double WntConcentration<DIM>::GetWntLevel(CellPtr pCell)
{
if (mUseConstantWntValueForTesting) // to test a cell and cell-cycle models without a cell population
{
return mConstantWntValueForTesting;
}
assert(mpCellPopulation!=nullptr);
assert(mTypeSet);
assert(mLengthSet);
double height;
if (mWntType == RADIAL)
{
double a = GetCryptProjectionParameterA();
double b = GetCryptProjectionParameterB();
height = a*pow(norm_2(mpCellPopulation->GetLocationOfCellCentre(pCell)), b);
}
else
{
height = mpCellPopulation->GetLocationOfCellCentre(pCell)[DIM-1];
}
return GetWntLevel(height);
}
AbstractCellCycleModel* VanLeeuwen2009WntSwatCellCycleModelHypothesisTwo::CreateCellCycleModel()
{
// Create a new cell-cycle model
VanLeeuwen2009WntSwatCellCycleModelHypothesisTwo* p_model = new VanLeeuwen2009WntSwatCellCycleModelHypothesisTwo(mpOdeSolver);
/*
* Set each member variable of the new cell-cycle model that inherits
* its value from the parent.
*
* Note 1: some of the new cell-cycle model's member variables (namely
* mBirthTime, mCurrentCellCyclePhase, mReadyToDivide, mDt, mpOdeSolver)
* will already have been correctly initialized in its constructor.
*
* Note 2: one or more of the new cell-cycle model's member variables
* may be set/overwritten as soon as InitialiseDaughterCell() is called on
* the new cell-cycle model.
*/
p_model->SetBirthTime(mBirthTime);
p_model->SetDimension(mDimension);
p_model->SetMinimumGapDuration(mMinimumGapDuration);
p_model->SetStemCellG1Duration(mStemCellG1Duration);
p_model->SetTransitCellG1Duration(mTransitCellG1Duration);
p_model->SetSDuration(mSDuration);
p_model->SetG2Duration(mG2Duration);
p_model->SetMDuration(mMDuration);
p_model->SetDivideTime(mDivideTime);
p_model->SetFinishedRunningOdes(mFinishedRunningOdes);
p_model->SetG2PhaseStartTime(mG2PhaseStartTime);
p_model->SetLastTime(mLastTime);
/*
* Create the new cell-cycle model's ODE system and use the current values
* of the state variables in mpOdeSystem as an initial condition.
*/
assert(mpOdeSystem);
double wnt_level = GetWntLevel();
p_model->InitialiseOdeSystem(wnt_level, mpCell->GetMutationState());
p_model->SetStateVariables(mpOdeSystem->rGetStateVariables());
return p_model;
}
