WeightedLeastSquares::TensorImageType::Pointer WeightedLeastSquares::ConvertGammaVector2DT(VectorialImageTensorType::Pointer vecTensorImage)
{
ScalarImageIterator itMask(m_HRmask, m_HRmask->GetLargestPossibleRegion());
VecTensorImageIterator itVec(vecTensorImage , vecTensorImage->GetLargestPossibleRegion());
TensorImageType::Pointer tempTensorImage = TensorImageType::New();
CopyImage cpImage;
cpImage.CopyTensorImage(m_tensorImage_init, tempTensorImage);
TensorImageIterator itTensor(tempTensorImage, tempTensorImage->GetLargestPossibleRegion());
for (itMask.GoToBegin(), itTensor.GoToBegin() ; !itMask.IsAtEnd(), !itTensor.IsAtEnd();
++itMask, ++itTensor)
{
if (itMask.Get() != 0)
{
VectorialTensorType gamma;
gamma = vecTensorImage->GetPixel(itMask.GetIndex());
DiffusionTensorType D;
D(0,0) = gamma[1];
D(1,1) = gamma[2];
D(2,2) = gamma[3];
D(0,1) = gamma[4];
D(1,2) = gamma[5];
D(0,2) = gamma[6];
itTensor.Set(D);
}
}
return tempTensorImage;
}
WeightedLeastSquares::ImageListType WeightedLeastSquares::ComputePredictedImage(TensorImageType::Pointer tensorImage)
{
//Compute Predicted Imge
CopyImage cpImage;
TensorUtilities utilsTensor;
int numOfImages = m_DWIListHR.size();
// Evaluate W
ScalarImageIterator itHRMask(m_HRmask, m_HRmask->GetLargestPossibleRegion());
ScalarImageIterator itB0(m_B0Image_HR, m_B0Image_HR->GetLargestPossibleRegion());
TensorImageIterator itTens(tensorImage, tensorImage->GetLargestPossibleRegion());
ImageListType PredImageList;
for (int i=0; i < numOfImages; i++)
{
ScalarImageType::Pointer predImage_HR_i = ScalarImageType::New();
cpImage.CopyScalarImage(m_B0Image_HR, predImage_HR_i);
ScalarImageIterator itPredHR(predImage_HR_i, predImage_HR_i->GetLargestPossibleRegion());
for (itHRMask.GoToBegin(), itPredHR.GoToBegin(), itB0.GoToBegin(), itTens.GoToBegin();
!itPredHR.IsAtEnd(), !itHRMask.IsAtEnd(), !itB0.IsAtEnd(), !itTens.IsAtEnd();
++itPredHR, ++itHRMask, ++itB0, ++itTens)
{
if (itHRMask.Get() != 0)
{
vnl_vector<double> g_i_temp = m_GradList[i]->GetPixel(itHRMask.GetIndex()).GetVnlVector();
vnl_vector<RealType> g_i; g_i.set_size(3);
vnl_copy(g_i_temp, g_i);
vnl_matrix<RealType> g_mat_i;
g_mat_i.set_size(3,1);
g_mat_i.set_column(0,g_i);
DiffusionTensorType D = itTens.Get();
MatrixType D_mat;
D_mat.set_size(3,3);
D_mat = utilsTensor.ConvertDT2Mat(D);
MatrixType temp; temp.set_size(1,1);
temp = g_mat_i.transpose()*D_mat*g_mat_i;
RealType atten_i = exp(temp(0,0)*(-1)*m_BVal)*itB0.Get();
itPredHR.Set(atten_i);
}
}
PredImageList.push_back(predImage_HR_i);
}
// Compute the difference
return PredImageList;
}
WeightedLeastSquares::VectorialImageTensorType::Pointer WeightedLeastSquares::ConvertDT2Vector(TensorImageType::Pointer tensorImage)
{
ScalarImageIterator itMask(m_HRmask, m_HRmask->GetLargestPossibleRegion());
TensorImageIterator itTensor(tensorImage, tensorImage->GetLargestPossibleRegion());
VectorialImageTensorType::Pointer vecImageTensor = VectorialImageTensorType::New();
vecImageTensor->SetOrigin(m_HRmask->GetOrigin());
vecImageTensor->SetDirection(m_HRmask->GetDirection());
vecImageTensor->SetSpacing(m_HRmask->GetSpacing());
vecImageTensor->SetRegions(m_HRmask->GetLargestPossibleRegion());
vecImageTensor->Allocate();
VectorialTensorType ZeroVecTensor; ZeroVecTensor.Fill(0);
vecImageTensor->FillBuffer(ZeroVecTensor);
TensorUtilities utils;
for (itMask.GoToBegin(), itTensor.GoToBegin(); !itMask.IsAtEnd(); ++itTensor, ++itMask)
{
if (itMask.Get() != 0)
{
DiffusionTensorType D = itTensor.Get();
vnl_matrix<double> P = utils.CholeskyDecomposition(D);
vnl_vector<double> Rho_vec;
Rho_vec.set_size(7);
Rho_vec[0] = log(m_B0Image_HR->GetPixel(itMask.GetIndex()));
/* Rho_vec[1] = P(0,0); // rho 2
Rho_vec[2] = P(1,1); // rho 3
Rho_vec[3] = P(2,2); // rho 4
Rho_vec[4] = P(0,1); // rho 5
Rho_vec[5] = P(1,2); // rho 6
Rho_vec[6] = P(0,2); // rho 7
*/
Rho_vec[1] = D(0,0);
Rho_vec[2] = D(1,1);
Rho_vec[3] = D(2,2);
Rho_vec[4] = D(0,1);
Rho_vec[5] = D(1,2);
Rho_vec[6] = D(0,2);
VectorialTensorType tempVec; tempVec.SetVnlVector(Rho_vec);
vecImageTensor->SetPixel(itMask.GetIndex(), tempVec);
}
}
return vecImageTensor;
}
WeightedLeastSquares::VectorialImageTensorType::Pointer WeightedLeastSquares::MakeGammaImage(TensorImageType::Pointer tensorImage)
{
ScalarImageIterator itMask(m_HRmask, m_HRmask->GetLargestPossibleRegion());
TensorImageIterator itTens(tensorImage, tensorImage->GetLargestPossibleRegion());
VectorialImageTensorType::Pointer GammaImage = VectorialImageTensorType::New();
GammaImage->SetOrigin(m_HRmask->GetOrigin());
GammaImage->SetDirection(m_HRmask->GetDirection());
GammaImage->SetSpacing(m_HRmask->GetSpacing());
GammaImage->SetRegions(m_HRmask->GetLargestPossibleRegion());
GammaImage->Allocate();
VectorialTensorType ZeroVecTensor; ZeroVecTensor.Fill(0);
GammaImage->FillBuffer(ZeroVecTensor);
for (itMask.GoToBegin(), itTens.GoToBegin(); !itMask.IsAtEnd(), !itTens.IsAtEnd(); ++itMask, ++itTens)
{
if (itMask.Get() != 0)
{
VectorialTensorType temp;
DiffusionTensorType D = itTens.Get();
temp[0] = log(m_B0Image_HR->GetPixel(itMask.GetIndex()));
temp[1] = D(0,0);
temp[2] = D(1,1);
temp[3] = D(2,2);
temp[4] = D(0,1);
temp[5] = D(1,2);
temp[6] = D(0,2);
GammaImage->SetPixel(itMask.GetIndex(), temp);
}
}
return GammaImage;
}
void QmitkTensorReconstructionView::ItkTensorReconstruction(mitk::DataStorage::SetOfObjects::Pointer inImages)
{
try
{
itk::TimeProbe clock;
int nrFiles = inImages->size();
if (!nrFiles) return;
QString status;
mitk::ProgressBar::GetInstance()->AddStepsToDo(nrFiles);
mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() );
mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() );
std::vector<mitk::DataNode::Pointer> nodes;
while ( itemiter != itemiterend ) // for all items
{
mitk::DiffusionImage<DiffusionPixelType>* vols =
static_cast<mitk::DiffusionImage<DiffusionPixelType>*>(
(*itemiter)->GetData());
std::string nodename;
(*itemiter)->GetStringProperty("name", nodename);
++itemiter;
// TENSOR RECONSTRUCTION
clock.Start();
MITK_DEBUG << "Tensor reconstruction ";
mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Tensor reconstruction for %s", nodename.c_str()).toAscii());
typedef itk::DiffusionTensor3DReconstructionImageFilter<
DiffusionPixelType, DiffusionPixelType, TTensorPixelType > TensorReconstructionImageFilterType;
TensorReconstructionImageFilterType::Pointer tensorReconstructionFilter =
TensorReconstructionImageFilterType::New();
tensorReconstructionFilter->SetGradientImage( vols->GetDirections(), vols->GetVectorImage() );
tensorReconstructionFilter->SetBValue(vols->GetB_Value());
tensorReconstructionFilter->SetThreshold( m_Controls->m_TensorReconstructionThreshold->value() );
tensorReconstructionFilter->Update();
clock.Stop();
MITK_DEBUG << "took " << clock.GetMeanTime() << "s.";
// TENSORS TO DATATREE
mitk::TensorImage::Pointer image = mitk::TensorImage::New();
typedef itk::Image<itk::DiffusionTensor3D<TTensorPixelType>, 3> TensorImageType;
TensorImageType::Pointer tensorImage;
tensorImage = tensorReconstructionFilter->GetOutput();
// Check the tensor for negative eigenvalues
if(m_Controls->m_CheckNegativeEigenvalues->isChecked())
{
typedef itk::ImageRegionIterator<TensorImageType> TensorImageIteratorType;
TensorImageIteratorType tensorIt(tensorImage, tensorImage->GetRequestedRegion());
tensorIt.GoToBegin();
while(!tensorIt.IsAtEnd())
{
typedef itk::DiffusionTensor3D<TTensorPixelType> TensorType;
//typedef itk::Tensor<TTensorPixelType, 3> TensorType2;
TensorType tensor = tensorIt.Get();
TensorType::EigenValuesArrayType ev;
tensor.ComputeEigenValues(ev);
for(unsigned int i=0; i<ev.Size(); i++)
{
if(ev[i] < 0.0)
{
tensor.Fill(0.0);
tensorIt.Set(tensor);
break;
}
}
++tensorIt;
}
}
tensorImage->SetDirection( vols->GetVectorImage()->GetDirection() );
image->InitializeByItk( tensorImage.GetPointer() );
image->SetVolume( tensorReconstructionFilter->GetOutput()->GetBufferPointer() );
mitk::DataNode::Pointer node=mitk::DataNode::New();
node->SetData( image );
QString newname;
newname = newname.append(nodename.c_str());
newname = newname.append("_dti");
SetDefaultNodeProperties(node, newname.toStdString());
nodes.push_back(node);
mitk::ProgressBar::GetInstance()->Progress();
}
std::vector<mitk::DataNode::Pointer>::iterator nodeIt;
for(nodeIt = nodes.begin(); nodeIt != nodes.end(); ++nodeIt)
GetDefaultDataStorage()->Add(*nodeIt);
mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Finished Processing %d Files", nrFiles).toAscii());
m_MultiWidget->RequestUpdate();
}
catch (itk::ExceptionObject &ex)
{
MITK_INFO << ex ;
QMessageBox::information(0, "Reconstruction not possible:", ex.GetDescription());
return;
}
}
void QmitkTensorReconstructionView::TensorReconstructionWithCorr
(mitk::DataStorage::SetOfObjects::Pointer inImages)
{
try
{
itk::TimeProbe clock;
int nrFiles = inImages->size();
if (!nrFiles) return;
QString status;
mitk::ProgressBar::GetInstance()->AddStepsToDo(nrFiles);
mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() );
mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() );
std::vector<mitk::DataNode::Pointer> nodes;
while ( itemiter != itemiterend ) // for all items
{
typedef mitk::DiffusionImage<DiffusionPixelType> DiffusionImageType;
DiffusionImageType* vols = static_cast<DiffusionImageType*>((*itemiter)->GetData());
std::string nodename;
(*itemiter)->GetStringProperty("name", nodename);
++itemiter;
// TENSOR RECONSTRUCTION
clock.Start();
MITK_INFO << "Tensor reconstruction with correction for negative eigenvalues";
mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Tensor reconstruction for %s", nodename.c_str()).toAscii());
typedef itk::TensorReconstructionWithEigenvalueCorrectionFilter< DiffusionPixelType, TTensorPixelType > ReconstructionFilter;
float b0Threshold = m_Controls->m_TensorReconstructionThreshold->value();
ReconstructionFilter::Pointer reconFilter = ReconstructionFilter::New();
reconFilter->SetGradientImage( vols->GetDirections(), vols->GetVectorImage() );
reconFilter->SetBValue(vols->GetB_Value());
reconFilter->SetB0Threshold(b0Threshold);
reconFilter->Update();
typedef itk::Image<itk::DiffusionTensor3D<TTensorPixelType>, 3> TensorImageType;
TensorImageType::Pointer outputTensorImg = reconFilter->GetOutput();
typedef itk::ImageRegionIterator<TensorImageType> TensorImageIteratorType;
TensorImageIteratorType tensorIt(outputTensorImg, outputTensorImg->GetRequestedRegion());
tensorIt.GoToBegin();
int negatives = 0;
while(!tensorIt.IsAtEnd())
{
typedef itk::DiffusionTensor3D<TTensorPixelType> TensorType;
TensorType tensor = tensorIt.Get();
TensorType::EigenValuesArrayType ev;
tensor.ComputeEigenValues(ev);
for(unsigned int i=0; i<ev.Size(); i++)
{
if(ev[i] < 0.0)
{
tensor.Fill(0.0);
tensorIt.Set(tensor);
negatives++;
break;
}
}
++tensorIt;
}
MITK_INFO << negatives << " tensors with negative eigenvalues" << std::endl;
mitk::TensorImage::Pointer image = mitk::TensorImage::New();
image->InitializeByItk( outputTensorImg.GetPointer() );
image->SetVolume( outputTensorImg->GetBufferPointer() );
mitk::DataNode::Pointer node=mitk::DataNode::New();
node->SetData( image );
QString newname;
newname = newname.append(nodename.c_str());
newname = newname.append("_dti_corrected");
SetDefaultNodeProperties(node, newname.toStdString());
nodes.push_back(node);
// Corrected diffusion image
// typedef itk::VectorImage<short, 3> ImageType;
// ImageType::Pointer correctedVols = reconFilter->GetVectorImage();
// DiffusionImageType::Pointer correctedDiffusion = DiffusionImageType::New();
// correctedDiffusion->SetVectorImage(correctedVols);
// correctedDiffusion->SetDirections(vols->GetDirections());
// correctedDiffusion->SetB_Value(vols->GetB_Value());
// correctedDiffusion->InitializeFromVectorImage();
// mitk::DataNode::Pointer diffNode = mitk::DataNode::New();
// diffNode->SetData( correctedDiffusion );
// QString diffname;
// diffname = diffname.append(nodename.c_str());
// diffname = diffname.append("corrDiff");
// SetDefaultNodeProperties(diffNode, diffname.toStdString());
// nodes.push_back(diffNode);
mitk::ProgressBar::GetInstance()->Progress();
}
std::vector<mitk::DataNode::Pointer>::iterator nodeIt;
for(nodeIt = nodes.begin(); nodeIt != nodes.end(); ++nodeIt)
GetDefaultDataStorage()->Add(*nodeIt);
mitk::StatusBar::GetInstance()->DisplayText(status.sprintf("Finished Processing %d Files", nrFiles).toAscii());
m_MultiWidget->RequestUpdate();
}
catch (itk::ExceptionObject &ex)
{
MITK_INFO << ex ;
QMessageBox::information(0, "Reconstruction not possible:", ex.GetDescription());
}
}
int main(int argc, char* *argv)
{
GetPot cl(argc, argv);
if( cl.size() == 1 || cl.search(2, "--help", "-h") )
{
std::cout << "Not enough arguments" << std::endl;
return -1;
}
const string image_n = cl.follow("NoFile", 1, "-i");
const string maskImage_n = cl.follow("NoFile", 1, "-m");
typedef itk::Image<float, 3> ImageType;
typedef itk::ImageFileReader<ImageType> ReaderType;
ReaderType::Pointer reader = ReaderType::New();
reader->SetFileName(maskImage_n.c_str());
reader-> Update();
ImageType::Pointer maskimage = reader->GetOutput();
typedef itk::ImageRegionIterator<ImageType> ImageIterator;
ImageIterator it(maskimage, maskimage->GetLargestPossibleRegion());
typedef itk::DiffusionTensor3D<float> DiffusionTensorType;
typedef itk::Image<DiffusionTensorType, 3> TensorImageType;
typedef itk::ImageFileReader<TensorImageType> TensorImageReaderType;
TensorImageReaderType::Pointer tensorReader = TensorImageReaderType::New();
tensorReader->SetFileName(image_n.c_str());
tensorReader->Update();
TensorImageType::Pointer tensorImage = tensorReader->GetOutput();
typedef itk::ImageRegionIterator<TensorImageType> TensorIterator;
TensorIterator itT(tensorImage, tensorImage->GetLargestPossibleRegion());
typedef DiffusionTensorType::EigenValuesArrayType EigenArrayType;
ImageType::Pointer Eig1 = ImageType::New();
ImageType::Pointer Eig2 = ImageType::New();
ImageType::Pointer Eig3 = ImageType::New();
CopyImage cpImage;
cpImage.CopyScalarImage(maskimage, Eig1);
cpImage.CopyScalarImage(maskimage, Eig2);
cpImage.CopyScalarImage(maskimage, Eig3);
TensorImageType::Pointer tensorProb = TensorImageType::New();
cpImage.CopyTensorImage(tensorImage, tensorProb);
DiffusionTensorType D_Identity;
vnl_matrix<float> ZeroD_mat; ZeroD_mat.set_size(3,3);
ZeroD_mat.set_identity();
TensorUtilities utils;
D_Identity = utils.ConvertMat2DT(ZeroD_mat);
//tensorProb->FillBuffer(D_Identity);
for (it.GoToBegin(), itT.GoToBegin(); !it.IsAtEnd(), !itT.IsAtEnd(); ++it, ++itT)
{
if (it.Get() != 0)
{
EigenArrayType eig;
DiffusionTensorType D = itT.Get();
D.ComputeEigenValues(eig);
if ( (eig[0] < 0) || (eig[1] < 0 ) || (eig[2] < 0) || eig[0] > 5 || (eig[1] > 5) || (eig[2] > 5))
{
tensorProb->SetPixel(itT.GetIndex(), D);
std::cout << eig << std::endl;
}
}
}
typedef itk::ImageFileWriter<TensorImageType> TensorImageWriter;
TensorImageWriter::Pointer tensorWriter = TensorImageWriter::New();
tensorWriter->SetFileName("TensorImage_Prob.nii.gz");
tensorWriter->SetInput(tensorProb);
tensorWriter->Update();
return 0;
}
void QmitkDiffusionQuantificationView::TensorQuantification(
mitk::DataStorage::SetOfObjects::Pointer inImages, int method)
{
itk::TimeProbe clock;
QString status;
int nrFiles = inImages->size();
if (!nrFiles) return;
mitk::DataStorage::SetOfObjects::const_iterator itemiter( inImages->begin() );
mitk::DataStorage::SetOfObjects::const_iterator itemiterend( inImages->end() );
std::vector<mitk::DataNode::Pointer> nodes;
while ( itemiter != itemiterend ) // for all items
{
typedef float TTensorPixelType;
typedef itk::DiffusionTensor3D< TTensorPixelType > TensorPixelType;
typedef itk::Image< TensorPixelType, 3 > TensorImageType;
mitk::Image* vol =
static_cast<mitk::Image*>((*itemiter)->GetData());
TensorImageType::Pointer itkvol = TensorImageType::New();
mitk::CastToItkImage<TensorImageType>(vol, itkvol);
std::string nodename;
(*itemiter)->GetStringProperty("name", nodename);
++itemiter;
// COMPUTE FA
clock.Start();
MBI_INFO << "Computing FA ";
mitk::StatusBar::GetInstance()->DisplayText(status.sprintf(
"Computing FA for %s", nodename.c_str()).toAscii());
typedef itk::Image< TTensorPixelType, 3 > FAImageType;
typedef itk::ShiftScaleImageFilter<FAImageType, FAImageType>
ShiftScaleFilterType;
ShiftScaleFilterType::Pointer multi =
ShiftScaleFilterType::New();
multi->SetShift(0.0);
multi->SetScale(m_Controls->m_ScaleImageValuesBox->value());//itk::NumericTraits<RealValueType>::max()
typedef itk::TensorDerivedMeasurementsFilter<TTensorPixelType> MeasurementsType;
if(method == 0) //FA
{
/* typedef itk::TensorFractionalAnisotropyImageFilter<
TensorImageType, FAImageType > FilterType;
FilterType::Pointer anisotropyFilter = FilterType::New();
anisotropyFilter->SetInput( itkvol.GetPointer() );
anisotropyFilter->Update();
multi->SetInput(anisotropyFilter->GetOutput());
nodename = QString(nodename.c_str()).append("_FA").toStdString();*/
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::FA);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_FA").toStdString();
}
else if(method == 1) //RA
{
/*typedef itk::TensorRelativeAnisotropyImageFilter<
TensorImageType, FAImageType > FilterType;
FilterType::Pointer anisotropyFilter = FilterType::New();
anisotropyFilter->SetInput( itkvol.GetPointer() );
anisotropyFilter->Update();
multi->SetInput(anisotropyFilter->GetOutput());
nodename = QString(nodename.c_str()).append("_RA").toStdString();*/
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::RA);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_RA").toStdString();
}
else if(method == 2) // AD (Axial diffusivity)
{
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::AD);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_AD").toStdString();
}
else if(method == 3) // RD (Radial diffusivity, (Lambda2+Lambda3)/2
{
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::RD);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_RD").toStdString();
}
else if(method == 4) // 1-(Lambda2+Lambda3)/(2*Lambda1)
{
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::CA);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_CA").toStdString();
}
else if(method == 5) // MD (Mean Diffusivity, (Lambda1+Lambda2+Lambda3)/3 )
{
MeasurementsType::Pointer measurementsCalculator = MeasurementsType::New();
measurementsCalculator->SetInput(itkvol.GetPointer() );
measurementsCalculator->SetMeasure(MeasurementsType::MD);
measurementsCalculator->Update();
multi->SetInput(measurementsCalculator->GetOutput());
nodename = QString(nodename.c_str()).append("_MD").toStdString();
}
multi->Update();
clock.Stop();
MBI_DEBUG << "took " << clock.GetMeanTime() << "s.";
// FA TO DATATREE
mitk::Image::Pointer image = mitk::Image::New();
image->InitializeByItk( multi->GetOutput() );
image->SetVolume( multi->GetOutput()->GetBufferPointer() );
mitk::DataNode::Pointer node=mitk::DataNode::New();
node->SetData( image );
node->SetProperty( "name", mitk::StringProperty::New(nodename) );
nodes.push_back(node);
mitk::StatusBar::GetInstance()->DisplayText("Computation complete.");
}
std::vector<mitk::DataNode::Pointer>::iterator nodeIt;
for(nodeIt = nodes.begin(); nodeIt != nodes.end(); ++nodeIt)
GetDefaultDataStorage()->Add(*nodeIt);
m_MultiWidget->RequestUpdate();
}
WeightedLeastSquares::VectorialImageTensorType::Pointer WeightedLeastSquares::ComputeDelSim(TensorImageType::Pointer tensorImage)
{
ScalarImageIterator itHRMask(m_HRmask, m_HRmask->GetLargestPossibleRegion());
TensorImageType::Pointer delSim = TensorImageType::New();
CopyImage cpImage;
cpImage.CopyTensorImage(tensorImage, delSim);
TensorImageIterator itDelSim(delSim, delSim->GetLargestPossibleRegion());
int numOfImages = m_DWIListHR.size();
//ComputePredictedImage;
ImageListType PredImageList = ComputePredictedImage(tensorImage);
//ComputeDifferenceImageList
ImageListType DiffImageList = ComputeDifferenceImage(PredImageList);
ScalarImageType::IndexType tempIndex;
tempIndex[0] = 70;
tempIndex[1] = 109;
tempIndex[2] = 81;
VectorialImageTensorType::Pointer DelSim = VectorialImageTensorType::New();
DelSim->SetOrigin(m_HRmask->GetOrigin());
DelSim->SetDirection(m_HRmask->GetDirection());
DelSim->SetSpacing(m_HRmask->GetSpacing());
DelSim->SetRegions(m_HRmask->GetLargestPossibleRegion());
DelSim->Allocate();
VectorialTensorType ZeroVecTensor; ZeroVecTensor.Fill(0);
DelSim->FillBuffer(ZeroVecTensor);
for(itHRMask.GoToBegin(), itDelSim.GoToBegin(); !itHRMask.IsAtEnd(), !itDelSim.IsAtEnd() ; ++itHRMask, ++itDelSim)
{
if (itHRMask.Get() != 0)
{
vnl_matrix<double> W; W.set_size(numOfImages, 7);
vnl_vector<double> S_vec; S_vec.set_size(numOfImages);
vnl_diag_matrix<double> S;
vnl_vector<double> r;
r.set_size(numOfImages);
DiffusionTensorType D = tensorImage->GetPixel(itHRMask.GetIndex());
vnl_matrix<double> J = ComputeJacobian(D);
for(int i=0; i < numOfImages; i++)
{
//Create W
vnl_vector<double> W_row_i = ComputeWeightMatrixRow(m_GradList[i]->GetPixel(itHRMask.GetIndex()));
W.set_row(i, W_row_i);
// Create S
S_vec[i] = PredImageList[i]->GetPixel(itHRMask.GetIndex());
//Create r
r[i] = DiffImageList[i]->GetPixel(itHRMask.GetIndex());
}
vnl_vector<double> delF;
S.set(S_vec);
delF = W.transpose()*S*r;
VectorialTensorType tempDelF;
tempDelF.SetVnlVector(delF);
DelSim->SetPixel(itHRMask.GetIndex(), tempDelF);
}
}
return DelSim;
}
bool itkDataTensorImageReaderBase::read (const QString &path)
{
if (this->io.IsNull())
return false;
this->readInformation ( path );
qDebug() << "Read with: " << this->identifier();
if (medAbstractData *medData = dynamic_cast<medAbstractData*>(this->data()) ) {
if (medData->identifier()=="itkDataTensorImageDouble3") {
if (this->io->GetNumberOfComponents()==6) {
typedef itk::Tensor<double, 3> TensorType;
typedef itk::Image<TensorType, 3> TensorImageType;
typedef itk::Vector<double, 6> VectorType;
typedef itk::Image<VectorType, 3> VectorImageType;
typedef itk::ImageFileReader<VectorImageType> ReaderType;
VectorImageType::Pointer image = 0;
{
ReaderType::Pointer reader = ReaderType::New();
reader->SetImageIO (this->io);
reader->SetFileName ( path.toAscii().constData() );
try {
reader->Update();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
image = reader->GetOutput();
}
TensorImageType::Pointer tensors = TensorImageType::New();
TensorImageType::RegionType region = image->GetLargestPossibleRegion();
tensors->SetRegions (region);
tensors->SetSpacing (image->GetSpacing());
tensors->SetOrigin (image->GetOrigin());
tensors->SetDirection (image->GetDirection());
try {
tensors->Allocate();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
itk::ImageRegionConstIteratorWithIndex<VectorImageType> itIn (image,
image->GetLargestPossibleRegion());
itk::ImageRegionIteratorWithIndex<TensorImageType> itOut(tensors,
tensors->GetLargestPossibleRegion());
while(!itOut.IsAtEnd()) {
VectorType vec = itIn.Get();
TensorType tensor;
for( unsigned int j=0; j<6; j++) {
tensor[j] = vec[j];
}
itOut.Set (tensor);
++itOut;
++itIn;
}
medData->setData (tensors);
}
else if (this->io->GetNumberOfComponents()==9) {
typedef itk::Tensor<double, 3> TensorType;
typedef itk::Image<TensorType, 3> TensorImageType;
typedef itk::Vector<double, 9> VectorType;
typedef itk::Image<VectorType, 3> VectorImageType;
typedef itk::ImageFileReader<VectorImageType> ReaderType;
VectorImageType::Pointer image = 0;
{
ReaderType::Pointer reader = ReaderType::New();
reader->SetImageIO (this->io);
reader->SetFileName ( path.toAscii().constData() );
try {
reader->Update();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
image = reader->GetOutput();
}
TensorImageType::Pointer tensors = TensorImageType::New();
TensorImageType::RegionType region = image->GetLargestPossibleRegion();
tensors->SetRegions (region);
tensors->SetSpacing (image->GetSpacing());
tensors->SetOrigin (image->GetOrigin());
tensors->SetDirection (image->GetDirection());
try {
tensors->Allocate();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
itk::ImageRegionConstIteratorWithIndex<VectorImageType> itIn (image,
image->GetLargestPossibleRegion());
itk::ImageRegionIteratorWithIndex<TensorImageType> itOut(tensors,
tensors->GetLargestPossibleRegion());
while(!itOut.IsAtEnd()) {
VectorType vec = itIn.Get();
TensorType tensor;
for (unsigned int i=0; i<3; i++)
for (unsigned int j=0; j<3; j++)
tensor.SetComponent (i, j, vec[i*3+j]);
itOut.Set (tensor);
++itOut;
++itIn;
}
medData->setData (tensors);
}
else {
qDebug() << "Unsupported number of components";
return false;
}
}
else if (medData->identifier()=="itkDataTensorImageFloat3") {
if (this->io->GetNumberOfComponents()==6) {
typedef itk::Tensor<float, 3> TensorType;
typedef itk::Image<TensorType, 3> TensorImageType;
typedef itk::Vector<float, 6> VectorType;
typedef itk::Image<VectorType, 3> VectorImageType;
typedef itk::ImageFileReader<VectorImageType> ReaderType;
VectorImageType::Pointer image = 0;
{
ReaderType::Pointer reader = ReaderType::New();
reader->SetImageIO (this->io);
reader->SetFileName ( path.toAscii().constData() );
try {
reader->Update();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
image = reader->GetOutput();
}
TensorImageType::Pointer tensors = TensorImageType::New();
TensorImageType::RegionType region = image->GetLargestPossibleRegion();
tensors->SetRegions (region);
tensors->SetSpacing (image->GetSpacing());
tensors->SetOrigin (image->GetOrigin());
tensors->SetDirection (image->GetDirection());
try {
tensors->Allocate();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
itk::ImageRegionConstIteratorWithIndex<VectorImageType> itIn (image,
image->GetLargestPossibleRegion());
itk::ImageRegionIteratorWithIndex<TensorImageType> itOut(tensors,
tensors->GetLargestPossibleRegion());
while(!itOut.IsAtEnd()) {
VectorType vec = itIn.Get();
TensorType tensor;
for( unsigned int j=0; j<6; j++) {
tensor[j] = vec[j];
}
itOut.Set (tensor);
++itOut;
++itIn;
}
medData->setData (tensors);
}
else if (this->io->GetNumberOfComponents()==9) {
typedef itk::Tensor<float, 3> TensorType;
typedef itk::Image<TensorType, 3> TensorImageType;
typedef itk::Vector<float, 9> VectorType;
typedef itk::Image<VectorType, 3> VectorImageType;
typedef itk::ImageFileReader<VectorImageType> ReaderType;
VectorImageType::Pointer image = 0;
{
ReaderType::Pointer reader = ReaderType::New();
reader->SetImageIO (this->io);
reader->SetFileName ( path.toAscii().constData() );
try {
reader->Update();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
image = reader->GetOutput();
}
TensorImageType::Pointer tensors = TensorImageType::New();
TensorImageType::RegionType region = image->GetLargestPossibleRegion();
tensors->SetRegions (region);
tensors->SetSpacing (image->GetSpacing());
tensors->SetOrigin (image->GetOrigin());
tensors->SetDirection (image->GetDirection());
try {
tensors->Allocate();
}
catch (itk::ExceptionObject &e) {
qDebug() << e.GetDescription();
return false;
}
itk::ImageRegionConstIteratorWithIndex<VectorImageType> itIn (image,
image->GetLargestPossibleRegion());
itk::ImageRegionIteratorWithIndex<TensorImageType> itOut(tensors,
tensors->GetLargestPossibleRegion());
while(!itOut.IsAtEnd()) {
VectorType vec = itIn.Get();
TensorType tensor;
for (unsigned int i=0; i<3; i++)
for (unsigned int j=0; j<3; j++)
tensor.SetComponent (i, j, vec[i*3+j]);
itOut.Set (tensor);
++itOut;
++itIn;
}
medData->setData (tensors);
}
else {
qDebug() << "Unsupported number of components";
return false;
}
}
else {
qDebug() << "Unsupported data type";
return false;
}
}
else {
qDebug() << "No data set or could not create one";
return false;
}
return true;
}
int main (int argc, char *argv[])
{
const unsigned int ImageDimension = 2;
GetPot cl (argc, const_cast<char**>(argv));
if( cl.size() == 1 || cl.search (2,"--help","-h") )
{
std::cout << "Not Enough Arguments" << std::endl;
std::cout << "Generate the Gradient Table" << std::endl;
std::cout << "Usage: return -1" << std::endl;
}
const string image_n = cl.follow("NoFile",1, "-i");
const string mask_n = cl.follow("NoFile", 1, "-m");
const string out_n = cl.follow("NoFile",1, "-o");
typedef itk::DiffusionTensor3D<float> DiffusionTensorType;
typedef itk::Image<DiffusionTensorType, 3> TensorImageType;
typedef itk::ImageFileReader<TensorImageType> TensorReaderType;
TensorReaderType::Pointer reader = TensorReaderType::New();
reader->SetFileName(image_n.c_str());
reader->Update();
TensorImageType::Pointer image = reader->GetOutput();
typedef itk::Image<float, 3> ScalarImageType;
typedef itk::ImageFileReader<ScalarImageType> ScalarReaderType;
ScalarReaderType::Pointer scalarReader = ScalarReaderType::New();
scalarReader->SetFileName(mask_n.c_str());
scalarReader->Update();
ScalarImageType::Pointer maskImage = scalarReader->GetOutput();
typedef itk::ImageRegionIterator<TensorImageType> TensorIterator;
typedef itk::ImageRegionIterator<ScalarImageType> ScalarIterator;
ScalarIterator itMask(maskImage, maskImage->GetLargestPossibleRegion());
TensorUtilities utilsTensor;
TensorImageType::Pointer logTensorImage = utilsTensor.LogTensorImageFilter(image, maskImage);
typedef itk::ImageFileWriter<TensorImageType> TensorImageWriterType;
TensorImageWriterType::Pointer tensorImageWriter = TensorImageWriterType::New();
tensorImageWriter->SetFileName("LogTensorImage_stupid.nii.gz");
tensorImageWriter->SetInput(logTensorImage);
tensorImageWriter->Update();
std::ofstream file;
file.open(out_n);
ScalarImageType::Pointer TraceImage = ScalarImageType::New();
CopyImage cpImage;
cpImage.CopyScalarImage(maskImage, TraceImage);
ScalarIterator itTr(TraceImage, TraceImage->GetLargestPossibleRegion());
TensorIterator itImg(logTensorImage, logTensorImage->GetLargestPossibleRegion());
for(itImg.GoToBegin(), itMask.GoToBegin(), itTr.GoToBegin(); !itTr.IsAtEnd(), !itImg.IsAtEnd(), !itMask.IsAtEnd(); ++itTr, ++itImg, ++itMask)
{
file << itImg.Get().GetTrace() << std::endl;
itTr.Set(itImg.Get().GetTrace()) ;
}
typedef itk::ImageFileWriter<ScalarImageType> WriterType;
WriterType::Pointer writer = WriterType::New();
writer->SetFileName("LogTense_Trace.nii.gz");
writer->SetInput(TraceImage);
writer->Update();
file.close();
return 0;
}