//*******************************************************//
int findTrajectory(std::vector<std::vector<fSet> >& G, int &targetDistance, int v0_index, classPoint2T &point, std::vector<std::vector<int> > &T, std::vector<std::vector<int> > &D){
/* This function find out the trajectory of a feasible point */
// Initialize a trajectory vector
std::vector<classPoint2T> traj;
// std::cout<<"Size of G table:"<<M<<" x "<<N<<std::endl;
int t = point.time;
int d = targetDistance;
int vend_index = point.vel;
// print T
std::cout<<"T table in findTrajectory:"<<std::endl;
for(int i=0; i<M; i++){
for(int j = 0; j<M; j++)
std::cout<<T[i][j]<<"\t";
std::cout<<"\n";
}
// Add starting point to the trajectory
classPoint2T startingPoint(0,v0_index);
traj.push_back(startingPoint);
/* Now travere the table and add vint and time to the trajectory. */
if(recursiveMove(traj, t, d, vend_index, v0_index, G, T, D) ) {
// std::cout<<"\t Successfully retrieve a plan"<<std::endl;
}
/* // if starting time is not 0, donot return the obtained plan
if(traj[0].time >= 1) {
std::cout<<"\t But starting time is not zero."<<std::endl;
return -1;
} */
std::cout<<"\tplan obtained with arrival point ";
point.print();
std::cout<<" is:" <<std::endl;
std::cout<<"[["<<targetDistance<<","<<v0_index<<","<<point.vel<<","<<point.time<<"],"<<std::endl;
std::cout<<"[";
for(unsigned int i =0;i<traj.size();++i){
traj[i].print();
if(i<traj.size() - 1)
std::cout<<",";
}
std::cout<<"]\n"<<std::endl;
return 1;
}
void FrameBuffer::DrawSegment(V3 pp0, V3 pp1, unsigned int color) {
float u0f = pp0[0];
float u1f = pp1[0];
float v0f = pp0[1];
float v1f = pp1[1];
float du = fabsf(u1f-u0f);
float dv = fabsf(v1f-v0f);
int stepsN = (du < dv) ? 1 + (int) dv : 1 + (int) du;
V3 startingPoint(pp0);
V3 endingPoint(pp1);
int segsN;
if (stepsN == 1)
segsN = 1;
else
segsN = stepsN-1;
V3 segmentStep = (endingPoint - startingPoint) / (float) segsN;
int i;
V3 currentPoint;
for (i = 0,
currentPoint = startingPoint;
i < stepsN;
i++,
currentPoint = currentPoint + segmentStep) {
int u = (int) currentPoint[0];
int v = (int) currentPoint[1];
if (IsOutsideFrame(u, v))
continue;
if (IsFarther(u, v, currentPoint[2]))
continue;
SetZ(u, v, currentPoint[2]);
Set(u, v, color);
currentPoint = currentPoint + segmentStep;
}
}
int main (int argc, char **argv) {
int n = 0;
int m = 0;
int s = 0;
int v = 0;
float d = 0;
char *parametro;
int i = 0;
int j = 0;
int x = 0;
int y = 0;
int cont = 0;
float g = 0;
point *firstPoint = malloc(sizeof(point *));
cell ***grid = NULL;
cell *conectados = malloc(sizeof(cell *));
cell *c = malloc(sizeof(cell *));
printf("Bem vindos ao programa do vini limdo =3\n");
for (i = 1; i < argc; i ++) { /*For para ler os parametros*/
parametro = argv[i];
if (parametro[1] == 'N') { /*Segurar essa linha contra acessos de chars alem da palavra do parametro*/
n = atoi(¶metro[2]);
}
else if (parametro[1] == 'M') {
m = atoi(¶metro[2]);
}
else if (parametro[1] == 's') {
s = atoi(¶metro[2]);
}
else if (parametro[1] == 'd') {
d = atof(¶metro[2]);
g = 1.0/d;
}
else if (parametro[1] == 'v') {
v = 1;
}
else if (parametro[1] == 'V') {
v = 2;
}
else if (parametro[1] == 'C') {
if (d == 0) {
printf ("Erro; falta o d.\n");
return 0; /*Sair bonitinho*/
}
printf ("Por favor, digite os pontos desejados e pressione ctrl+d no final.\n");
grid = malloc((g+2)*sizeof(cell **));
for (i = 0; i<g+2; i++) {
grid[i] = malloc((g+2)*sizeof(cell *));
for (j=0; j<g+2; j++) {
cell newCell;
newCell.point = NULL;
newCell.prox = NULL;
grid[i][j] = &newCell;
}
}
while (scanf("%d %d", &x, &y) == 1) {
cell *cab = grid[(int)(x/d +1)][(int)(y/d + 1)]; /*pointeiro para a cabeca da lista do grid na posição em que o novo ponto deve ser inserido*/
point newPoint; /*allocação de memória para a nova célula e seu respectivo ponto*/
cell newCell;
newPoint.x = x; /*insere as informações no novo ponto*/
newPoint.y = y;
newPoint.link = 0;
newCell.point = &newPoint; /*associa a célula com o ponto*/
newCell.prox = cab->prox; /*insere a célula no começo da respeciva lista do grid*/
cab->prox = &newCell;
n++; /*incrementa o n*/
}
printf("Pontos gerados.\n");
}
}
srand(s); /*Atualiza a seed do random*/
printf("Parametros:\n n = %d\n m = %d\n s = %d\n d = %f\n v = %d\n", n, m, s, d, v); /*Imprime os parâmetros para depuração*/
if (d != 0) { /*primeira opção*/
if (grid == NULL && n != 0) { /*Se o grid não existir e tivermos N, devemos inicialliza-lo com números aleatórios.*/
printf ("Gerando pontos aleatórios....\n");
grid = malloc((g+4)*sizeof(cell **)); /*malloc a da 1a dimensao*/
for (i = 0; i<g+4; i++) {
grid[i] = malloc((g+4)*sizeof(cell *)); /*malloc da 2a*/
for (j=0; j<g+4; j++) { /*preenche cada espaço com uma célula vazia*/
cell *newCell = malloc(sizeof(cell *));
newCell->point = NULL;
newCell->prox = NULL;
grid[i][j] = newCell;
}
}
for (i = 0; i < n; i ++) { /*coloca valores aleatórios no grid*/
cell *cab = malloc(sizeof(cell *)); /*Ponteiro para a cabeça da lista no lugar certo do grid*/
point *newPoint = malloc(sizeof(point *)); /*ponto a ser inserido*/
cell *newCell = malloc(sizeof(cell *)); /*célula referente a esse ponto*/
newPoint->x = (rand()*1.0)/RAND_MAX; /*insere valores no ponto*/
newPoint->y = (rand()*1.0)/RAND_MAX;
newPoint->link = i;
newCell->point = newPoint; /*conecta a celula com o ponto*/
newCell->prox = NULL;
cab = grid[(int)(newPoint->x/d +2)][(int)(newPoint->y/d +2)]; /*cabeca aponta para o lugar certo*/
newCell->prox = cab->prox; /*insere a celula criada logo após a cabeça*/
cab->prox = newCell;
}
}
else if (n == 0) {
printf ("Houve um erro no cálculo no número de pontos ou ele não foi fornecido, apesar de ser necessário.\n");
return 0;
}
c = NULL;
cont = 0;
if (v == 1)
for (i = 0; i < g+4; i ++)
for (j = 0; j < g+4; j ++)
for (c = grid[i][j]; c->prox != NULL; c = c->prox)
printf ("Point %d at grid[%d][%d]:\n x=%f, y=%f\n", cont++, i, j, c->prox->point->x, c->prox->point->y);
firstPoint = startingPoint(grid, g);
if (firstPoint == NULL) {
printf("Houve um erro ao pegar um ponto arbitrário do grafo em que começar o algoritmo.\n");
return 0;
}
c = NULL;
conectados->prox = NULL;
conectados->point = firstPoint;
cont = n;
float a, b, f, e;
while (conectados != NULL) {
for (i = conectados->point->x/d +2 -1; i <= conectados->point->x/d +2 +1; i++) {
for (j = conectados->point->y/d +2 -1; j <= conectados->point->y/d +2 +1; j++) {
for (c = grid[i][j]; c->prox != NULL;) {
a = conectados->point->x;
b = conectados->point->y;
f = c->prox->point->x;
e = c->prox->point->y;
if (((a-f)*(a-f)) + ((b-e)*(b-e)) <= d*d) {
/*Remove c->prox do grid e coloca ela no conectados*/
cont --;
cell *aux2 = malloc(sizeof(cell *));
cell *aux3 = malloc(sizeof(cell *));
aux2 = c->prox;
c->prox = aux2->prox;
if (conectados == NULL) {
conectados = aux2;
aux2->prox = NULL;
}
else {
aux3 = conectados->prox;
conectados->prox = aux2;
aux2->prox = aux3;
}
}
else {
c = c->prox;
}
}
}
}
if (cont == 0) break;
if (conectados != NULL) {
/*Remove uma celula do conectados*/
cell *aux = malloc(sizeof(cell *));
aux = conectados;
conectados = conectados->prox;
free(aux);
}
}
/*cont = linkAroundTheWorld(firstPoint, grid, d); /*checa se o grafo é conexo*/
if (cont == 0) {
printf("O grafo é conexo!!\n");
return 0;
}
else if (cont > 0) {
printf("O grafo não é conexo.\n");
return 0;
}
else {
printf("Houve um erro na implementação do algoritmo. (erro 1)\n");
return 0;
}
}
return 0;
}
EndCriteria::Type HybridSimulatedAnnealing<Sampler, Probability, Temperature, Reannealing>::minimize(Problem &P, const EndCriteria &endCriteria) {
EndCriteria::Type ecType = EndCriteria::None;
P.reset();
reannealing_.setProblem(P);
Array x = P.currentValue();
Size n = x.size();
Size k = 1;
Size kStationary = 1;
Size kReAnneal = 1;
Size kReset = 1;
Size maxK = endCriteria.maxIterations();
Size maxKStationary = endCriteria.maxStationaryStateIterations();
bool temperatureBreached = false;
Array currentTemperature(n, startTemperature_);
Array annealStep(n, 1.0);
Array bestPoint(x);
Array currentPoint(x);
Array startingPoint(x);
Array newPoint(x);
Real bestValue = P.value(bestPoint);
Real currentValue = bestValue;
Real startingValue = bestValue; //to reset to starting point if desired
while (k <= maxK && kStationary <= maxKStationary && !temperatureBreached)
{
//Draw a new sample point
sampler_(newPoint, currentPoint, currentTemperature);
//Evaluate new point
Real newValue = P.value(newPoint);
//Determine if new point is accepted
if (probability_(currentValue, newValue, currentTemperature)) {
if (optimizeScheme_ == EveryNewPoint) {
P.setCurrentValue(newPoint);
P.setFunctionValue(newValue);
localOptimizer_->minimize(P, endCriteria);
newPoint = P.currentValue();
newValue = P.functionValue();
}
currentPoint = newPoint;
currentValue = newValue;
}
//Check if we have a new best point
if (newValue < bestValue) {
if (optimizeScheme_ == EveryBestPoint) {
P.setCurrentValue(newPoint);
P.setFunctionValue(newValue);
localOptimizer_->minimize(P, endCriteria);
newPoint = P.currentValue();
newValue = P.functionValue();
}
kStationary = 0;
bestValue = newValue;
bestPoint = newPoint;
}
//Increase steps
k++;
kStationary++;
for (Size i = 0; i < annealStep.size(); i++)
annealStep[i]++;
//Reanneal if necessary
if (kReAnneal == reAnnealSteps_) {
kReAnneal = 0;
reannealing_(annealStep, currentPoint, currentValue, currentTemperature);
}
kReAnneal++;
//Reset if necessary
if (kReset == resetSteps_) {
kReset = 0;
switch (resetScheme_) {
case NoResetScheme:
break;
case ResetToBestPoint:
currentPoint = startingPoint;
currentValue = startingValue;
break;
case ResetToOrigin:
currentPoint = bestPoint;
currentValue = bestValue;
break;
}
}
kReset++;
//Update the current temperature according to current step
temperature_(currentTemperature, currentTemperature, annealStep);
//Check if temperature condition is breached
for (Size i = 0; i < n; i++)
temperatureBreached = temperatureBreached && currentTemperature[i] < endTemperature_;
}
//Change end criteria type if appropriate
if (k > maxK)
ecType = EndCriteria::MaxIterations;
else if (kStationary > maxKStationary)
ecType = EndCriteria::StationaryPoint;
//Set result to best point
P.setCurrentValue(bestPoint);
P.setFunctionValue(bestValue);
return ecType;
}
// main function of verifyBamID
int execute(int argc, char** argv) {
printf("verifyBamID %s -- verify identity and purity of sequence data\n"
"(c) 2010-2014 Hyun Min Kang, Goo Jun, and Goncalo Abecasis\n\n", VERSION);
VerifyBamIDArgs args;
ParameterList pl;
BEGIN_LONG_PARAMETERS(longParameters)
LONG_PARAMETER_GROUP("Input Files")
LONG_STRINGPARAMETER("vcf",&args.sVcfFile)
LONG_STRINGPARAMETER("bam",&args.sBamFile)
LONG_STRINGPARAMETER("subset",&args.sSubsetInds)
LONG_STRINGPARAMETER("smID",&args.sSMID)
LONG_PARAMETER_GROUP("VCF analysis options")
LONG_DOUBLEPARAMETER("genoError",&args.genoError)
LONG_DOUBLEPARAMETER("minAF",&args.minAF)
LONG_DOUBLEPARAMETER("minCallRate",&args.minCallRate)
LONG_PARAMETER_GROUP("Individuals to compare with chip data")
EXCLUSIVE_PARAMETER("site",&args.bSiteOnly)
EXCLUSIVE_PARAMETER("self",&args.bSelfOnly)
EXCLUSIVE_PARAMETER("best",&args.bFindBest)
LONG_PARAMETER_GROUP("Chip-free optimization options")
EXCLUSIVE_PARAMETER("free-none",&args.bFreeNone)
EXCLUSIVE_PARAMETER("free-mix",&args.bFreeMixOnly)
EXCLUSIVE_PARAMETER("free-refBias",&args.bFreeRefBiasOnly)
EXCLUSIVE_PARAMETER("free-full",&args.bFreeFull)
LONG_PARAMETER_GROUP("With-chip optimization options")
EXCLUSIVE_PARAMETER("chip-none",&args.bChipNone)
EXCLUSIVE_PARAMETER("chip-mix",&args.bChipMixOnly)
EXCLUSIVE_PARAMETER("chip-refBias",&args.bChipRefBiasOnly)
EXCLUSIVE_PARAMETER("chip-full",&args.bChipFull)
LONG_PARAMETER_GROUP("BAM analysis options")
LONG_PARAMETER("ignoreRG",&args.bIgnoreRG)
LONG_PARAMETER("ignoreOverlapPair",&args.bIgnoreOverlapPair)
LONG_PARAMETER("noEOF",&args.bNoEOF)
LONG_PARAMETER("precise",&args.bPrecise)
LONG_INTPARAMETER("minMapQ",&args.minMapQ)
LONG_INTPARAMETER("maxDepth",&args.maxDepth)
LONG_INTPARAMETER("minQ",&args.minQ)
LONG_INTPARAMETER("maxQ",&args.maxQ)
LONG_DOUBLEPARAMETER("grid",&args.grid)
LONG_PARAMETER_GROUP("Modeling Reference Bias")
LONG_DOUBLEPARAMETER("refRef",&args.pRefRef)
LONG_DOUBLEPARAMETER("refHet",&args.pRefHet)
LONG_DOUBLEPARAMETER("refAlt",&args.pRefAlt)
LONG_PARAMETER_GROUP("Output options")
LONG_STRINGPARAMETER("out",&args.sOutFile)
LONG_PARAMETER("verbose",&args.bVerbose)
LONG_PHONEHOME(VERSION)
END_LONG_PARAMETERS();
pl.Add(new LongParameters("Available Options",longParameters));
pl.Read(argc, argv);
pl.Status();
// check the validity of input files
if ( args.sVcfFile.IsEmpty() ) {
error("--vcf [vcf file] required");
}
if ( args.sBamFile.IsEmpty() ) {
error("--bam [bam file] is required");
}
if ( args.sOutFile.IsEmpty() ) {
error("--out [output prefix] is required");
}
Logger::gLogger = new Logger((args.sOutFile + ".log").c_str(), args.bVerbose);
if ( ! ( args.bSiteOnly || args.bSelfOnly || args.bFindBest ) ) {
warning("--self option was autotomatically turned on by default. Specify --best option if you wanted to check across all possible samples in the VCF");
args.bSelfOnly = true;
}
if ( ( args.maxDepth > 20 ) && ( !args.bPrecise ) ) {
warning("--precise option is not turned on at --maxDepth %d : may be prone to precision errors",args.maxDepth);
}
if ( ( args.bChipRefBiasOnly ) && ( !args.bSelfOnly ) ) {
error("--self must be set for --chip-refBias to work. Skipping..");
}
// check timestamp
time_t t;
time(&t);
Logger::gLogger->writeLog("Analysis started on %s",ctime(&t));
// load arguments
VerifyBamID vbid(&args);
// load input VCF and BAM files
Logger::gLogger->writeLog("Opening Input Files");
vbid.loadFiles(args.sBamFile.c_str(), args.sVcfFile.c_str());
// Check which genotype-free method is used
if ( args.bFreeNone ) { // if no genotype-free mode is tested. skip it
// do nothing for genotype-free estimation
Logger::gLogger->writeLog("Skipping chip-free estimation of sample mixture");
}
else if ( args.bFreeMixOnly ) { // only mixture is estimated.
// genotype-free method
Logger::gLogger->writeLog("Performing chip-free estimation of sample mixture at fixed reference bias parameters (%lf, %lf, %lf)",args.pRefRef,args.pRefHet,args.pRefAlt);
// scan across multiple readgroups
for(int rg=-1; rg < vbid.nRGs - (int)args.bIgnoreRG; ++rg) {
VerifyBamID::mixLLK mix(&vbid);
mix.OptimizeLLK(rg);
Logger::gLogger->writeLog("Optimal per-sample fMix = %lf, LLK0 = %lf, LLK1 = %lf\n",mix.fMix,mix.llk0,mix.llk1);
vbid.mixOut.llk0s[rg+1] = mix.llk0;
vbid.mixOut.llk1s[rg+1] = mix.llk1;
vbid.mixOut.fMixs[rg+1] = mix.fMix;
}
//vbid.mixRefHet = 0.5;
//vbid.mixRefAlt = 0.00;
}
else if ( args.bFreeRefBiasOnly ) {
Logger::gLogger->writeLog("Performing chip-free estimation of reference-bias without sample mixture");
for(int rg=-1; rg < vbid.nRGs - (int)args.bIgnoreRG; ++rg) {
VerifyBamID::refBiasMixLLKFunc myFunc(&vbid, rg);
AmoebaMinimizer myMinimizer;
Vector startingPoint(2);
startingPoint[0] = 0; // pRefHet = 0.5
startingPoint[1] = -4.595; // pRefAlt = 0.01
myMinimizer.func = &myFunc;
myMinimizer.Reset(2);
myMinimizer.point = startingPoint;
myMinimizer.Minimize(1e-6);
double pRefHet = VerifyBamID::invLogit(myMinimizer.point[0]);
double pRefAlt = VerifyBamID::invLogit(myMinimizer.point[1]);
Logger::gLogger->writeLog("Reference Bias Estimated as ( Pr[refBase|HET] = %lf, Pr[refBase|ALT] = %lf) with LLK = %lf at readGroup %d",pRefHet,pRefAlt,myMinimizer.fmin,rg);
//vbid.setRefBiasParams(1.0, pRefHet, pRefAlt);
vbid.mixOut.llk0s[rg+1] = myFunc.llk0;
vbid.mixOut.llk1s[rg+1] = myFunc.llk1;
vbid.mixOut.refHets[rg+1] = myFunc.pRefHet;
vbid.mixOut.refAlts[rg+1] = myFunc.pRefAlt;
}
}
else if ( args.bFreeFull ) {
Logger::gLogger->writeLog("Performing chip-free estimation of reference-bias and sample mixture together");
for(int rg = -1; rg < vbid.nRGs - args.bIgnoreRG; ++rg) {
VerifyBamID::fullMixLLKFunc myFunc(&vbid, rg);
AmoebaMinimizer myMinimizer;
Vector startingPoint(3);
startingPoint[0] = -3.91; // start with fMix = 0.01
startingPoint[1] = 0; // pRefHet = 0.5
startingPoint[2] = -4.595; // pRefAlt = 0.01
myMinimizer.func = &myFunc;
myMinimizer.Reset(3);
myMinimizer.point = startingPoint;
myMinimizer.Minimize(1e-6);
double fMix = VerifyBamID::invLogit(myMinimizer.point[0]);
if ( fMix > 0.5 )
fMix = 1.-fMix;
double pRefHet = VerifyBamID::invLogit(myMinimizer.point[1]);
double pRefAlt = VerifyBamID::invLogit(myMinimizer.point[2]);
Logger::gLogger->writeLog("Optimal per-sample fMix = %lf\n",fMix);
Logger::gLogger->writeLog("Reference Bias Estimated as ( Pr[refBase|HET] = %lf, Pr[refBase|ALT] = %lf) with LLK = %lf",pRefHet,pRefAlt,myMinimizer.fmin);
//vbid.setRefBiasParams(1.0, pRefHet, pRefAlt);
vbid.mixOut.llk0s[rg+1] = myFunc.llk0;
vbid.mixOut.llk1s[rg+1] = myFunc.llk1;
vbid.mixOut.fMixs[rg+1] = myFunc.fMix;
vbid.mixOut.refHets[rg+1] = myFunc.pRefHet;
vbid.mixOut.refAlts[rg+1] = myFunc.pRefAlt;
}
}
Logger::gLogger->writeLog("calculating depth distribution");
vbid.calculateDepthDistribution(args.maxDepth, vbid.mixOut);
Logger::gLogger->writeLog("finished calculating depth distribution");
std::vector<int> bestInds(vbid.nRGs+1,-1);
std::vector<int> selfInds(vbid.nRGs+1,-1);
if ( args.bChipNone ) {
// do nothing
Logger::gLogger->writeLog("Skipping with-chip estimation of sample mixture");
}
else if ( args.bChipMixOnly ) {
Logger::gLogger->writeLog("Performing with-chip estimation of sample mixture at fixed reference bias parameter (%lf, %lf, %lf)",args.pRefRef,args.pRefHet,args.pRefAlt);
for(int rg=-1; rg < (vbid.nRGs - (int)args.bIgnoreRG); ++rg) {
double maxIBD = -1;
VerifyBamID::ibdLLK ibd(&vbid);
for(int i=0; i < (int)vbid.pGenotypes->indids.size(); ++i) {
double fIBD = ibd.OptimizeLLK(i, rg);
Logger::gLogger->writeLog("Comparing with individual %s.. Optimal fIBD = %lf, LLK0 = %lf, LLK1 = %lf for readgroup %d",vbid.pGenotypes->indids[i].c_str(),fIBD, ibd.llk0, ibd.llk1, rg);
if ( maxIBD < fIBD ) {
bestInds[rg+1] = i;
vbid.bestOut.llk0s[rg+1] = ibd.llk0;
vbid.bestOut.llk1s[rg+1] = ibd.llk1;
vbid.bestOut.fMixs[rg+1] = 1-ibd.fIBD;
maxIBD = ibd.fIBD;
}
if ( ( (rg < 0) && (vbid.pPile->sBamSMID == vbid.pGenotypes->indids[i] ) ) || ( ( rg >= 0 ) && ( vbid.pPile->vsSMIDs[rg] == vbid.pGenotypes->indids[i]) ) ) {
selfInds[rg+1] = i;
vbid.selfOut.llk0s[rg+1] = ibd.llk0;
vbid.selfOut.llk1s[rg+1] = ibd.llk1;
vbid.selfOut.fMixs[rg+1] = 1-ibd.fIBD;
}
}
if ( bestInds[rg+1] >= 0 ) {
Logger::gLogger->writeLog("Best Matching Individual is %s with IBD = %lf",vbid.pGenotypes->indids[bestInds[rg+1]].c_str(),maxIBD);
vbid.calculateDepthByGenotype(bestInds[rg+1],rg,vbid.bestOut);
}
if ( selfInds[rg+1] >= 0 ) {
Logger::gLogger->writeLog("Self Individual is %s with IBD = %lf",vbid.pGenotypes->indids[selfInds[rg+1]].c_str(),vbid.selfOut.fMixs[rg+1]);
vbid.calculateDepthByGenotype(selfInds[rg+1],rg,vbid.selfOut);
}
}
}
else if ( args.bChipRefBiasOnly ) {
Logger::gLogger->writeLog("Performing with-chip estimation of reference-bias without sample mixture");
if ( args.bSelfOnly ) {
for(int rg=-1; rg < (vbid.nRGs - (int)args.bIgnoreRG); ++rg) {
VerifyBamID::refBiasIbdLLKFunc myFunc(&vbid, rg);
AmoebaMinimizer myMinimizer;
Vector startingPoint(2);
startingPoint[0] = 0; // pRefHet = 0.5
startingPoint[1] = -4.595; // pRefAlt = 0.01
myMinimizer.func = &myFunc;
myMinimizer.Reset(2);
myMinimizer.point = startingPoint;
myMinimizer.Minimize(1e-6);
double pRefHet = VerifyBamID::invLogit(myMinimizer.point[0]);
double pRefAlt = VerifyBamID::invLogit(myMinimizer.point[1]);
Logger::gLogger->writeLog("Reference Bias Estimated as ( Pr[refBase|HET] = %lf, Pr[refBase|ALT] = %lf) with LLK = %lf",pRefHet,pRefAlt,myMinimizer.fmin);
//vbid.setRefBiasParams(1.0, pRefHet, pRefAlt);
vbid.selfOut.llk0s[rg+1] = myFunc.llk0;
vbid.selfOut.llk1s[rg+1] = myFunc.llk1;
vbid.selfOut.refHets[rg+1] = myFunc.pRefHet;
vbid.selfOut.refAlts[rg+1] = myFunc.pRefAlt;
vbid.calculateDepthByGenotype(0,rg,vbid.selfOut);
}
}
else {
Logger::gLogger->warning("--self must be set for --chip-refBias to work. Skipping..");
}
}
else if ( args.bChipFull ) {
Logger::gLogger->writeLog("Performing with-chip estimation of reference-bias and sample mixture together");
for(int rg=-1; rg < (vbid.nRGs - (int)args.bIgnoreRG); ++rg) {
double maxIBD = -1;
for(int i=0; i < (int)vbid.pGenotypes->indids.size(); ++i) {
VerifyBamID::fullIbdLLKFunc myFunc(&vbid,i,rg);
AmoebaMinimizer myMinimizer;
Vector startingPoint(3);
startingPoint[0] = 3.91; // start with fIBD = 0.99
startingPoint[1] = 0; // pRefHet = 0.5
startingPoint[2] = -4.595; // pRefAlt = 0.01
myMinimizer.func = &myFunc;
myFunc.indIdx = i;
myMinimizer.Reset(3);
myMinimizer.point = startingPoint;
myMinimizer.Minimize(1e-6);
double fIBD = VerifyBamID::invLogit(myMinimizer.point[0]);
double pRefHet = VerifyBamID::invLogit(myMinimizer.point[1]);
double pRefAlt = VerifyBamID::invLogit(myMinimizer.point[2]);
Logger::gLogger->writeLog("Comparing with individual %s.. Optimal fIBD = %lf, LLK0 = %lf, LLK1 = %lf for readgroup %d",vbid.pGenotypes->indids[i].c_str(), fIBD, myFunc.llk0, myFunc.llk1, rg);
//Logger::gLogger->writeLog("Optimal per-sample fIBD = %lf, ",fIBD);
Logger::gLogger->writeLog("Reference Bias Estimated as ( Pr[refBase|HET] = %lf, Pr[refBase|ALT] = %lf ) with LLK = %lf",pRefHet,pRefAlt,myMinimizer.fmin);
if ( maxIBD < fIBD ) {
bestInds[rg+1] = i;
maxIBD = fIBD;
vbid.bestOut.llk0s[rg+1] = myFunc.llk0;
vbid.bestOut.llk1s[rg+1] = myFunc.llk1;
vbid.bestOut.fMixs[rg+1] = 1.-myFunc.fIBD;
vbid.bestOut.refHets[rg+1] = myFunc.pRefHet;
vbid.bestOut.refAlts[rg+1] = myFunc.pRefAlt;
}
if ( ( (rg < 0) && (vbid.pPile->sBamSMID == vbid.pGenotypes->indids[i] ) ) || ( ( rg >= 0 ) && ( vbid.pPile->vsSMIDs[rg] == vbid.pGenotypes->indids[i]) ) ) {
selfInds[rg+1] = i;
vbid.selfOut.llk0s[rg+1] = myFunc.llk0;
vbid.selfOut.llk1s[rg+1] = myFunc.llk1;
vbid.selfOut.fMixs[rg+1] = 1.-myFunc.fIBD;
vbid.selfOut.refHets[rg+1] = myFunc.pRefHet;
vbid.selfOut.refAlts[rg+1] = myFunc.pRefAlt;
vbid.calculateDepthByGenotype(i, rg, vbid.selfOut);
}
}
//vbid.setRefBiasParams(1.0, pRefHet, pRefAlt);
if ( bestInds[rg+1] >= 0 ) {
Logger::gLogger->writeLog("Best Matching Individual is %s with IBD = %lf",vbid.pGenotypes->indids[bestInds[rg+1]].c_str(),maxIBD);
vbid.calculateDepthByGenotype(bestInds[rg+1], rg, vbid.bestOut);
}
if ( selfInds[rg+1] >= 0 ) {
Logger::gLogger->writeLog("Self Individual is %s with IBD = %lf",vbid.pGenotypes->indids[selfInds[rg+1]].c_str(),vbid.selfOut.fMixs[rg+1]);
vbid.calculateDepthByGenotype(selfInds[rg+1],rg,vbid.selfOut);
}
}
}
// PRINT OUTPUT FILE - ".selfSM"
// [SEQ_ID] : SAMPLE ID in the sequence file
// [CHIP_ID] : SAMPLE ID in the chip file (NA if not available)
// [#SNPS] : Number of markers evaluated
// [#READS] : Number of reads evaluated
// [AVG_DP] : Mean depth
// [FREEMIX] : Chip-free estimated alpha (% MIX in 0-1 scale), NA if unavailable
// [FREELK1] : Chip-free log-likelihood at estimated alpha
// [FREELK0] : Chip-free log-likelihood at 0% contamination
// [CHIPIBD] : With-chip estimated alpha (% MIX in 0-1 scale)
// [CHIPLK1] : With-chip log-likelihood at estimated alpha
// [CHIPLK0] : With-chip log-likelihood at 0% contamination
// [DPREF] : Depth at reference site in the chip
// [RDPHET] : Relative depth at HET site in the chip
// [RDPALT] : Relative depth at HOMALT site in the chip
// [FREE_RF] : Pr(Ref|Ref) site estimated without chip data
// [FREE_RH] : Pr(Ref|Het) site estimated without chip data
// [FREE_RA] : Pr(Ref|Alt) site estimated without chip data
// [CHIP_RF] : Pr(Ref|Ref) site estimated with chip data
// [CHIP_RH] : Pr(Ref|Het) site estimated with chip data
// [CHIP_RA] : Pr(Ref|Alt) site estimated with chip data
// [DPREF] : Depth at reference alleles
// [RDPHET] : Relative depth at heterozygous alleles
// [RDPALT] : Relative depth at hom-alt alleles
String selfSMFN = args.sOutFile + ".selfSM";
String bestSMFN = args.sOutFile + ".bestSM";
String selfRGFN = args.sOutFile + ".selfRG";
String bestRGFN = args.sOutFile + ".bestRG";
String dpSMFN = args.sOutFile + ".depthSM";
String dpRGFN = args.sOutFile + ".depthRG";
IFILE selfSMF = ifopen(selfSMFN,"wb");
IFILE bestSMF = (args.bFindBest ? ifopen(bestSMFN,"wb") : NULL);
IFILE selfRGF = (args.bIgnoreRG ? NULL : ifopen(selfRGFN,"wb"));
IFILE bestRGF = (args.bFindBest && !args.bIgnoreRG) ? ifopen(bestRGFN,"wb") : NULL;
IFILE dpSMF = ifopen(dpSMFN,"wb");
IFILE dpRGF = (args.bIgnoreRG ? NULL : ifopen(dpRGFN,"wb"));
if ( selfSMF == NULL ) {
Logger::gLogger->error("Cannot write to %s",selfSMF);
}
if ( args.bFindBest && ( bestSMF == NULL ) ) {
Logger::gLogger->error("Cannot write to %s",bestSMF);
}
if ( dpSMF == NULL ) {
Logger::gLogger->error("Cannot write to %s",dpSMF);
}
ifprintf(dpSMF,"#RG\tDEPTH\t#SNPs\t%%SNPs\t%%CUMUL\n");
int nCumMarkers = 0;
for(int i=args.maxDepth; i >= 0; --i) {
nCumMarkers += vbid.mixOut.depths[i];
ifprintf(dpSMF,"ALL\t%d\t%d\t%.5lf\t%.5lf\n",i, vbid.mixOut.depths[i],(double) vbid.mixOut.depths[i]/(double)vbid.nMarkers,(double)nCumMarkers/(double)vbid.nMarkers);
}
ifclose(dpSMF);
if ( dpRGF != NULL ) {
ifprintf(dpRGF,"#RG\tDEPTH\t#SNPs\t%%SNPs\t%%CUMUL\n");
for(int rg=0; rg < (vbid.nRGs - (int)args.bIgnoreRG); ++rg) {
const char* rgID = vbid.pPile->vsRGIDs[rg].c_str();
int nMarkers = 0;
for(int i=args.maxDepth; i >= 0; --i) {
nMarkers += vbid.mixOut.depths[(rg+1)*(args.maxDepth+1) + i];
}
nCumMarkers = 0;
for(int i=args.maxDepth; i >= 0; --i) {
int d = vbid.mixOut.depths[(rg+1)*(args.maxDepth+1) + i];
nCumMarkers += d;
ifprintf(dpRGF,"%s\t%d\t%d\t%.5lf\t%.5lf\n",rgID,i,d,(double)d/(double)vbid.nMarkers,(double)nCumMarkers/(double)nMarkers);
}
}
ifclose(dpRGF);
}
const char* headers[] = {"#SEQ_ID","RG","CHIP_ID","#SNPS","#READS","AVG_DP","FREEMIX","FREELK1","FREELK0","FREE_RH","FREE_RA","CHIPMIX","CHIPLK1","CHIPLK0","CHIP_RH","CHIP_RA","DPREF","RDPHET","RDPALT"};
int nheaders = sizeof(headers)/sizeof(headers[0]);
for(int i=0; i < nheaders; ++i) { ifprintf(selfSMF,"%s%s",i>0 ? "\t" : "",headers[i]); }
ifprintf(selfSMF,"\n");
ifprintf(selfSMF,"%s\tALL",vbid.pPile->sBamSMID.c_str());
ifprintf(selfSMF,"\t%s",selfInds[0] >= 0 ? vbid.pGenotypes->indids[selfInds[0]].c_str() : "NA");
ifprintf(selfSMF,"\t%d\t%d\t%.2lf",vbid.nMarkers,vbid.mixOut.numReads[0],(double)vbid.mixOut.numReads[0]/(double)vbid.nMarkers);
if ( args.bFreeNone ) { ifprintf(selfSMF,"\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bFreeMixOnly ) { ifprintf(selfSMF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA",vbid.mixOut.fMixs[0],vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0]); }
else if ( args.bFreeRefBiasOnly ) { ifprintf(selfSMF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0],vbid.mixOut.refHets[0],vbid.mixOut.refAlts[0]); }
else if ( args.bFreeFull ) { ifprintf(selfSMF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.fMixs[0],vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0],vbid.mixOut.refHets[0],vbid.mixOut.refAlts[0]); }
else { error("Invalid option in handling bFree"); }
if ( args.bChipNone || bestInds[0] < 0 ) { ifprintf(selfSMF,"\tNA\tNA\tNA\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bChipMixOnly ) { ifprintf(selfSMF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA\t%.3lf\t%.4lf\t%.4lf",vbid.selfOut.fMixs[0],vbid.selfOut.llk1s[0],vbid.selfOut.llk0s[0],(double)vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[1], (double)vbid.selfOut.numReads[2]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[2], (double)vbid.selfOut.numReads[3]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[3]); }
else if ( args.bChipMixOnly ) { ifprintf(selfSMF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf",vbid.selfOut.llk1s[0], vbid.selfOut.llk0s[0], vbid.selfOut.refHets[0], vbid.selfOut.refAlts[0], (double)vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[1], (double)vbid.selfOut.numReads[2]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[2], (double)vbid.selfOut.numReads[3]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[3]); }
else if ( args.bChipFull ) { ifprintf(selfSMF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf", vbid.selfOut.fMixs[0], vbid.selfOut.llk1s[0], vbid.selfOut.llk0s[0], vbid.selfOut.refHets[0], vbid.selfOut.refAlts[0], (double)vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[1], (double)vbid.selfOut.numReads[2]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[2], (double)vbid.selfOut.numReads[3]*vbid.selfOut.numGenos[1]/vbid.selfOut.numReads[1]/vbid.selfOut.numGenos[3]); }
else { error("Invalid option in handling bChip"); }
ifprintf(selfSMF,"\n");
ifclose(selfSMF);
if ( bestSMF != NULL ) {
for(int i=0; i < nheaders; ++i) { ifprintf(bestSMF,"%s%s",i>0 ? "\t" : "",headers[i]); }
ifprintf(bestSMF,"\n");
ifprintf(bestSMF,"%s\tALL",vbid.pPile->sBamSMID.c_str());
ifprintf(bestSMF,"\t%s",bestInds[0] >= 0 ? vbid.pGenotypes->indids[bestInds[0]].c_str() : "NA");
ifprintf(bestSMF,"\t%d\t%d\t%.2lf",vbid.nMarkers,vbid.mixOut.numReads[0],(double)vbid.mixOut.numReads[0]/(double)vbid.nMarkers);
if ( args.bFreeNone ) { ifprintf(bestSMF,"\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bFreeMixOnly ) { ifprintf(bestSMF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA",vbid.mixOut.fMixs[0],vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0]); }
else if ( args.bFreeRefBiasOnly ) { ifprintf(bestSMF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0],vbid.mixOut.refHets[0],vbid.mixOut.refAlts[0]); }
else if ( args.bFreeFull ) { ifprintf(bestSMF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.fMixs[0],vbid.mixOut.llk1s[0],vbid.mixOut.llk0s[0],vbid.mixOut.refHets[0],vbid.mixOut.refAlts[0]); }
else { error("Invalid option in handling bFree"); }
if ( args.bChipNone || bestInds[0] < 0 ) { ifprintf(bestSMF,"\tNA\tNA\tNA\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bChipMixOnly ) { ifprintf(bestSMF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA\t%.3lf\t%.4lf\t%.4lf",vbid.bestOut.fMixs[0],vbid.bestOut.llk1s[0],vbid.bestOut.llk0s[0],(double)vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[1], (double)vbid.bestOut.numReads[2]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[2], (double)vbid.bestOut.numReads[3]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[3]); }
else if ( args.bChipMixOnly ) { ifprintf(bestSMF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf",vbid.bestOut.llk1s[0], vbid.bestOut.llk0s[0], vbid.bestOut.refHets[0], vbid.bestOut.refAlts[0], (double)vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[1], (double)vbid.bestOut.numReads[2]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[2], (double)vbid.bestOut.numReads[3]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[3]); }
else if ( args.bChipFull ) { ifprintf(bestSMF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf", vbid.bestOut.fMixs[0], vbid.bestOut.llk1s[0], vbid.bestOut.llk0s[0], vbid.bestOut.refHets[0], vbid.bestOut.refAlts[0], (double)vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[1], (double)vbid.bestOut.numReads[2]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[2], (double)vbid.bestOut.numReads[3]*vbid.bestOut.numGenos[1]/vbid.bestOut.numReads[1]/vbid.bestOut.numGenos[3]); }
else { error("Invalid option in handling bChip"); }
ifprintf(bestSMF,"\n");
ifclose(bestSMF);
}
if ( selfRGF != NULL ) {
for(int i=0; i < nheaders; ++i) { ifprintf(selfRGF,"%s%s",i>0 ? "\t" : "",headers[i]); }
ifprintf(selfRGF,"\n");
for(int rg=0; rg < vbid.nRGs; ++rg) {
ifprintf(selfRGF,"%s\t%s",vbid.pPile->sBamSMID.c_str(),vbid.pPile->vsRGIDs[rg].c_str());
ifprintf(selfRGF,"\t%s",bestInds[rg] >= 0 ? vbid.pGenotypes->indids[bestInds[rg]].c_str() : "NA");
ifprintf(selfRGF,"\t%d\t%d\t%.2lf",vbid.nMarkers,vbid.mixOut.numReads[(rg+1)*4],(double)vbid.mixOut.numReads[(rg+1)*4]/(double)vbid.mixOut.numGenos[(rg+1)*4]);
if ( args.bFreeNone ) { ifprintf(selfRGF,"\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bFreeMixOnly ) { ifprintf(selfRGF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA",vbid.mixOut.fMixs[rg+1],vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1]); }
else if ( args.bFreeRefBiasOnly ) { ifprintf(selfRGF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1],vbid.mixOut.refHets[rg+1],vbid.mixOut.refAlts[rg+1]); }
else if ( args.bFreeFull ) { ifprintf(selfRGF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.fMixs[rg+1],vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1],vbid.mixOut.refHets[rg+1],vbid.mixOut.refAlts[rg+1]); }
else { error("Invalid option in handling bFree"); }
if ( args.bChipNone || bestInds[0] < 0 ) { ifprintf(selfRGF,"\tNA\tNA\tNA\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bChipMixOnly ) { ifprintf(selfRGF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA\t%.3lf\t%.4lf\t%.4lf",vbid.selfOut.fMixs[rg+1], vbid.selfOut.llk1s[rg+1], vbid.selfOut.llk0s[rg+1], (double)vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+1], (double)vbid.selfOut.numReads[(rg+1)*4+2]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+2], (double)vbid.selfOut.numReads[(rg+1)*4+3]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+3]); }
else if ( args.bChipMixOnly ) { ifprintf(selfRGF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf",vbid.selfOut.llk1s[rg+1], vbid.selfOut.llk0s[rg+1], vbid.selfOut.refHets[rg+1], vbid.selfOut.refAlts[rg+1], (double)vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+1], (double)vbid.selfOut.numReads[(rg+1)*4+2]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4]/vbid.selfOut.numGenos[(rg+1)*4+2], (double)vbid.selfOut.numReads[(rg+1)*4+3]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+3]); }
else if ( args.bChipFull ) { ifprintf(selfRGF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf", vbid.selfOut.fMixs[rg+1], vbid.selfOut.llk1s[rg+1], vbid.selfOut.llk0s[rg+1], vbid.selfOut.refHets[rg+1], vbid.selfOut.refAlts[rg+1], (double)vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+1], (double)vbid.selfOut.numReads[(rg+1)*4+2]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+2], (double)vbid.selfOut.numReads[(rg+1)*4+3]*vbid.selfOut.numGenos[(rg+1)*4+1]/vbid.selfOut.numReads[(rg+1)*4+1]/vbid.selfOut.numGenos[(rg+1)*4+3]); }
else { error("Invalid option in handling bChip"); }
ifprintf(selfRGF,"\n");
}
ifclose(selfRGF);
}
if ( bestRGF != NULL ) {
for(int i=0; i < nheaders; ++i) { ifprintf(bestRGF,"%s%s",i>0 ? "\t" : "",headers[i]); }
ifprintf(bestRGF,"\n");
for(int rg=0; rg < vbid.nRGs; ++rg) {
ifprintf(bestRGF,"%s\t%s",vbid.pPile->sBamSMID.c_str(),vbid.pPile->vsRGIDs[rg].c_str());
ifprintf(bestRGF,"\t%s",bestInds[rg] >= 0 ? vbid.pGenotypes->indids[bestInds[rg]].c_str() : "NA");
ifprintf(bestRGF,"\t%d\t%d\t%.2lf",vbid.nMarkers,vbid.mixOut.numReads[(rg+1)*4],(double)vbid.mixOut.numReads[(rg+1)*4]/(double)vbid.mixOut.numGenos[(rg+1)*4]);
if ( args.bFreeNone ) { ifprintf(bestRGF,"\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bFreeMixOnly ) { ifprintf(bestRGF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA",vbid.mixOut.fMixs[rg+1],vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1]); }
else if ( args.bFreeRefBiasOnly ) { ifprintf(bestRGF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1],vbid.mixOut.refHets[rg+1],vbid.mixOut.refAlts[rg+1]); }
else if ( args.bFreeFull ) { ifprintf(bestRGF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf",vbid.mixOut.fMixs[rg+1],vbid.mixOut.llk1s[rg+1],vbid.mixOut.llk0s[rg+1],vbid.mixOut.refHets[rg+1],vbid.mixOut.refAlts[rg+1]); }
else { error("Invalid option in handling bFree"); }
if ( args.bChipNone || bestInds[0] < 0 ) { ifprintf(bestRGF,"\tNA\tNA\tNA\tNA\tNA\tNA\tNA\tNA"); }
else if ( args.bChipMixOnly ) { ifprintf(bestRGF,"\t%.5lf\t%.2lf\t%.2lf\tNA\tNA\t%.3lf\t%.4lf\t%.4lf",vbid.bestOut.fMixs[rg+1], vbid.bestOut.llk1s[rg+1], vbid.bestOut.llk0s[rg+1], (double)vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+1], (double)vbid.bestOut.numReads[(rg+1)*4+2]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+2], (double)vbid.bestOut.numReads[(rg+1)*4+3]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+3]); }
else if ( args.bChipMixOnly ) { ifprintf(bestRGF,"\tNA\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf",vbid.bestOut.llk1s[rg+1], vbid.bestOut.llk0s[rg+1], vbid.bestOut.refHets[rg+1], vbid.bestOut.refAlts[rg+1], (double)vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+1], (double)vbid.bestOut.numReads[(rg+1)*4+2]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4]/vbid.bestOut.numGenos[(rg+1)*4+2], (double)vbid.bestOut.numReads[(rg+1)*4+3]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+3]); }
else if ( args.bChipFull ) { ifprintf(bestRGF,"\t%.5lf\t%.2lf\t%.2lf\t%.5lf\t%.5lf\t%.3lf\t%.4lf\t%.4lf", vbid.bestOut.fMixs[rg+1], vbid.bestOut.llk1s[rg+1], vbid.bestOut.llk0s[rg+1], vbid.bestOut.refHets[rg+1], vbid.bestOut.refAlts[rg+1], (double)vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+1], (double)vbid.bestOut.numReads[(rg+1)*4+2]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+2], (double)vbid.bestOut.numReads[(rg+1)*4+3]*vbid.bestOut.numGenos[(rg+1)*4+1]/vbid.bestOut.numReads[(rg+1)*4+1]/vbid.bestOut.numGenos[(rg+1)*4+3]); }
else { error("Invalid option in handling bChip"); }
ifprintf(bestRGF,"\n");
}
ifclose(bestRGF);
}
time(&t);
Logger::gLogger->writeLog("Analysis finished on %s",ctime(&t));
return 0;
}