예제 #1
0
파일: gc_content.c 프로젝트: 9beckert/TIR
void gt_gc_content_show(const char *seq, unsigned long len,
                        GtAlphabet *alphabet, GtFile *outfp)
{
  unsigned long i,
                gc = 0, /* number of G/C bases */
                at = 0, /* number of A/T bases */
                n  = 0; /* number of N   bases */
  unsigned int a_code, c_code, g_code, t_code, n_code, cc;
  gt_assert(seq && alphabet);
  gt_assert(gt_alphabet_is_dna(alphabet));
  a_code = gt_alphabet_encode(alphabet, 'A');
  c_code = gt_alphabet_encode(alphabet, 'C');
  g_code = gt_alphabet_encode(alphabet, 'G');
  t_code = gt_alphabet_encode(alphabet, 'T');
  n_code = gt_alphabet_encode(alphabet, 'N');
  for (i = 0; i < len; i++) {
    cc = gt_alphabet_encode(alphabet, seq[i]);
    if (cc == g_code || cc == c_code)
      gc++;
    else if (cc == a_code || cc == t_code)
      at++;
    else if (cc == n_code)
      n++;
    else {
      gt_assert(0);
    }
  }
  gt_file_xprintf(outfp, "GC-content: %.2f%% (AT-content: %.2f%%, "
                         "N-content: %.2f%%)\n",
                  ((double) gc / len) * 100.0, ((double) at / len) * 100.0,
                  ((double) n  / len) * 100.0);
}
예제 #2
0
static int decode_sequence_file(const char *seqfile,
                                GtEncseqDecodeArguments *args,
                                GtError *err)
{
  GtEncseqLoader *encseq_loader;
  GtEncseq *encseq;
  int had_err = 0;
  gt_error_check(err);
  gt_assert(seqfile);
  encseq_loader = gt_encseq_loader_new();
  if (!had_err && gt_encseq_options_lossless_value(args->eopts)) {
    gt_encseq_loader_require_lossless_support(encseq_loader);
  }
  if (!(encseq = gt_encseq_loader_load(encseq_loader, seqfile, err)))
    had_err = -1;
  if (!had_err && gt_encseq_options_mirrored_value(args->eopts)) {
    if (!gt_alphabet_is_dna(gt_encseq_alphabet(encseq))) {
      gt_error_set(err, "mirroring is only defined on DNA sequences");
      had_err = -1;
    }
    if (!had_err)
      had_err = gt_encseq_mirror(encseq, err);
  }
  if (!had_err)
    had_err = output_sequence(encseq, args, seqfile, err);
  gt_encseq_delete(encseq);
  gt_encseq_loader_delete(encseq_loader);
  return had_err;
}
예제 #3
0
void gt_bioseq_show_gc_content(GtBioseq *bs, GtFile *outfp)
{
  gt_assert(bs);
  if (gt_alphabet_is_dna(gt_encseq_alphabet(bs->encseq))) {
    GtUword i, GT_UNUSED purecharlen;
    GtStr *str = gt_str_new();
    purecharlen = gt_encseq_total_length(bs->encseq)
                    - gt_encseq_num_of_sequences(bs->encseq) + 1;
    for (i=0; i < gt_encseq_num_of_sequences(bs->encseq); i++) {
      char *tmp;
      tmp = gt_bioseq_get_sequence(bs, i);
      gt_str_append_cstr(str, tmp);
      gt_free(tmp);
    }
    gt_assert(gt_str_length(str) == purecharlen);
    gt_file_xprintf(outfp, "showing GC-content for sequence file \"%s\"\n",
                    gt_str_get(bs->sequence_file));
    gt_gc_content_show(gt_str_get(str),
                       gt_str_length(str),
                       gt_encseq_alphabet(bs->encseq),
                       outfp);
    gt_str_delete(str);
  }
}
예제 #4
0
static int gt_seed_extend_runner(GT_UNUSED int argc,
                                 GT_UNUSED const char **argv,
                                 GT_UNUSED int parsed_args,
                                 void *tool_arguments,
                                 GtError *err)
{
  GtSeedExtendArguments *arguments = tool_arguments;
  GtEncseqLoader *encseq_loader = NULL;
  GtEncseq *aencseq = NULL, *bencseq = NULL;
  GtGreedyextendmatchinfo *grextinfo = NULL;
  GtXdropmatchinfo *xdropinfo = NULL;
  GtQuerymatchoutoptions *querymatchoutopt = NULL;
  GtTimer *seedextendtimer = NULL;
  GtExtendCharAccess cam = GT_EXTEND_CHAR_ACCESS_ANY;
  GtUword errorpercentage = 0UL;
  int had_err = 0;

  gt_error_check(err);
  gt_assert(arguments != NULL);
  gt_assert(arguments->se_minidentity >= GT_EXTEND_MIN_IDENTITY_PERCENTAGE &&
            arguments->se_minidentity <= 100UL);

  /* Calculate error percentage from minidentity */
  errorpercentage = 100UL - arguments->se_minidentity;

  /* Measure whole running time */
  if (arguments->benchmark || arguments->verbose) {
    gt_showtime_enable();
  }
  if (gt_showtime_enabled())
  {
    seedextendtimer = gt_timer_new();
    gt_timer_start(seedextendtimer);
  }

  /* Load encseq A */
  encseq_loader = gt_encseq_loader_new();
  gt_encseq_loader_enable_autosupport(encseq_loader);
  aencseq = gt_encseq_loader_load(encseq_loader,
                                  gt_str_get(arguments->dbs_indexname),
                                  err);
  if (aencseq == NULL)
    had_err = -1;

  /* If there is a 2nd read set: Load encseq B */
  if (!had_err) {
    if (strcmp(gt_str_get(arguments->dbs_queryname), "") != 0) {
      bencseq = gt_encseq_loader_load(encseq_loader,
                                      gt_str_get(arguments->dbs_queryname),
                                      err);
    } else {
      bencseq = gt_encseq_ref(aencseq);
    }
    if (bencseq == NULL) {
      had_err = -1;
      gt_encseq_delete(aencseq);
    }
  }
  gt_encseq_loader_delete(encseq_loader);

  /* set character access method */
  if (!had_err && (gt_option_is_set(arguments->se_option_greedy) ||
                   gt_option_is_set(arguments->se_option_xdrop) ||
                   arguments->se_alignmentwidth > 0))
  {
    cam = gt_greedy_extend_char_access(gt_str_get
                                       (arguments->se_char_access_mode),
                                       err);
    if ((int) cam == -1) {
      had_err = -1;
      gt_encseq_delete(aencseq);
      gt_encseq_delete(bencseq);
    }
  }

  /* Use bias dependent parameters, adapted from E. Myers' DALIGNER */
  if (!had_err && arguments->bias_parameters) {
    const GtAlphabet *alpha = gt_encseq_alphabet(aencseq);
    const double bias_factor[10] = {.690, .690, .690, .690, .780,
                                    .850, .900, .933, .966, 1.000};

    if (gt_alphabet_is_dna(alpha)) {
      GtUword at, cg;
      at = gt_encseq_charcount(aencseq, gt_alphabet_encode(alpha, 'a'));
      at += gt_encseq_charcount(aencseq, gt_alphabet_encode(alpha, 't'));
      cg = gt_encseq_charcount(aencseq, gt_alphabet_encode(alpha, 'c'));
      cg += gt_encseq_charcount(aencseq, gt_alphabet_encode(alpha, 'g'));
      if (at + cg > 0) {
        const double ratio = (double)MIN(at, cg) / (at + cg);
        int bias_index = (int)MAX(0.0, (ratio + 0.025) * 20.0 - 1.0);
        gt_assert(bias_index < 10);
        arguments->se_maxalilendiff = 30;
        arguments->se_perc_match_hist = (GtUword)(100.0 - errorpercentage *
                                                  bias_factor[bias_index]);
        if (arguments->verbose) {
          printf("# Base ratio = %4.2lf -> percmathistory = "GT_WU"\n",
                 ratio, arguments->se_perc_match_hist);
        }
      } else {
        had_err = -1;
      }
    } else {
      had_err = -1;
    }
    if (had_err) {
      gt_error_set(err, "option \"-bias-parameters\" can only be applied to "
                   "the DNA alphabet");
      gt_encseq_delete(aencseq);
      gt_encseq_delete(bencseq);
    }
  }

  /* Prepare options for greedy extension */
  if (!had_err && gt_option_is_set(arguments->se_option_greedy)) {
    grextinfo = gt_greedy_extend_matchinfo_new(errorpercentage,
                                               arguments->se_maxalilendiff,
                                               arguments->se_historysize,
                                               arguments->se_perc_match_hist,
                                               arguments->se_alignlength,
                                               cam,
                                               arguments->se_extendgreedy);
    if (arguments->benchmark) {
      gt_greedy_extend_matchinfo_silent_set(grextinfo);
    }
  }

  /* Prepare options for xdrop extension */
  if (!had_err && gt_option_is_set(arguments->se_option_xdrop)) {
    xdropinfo = gt_xdrop_matchinfo_new(arguments->se_alignlength,
                                       errorpercentage,
                                       arguments->se_xdropbelowscore,
                                       arguments->se_extendxdrop);
    if (arguments->benchmark) {
      gt_xdrop_matchinfo_silent_set(xdropinfo);
    }
  }

  /* Prepare output options */
  if (!had_err && (arguments->se_alignmentwidth > 0 ||
                   gt_option_is_set(arguments->se_option_xdrop)))
  {
    querymatchoutopt
      = gt_querymatchoutoptions_new(arguments->se_alignmentwidth);

    if (gt_option_is_set(arguments->se_option_xdrop) ||
        gt_option_is_set(arguments->se_option_greedy))
    {
      const GtUword sensitivity = gt_option_is_set(arguments->se_option_greedy)
                                    ? arguments->se_extendgreedy : 100;

      gt_querymatchoutoptions_extend(querymatchoutopt,
                                     errorpercentage,
                                     arguments->se_maxalilendiff,
                                     arguments->se_historysize,
                                     arguments->se_perc_match_hist,
                                     cam,
                                     sensitivity);
    }
  }

  /* Start algorithm */
  if (!had_err) {
    GtDiagbandseed dbsarguments;
    dbsarguments.errorpercentage = errorpercentage;
    dbsarguments.userdefinedleastlength = arguments->se_alignlength;
    dbsarguments.seedlength = arguments->dbs_seedlength;
    dbsarguments.logdiagbandwidth = arguments->dbs_logdiagbandwidth;
    dbsarguments.mincoverage = arguments->dbs_mincoverage;
    dbsarguments.maxfreq = arguments->dbs_maxfreq;
    dbsarguments.memlimit = arguments->dbs_memlimit;
    dbsarguments.mirror = arguments->mirror;
    dbsarguments.overlappingseeds = arguments->overlappingseeds;
    dbsarguments.verify = arguments->dbs_verify;
    dbsarguments.verbose = arguments->verbose;
    dbsarguments.debug_kmer = arguments->dbs_debug_kmer;
    dbsarguments.debug_seedpair = arguments->dbs_debug_seedpair;
    dbsarguments.seed_display = arguments->seed_display;
    dbsarguments.extendgreedyinfo = grextinfo;
    dbsarguments.extendxdropinfo = xdropinfo;
    dbsarguments.querymatchoutopt = querymatchoutopt;

    had_err = gt_diagbandseed_run(aencseq, bencseq, &dbsarguments, err);

    /* clean up */
    gt_encseq_delete(aencseq);
    gt_encseq_delete(bencseq);
    if (gt_option_is_set(arguments->se_option_greedy)) {
      gt_greedy_extend_matchinfo_delete(grextinfo);
    }
    if (gt_option_is_set(arguments->se_option_xdrop)) {
      gt_xdrop_matchinfo_delete(xdropinfo);
    }
    if (arguments->se_alignmentwidth > 0 ||
        gt_option_is_set(arguments->se_option_xdrop)) {
      gt_querymatchoutoptions_delete(querymatchoutopt);
    }
  }

  if (gt_showtime_enabled()) {
    if (!had_err) {
      char *keystring
        = gt_seed_extend_params_keystring(gt_option_is_set(arguments->
                                                           se_option_greedy),
                                          gt_option_is_set(arguments->
                                                           se_option_xdrop),
                                          arguments->dbs_seedlength,
                                          arguments->se_alignlength,
                                          arguments->se_minidentity,
                                          arguments->se_maxalilendiff,
                                          arguments->se_perc_match_hist,
                                          arguments->se_extendgreedy,
                                          arguments->se_extendxdrop,
                                          arguments->se_xdropbelowscore);
      printf("# TIME seedextend-%s", keystring);
      gt_free(keystring);
      gt_timer_show_formatted(seedextendtimer,
                              " overall " GT_WD ".%06ld\n",
                              stdout);
    }
    gt_timer_delete(seedextendtimer);
  }
  return had_err;
}
예제 #5
0
static int gt_encseq_check_runner(GT_UNUSED int argc, const char **argv,
                                  int parsed_args, void *tool_arguments,
                                  GtError *err)
{
  GtEncseqCheckArguments *arguments = tool_arguments;
  int had_err = 0;
  GtEncseqLoader *encseq_loader;
  GtEncseq *encseq;
  gt_error_check(err);
  gt_assert(arguments);

  encseq_loader = gt_encseq_loader_new();
  if (!(encseq = gt_encseq_loader_load(encseq_loader, argv[parsed_args], err)))
    had_err = -1;
  if (!had_err) {
    int readmode;
    gt_encseq_check_startpositions(encseq);
    for (readmode = 0; readmode < 4; readmode++)
    {
      if (gt_alphabet_is_dna(gt_encseq_alphabet(encseq)) ||
           ((GtReadmode) readmode) == GT_READMODE_FORWARD ||
           ((GtReadmode) readmode) == GT_READMODE_REVERSE)
      {
        if (gt_encseq_check_consistency(encseq,
                           gt_encseq_filenames(encseq),
                           (GtReadmode) readmode,
                           arguments->scantrials,
                           arguments->multicharcmptrials,
                           gt_encseq_has_multiseq_support(encseq),
                           err) != 0)
        {
          had_err = -1;
          break;
        }
      }
    }
    if (!had_err)
    {
      gt_encseq_check_specialranges(encseq);
    }
    if (!had_err)
    {
      gt_encseq_check_markpos(encseq);
    }
    if (!had_err)
    {
      had_err = gt_encseq_check_minmax(encseq, err);
    }
    if (!had_err &&
           arguments->prefixlength > 0)
    {
      if (gt_verifymappedstr(encseq,
                             arguments->prefixlength,
                             err) != 0)
      {
        had_err = -1;
      }
    }
  }
  gt_encseq_delete(encseq);
  gt_encseq_loader_delete(encseq_loader);
  return had_err;
}
예제 #6
0
int gt_genomediff_pck_shu_simple(GtLogger *logger,
                                 const GtGenomediffArguments *arguments,
                                 GtError *err)
{
  int had_err = 0;
  int retval;
  GtSeqIterator *queries = NULL;
  const GtUchar *symbolmap, *currentQuery;
  const GtAlphabet *alphabet;
  GtUchar c_sym = 0,
          g_sym = 0;
  uint64_t queryNo;
  char *description = NULL;
  unsigned long queryLength,
                subjectLength = 0,
                currentSuffix;
  double avgShuLength,
         currentShuLength = 0.0,
         /*gc_subject,*/
         gc_query /*, gc*/;
  const FMindex *subjectindex = NULL;
  Genericindex *genericindexSubject;
  const GtEncseq *encseq = NULL;
  double *ln_n_fac;

  /* get the precalculation of ln(n!) for 0<n<max_ln_n_fac */
  ln_n_fac = gt_get_ln_n_fac(arguments->max_ln_n_fac);
  gt_log_log("ln(max_ln_n_fac!) = %f\n",
             ln_n_fac[arguments->max_ln_n_fac]);

  genericindexSubject = genericindex_new(gt_str_get(
                                           arguments->indexname),
                                         arguments->with_esa,
                                         true,
                                         false,
                                         true,
                                         arguments->user_max_depth,
                                         logger,
                                         err);
  if (genericindexSubject == NULL)
  {
    had_err = 1;
  }
  else
  {
    encseq = genericindex_getencseq(genericindexSubject);
  }

  if (!had_err)
  {
    subjectLength = genericindex_get_totallength(genericindexSubject) - 1;
    /*subjectLength /= 2;*/
    /*gt_log_log("subject length: %lu", subjectLength);*/
    subjectindex = genericindex_get_packedindex(genericindexSubject);

    queries = gt_seqiterator_sequence_buffer_new(
                                          arguments->queryname,
                                          err);
    gt_assert(queries);
    alphabet = gt_encseq_alphabet(encseq);
    /* makes assumption that alphabet is dna, it has to calculate the gc! */
    if (!gt_alphabet_is_dna(alphabet))
    {
      fprintf(stderr, "error: Sequences need to be dna");
      had_err = 1;
    }
    else
    {
      symbolmap = gt_alphabet_symbolmap(alphabet);
      gt_seqiterator_set_symbolmap(queries, symbolmap);
      c_sym = gt_alphabet_encode(alphabet, 'c');
      g_sym = gt_alphabet_encode(alphabet, 'g');
    }
  }

  for (queryNo = 0; !had_err; queryNo++)
  {
    retval = gt_seqiterator_next(queries,
                                 &currentQuery,
                                 &queryLength,
                                 &description,
                                 err);
    if ( retval != 1)
    {
      if (retval < 0)
      {
        gt_free(description);
      }
      break;
    }
    gt_logger_log(logger,
                  "found query of length: %lu",
                  queryLength);
    avgShuLength = 0.0;
    gc_query = 0.0;
    for (currentSuffix = 0; currentSuffix < queryLength; currentSuffix++)
    {
      currentShuLength = (double) gt_pck_getShuStringLength(
                    subjectindex,
                    &currentQuery[currentSuffix],
                    queryLength - currentSuffix);
      avgShuLength += currentShuLength;
      if (currentQuery[currentSuffix] == c_sym ||
          currentQuery[currentSuffix] == g_sym)
      {
        gc_query++;
      }
    }
    if (arguments->shulen_only)
    {
      printf("# Query %d sum of shulen:\n %.0f\n",
             (int) queryNo, avgShuLength);
    }
    else
    {
      avgShuLength /= (double) queryLength;
      gc_query /= (double) queryLength;

      gt_logger_log(logger, "Query %d has an average SHUstring length "
                            "of\n# shulength: %f",
                            (int) queryNo, avgShuLength);
      gt_logger_log(logger, "Query description: %s", description);
      gt_log_log("Query (i): %s", description);

  /* XXX Fehlerabfragen einbauen */

      if ( !had_err )
      {
        double div, kr;

        gt_logger_log(logger, "shulen:\n%f", avgShuLength);
        gt_log_log("shu: %f, gc: %f, len: %lu",
            avgShuLength, gc_query, subjectLength);
        div =  gt_divergence(arguments->divergence_rel_err,
                             arguments->divergence_abs_err,
                             arguments->divergence_m,
                             arguments->divergence_threshold,
                             avgShuLength,
                             subjectLength,
                             gc_query,
                             ln_n_fac,
                             arguments->max_ln_n_fac);
        gt_logger_log(logger, "divergence:\n%f", div);

        kr = gt_calculateKr(div);

        printf("# Kr:\n%f\n", kr);
      }
    }
  }
  gt_free(ln_n_fac);
  gt_seqiterator_delete(queries);
  genericindex_delete(genericindexSubject);
  return had_err;
}
예제 #7
0
double *gt_encseq_get_gc(const GtEncseq *encseq,
                         bool with_special,
                         bool calculate,
                         GT_UNUSED GtError *err)
{
  GtEncseqReader *reader;
  GtAlphabet *alphabet;
  double *gc_content;
  /* unit = file or sequence depending on per_file */
  unsigned long char_idx, totallength, max_unit,
                seq_idx = 0,
                nextsep = 0,
                at_count = 0,
                gc_count = 0,
                default_count = 0;
  bool is_mirrored_encseq;
  GtUchar acgt[8], current_c;

  alphabet = gt_encseq_alphabet(encseq);
  gt_assert(gt_alphabet_is_dna(alphabet));
  gt_alphabet_encode_seq(alphabet, acgt,
                         "aAtTcCgG", 8UL);
  totallength = gt_encseq_total_length(encseq);
  reader = gt_encseq_create_reader_with_readmode(encseq,
                                                 GT_READMODE_FORWARD,
                                                 0);
  is_mirrored_encseq = gt_encseq_is_mirrored(encseq);
  if (is_mirrored_encseq)
  {
    max_unit = GT_DIV2(gt_encseq_num_of_sequences(encseq));
    gc_content = gt_calloc((size_t) GT_MULT2(max_unit), sizeof (double));
  }
  else
  {
    max_unit = gt_encseq_num_of_sequences(encseq);
    gc_content = gt_calloc((size_t) max_unit, sizeof (double));
  }

  nextsep = gt_encseq_seqstartpos(encseq, seq_idx) +
            gt_encseq_seqlength(encseq, seq_idx);

  for (char_idx = 0; char_idx < totallength; char_idx++)
  {
    if (nextsep == char_idx)
    {
      if (calculate)
      {
        calculate_gc(encseq,
                     gc_content,
                     with_special,
                     seq_idx,
                     gc_count,
                     at_count);
      }
      else
      {
        gc_content[seq_idx] = (double) gc_count;
      }

      seq_idx++;

      nextsep = gt_encseq_seqstartpos(encseq, seq_idx) +
                gt_encseq_seqlength(encseq, seq_idx);

      gt_encseq_reader_reinit_with_readmode(reader,
                                            encseq,
                                            GT_READMODE_FORWARD,
                                            char_idx + 1UL);
      gc_count = at_count = default_count = 0UL;
      continue;
    }
    current_c = gt_encseq_reader_next_encoded_char(reader);
    if (current_c == acgt[0] ||
        current_c == acgt[1] ||
        current_c == acgt[2] ||
        current_c == acgt[3])
    {
       at_count++;
    }
    else
    {
      if (current_c == acgt[4] ||
          current_c == acgt[5] ||
          current_c == acgt[6] ||
          current_c == acgt[7])
      {
         gc_count++;
      }
      else
      {
        default_count++;
      }
    }
  }
  if (calculate)
  {
    calculate_gc(encseq,
                 gc_content,
                 with_special,
                 seq_idx,
                 gc_count,
                 at_count);
  }
  else
  {
    gc_content[seq_idx] = (double) gc_count;
  }
  gt_encseq_reader_delete(reader);
  if (is_mirrored_encseq)
  {
    unsigned long double_max_unit = GT_MULT2(max_unit);
    for (seq_idx = 0; seq_idx < max_unit; seq_idx++)
    {
      gc_content[double_max_unit - seq_idx - 1] =
        gc_content[seq_idx];
    }
  }
  return gc_content;
}
예제 #8
0
static int gt_encseq_info_runner(GT_UNUSED int argc, const char **argv,
                           int parsed_args, void *tool_arguments,
                           GtError *err)
{
  GtEncseqInfoArguments *arguments = tool_arguments;
  int had_err = 0;
  GtAlphabet *alpha;
  const GtUchar *chars;
  gt_error_check(err);
  gt_assert(arguments);

  if (arguments->nomap) {
    GtEncseqMetadata *emd = gt_encseq_metadata_new(argv[parsed_args], err);
    if (!emd)
      had_err = -1;

    if (!had_err) {
      if (!arguments->noindexname) {
        gt_file_xprintf(arguments->outfp, "index name: ");
        gt_file_xprintf(arguments->outfp, "%s\n", argv[parsed_args]);
      }

      gt_file_xprintf(arguments->outfp, "file format version: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                          gt_encseq_metadata_version(emd));

      gt_file_xprintf(arguments->outfp, "64-bit file: ");
      gt_file_xprintf(arguments->outfp, "%s\n", gt_encseq_metadata_is64bit(emd)
                                                  ? "yes"
                                                  : "no");

      gt_file_xprintf(arguments->outfp, "total length: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                        gt_encseq_metadata_total_length(emd));

      gt_file_xprintf(arguments->outfp, "number of sequences: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                      gt_encseq_metadata_num_of_sequences(emd));

      gt_file_xprintf(arguments->outfp, "number of files: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                        gt_encseq_metadata_num_of_files(emd));

      gt_file_xprintf(arguments->outfp, "length of shortest/longest "
                                        "sequence: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"/"GT_WU"\n",
                                        gt_encseq_metadata_min_seq_length(emd),
                                        gt_encseq_metadata_max_seq_length(emd));

      gt_file_xprintf(arguments->outfp, "accesstype: ");
      gt_file_xprintf(arguments->outfp, "%s\n",
                 gt_encseq_access_type_str(gt_encseq_metadata_accesstype(emd)));

      alpha = gt_encseq_metadata_alphabet(emd);
      chars = gt_alphabet_characters(alpha);
      gt_file_xprintf(arguments->outfp, "alphabet size: ");
      gt_file_xprintf(arguments->outfp, "%u\n",
                                        gt_alphabet_num_of_chars(alpha));
      gt_file_xprintf(arguments->outfp, "alphabet characters: ");
      gt_file_xprintf(arguments->outfp, "%.*s", gt_alphabet_num_of_chars(alpha),
                                        (char*) chars);
      if (gt_alphabet_is_dna(alpha))
        gt_file_xprintf(arguments->outfp, " (DNA)");
      if (gt_alphabet_is_protein(alpha))
        gt_file_xprintf(arguments->outfp, " (Protein)");
      gt_file_xprintf(arguments->outfp, "\n");
      if (arguments->show_alphabet) {
        GtStr *out = gt_str_new();
        gt_alphabet_to_str(alpha, out);
        gt_file_xprintf(arguments->outfp, "alphabet definition:\n");
        gt_file_xprintf(arguments->outfp, "%s\n", gt_str_get(out));
        gt_str_delete(out);
      }

    }
    gt_encseq_metadata_delete(emd);
  } else {
    GtEncseqLoader *encseq_loader;
    GtEncseq *encseq;

    encseq_loader = gt_encseq_loader_new();
    if (arguments->mirror)
      gt_encseq_loader_mirror(encseq_loader);
    if (!(encseq = gt_encseq_loader_load(encseq_loader,
                                         argv[parsed_args], err)))
      had_err = -1;

    if (!had_err) {
      const GtStrArray *filenames;
      GtUword i;

      if (!arguments->noindexname) {
        gt_file_xprintf(arguments->outfp, "index name: ");
        gt_file_xprintf(arguments->outfp, "%s\n", argv[parsed_args]);
      }

      gt_file_xprintf(arguments->outfp, "file format version: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n", gt_encseq_version(encseq));

      gt_file_xprintf(arguments->outfp, "64-bit file: ");
      gt_file_xprintf(arguments->outfp, "%s\n", gt_encseq_is_64_bit(encseq)
                                                   ? "yes"
                                                   : "no");

      gt_file_xprintf(arguments->outfp, "total length: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                        gt_encseq_total_length(encseq));

      gt_file_xprintf(arguments->outfp, "compressed size: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU" bytes\n",
                                        gt_encseq_sizeofrep(encseq));

      gt_file_xprintf(arguments->outfp, "number of sequences: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                        gt_encseq_num_of_sequences(encseq));

      gt_file_xprintf(arguments->outfp, "number of files: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                        gt_encseq_num_of_files(encseq));

      gt_file_xprintf(arguments->outfp, "length of shortest/longest "
                                        "sequence: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"/"GT_WU"\n",
                                      gt_encseq_min_seq_length(encseq),
                                      gt_encseq_max_seq_length(encseq));

      filenames = gt_encseq_filenames(encseq);
      gt_file_xprintf(arguments->outfp, "original filenames:\n");
      for (i = 0; i < gt_str_array_size(filenames); i++) {
        gt_file_xprintf(arguments->outfp, "\t%s ("GT_WU" characters)\n",
                                          gt_str_array_get(filenames, i),
                                          (GtUword)
                                     gt_encseq_effective_filelength(encseq, i));
      }

      alpha = gt_encseq_alphabet(encseq);
      chars = gt_alphabet_characters(alpha);
      gt_file_xprintf(arguments->outfp, "alphabet size: ");
      gt_file_xprintf(arguments->outfp, "%u\n",
                                        gt_alphabet_num_of_chars(alpha));
      gt_file_xprintf(arguments->outfp, "alphabet characters: ");
      gt_file_xprintf(arguments->outfp, "%.*s", gt_alphabet_num_of_chars(alpha),
                                        (char*) chars);
      if (gt_alphabet_is_dna(alpha))
        gt_file_xprintf(arguments->outfp, " (DNA)");
      if (gt_alphabet_is_protein(alpha))
        gt_file_xprintf(arguments->outfp, " (Protein)");
      gt_file_xprintf(arguments->outfp, "\n");
      if (arguments->show_alphabet) {
        GtStr *out = gt_str_new();
        gt_alphabet_to_str(alpha, out);
        gt_file_xprintf(arguments->outfp, "alphabet definition:\n");
        gt_file_xprintf(arguments->outfp, "%s\n", gt_str_get(out));
        gt_str_delete(out);
      }

      gt_file_xprintf(arguments->outfp, "character distribution:\n");
      for (i = 0; i < gt_alphabet_num_of_chars(alpha); i++) {
        GtUword cc;
        cc = gt_encseq_charcount(encseq, gt_alphabet_encode(alpha, chars[i]));
        gt_file_xprintf(arguments->outfp, "\t%c: "GT_WU" (%.2f%%)\n",
                                          (char) chars[i],
                                          cc,
                             (cc /(double) (gt_encseq_total_length(encseq)
                                  - gt_encseq_num_of_sequences(encseq)+1))*100);
      }

      gt_file_xprintf(arguments->outfp, "number of wildcards: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU" ("GT_WU" range(s))\n",
                                        gt_encseq_wildcards(encseq),
                                        gt_encseq_realwildcardranges(encseq));

      gt_file_xprintf(arguments->outfp, "number of special characters: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU" ("GT_WU" range(s))\n",
                                        gt_encseq_specialcharacters(encseq),
                                        gt_encseq_realspecialranges(encseq));

      gt_file_xprintf(arguments->outfp, "length of longest non-special "
                                        "character stretch: ");
      gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                   gt_encseq_lengthoflongestnonspecial(encseq));

      gt_file_xprintf(arguments->outfp, "accesstype: ");
      gt_file_xprintf(arguments->outfp, "%s\n",
                   gt_encseq_access_type_str(gt_encseq_accesstype_get(encseq)));

      gt_file_xprintf(arguments->outfp, "bits used per character: ");
      gt_file_xprintf(arguments->outfp, "%f\n",
        (double) ((uint64_t) CHAR_BIT *
                  (uint64_t) gt_encseq_sizeofrep(encseq)) /
        (double) gt_encseq_total_length(encseq));

      gt_file_xprintf(arguments->outfp, "has special ranges: ");
      gt_file_xprintf(arguments->outfp, "%s\n",
                                        gt_encseq_has_specialranges(encseq)
                                          ? "yes"
                                          : "no");

      gt_file_xprintf(arguments->outfp, "has description support: ");
      gt_file_xprintf(arguments->outfp, "%s\n",
                                       gt_encseq_has_description_support(encseq)
                                          ? "yes"
                                          : "no");

      if (gt_encseq_has_description_support(encseq)) {
        gt_file_xprintf(arguments->outfp, "length of longest description: ");
        gt_file_xprintf(arguments->outfp, ""GT_WU"\n",
                                          gt_encseq_max_desc_length(encseq));
      }

      gt_file_xprintf(arguments->outfp, "has multiple sequence support: ");
      gt_file_xprintf(arguments->outfp, "%s\n",
                                        gt_encseq_has_multiseq_support(encseq)
                                          ? "yes"
                                          : "no");
    }
    gt_encseq_delete(encseq);
    gt_encseq_loader_delete(encseq_loader);
  }

  return had_err;
}