void GenericDrug::PkPdParameterValidation()
{
if ( durability_time_profile == PKPDModel::CONCENTRATION_VERSUS_TIME )
{
// Validate that long-decay mode (slow_decay_time_constant) is longer than short-decay mode (fast_decay_time_constant)
// N.B. In the case that they are equal, Vd is ignored and the system reverts to a single-compartment PkPd model.
if ( slow_decay_time_constant < fast_decay_time_constant )
{
//throw IncoherentInitializationException( __FILE__, __LINE__, __FUNCTION__, "slow_decay_time_constant", slow_decay_time_constant, "fast_decay_time_constant", fast_decay_time_constant );
throw InitializationException( __FILE__, __LINE__, __FUNCTION__, "Value of drug \'slow_decay_time_constant\' must be greater or equal to \'fast_decay_time_constant\'." );
}
// Validate that (slow_decay_time_constant/Vd) is greater than fast_decay_time_constant.
// Or else, the input parameters do not make sense as a solution to the two-compartment PkPd model
// with the concentration in the central compartment as the sum of two exponentials with the two eigenvalues
// being the specified decay times.
if ( (slow_decay_time_constant != fast_decay_time_constant) && (slow_decay_time_constant / Vd) <= fast_decay_time_constant )
{
throw InitializationException( __FILE__, __LINE__, __FUNCTION__, "Ratio of drug value \'slow_decay_time_constant\' over \'Drug_Vd\' must be greater than \'primary_decay_constant\'. Otherwise, the parameters do not make sense as a solution to the two-compartment PkPd model, with the concentration in the central compartment as the sum of two exponentials with the two eigenvalues being the specified decay times:\n\n _______________________ __________________________\n Cmax(t=0) ---> / Central compartment \\ ---- k_CP ---> / Peripheral compartment \\\n \\_______________________/ <--- k_PC ---- \\__________________________/\n |\n k_out\n |\n v" );
}
// _______________________ __________________________
// Cmax(t=0) ---> / Central compartment \ ---- k_CP ---> / Peripheral compartment \
// \_______________________/ <--- k_PC ---- \__________________________/
// |
// k_out
// |
// v
}
}
void SocketTCP::connectSocket() {
TRACE(logger, "connectSocket()");
if (isConnected) {
throw InitializationException("void SocketTCP::connectSocket()\n"
"Socket is already connected.",
"br::ufscar::lince::mmi::socketconn::SocketTCP",
"connectSocket()");
}
int ret = connect(_socket, (struct sockaddr *) &addres, sizeof(addres));
if (ret < 0) {
string errMsg = strerror(errno);
throw NetworkException("void SocketTCP::connectSocket()\n"
"Couldn't connect:" + errMsg + "\n",
"br::ufscar::lince::mmi::socketconn::SocketTCP",
"connectSocket()");
}
isConnected = true;
}
