rfCenterBack + ssr_grad.duration; busy2 = tep + nav_grad.duration*(epi_grad.center_echo + 0.5); if (navigator[0] == 'y') busy2 += (tep + nav_grad.duration + per_grad.duration); /* How much extra time do we have in each TE/2 period? */ if (spinecho[0] == 'y') { busy1 += (GDELAY + ss2_grad.rfCenterFront); busy2 += ss2_grad.rfCenterBack; temin = MAX(busy1,busy2)*2; if (use_minte) te = temin; te_delay1 = te/2 - busy1; te_delay2 = te/2 - busy2; if (temin > te) { /* Use min TE and try and catch further violations of min TE */ te_delay1 = temin/2 - busy1; te_delay2 = temin/2 - busy2; } } else { /* Gradient echo */ temin = (busy1 + busy2); if (use_minte) te = temin; te_delay1 = te - temin; te_delay2 = 0; if (temin > te) te_delay1 = 0; } /* Now fill in the diffusion delays: del1 = between 90 and 1st diffusion gradient del2 = after 1st diffusion gradient del3 = before 2nd diffusion gradient when both in same TE/2 period del4 = before 2nd diffusion gradient when in different TE/2 period del5 = before acquisition Ie, the order is: 90 - del1 - diff - del2 - (diff - del3) - 180 - (del4 - diff) - del5 - acq where one and only one of the two options (diff - del3) or (del4 - diff) is used */ if (diff[0] == 'y') { tmp_ss2 = GDELAY + ss2_grad.duration; /* ss2 grad + 4us delay */ del1 = del2 = del3 = del4 = del5 = 0; if (tDELTA < (diff_grad.duration + tmp_ss2)) /* Minimum DELTA */ abort_message("ERROR %s: tDELTA is too short, minimum is %.2fms\n", seqfil,(diff_grad.duration + tmp_ss2)*1000+0.005); if (tDELTA + diff_grad.duration > te_delay1 + tmp_ss2 + te_delay2) { if (!use_minte) { abort_message("ERROR %s: Maximum tDELTA is %.2fms", seqfil,te_delay1 + ss2_grad.duration + te_delay2 - diff_grad.duration); } else { tmp = (tDELTA + diff_grad.duration) - (te_delay1 + tmp_ss2 + te_delay2); if (spinecho[0] == 'y') { te_delay1 += (tmp/2); te_delay2 += (tmp/2); } else te_delay1 += tmp; temin += tmp; } } if (spinecho[0] == 'y') { if (te_delay1 >= (tDELTA + diff_grad.duration)) { /* Put them both in 1st TE/2 period, */ diff_in_one = (diff[0] == 'y'); /* no need to increase temin */ del2 = tDELTA - diff_grad.duration; /* time between diffusion gradients */ del3 = te_delay1 - (tDELTA+diff_grad.duration); /* time after diffusion gradients */ del5 = te_delay2; /* delay in second TE/2 period */ } else { /* put them on each side of the 180 */ diff_in_one = 0; busy1 += diff_grad.duration; busy2 += diff_grad.duration; temin = 2*MAX(busy1,busy2); /* Optimally, the 2nd diff grad is right after the 180 */ del2 = tDELTA - diff_grad.duration - tmp_ss2; /* This is always > 0, or we would have aborted above */ del1 = te_delay1 - (diff_grad.duration + del2); if (del1 < 0) { del1 = 0; /* Place the 1st right after the 90 and push the 2nd out */ del4 = tDELTA - te_delay1 - ss2_grad.duration; } del5 = te_delay2 - (del4 + diff_grad.duration); /* del5 could still be < 0, when te_delay2 < diff_grad.duration */ if (del5 < 0) { del1 += fabs(del5); /* Increase each TE/2 period by abs(del5) */ del5 = 0; } } } else { /* gradient echo */ diff_in_one = (diff[0] == 'y'); del1 = 0; del2 = tDELTA - diff_grad.duration; /* time between diffusion gradients */ del3 = 0; del4 = 0; if (!use_minte) /* user defined TE */ del5 = te_delay1 - (tDELTA + diff_grad.duration); } } /* End of Diffusion block */ else { del1 = te_delay1; del5 = te_delay2; del2 = del3 = del4 = 0; } if (sgldisplay) { text_message("busy1/2, temin = %f, %f, %f",busy1*1e3, busy2*1e3, temin*1e3); text_message("te_delay1/2 = %f, %f",te_delay1*1e3, te_delay2*1e3); text_message("delays 1-5: %.2f, %.2f, %.2f, %.2f, %.2fms\n",del1*1000,del2*1000,del3*1000,del4*1000,del5*1000); } /* Check if TE is long enough */ temin = ceil(temin*1e6)/1e6; /* round to nearest us */ if (use_minte) { te = temin; putvalue("te",te); } else if (temin > te) { abort_message("TE too short, minimum is %.2f ms\n",temin*1000); } if (ir[0] == 'y') { ti_delay = ti - (pi*ssi_grad.rfFraction + rof2 + ssi_grad.rfDelayBack) - (ss_grad.rfDelayFront + rof1 + p1*(1-ss_grad.rfFraction)); if (ti_delay < 0) { abort_message("TI too short, minimum is %.2f ms\n",(ti-ti_delay)*1000); } } else ti_delay = 0; invTime = GDELAY + ssi_grad.duration + ti_delay; /* Minimum TR per slice, w/o options */ seqtime = GDELAY + ss_grad.rfCenterFront // Before TE + te + (epiro_grad.duration - nav_grad.duration*(epi_grad.center_echo+0.5)); // After TE /* Add in time for options outside of TE */ if (ir[0] == 'y') seqtime += invTime; if (fsat[0] == 'y') seqtime += fsatTime; trmin = seqtime + 4e-6; /* ensure a minimum of 4us in tr_delay */ trmin *= ns; if (tr - trmin < 0.0) { abort_message("%s: Requested tr too short. Min tr = %.2f ms\n", seqfil,ceil(trmin*100000)/100.00); } /* spread out multi-slice acquisition over total TR */ tr_delay = (tr - ns*seqtime)/ns; /******************************************************/ /* Return gradient values to VnmrJ interface */ /******************************************************/ putvalue("etl",epi_grad.etl+2*ssepi); putvalue("gro",epiro_grad.amp); putvalue("rgro",epiro_grad.tramp); putvalue("gror",ror_grad.amp); putvalue("tror",ror_grad.duration); putvalue("rgror",ror_grad.tramp); putvalue("gpe",epipe_grad.amp); putvalue("rgpe",epipe_grad.tramp); putvalue("gped",per_grad.amp); putvalue("tped",per_grad.duration); putvalue("rgped",per_grad.tramp); putvalue("gss",ss_grad.amp); putvalue("gss2",ss2_grad.ssamp); putvalue("rgss",ss_grad.tramp); putvalue("gssr",ssr_grad.amp); putvalue("tssr",ssr_grad.duration); putvalue("rgssr",ssr_grad.tramp); putvalue("rgss2",ss2_grad.crusher1RampToSsDuration); putvalue("rgssi",ssi_grad.crusher1RampToSsDuration); putvalue("rgcrush",ssi_grad.crusher1RampToCrusherDuration); putvalue("at_full",epi_grad.duration); putvalue("at_one",nav_grad.duration); putvalue("rcrush",ss2_grad.crusher1RampToCrusherDuration); putvalue("np_ramp",epi_grad.np_ramp); putvalue("np_flat",epi_grad.np_flat); if (diff[0] == 'y') { /* CALCULATE B VALUES */ /* Get multiplication factors and make sure they have same # elements */ /* All this is only necessary because putCmd only work for ix==1 */ nbro = (int) getarray("dro",roarr); nbval = nbro; nbpe = (int) getarray("dpe",pearr); if (nbpe > nbval) nbval = nbpe; nbsl = (int) getarray("dsl",slarr); if (nbsl > nbval) nbval = nbsl; if ((nbro != nbval) && (nbro != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (readout)",seqfil); if ((nbpe != nbval) && (nbpe != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (phase)",seqfil); if ((nbsl != nbval) && (nbsl != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (slice)",seqfil); if (nbro == 1) for (i = 1; i < nbval; i++) roarr[i] = roarr[0]; if (nbpe == 1) for (i = 1; i < nbval; i++) pearr[i] = pearr[0]; if (nbsl == 1) for (i = 1; i < nbval; i++) slarr[i] = slarr[0]; } else { nbval = 1; roarr[0] = 0; pearr[0] = 0; slarr[0] = 0; } for (i = 0; i < nbval; i++) { /* We need to worry about slice gradients & crushers for slice gradients */ /* Everything else is outside diffusion gradients, and thus constant */ /* for all b-values/directions */ /* Readout */ bro[i] = bval(gdiff*roarr[i],tdelta,tDELTA); /* Phase */ bpe[i] = bval(gdiff*pearr[i],tdelta,tDELTA); /* Slice */ dgss2 = p2/2; Dgss2 = dgss2; dcrush = tcrush; Dcrush = dcrush + p2; bsl[i] = bval(gdiff*slarr[i],tdelta,tDELTA); if (spinecho[0] == 'y') { bsl[i] += bval(ss2_grad.ssamp,dgss2,Dgss2); bsl[i] += bval(gcrush,dcrush,Dcrush); bsl[i] += bval_nested(gcrush,dcrush,Dcrush,ss2_grad.ssamp,dgss2,Dgss2); } if (!diff_in_one) { bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); } /* Readout/Slice Cross-terms */ brs[i] = bval2(gdiff*roarr[i],gdiff*slarr[i],tdelta,tDELTA); if (spinecho[0] == 'y') { brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); } /* Readout/Phase Cross-terms */ brp[i] = bval2(gdiff*roarr[i],gdiff*pearr[i],tdelta,tDELTA); /* Slice/Phase Cross-terms */ bsp[i] = bval2(gdiff*slarr[i],gdiff*pearr[i],tdelta,tDELTA); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA,gcrush,dcrush,Dcrush); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); btrace[i] = (bro[i]+bsl[i]+bpe[i]); if (max_bval < btrace[i]) { max_bval = (bro[i]+bsl[i]+bpe[i]); } } /* End for-all-directions */ putarray("bvalrr",bro,nbval); putarray("bvalpp",bpe,nbval); putarray("bvalss",bsl,nbval); putarray("bvalrp",brp,nbval); putarray("bvalrs",brs,nbval); putarray("bvalsp",bsp,nbval); putarray("bvalue",btrace,nbval); putvalue("max_bval",max_bval); /* Set all gradients depending on whether we do */ /* Use separate variables, because we only initialize & calculate gradients for ix==1 */ peamp = epipe_grad.amp; perinc = per_grad.increment; peramp = per_grad.amp; roamp = epiro_grad.amp; roramp = ror_grad.amp; switch ((int)image) { case 1: /* Real image scan, don't change anything */ break; case 0: /* Normal reference scan */ peamp = 0; perinc = 0; peramp = 0; roamp = epiro_grad.amp; roramp = ror_grad.amp; break; case -1: /* Inverted image scan */ roamp = -epiro_grad.amp; roramp = -ror_grad.amp; break; case -2: /* Inverted reference scan */ peamp = 0; perinc = 0; peramp = 0; roamp = -epiro_grad.amp; roramp = -ror_grad.amp; break; default: break; } /* Generate phase-ramped pulses: 90, 180, and IR */ offsetlist(pss,ss_grad.ssamp,0,freq90,ns,seqcon[1]); shape90 = shapelist(p1pat,ss_grad.rfDuration,freq90,ns,0,seqcon[1]); if (spinecho[0] == 'y') { offsetlist(pss,ss2_grad.ssamp,0,freq180,ns,seqcon[1]); shape180 = shapelist(p2pat,ss2_grad.rfDuration,freq180,ns,0,seqcon[1]); } if (ir[0] == 'y') { offsetlist(pss,ssi_grad.ssamp,0,freqIR,ns,seqcon[1]); shapeIR = shapelist(pipat,ssi_grad.rfDuration,freqIR,ns,0,seqcon[1]); } sgl_error_check(sglerror); roff1 = -poffset(pro,epi_grad.amppos); roff2 = -poffset(pro,epi_grad.ampneg); roffn = -poffset(pro,nav_grad.amp); roff1 = -poffset(pro,epi_grad.amppos*roamp/epiro_grad.amp); roff2 = -poffset(pro,epi_grad.ampneg*roamp/epiro_grad.amp); roffn = -poffset(pro,nav_grad.amp); dw = granularity(1/sw,1/epi_grad.ddrsr); /* Total Scan Time */ g_setExpTime(tr*nt*nseg*arraydim); /******************************************************/ /* PULSE SEQUENCE *************************************/ /******************************************************/ rotate(); F_initval(epi_grad.etl/2, vetl); /* vetl is the loop counter in the acquisition loop */ /* that includes both a positive and negative readout lobe */ F_initval(nseg, vnseg); /* NB. F_initval(-ssepi,vssepi); currently gives errors */ initval(-ssepi,vssepi); /* gradient steady state lobes */ obsoffset(resto); delay(GDELAY); ifzero(rtonce); grad_advance(gpropdelay); endif(rtonce); loop(vnseg,vnseg_ctr); /* Loop through segments in segmented EPI */ msloop(seqcon[1],ns,vms_slices,vms_ctr); /* Multislice loop */ assign(vssepi,vssepi_ctr); sp1on(); delay(4e-6); sp1off(); /* Output trigger to look at scope */ if (ticks) { xgate(ticks); grad_advance(gpropdelay); delay(4e-6); } getelem(t2,vnseg_ctr,vblip); /* vblip = t2[vnseg_ctr]; either 1 or -1 for pos/neg blip */ /* Optional FAT SAT */ if (fsat[0] == 'y') { fatsat(); } /* Optional IR + TI delay */ if (ir[0] == 'y') { obspower(ir_rf.powerCoarse); obspwrf(ir_rf.powerFine); delay(GDELAY); obl_shapedgradient(ssi_grad.name,ssi_grad.duration,0.0,0.0,ssi_grad.amp,NOWAIT); delay(ssi_grad.rfDelayBack); shapedpulselist(shapeIR,ssi_grad.rfDuration,oph,rof1,rof1,seqcon[1],vms_ctr); delay(ssi_grad.rfDelayBack); delay(ti_delay); } /* 90 ss degree pulse */ obspower(p1_rf.powerCoarse); obspwrf(p1_rf.powerFine); delay(GDELAY); obl_shapedgradient(ss_grad.name,ss_grad.duration,0.0,0.0,ss_grad.amp,NOWAIT); delay(ss_grad.rfDelayFront); shapedpulselist(shape90,p1_rf.rfDuration,oph,rof1,rof2,seqcon[1],vms_ctr); delay(ss_grad.rfDelayBack); /* Slice refocus */ obl_shapedgradient(ssr_grad.name,ssr_grad.duration,0,0,-ssr_grad.amp,WAIT); delay(del1); if (diff[0] == 'y') obl_shapedgradient(diff_grad.name,diff_grad.duration, diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); delay(del2); if (diff_in_one) obl_shapedgradient(diff_grad.name,diff_grad.duration, -diff_grad.amp*dro,-diff_grad.amp*dpe,-diff_grad.amp*dsl,WAIT); delay(del3); /* Optional 180 ss degree pulse with crushers */ if (spinecho[0] == 'y') { obspower(p2_rf.powerCoarse); obspwrf(p2_rf.powerFine); delay(GDELAY); obl_shapedgradient(ss2_grad.name,ss2_grad.duration,0.0,0.0,ss2_grad.amp,NOWAIT); delay(ss2_grad.rfDelayFront); shapedpulselist(shape180,ss2_grad.rfDuration,oph,rof1,rof1,seqcon[1],vms_ctr); delay(ss2_grad.rfDelayBack); } delay(del4); if ((diff[0] == 'y') && !diff_in_one) obl_shapedgradient(diff_grad.name,diff_grad.duration, diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); delay(del5); /* Optional navigator echo */ if (navigator[0] == 'y') { obl_shapedgradient(ror_grad.name,ror_grad.duration,roramp,0,0,WAIT); obl_shapedgradient(nav_grad.name,nav_grad.duration, -nav_grad.amp,0,0,NOWAIT); delay(tep); roff = roffn; /* Set receiver offset for navigator gradient */ delay(epi_grad.skip-alfa); /* ramp up */ startacq(alfa); for(i=0;i<np/2;i++){ sample(dw); delay((epi_grad.dwell[i] - dw)); } sample(aqtm-at); endacq(); delay(epi_grad.skip - dw - (aqtm-at)); /* Phase encode dephaser here if navigator echo was acquired */ var_shapedgradient(per_grad.name,per_grad.duration,0,-peramp,0,perinc,vnseg_ctr,WAIT); } else { var_shapedgradient(per_grad.name,per_grad.duration, -roramp,-peramp,0,perinc,vnseg_ctr,WAIT); } /* Start readout and phase encode gradient waveforms, NOWAIT */ /* If alternating ky-ordering, get polarity on blips from table */ var_shaped3gradient(epiro_grad.name,epipe_grad.name,"", /* patterns */ epiro_grad.duration, /* duration */ roamp,0,0, /* amplitudes */ peamp,vblip, /* step and multiplier */ NOWAIT); /* Don't wait */ delay(tep); /* Acquisition loop */ assign(one,vacquire); // real-time acquire flag nowait_loop(epi_grad.etl/2 + ssepi,vetl,vetl_ctr); ifzero(vssepi_ctr); //vssepi_ctr = -ssepi, -ssepi+1, ..., 0, 1,2,... assign(zero,vacquire); // turn on acquisition after all ss lobes endif(vssepi_ctr); incr(vssepi_ctr); setacqvar(vacquire); // Set acquire flag roff = roff1; /* Set receiver offset for positive gradient */ delay(epi_grad.skip-alfa); /* ramp up */ startacq(alfa); for(i=0;i<np/2;i++){ sample(dw); //dw = 1/sw delay((epi_grad.dwell[i] - dw)); } if (aqtm > at) sample(aqtm-at); endacq(); delay(epi_grad.skip - dw - (aqtm-at)); roff = roff2; /* Set receiver offset for negative gradient */ delay(epi_grad.skip-alfa); startacq(alfa); for(i=0;i<np/2;i++){ sample(dw); delay((epi_grad.dwell[i] - dw)); } if (aqtm > at) sample(aqtm-at); endacq(); delay(epi_grad.skip - dw - (aqtm-at)); nowait_endloop(vetl_ctr); delay(tr_delay); endmsloop(seqcon[1],vms_ctr); /* end multislice loop */ endloop(vnseg_ctr); /* end segments loop */ } /* end pulsesequence */
void processLightMenu_three(int option) { switch (option) { case 0: //off glDisable(GL_LIGHT2); //you could alternatively use the color code for no_light break; case 1: //white putarray(amb3,white_light); putarray(diff3,white_light); putarray(spec3,white_light); glEnable(GL_LIGHT2); if (specflag== 1) { glLightfv(GL_LIGHT2, GL_SPECULAR, spec3); } else if (specflag==0) { glLightfv(GL_LIGHT2, GL_SPECULAR, offspec3); }; if (difflag ==1) { glLightfv(GL_LIGHT2, GL_DIFFUSE, diff3); } else if(difflag ==0) { glLightfv(GL_LIGHT2, GL_DIFFUSE, offdiff3); } glLightfv(GL_LIGHT2, GL_AMBIENT, amb3); break; case 2: //red putarray(amb3,red_light); putarray(diff3,red_light); putarray(spec3,red_light); glEnable(GL_LIGHT2); if (specflag== 1) { glLightfv(GL_LIGHT2, GL_SPECULAR, spec3); } else if (specflag==0) { glLightfv(GL_LIGHT2, GL_SPECULAR, offspec3); }; if (difflag ==1) { glLightfv(GL_LIGHT2, GL_DIFFUSE, diff3); } else if(difflag ==0) { glLightfv(GL_LIGHT2, GL_DIFFUSE, offdiff3); } glLightfv(GL_LIGHT2, GL_AMBIENT, amb3); break; case 3: //blue putarray(amb3,blue_light); putarray(diff3,blue_light); putarray(spec3,blue_light); glEnable(GL_LIGHT2); if (specflag== 1) { glLightfv(GL_LIGHT2, GL_SPECULAR, spec3); } else if (specflag==0) { glLightfv(GL_LIGHT2, GL_SPECULAR, offspec3); }; if (difflag ==1) { glLightfv(GL_LIGHT2, GL_DIFFUSE, diff3); } else if(difflag ==0) { glLightfv(GL_LIGHT2, GL_DIFFUSE, offdiff3); } glLightfv(GL_LIGHT2, GL_AMBIENT, amb3); break; case 4: //green putarray(amb3,green_light); putarray(diff3,green_light); putarray(spec3,green_light); glEnable(GL_LIGHT2); if (specflag== 1) { glLightfv(GL_LIGHT2, GL_SPECULAR, spec3); } else if (specflag==0) { glLightfv(GL_LIGHT2, GL_SPECULAR, offspec3); }; if (difflag ==1) { glLightfv(GL_LIGHT2, GL_DIFFUSE, diff3); } else if(difflag ==0) { glLightfv(GL_LIGHT2, GL_DIFFUSE, offdiff3); } glLightfv(GL_LIGHT2, GL_AMBIENT, amb3); break; }; glutPostRedisplay(); }
void pulsesequence() { /* Internal variable declarations *************************/ int shapelist90,shapelist180; double seqtime,tau1,tau2,tau3,te1_delay,te2_delay,te3_delay,tr_delay; double freq90[MAXNSLICE], freq180[MAXNSLICE]; /* Diffusion variables */ double te1, te1min, del1, del2, del3, del4; double te_diff1, te_diff2, tmp1, tmp2; double diffamp; char diffpat[MAXSTR]; /* Navigator variables */ double etlnav; /* Variable crushers */ double cscale; double vcrush; // flag /* Diffusion parameters */ #define MAXDIR 1024 /* Will anybody do more than 1024 directions or b-values? */ double roarr[MAXDIR], pearr[MAXDIR], slarr[MAXDIR]; int nbval, /* Total number of bvalues*directions */ nbro, nbpe, nbsl, i; double bro[MAXDIR], bpe[MAXDIR], bsl[MAXDIR], /* b-values along RO, PE, SL */ brs[MAXDIR], brp[MAXDIR], bsp[MAXDIR], /* and the cross-terms */ btrace[MAXDIR], /* and the trace */ max_bval=0, dcrush, dgss2, /* "delta" for crusher and gss2 gradients */ Dro, Dcrush, Dgss2; /* "DELTA" for readout, crusher and gss2 gradients */ /* Real-time variables used in this sequence **************/ int vpe_ctr = v1; // PE loop counter int vpe_mult = v2; // PE multiplier, ranges from -PE/2 to PE/2 int vpe2_ctr = v3; // PE loop counter int vpe2_mult = v4; // PE multiplier, ranges from -PE/2 to PE/2 int vpe2_offset = v5; int vpe2_steps = v6; int vms_slices = v7; // Number of slices int vms_ctr = v8; // Slice loop counter int vseg = v9; // Number of ETL segments int vseg_ctr = v10; // Segment counter int vetl = v11; // Echo train length int vetl_ctr = v12; // Echo train loop counter int vssc = v13; // Compressed steady-states int vtrimage = v14; // Counts down from nt, trimage delay when 0 int vacquire = v15; // Argument for setacqvar, to skip steady state acquires int vphase180 = v16; // phase of 180 degree refocusing pulse int vetl_loop = v17; // Echo train length MINUS ONE, used on etl loop int vnav = v18; // Echo train length int vcr_ctr = v19; // variable crusher, index into table int vcr1 = v20; // multiplier along RO int vcr2 = v21; // multiplier along PE int vcr3 = v22; // multiplier along SL int vetl1 = v23; // = etl-1, determine navigator echo location in echo loop int vcr_reset = v24; // check for navigator echoes, reset crushers /* Initialize paramaters **********************************/ get_parameters(); te1 = getval("te1"); /* te1 is the echo time for the first echo */ cscale = getval("cscale"); /* Scaling factor on first 180 crushers */ vcrush = getval("vcrush"); /* Variable crusher or set amplitude? */ getstr("diffpat",diffpat); /* Load external PE table ********************************/ if (strcmp(petable,"n") && strcmp(petable,"N") && strcmp(petable,"")) { loadtable(petable); } else { abort_message("petable undefined"); } /* Hold variable crushers in tables 5, 6, 7 */ settable(t5,8,crro); settable(t6,8,crpe); settable(t7,8,crss); seqtime = 0.0; espmin = 0.0; /* RF Power & Bandwidth Calculations **********************/ init_rf(&p1_rf,p1pat,p1,flip1,rof1,rof2); init_rf(&p2_rf,p2pat,p2,flip2,rof1,rof2); // shape_rf(&p1_rf,"p1",p1pat,p1,flip1,rof1,rof2); // shape_rf(&p2_rf,"p2",p2pat,p2,flip2,rof1,rof2); calc_rf(&p1_rf,"tpwr1","tpwr1f"); calc_rf(&p2_rf,"tpwr2","tpwr2f"); /* Initialize gradient structures *************************/ init_readout(&ro_grad,"ro",lro,np,sw); init_readout_refocus(&ror_grad,"ror"); init_phase(&pe_grad,"pe",lpe,nv); init_phase(&pe2_grad,"pe2",lpe2,nv2); init_slice(&ss_grad,"ss",thk); /* NOTE assume same band widths for p1 and p2 */ init_slice(&ss2_grad,"ss2",thk); /* not butterfly, want to scale crushers w/ echo */ init_slice_refocus(&ssr_grad,"ssr"); /* Gradient calculations **********************************/ calc_readout(&ro_grad,WRITE,"gro","sw","at"); calc_readout_refocus(&ror_grad,&ro_grad,NOWRITE,"gror"); calc_phase(&pe_grad,NOWRITE,"gpe","tpe"); calc_phase(&pe2_grad,NOWRITE,"gpe2","tpe2"); calc_slice(&ss_grad,&p1_rf,WRITE,"gss"); calc_slice(&ss2_grad,&p1_rf,WRITE,""); calc_slice_refocus(&ssr_grad,&ss_grad,WRITE,"gssr"); /* Equalize refocus and PE gradient durations *************/ calc_sim_gradient(&ror_grad,&pe_grad,&pe2_grad,0.0,WRITE); /* Variable crusher */ init_generic(&crush_grad,"crush",gcrush,tcrush); calc_generic(&crush_grad,WRITE,"",""); /* Create optional prepulse events ************************/ if (sat[0] == 'y') create_satbands(); if (fsat[0] == 'y') create_fatsat(); if (mt[0] == 'y') create_mtc(); /* Optional Diffusion gradient */ if (diff[0] == 'y') { init_generic(&diff_grad,"diff",gdiff,tdelta); if (!strcmp("sine",diffpat)) { diff_grad.shape = SINE; diffamp = gdiff*1; } /* adjust duration, so tdelta is from start ramp up to start ramp down */ if ((ix == 1) && (diff_grad.shape == TRAPEZOID)) { calc_generic(&diff_grad,NOWRITE,"",""); diff_grad.duration += diff_grad.tramp; } calc_generic(&diff_grad,WRITE,"",""); } /* Set up frequency offset pulse shape list ********/ offsetlist(pss,ss_grad.amp,0,freq90,ns,seqcon[1]); offsetlist(pss,ss2_grad.ssamp,0,freq180,ns,seqcon[1]); shapelist90 = shapelist(p1_rf.pulseName,ss_grad.rfDuration, freq90, ns,0,seqcon[1]); shapelist180 = shapelist(p2_rf.pulseName,ss2_grad.rfDuration,freq180,ns,0,seqcon[1]); /* same slice selection gradient and RF pattern used */ if (ss_grad.rfFraction != 0.5) abort_message("RF pulse must be symmetric (RF fraction = %.2f)",ss_grad.rfFraction); if (ro_grad.echoFraction != 1) abort_message("Echo Fraction must be 1"); /*****************************************************/ /* TIMING FOR ECHOES *********************************/ /*****************************************************/ /* First echo time, without diffusion */ tau1 = ss_grad.rfCenterBack + ssr_grad.duration + crush_grad.duration + ss2_grad.rfCenterFront; tau2 = ss2_grad.rfCenterBack + crush_grad.duration + pe_grad.duration + ro_grad.timeToEcho; te1min = 2*MAX(tau1,tau2); if (te1 < te1min + 2*4e-6) { abort_message("First echo time too small, minimum is %.2fms\n",(te1min+2*4e-6)*1000); } /* Each half-echo period in the ETL loop ********/ tau3 = ro_grad.timeFromEcho + pe_grad.duration + crush_grad.duration + ss2_grad.rfCenterFront; espmin = 2*MAX(tau2,tau3); // Minimum echo spacing if (minesp[0] == 'y') { esp = espmin + 2*4e-6; putvalue("esp",esp); } if (esp - (espmin + 2*4e-6) < -12.5e-9) { abort_message("Echo spacing too small, minimum is %.2fms\n",(espmin+2*4e-6)*1000); } te1_delay = te1/2.0 - tau1; te2_delay = esp/2.0 - tau2; te3_delay = esp/2.0 - tau3; /*****************************************************/ /* TIMING FOR DIFFUSION ******************************/ /*****************************************************/ del1 = te1/2.0 - tau1; del2 = 0; del3 = te1/2.0 - tau2; del4 = 0; if (diff[0] == 'y') { tau1 += diff_grad.duration; tau2 += diff_grad.duration; te1min = 2*MAX(tau1,tau2); if (te1 < te1min + 4*4e-6) { /* te1 is split into 4 delays, each of which must be >= 4us */ abort_message("ERROR %s: First echo time too small, minimum is %.2fms\n",seqfil,te1min*1000); } /* te1 is the echo time for the first echo */ te_diff1 = te1/2 - tau1; /* Available time in first half of first echo */ te_diff2 = te1/2 - tau2; /* Available time in second half of first echo */ tmp1 = ss2_grad.duration + 2*crush_grad.duration; /* duration of 180 block */ /* Is tDELTA long enough? */ if (tDELTA < diff_grad.duration + tmp1) abort_message("DELTA too short, increase to %.2fms", (diff_grad.duration + tmp1)*1000); /* Is tDELTA too long? */ tmp2 = diff_grad.duration + te_diff1 + tmp1 + te_diff2; if (tDELTA > tmp2) { abort_message("DELTA too long, increase te1 to %.2fms", (te1 + (tDELTA-tmp2))*1000); } /* First attempt to put lobes right after slice select, ie del1 = 0 */ del1 = 4e-6; /* At least 4us after setting power for 180 */ del2 = te_diff1 - del1; del3 = tDELTA - (diff_grad.duration + del2 + tmp1); if (del3 < 4e-6) { /* shift diffusion block towards acquisition */ del3 = 4e-6; del2 = tDELTA - (diff_grad.duration + tmp1 + del3); } del1 = te_diff1 - del2; del4 = te_diff2 - del3; if (fabs(del4) < 12.5e-9) del4 = 0; } te = te1 + (kzero-1)*esp; // Return effective TE putvalue("te",te); /* How many echoes in the echo loop, including navigators? */ etlnav = (etl-1)+(navigator[0]=='y')*2.0; /* Minimum TR **************************************/ seqtime = 4e-6 + 2*nseg*ns*4e-6; /* count all the 4us delays */ seqtime += ns*(ss_grad.duration/2 + te1 + (etlnav)*esp + ro_grad.timeFromEcho + pe_grad.duration + te3_delay); /* Increase TR if any options are selected****************/ if (sat[0] == 'y') seqtime += ns*satTime; if (fsat[0] == 'y') seqtime += ns*fsatTime; if (mt[0] == 'y') seqtime += ns*mtTime; trmin = seqtime + ns*4e-6; /* Add 4us to ensure that tr_delay is always >= 4us */ if (mintr[0] == 'y'){ tr = trmin; putvalue("tr",tr+1e-6); } if (tr < trmin) { abort_message("TR too short. Minimum TR = %.2fms\n",trmin*1000); } tr_delay = (tr - seqtime)/ns; /* Set number of segments for profile or full image **********/ nseg = prep_profile(profile[0],nv/etl,&pe_grad,&per_grad); pe2_steps = prep_profile(profile[1],nv2,&pe2_grad,&pe2r_grad); /* Calculate total scan time */ g_setExpTime(tr*(nt*nseg*pe2_steps*arraydim + ssc)); /***************************************************/ /* CALCULATE B VALUES ******************************/ if (diff[0] == 'y') { /* Get multiplication factors and make sure they have same # elements */ /* All this is only necessary because putCmd only work for ix==1 */ nbro = (int) getarray("dro",roarr); nbval = nbro; nbpe = (int) getarray("dpe",pearr); if (nbpe > nbval) nbval = nbpe; nbsl = (int) getarray("dsl",slarr); if (nbsl > nbval) nbval = nbsl; if ((nbro != nbval) && (nbro != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (readout)",seqfil); if ((nbpe != nbval) && (nbpe != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (phase)",seqfil); if ((nbsl != nbval) && (nbsl != 1)) abort_message("%s: Number of directions/b-values must be the same for all axes (slice)",seqfil); if (nbro == 1) for (i = 1; i < nbval; i++) roarr[i] = roarr[0]; if (nbpe == 1) for (i = 1; i < nbval; i++) pearr[i] = pearr[0]; if (nbsl == 1) for (i = 1; i < nbval; i++) slarr[i] = slarr[0]; } else { nbval = 1; roarr[0] = 0; pearr[0] = 0; slarr[0] = 0; } for (i = 0; i < nbval; i++) { dcrush = crush_grad.duration; //"delta" for crusher Dcrush = dcrush + ss_grad.duration; //"DELTA" for crusher /* Readout */ Dro = ror_grad.duration; bro[i] = bval(gdiff*roarr[i],tdelta,tDELTA); bro[i] += bval(ro_grad.amp,ro_grad.timeToEcho,Dro); bro[i] += bval(crush_grad.amp,dcrush,Dcrush); bro[i] += bval_nested(gdiff*roarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); /* Slice */ dgss2 = Dgss2 = ss_grad.rfCenterFront; bsl[i] = bval(gdiff*slarr[i],tdelta,tDELTA); bsl[i] += bval(crush_grad.amp,dcrush,Dcrush); bsl[i] += bval(ss2_grad.ssamp,dgss2,Dgss2); bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); bsl[i] += bval_nested(gdiff*slarr[i],tdelta,tDELTA,ss2_grad.ssamp,dgss2,Dgss2); bsl[i] += bval_nested(ss2_grad.ssamp,dgss2,Dgss2, crush_grad.amp,dcrush,Dcrush); /* Phase */ bpe[i] = bval(gdiff*pearr[i],tdelta,tDELTA); bpe[i] += bval(crush_grad.amp,dcrush,Dcrush); bpe[i] += bval_nested(gdiff*pearr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); /* Readout/Slice Cross-terms */ brs[i] = bval2(gdiff*roarr[i],gdiff*slarr[i],tdelta,tDELTA); brs[i] += bval2(crush_grad.amp, crush_grad.amp,dcrush,Dcrush); brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); brs[i] += bval_cross(gdiff*slarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); brs[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA, ss2_grad.ssamp,dgss2,Dgss2); brs[i] += bval_cross(crush_grad.amp,dcrush,Dcrush, ss2_grad.ssamp,dgss2,Dgss2); /* Readout/Phase Cross-terms */ brp[i] = bval2(gdiff*roarr[i],gdiff*pearr[i],tdelta,tDELTA); brp[i] += bval2(crush_grad.amp, crush_grad.amp,dcrush,Dcrush); brp[i] += bval_cross(gdiff*roarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); brp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); /* Slice/Phase Cross-terms */ bsp[i] = bval2(gdiff*pearr[i],gdiff*slarr[i],tdelta,tDELTA); bsp[i] += bval2(crush_grad.amp, crush_grad.amp,dcrush,Dcrush); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); bsp[i] += bval_cross(gdiff*slarr[i],tdelta,tDELTA, crush_grad.amp,dcrush,Dcrush); bsp[i] += bval_cross(gdiff*pearr[i],tdelta,tDELTA, ss2_grad.ssamp,dgss2,Dgss2); bsp[i] += bval_cross(crush_grad.amp,dcrush,Dcrush, ss2_grad.ssamp,dgss2,Dgss2); btrace[i] = (bro[i]+bsl[i]+bpe[i]); if (max_bval < btrace[i]) { max_bval = (bro[i]+bsl[i]+bpe[i]); } } /* End for-all-directions */ putarray("bvalrr",bro,nbval); putarray("bvalpp",bpe,nbval); putarray("bvalss",bsl,nbval); putarray("bvalrp",brp,nbval); putarray("bvalrs",brs,nbval); putarray("bvalsp",bsp,nbval); putarray("bvalue",btrace,nbval); putvalue("max_bval",max_bval); /* Shift DDR for pro *******************************/ roff = -poffset(pro,ro_grad.roamp); /* PULSE SEQUENCE *************************************/ if (ix == 1) grad_advance(tep); initval(fabs(ssc),vssc); // Compressed steady-state counter setacqvar(vacquire); // Control acquisition through vacquire assign(one,vacquire); // Turn on acquire when vacquire is zero /* Phase cycle: Alternate 180 phase to cancel residual FID */ mod2(ct,vphase180); // 0101 dbl(vphase180,vphase180); // 0202 add(vphase180,one,vphase180); // 1313 Phase difference from 90 add(vphase180,oph,vphase180); obsoffset(resto); delay(4e-6); initval(nseg,vseg); initval(pe2_steps/2.0,vpe2_offset); initval(etl,vetl); initval(etl-1,vetl1); peloop2(seqcon[3],pe2_steps,vpe2_steps,vpe2_ctr); /* Use standard encoding order for 2nd PE dimension */ sub(vpe2_ctr,vpe2_offset,vpe2_mult); loop(vseg,vseg_ctr); /* Compressed steady-states: 1st array & transient, all arrays if ssc is negative */ if ((ix > 1) && (ssc > 0)) assign(zero,vssc); sub(vseg_ctr,vssc,vseg_ctr); // vpe_ctr counts up from -ssc assign(zero,vssc); ifzero(vseg_ctr); assign(zero,vacquire); // Start acquiring when vseg_ctr reaches zero endif(vseg_ctr); msloop(seqcon[1],ns,vms_slices,vms_ctr); if (ticks) { xgate(ticks); grad_advance(tep); } sp1on(); delay(4e-6); sp1off(); // Scope trigger /* Prepulse options ***********************************/ if (sat[0] == 'y') satbands(); if (fsat[0] == 'y') fatsat(); if (mt[0] == 'y') mtc(); /* 90 degree pulse ************************************/ rotate(); obspower(p1_rf.powerCoarse); obspwrf(p1_rf.powerFine); delay(4e-6); obl_shapedgradient(ss_grad.name,ss_grad.duration,0,0,ss_grad.amp,NOWAIT); delay(ss_grad.rfDelayFront); shapedpulselist(shapelist90,ss_grad.rfDuration,oph,rof1,rof2,seqcon[1],vms_ctr); delay(ss_grad.rfDelayBack); /* Read dephase and Slice refocus *********************/ obl_shapedgradient(ssr_grad.name,ssr_grad.duration,0.0,0.0,-ssr_grad.amp,WAIT); /* First half-TE delay ********************************/ obspower(p2_rf.powerCoarse); obspwrf(p2_rf.powerFine); delay(del1); /* DIFFUSION GRADIENT */ if (diff[0] == 'y') obl_shapedgradient(diff_grad.name,diff_grad.duration,diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); delay(del2); /*****************************************************/ /* FIRST ECHO OUTSIDE LOOP ***************************/ /*****************************************************/ ifzero(vacquire); // real acquisition, get PE multiplier from table mult(vseg_ctr,vetl,vpe_ctr); getelem(t1,vpe_ctr,vpe_mult); elsenz(vacquire); // steady state scan assign(zero,vpe_mult); endif(vacquire); /* Variable crusher */ assign(zero,vcr_ctr); getelem(t5,vcr_ctr,vcr1); getelem(t6,vcr_ctr,vcr2); getelem(t7,vcr_ctr,vcr3); if(vcrush) phase_encode3_oblshapedgradient(crush_grad.name,crush_grad.name,crush_grad.name, crush_grad.duration, (double)0,(double)0,(double)0, // base levels crush_grad.amp*cscale,crush_grad.amp*cscale,crush_grad.amp*cscale, // step size vcr1,vcr2,vcr3, // multipliers (double)1.0,(double)1.0,(double)1.0, // upper limit on multipliers 1,WAIT,0); else obl_shapedgradient(crush_grad.name,crush_grad.duration, crush_grad.amp,crush_grad.amp,crush_grad.amp,WAIT); /* 180 degree pulse *******************************/ obl_shapedgradient(ss2_grad.name,ss2_grad.duration,0,0,ss2_grad.amp,NOWAIT); delay(ss2_grad.rfDelayFront); shapedpulselist(shapelist180,ss2_grad.rfDuration,vphase180,rof1,rof2,seqcon[1],vms_ctr); delay(ss2_grad.rfDelayBack); if (vcrush) phase_encode3_oblshapedgradient(crush_grad.name,crush_grad.name,crush_grad.name, crush_grad.duration, (double)0,(double)0,(double)0, // base levels crush_grad.amp*cscale,crush_grad.amp*cscale,crush_grad.amp*cscale, // step size vcr1,vcr2,vcr3, // multipliers (double)1.0,(double)1.0,(double)1.0, // upper limit on multipliers 1,WAIT,0); else obl_shapedgradient(crush_grad.name,crush_grad.duration, crush_grad.amp,crush_grad.amp,crush_grad.amp,WAIT); delay(del3); /* DIFFUSION GRADIENT */ if (diff[0] == 'y') obl_shapedgradient(diff_grad.name,diff_grad.duration,diff_grad.amp*dro,diff_grad.amp*dpe,diff_grad.amp*dsl,WAIT); delay(del4); /* Phase-encode gradient ******************************/ pe2_shapedgradient(pe_grad.name,pe_grad.duration,-ror_grad.amp,0,0, -pe_grad.increment,-pe2_grad.increment,vpe_mult,vpe2_mult,WAIT); /* Readout gradient ************************************/ obl_shapedgradient(ro_grad.name,ro_grad.duration,ro_grad.roamp,0,0,NOWAIT); delay(ro_grad.atDelayFront); /* Acquire data ****************************************/ startacq(10e-6); acquire(np,1.0/sw); endacq(); delay(ro_grad.atDelayBack); /* Rewinding phase-encode gradient ********************/ pe2_shapedgradient(pe_grad.name,pe_grad.duration,0,0,0, pe_grad.increment,pe2_grad.increment,vpe_mult,vpe2_mult,WAIT); /* Second half-TE delay *******************************/ delay(te3_delay); /*****************************************************/ /* LOOP THROUGH THE REST OF ETL **********************/ /*****************************************************/ peloop(seqcon[2],etlnav,vetl_loop,vetl_ctr); ifzero(vacquire); // real acquisition, get PE multiplier from table mult(vseg_ctr,vetl,vpe_ctr); add(vpe_ctr,vetl_ctr,vpe_ctr); add(vpe_ctr,one,vpe_ctr); getelem(t1,vpe_ctr,vpe_mult); elsenz(vacquire); // steady state scan assign(zero,vpe_mult); endif(vacquire); /* But don't phase encode navigator echoes */ ifrtGE(vetl_ctr,vetl1,vnav); assign(zero,vpe_mult); endif(vnav); /* Variable crusher */ incr(vcr_ctr); /* Get next crusher level */ /* Except if we're doing navigators, start over */ sub(vetl1,vetl_ctr,vcr_reset); ifzero(vcr_reset); assign(zero,vcr_ctr); endif(vcr_reset); getelem(t5,vcr_ctr,vcr1); getelem(t6,vcr_ctr,vcr2); getelem(t7,vcr_ctr,vcr3); phase_encode3_oblshapedgradient(crush_grad.name,crush_grad.name,crush_grad.name, crush_grad.duration, (double)0,(double)0,(double)0, // base levels crush_grad.amp,crush_grad.amp,crush_grad.amp, // step size vcr1,vcr2,vcr3, // multipliers (double)1.0,(double)1.0,(double)1.0, // upper limit on multipliers 1,WAIT,0); /* 180 degree pulse *******************************/ obl_shapedgradient(ss2_grad.name,ss2_grad.duration,0,0,ss2_grad.amp,NOWAIT); delay(ss2_grad.rfDelayFront); shapedpulselist(shapelist180,ss2_grad.rfDuration,vphase180,rof1,rof2,seqcon[1],vms_ctr); delay(ss2_grad.rfDelayBack); /* Variable crusher */ phase_encode3_oblshapedgradient(crush_grad.name,crush_grad.name,crush_grad.name, crush_grad.duration, (double)0,(double)0,(double)0, // base levels crush_grad.amp,crush_grad.amp,crush_grad.amp, // step size vcr1,vcr2,vcr3, // multipliers (double)1.0,(double)1.0,(double)1.0, // upper limit on multipliers 1,WAIT,0); /* Phase-encode gradient ******************************/ pe2_shapedgradient(pe_grad.name,pe_grad.duration,0,0,0, -pe_grad.increment,-pe2_grad.increment,vpe_mult,vpe2_mult,WAIT); /* Second half-TE period ******************************/ delay(te2_delay); /* Readout gradient ************************************/ obl_shapedgradient(ro_grad.name,ro_grad.duration,ro_grad.roamp,0,0,NOWAIT); delay(ro_grad.atDelayFront); startacq(10e-6); acquire(np,1.0/sw); endacq(); delay(ro_grad.atDelayBack); /* Rewinding phase-encode gradient ********************/ pe2_shapedgradient(pe_grad.name,pe_grad.duration,0,0,0, pe_grad.increment,pe2_grad.increment,vpe_mult,vpe2_mult,WAIT); /* Second half-TE delay *******************************/ delay(te3_delay); endpeloop(seqcon[2],vetl_ctr); /* Relaxation delay ***********************************/ if (!trtype) delay(tr_delay); endmsloop(seqcon[1],vms_ctr); if (trtype) delay(ns*tr_delay); endloop(vseg_ctr); endpeloop(seqcon[3],vpe2_ctr); /* Inter-image delay **********************************/ sub(ntrt,ct,vtrimage); decr(vtrimage); ifzero(vtrimage); delay(trimage); endif(vtrimage); }