int main(int argc, char *argv[])
{
  char **av, *surf_name, *out_prefix, *fname;

  int nargs, ac, i, nsubjects, total, index;

  double scalar, std, tmp, maxV, minV, meanV;

  MRI *SrcVals[2], *AvgVals;

  MRI_SURFACE *BaseSurf;

  /* rkt: check for and handle version tag */
  nargs = handle_version_option (argc, argv, "$Id: mris_diff_on_surface.c,v 1.3 2011/03/02 00:04:55 nicks Exp $", "$Name:  $");
  if (nargs && argc - nargs == 1)
    exit (0);
  argc -= nargs;

  Progname = argv[0] ;
  ErrorInit(NULL, NULL, NULL) ;
  DiagInit(NULL, NULL, NULL) ;

  ac = argc ;
  av = argv ;
  for ( ; argc > 1 && ISOPTION(*argv[1]) ; argc--, argv++)
  {
    nargs = get_option(argc, argv) ;
    argc -= nargs ;
    argv += nargs ;
  }

  /* command line: <surf> <datafile 1> <datafile 2> <output prefix> */

  if (argc != 5)
    usage_exit();

  surf_name = argv[1];
  out_prefix = argv[argc - 1];

  if (srctypestring == NULL || trgtypestring == NULL)
  {
    printf("Please specify both input and output data type!\n");
    usage_exit();
  }

  printf("Reading underlying surface file\n");
  BaseSurf = MRISread(surf_name);
  if (!BaseSurf)
    ErrorExit(ERROR_NOFILE, "%s:could not read surface %s", Progname, surf_name);

  printf("Base surface has %d vertices\n", BaseSurf->nvertices);


  /* Read in the first data file */
  fname = argv[2];
  /* only two data types are supported */
  if (!strcmp(srctypestring,"curv"))
  { /* curvature file */
    if (MRISreadCurvatureFile(BaseSurf, fname) != 0)
    {
      printf("ERROR: reading curvature file\n");
      exit(1);
    }
    SrcVals[0] = MRIcopyMRIS(NULL, BaseSurf, 0, "curv");
  }
  else if (!strcmp(srctypestring,"paint") || !strcmp(srctypestring,"w"))
  {
    MRISreadValues(BaseSurf,fname);
    SrcVals[0] = MRIcopyMRIS(NULL, BaseSurf, 0, "val");
  }
  else
  {
    printf("ERROR: unknown data file format\n");
    exit(1);
  }

  if (SrcVals[0] == NULL)
  {
    fprintf(stderr, "ERROR loading data values from %s\n", fname);
  }

  /* Read in the second data file */
  fname = argv[3];
  /* only two data types are supported */
  if (!strcmp(srctypestring,"curv"))
  { /* curvature file */
    if (MRISreadCurvatureFile(BaseSurf, fname) != 0)
    {
      printf("ERROR: reading curvature file\n");
      exit(1);
    }
    SrcVals[1] = MRIcopyMRIS(NULL, BaseSurf, 0, "curv");
  }
  else if (!strcmp(srctypestring,"paint") || !strcmp(srctypestring,"w"))
  {
    MRISreadValues(BaseSurf,fname);
    SrcVals[1] = MRIcopyMRIS(NULL, BaseSurf, 0, "val");
  }
  else
  {
    printf("ERROR: unknown data file format\n");
    exit(1);
  }

  if (SrcVals[1] == NULL)
  {
    fprintf(stderr, "ERROR loading data values from %s\n", fname);
  }

  if (debugflag)
  {
    for (i=0; i < 2; i++)
    {
      printf("Data%d at vertex %d has value %g\n",i, debugvtx,  MRIFseq_vox(SrcVals[i], debugvtx, 0, 0, 0));
    }
  }

#if 0
  AvgVals = MRIclone(SrcVals[0], NULL);

  if (negflag) /* Add the two data sets */
    AvgVals = MRIadd(SrcVals[0], SrcVals[1], AvgVals);
  else /* Data1 - Data2 */
    AvgVals = MRIsubtract(SrcVals[0], SrcVals[1], AvgVals);
#endif

  AvgVals = MRIcopy(SrcVals[0], NULL);

  if (negflag)
  {
    for (index=0; index < BaseSurf->nvertices; index++)
    {
      MRIFseq_vox(AvgVals, index, 0, 0, 0) =  MRIFseq_vox(SrcVals[0], index, 0, 0, 0) +
                                              MRIFseq_vox(SrcVals[1], index, 0, 0, 0);
    }
  }
  else
  {
    for (index=0; index < BaseSurf->nvertices; index++)
    {
      MRIFseq_vox(AvgVals, index, 0, 0, 0) =  MRIFseq_vox(SrcVals[0], index, 0, 0, 0) -
                                              MRIFseq_vox(SrcVals[1], index, 0, 0, 0);
    }
  }

  maxV = -1000.0;
  minV = 1000.0;
  meanV=0.0;

  for (index=0; index < BaseSurf->nvertices; index++)
  {
    scalar = MRIFseq_vox(AvgVals, index, 0, 0, 0);
    if (maxV < scalar) maxV = scalar;
    if (minV > scalar) minV = scalar;
    meanV += scalar;
  }

  meanV /= BaseSurf->nvertices;

  printf("Output max = %g, min = %g, mean = %g\n", maxV, minV, meanV);

  if (debugflag)
  {
    printf("Output at vertex %d has value %g\n", debugvtx,  MRIFseq_vox(AvgVals, debugvtx, 0, 0, 0));
  }

  if (pathflag)
    sprintf(fname, "%s", out_prefix);
  else
  {
    if (negflag)
      sprintf(fname, "%s.sum.w", out_prefix) ;
    else
      sprintf(fname, "%s.diff.w", out_prefix) ;
  }

  if (!strcmp(trgtypestring,"paint") || !strcmp(trgtypestring,"w"))
  {

    /* This function will remove a zero-valued vertices */
    /* Make sense, since default value is considered as zero */
    /* But it will confuse the processing with matlab! */
    /* So I copy the data to the curv field to force every value is
     *  written out
     */
    /* MRIScopyMRI(BaseSurf, AvgVals, framesave, "val");*/
    /* MRISwriteValues(BaseSurf,fname); */
    MRIScopyMRI(BaseSurf, AvgVals, framesave, "curv");
    MRISwriteCurvatureToWFile(BaseSurf,fname);

  }
  else
  {
    fprintf(stderr, "ERROR unknown output file format.\n");
  }

  /* Free memories */
  MRISfree(&BaseSurf);
  MRIfree(&AvgVals);
  for (i=0; i < 2; i++)
  {
    MRIfree(&SrcVals[i]);
  }

  return 0;
}
示例#2
0
/*---------------------------------------------------------------*/
int main(int argc, char *argv[]) {
  int nargs, n, err;
  char tmpstr[2000], *signstr=NULL,*SUBJECTS_DIR, fname[2000];
  //char *OutDir = NULL;
  RFS *rfs;
  int nSmoothsPrev, nSmoothsDelta;
  MRI *z, *zabs=NULL, *sig=NULL, *p=NULL;
  int FreeMask = 0;
  int nthSign, nthFWHM, nthThresh;
  double sigmax, zmax, threshadj, csize, csizeavg, searchspace,avgvtxarea;
  int csizen;
  int nClusters, cmax,rmax,smax;
  SURFCLUSTERSUM *SurfClustList;
  struct timeb  mytimer;
  LABEL *clabel;
  FILE *fp, *fpLog=NULL;

  nargs = handle_version_option (argc, argv, vcid, "$Name: stable5 $");
  if (nargs && argc - nargs == 1) exit (0);
  argc -= nargs;
  cmdline = argv2cmdline(argc,argv);
  uname(&uts);
  getcwd(cwd,2000);

  Progname = argv[0] ;
  argc --;
  argv++;
  ErrorInit(NULL, NULL, NULL) ;
  DiagInit(NULL, NULL, NULL) ;
  if (argc == 0) usage_exit();
  parse_commandline(argc, argv);
  check_options();
  if (checkoptsonly) return(0);
  dump_options(stdout);

  if(LogFile){
    fpLog = fopen(LogFile,"w");
    if(fpLog == NULL){
      printf("ERROR: opening %s\n",LogFile);
      exit(1);
    }
    dump_options(fpLog);
  } 

  if(SynthSeed < 0) SynthSeed = PDFtodSeed();
  srand48(SynthSeed);

  SUBJECTS_DIR = getenv("SUBJECTS_DIR");

  // Create output directory
  printf("Creating %s\n",OutTop);
  err = fio_mkdirp(OutTop,0777);
  if(err) exit(1);
  for(nthFWHM=0; nthFWHM < nFWHMList; nthFWHM++){
    for(nthThresh = 0; nthThresh < nThreshList; nthThresh++){
      for(nthSign = 0; nthSign < nSignList; nthSign++){
	if(SignList[nthSign] ==  0) signstr = "abs"; 
	if(SignList[nthSign] == +1) signstr = "pos"; 
	if(SignList[nthSign] == -1) signstr = "neg"; 
	sprintf(tmpstr,"%s/fwhm%02d/%s/th%02d",
		OutTop,(int)round(FWHMList[nthFWHM]),
		signstr,(int)round(10*ThreshList[nthThresh]));
	sprintf(fname,"%s/%s.csd",tmpstr,csdbase);
	if(fio_FileExistsReadable(fname)){
	  printf("ERROR: output file %s exists\n",fname);
	  if(fpLog) fprintf(fpLog,"ERROR: output file %s exists\n",fname);
          exit(1);
	}
	err = fio_mkdirp(tmpstr,0777);
	if(err) exit(1);
      }
    }
  }

  // Load the target surface
  sprintf(tmpstr,"%s/%s/surf/%s.%s",SUBJECTS_DIR,subject,hemi,surfname);
  printf("Loading %s\n",tmpstr);
  surf = MRISread(tmpstr);
  if(!surf) return(1);

  // Handle masking
  if(LabelFile){
    printf("Loading label file %s\n",LabelFile);
    sprintf(tmpstr,"%s/%s/label/%s.%s.label",
	    SUBJECTS_DIR,subject,hemi,LabelFile);
    if(!fio_FileExistsReadable(tmpstr)){
      printf(" Cannot find label file %s\n",tmpstr);
      sprintf(tmpstr,"%s",LabelFile);
      printf(" Trying label file %s\n",tmpstr);
      if(!fio_FileExistsReadable(tmpstr)){
	printf("  ERROR: cannot read or find label file %s\n",LabelFile);
	exit(1);
      }
    }
    printf("Loading %s\n",tmpstr);
    clabel = LabelRead(NULL, tmpstr);
    mask = MRISlabel2Mask(surf, clabel, NULL);
    FreeMask = 1;
  }
  if(MaskFile){
    printf("Loading %s\n",MaskFile);
    mask = MRIread(MaskFile);
    if(mask == NULL) exit(1);
  }
  if(mask && SaveMask){
    sprintf(tmpstr,"%s/mask.mgh",OutTop);
    printf("Saving mask to %s\n",tmpstr);
    err = MRIwrite(mask,tmpstr);
    if(err) exit(1);
  }

  // Compute search space
  searchspace = 0;
  nmask = 0;
  for(n=0; n < surf->nvertices; n++){
    if(mask && MRIgetVoxVal(mask,n,0,0,0) < 0.5) continue;
    searchspace += surf->vertices[n].area;
    nmask++;
  }
  printf("Found %d voxels in mask\n",nmask);
  if(surf->group_avg_surface_area > 0)
    searchspace *= (surf->group_avg_surface_area/surf->total_area);
  printf("search space %g mm2\n",searchspace);
  avgvtxarea = searchspace/nmask;
  printf("average vertex area %g mm2\n",avgvtxarea);

  // Determine how many iterations are needed for each FWHM
  nSmoothsList = (int *) calloc(sizeof(int),nFWHMList);
  for(nthFWHM=0; nthFWHM < nFWHMList; nthFWHM++){
    nSmoothsList[nthFWHM] = MRISfwhm2niters(FWHMList[nthFWHM], surf);
    printf("%2d %5.1f  %4d\n",nthFWHM,FWHMList[nthFWHM],nSmoothsList[nthFWHM]);
    if(fpLog) fprintf(fpLog,"%2d %5.1f  %4d\n",nthFWHM,FWHMList[nthFWHM],nSmoothsList[nthFWHM]);
  }
  printf("\n");

  // Allocate the CSDs
  for(nthFWHM=0; nthFWHM < nFWHMList; nthFWHM++){
    for(nthThresh = 0; nthThresh < nThreshList; nthThresh++){
      for(nthSign = 0; nthSign < nSignList; nthSign++){
	csd = CSDalloc();
	sprintf(csd->simtype,"%s","null-z");
	sprintf(csd->anattype,"%s","surface");
	sprintf(csd->subject,"%s",subject);
	sprintf(csd->hemi,"%s",hemi);
	sprintf(csd->contrast,"%s","NA");
	csd->seed = SynthSeed;
	csd->nreps = nRepetitions;
	csd->thresh = ThreshList[nthThresh];
	csd->threshsign = SignList[nthSign];
	csd->nullfwhm = FWHMList[nthFWHM];
	csd->varfwhm = -1;
	csd->searchspace = searchspace;
	CSDallocData(csd);
	csdList[nthFWHM][nthThresh][nthSign] = csd;
      }
    }
  }

  // Alloc the z map
  z = MRIallocSequence(surf->nvertices, 1,1, MRI_FLOAT, 1);

  // Set up the random field specification
  rfs = RFspecInit(SynthSeed,NULL);
  rfs->name = strcpyalloc("gaussian");
  rfs->params[0] = 0;
  rfs->params[1] = 1;

  printf("Thresholds (%d): ",nThreshList);
  for(n=0; n < nThreshList; n++) printf("%5.2f ",ThreshList[n]);
  printf("\n");
  printf("Signs (%d): ",nSignList);
  for(n=0; n < nSignList; n++)  printf("%2d ",SignList[n]);
  printf("\n");
  printf("FWHM (%d): ",nFWHMList);
  for(n=0; n < nFWHMList; n++) printf("%5.2f ",FWHMList[n]);
  printf("\n");

  // Start the simulation loop
  printf("\n\nStarting Simulation over %d Repetitions\n",nRepetitions);
  if(fpLog) fprintf(fpLog,"\n\nStarting Simulation over %d Repetitions\n",nRepetitions);
  TimerStart(&mytimer) ;
  for(nthRep = 0; nthRep < nRepetitions; nthRep++){
    msecTime = TimerStop(&mytimer) ;
    printf("%5d %7.1f ",nthRep,(msecTime/1000.0)/60);
    if(fpLog) {
      fprintf(fpLog,"%5d %7.1f ",nthRep,(msecTime/1000.0)/60);
      fflush(fpLog);
    }
    // Synthesize an unsmoothed z map
    RFsynth(z,rfs,mask); 
    nSmoothsPrev = 0;
    
    // Loop through FWHMs
    for(nthFWHM=0; nthFWHM < nFWHMList; nthFWHM++){
      printf("%d ",nthFWHM);
      if(fpLog) {
	fprintf(fpLog,"%d ",nthFWHM);
	fflush(fpLog);
      }
      nSmoothsDelta = nSmoothsList[nthFWHM] - nSmoothsPrev;
      nSmoothsPrev = nSmoothsList[nthFWHM];
      // Incrementally smooth z
      MRISsmoothMRI(surf, z, nSmoothsDelta, mask, z); // smooth z
      // Rescale
      RFrescale(z,rfs,mask,z);
      // Slightly tortured way to get the right p-values because
      //   RFstat2P() computes one-sided, but I handle sidedness
      //   during thresholding.
      // First, use zabs to get a two-sided pval bet 0 and 0.5
      zabs = MRIabs(z,zabs);
      p = RFstat2P(zabs,rfs,mask,0,p);
      // Next, mult pvals by 2 to get two-sided bet 0 and 1
      MRIscalarMul(p,p,2.0);
      sig = MRIlog10(p,NULL,sig,1); // sig = -log10(p)
      for(nthThresh = 0; nthThresh < nThreshList; nthThresh++){
	for(nthSign = 0; nthSign < nSignList; nthSign++){
	  csd = csdList[nthFWHM][nthThresh][nthSign];

	  // If test is not ABS then apply the sign
	  if(csd->threshsign != 0) MRIsetSign(sig,z,0);
	  // Get the max stats
	  sigmax = MRIframeMax(sig,0,mask,csd->threshsign,
			       &cmax,&rmax,&smax);
	  zmax = MRIgetVoxVal(z,cmax,rmax,smax,0);
	  if(csd->threshsign == 0){
	    zmax = fabs(zmax);
	    sigmax = fabs(sigmax);
	  }
	  // Mask
	  if(mask) MRImask(sig,mask,sig,0.0,0.0);

	  // Surface clustering
	  MRIScopyMRI(surf, sig, 0, "val");
	  if(csd->threshsign == 0) threshadj = csd->thresh;
	  else threshadj = csd->thresh - log10(2.0); // one-sided test
	  SurfClustList = sclustMapSurfClusters(surf,threshadj,-1,csd->threshsign,
						0,&nClusters,NULL);
	  // Actual area of cluster with max area
	  csize  = sclustMaxClusterArea(SurfClustList, nClusters);
	  // Number of vertices of cluster with max number of vertices. 
	  // Note: this may be a different cluster from above!
	  csizen = sclustMaxClusterCount(SurfClustList, nClusters);
	  // Area of this cluster based on average vertex area. This just scales
	  // the number of vertices.
	  csizeavg = csizen * avgvtxarea;
	  if(UseAvgVtxArea) csize = csizeavg;
	  // Store results
	  csd->nClusters[nthRep] = nClusters;
	  csd->MaxClusterSize[nthRep] = csize;
	  csd->MaxSig[nthRep] = sigmax;
	  csd->MaxStat[nthRep] = zmax;
	} // Sign
      } // Thresh
    } // FWHM
    printf("\n");
    if(fpLog) fprintf(fpLog,"\n");
    if(SaveEachIter || fio_FileExistsReadable(SaveFile)) SaveOutput();
    if(fio_FileExistsReadable(StopFile)) {
      printf("Found stop file %s\n",StopFile);
      goto finish;
    }
  } // Simulation Repetition

 finish:

  SaveOutput();

  msecTime = TimerStop(&mytimer) ;
  printf("Total Sim Time %g min (%g per rep)\n",
	 msecTime/(1000*60.0),(msecTime/(1000*60.0))/nthRep);
  if(fpLog) fprintf(fpLog,"Total Sim Time %g min (%g per rep)\n",
		    msecTime/(1000*60.0),(msecTime/(1000*60.0))/nthRep);

  if(DoneFile){
    fp = fopen(DoneFile,"w");
    fprintf(fp,"%g\n",msecTime/(1000*60.0));
    fclose(fp);
  }
  printf("mri_mcsim done\n");
  if(fpLog){
    fprintf(fpLog,"mri_mcsim done\n");
    fclose(fpLog);
  }
  exit(0);
}
示例#3
0
/*---------------------------------------------------------------*/
int main(int argc, char **argv)
{
  int c,r,s,f;
  double val,rval;
  FILE *fp;
  MRI *mritmp;

  Progname = argv[0] ;
  argc --;
  argv++;
  ErrorInit(NULL, NULL, NULL) ;
  DiagInit(NULL, NULL, NULL) ;

  /* assign default geometry */
  cdircos[0] = 1.0;
  cdircos[1] = 0.0;
  cdircos[2] = 0.0;
  rdircos[0] = 0.0;
  rdircos[1] = 1.0;
  rdircos[2] = 0.0;
  sdircos[0] = 0.0;
  sdircos[1] = 0.0;
  sdircos[2] = 1.0;
  res[0] = 1.0;
  res[1] = 1.0;
  res[2] = 1.0;
  cras[0] = 0.0;
  cras[1] = 0.0;
  cras[2] = 0.0;
  res[3] = 2.0; /* TR */

  if (argc == 0) usage_exit();

  parse_commandline(argc, argv);
  check_options();
  dump_options(stdout);

  if(tempid != NULL) {
    printf("INFO: reading template header\n");
    if(! DoCurv) mritemp = MRIreadHeader(tempid,tempfmtid);
    else         mritemp = MRIread(tempid);
    if (mritemp == NULL) {
      printf("ERROR: reading %s header\n",tempid);
      exit(1);
    }
    if(NewVoxSizeSpeced){
      dim[0] = round(mritemp->width*mritemp->xsize/res[0]);
      dim[1] = round(mritemp->height*mritemp->ysize/res[1]);
      dim[2] = round(mritemp->depth*mritemp->zsize/res[2]);
      dim[3] = mritemp->nframes;
      res[3] = mritemp->tr;
      dimSpeced = 1;
    }
    if(dimSpeced){
      mritmp = MRIallocSequence(dim[0],dim[1],dim[2],MRI_FLOAT,dim[3]);
      MRIcopyHeader(mritemp,mritmp);
      MRIfree(&mritemp);
      mritemp = mritmp;
    }
    if(resSpeced){
      mritemp->xsize = res[0];
      mritemp->ysize = res[1];
      mritemp->zsize = res[2];
      mritemp->tr    = res[3];
    }

    dim[0] = mritemp->width;
    dim[1] = mritemp->height;
    dim[2] = mritemp->depth;
    if (nframes > 0) dim[3] = nframes;
    else             dim[3] = mritemp->nframes;
    mritemp->nframes = dim[3];
  }

  if(mritemp) {
    if(SpikeTP >= mritemp->nframes){
      printf("ERROR: SpikeTP = %d >= mritemp->nframes = %d\n",
             SpikeTP,mritemp->nframes);
      exit(1);
    }
  }

  printf("Synthesizing\n");
  srand48(seed);
  if (strcmp(pdfname,"gaussian")==0)
    mri = MRIrandn(dim[0], dim[1], dim[2], dim[3], gausmean, gausstd, NULL);
  else if (strcmp(pdfname,"uniform")==0)
    mri = MRIdrand48(dim[0], dim[1], dim[2], dim[3], 0, 1, NULL);
  else if (strcmp(pdfname,"const")==0)
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], ValueA, NULL);
  else if (strcmp(pdfname,"sphere")==0) {
    if(voxradius < 0)
      voxradius =
        sqrt( pow(dim[0]/2.0,2)+pow(dim[1]/2.0,2)+pow(dim[2]/2.0,2) )/2.0;
    printf("voxradius = %lf\n",voxradius);
    mri = MRIsphereMask(dim[0], dim[1], dim[2], dim[3],
                        dim[0]/2.0, dim[1]/2.0, dim[2]/2.0,
                        voxradius, ValueA, NULL);
  } else if (strcmp(pdfname,"delta")==0) {
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], delta_off_value, NULL);
    if (delta_crsf_speced == 0) {
      delta_crsf[0] = dim[0]/2;
      delta_crsf[1] = dim[1]/2;
      delta_crsf[2] = dim[2]/2;
      delta_crsf[3] = dim[3]/2;
    }
    printf("delta set to %g at %d %d %d %d\n",delta_value,delta_crsf[0],
           delta_crsf[1],delta_crsf[2],delta_crsf[3]);
    MRIFseq_vox(mri,
                delta_crsf[0],
                delta_crsf[1],
                delta_crsf[2],
                delta_crsf[3]) = delta_value;
  } else if (strcmp(pdfname,"chi2")==0) {
    rfs = RFspecInit(seed,NULL);
    rfs->name = strcpyalloc("chi2");
    rfs->params[0] = dendof;
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    printf("Synthesizing chi2 with dof=%d\n",dendof);
    RFsynth(mri,rfs,NULL);
  } else if (strcmp(pdfname,"z")==0) {
    printf("Synthesizing z \n");
    rfs = RFspecInit(seed,NULL);
    rfs->name = strcpyalloc("gaussian");
    rfs->params[0] = 0; // mean
    rfs->params[1] = 1; // std
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri,rfs,NULL);
  } else if (strcmp(pdfname,"t")==0) {
    printf("Synthesizing t with dof=%d\n",dendof);
    rfs = RFspecInit(seed,NULL);
    rfs->name = strcpyalloc("t");
    rfs->params[0] = dendof;
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri,rfs,NULL);
  } else if (strcmp(pdfname,"tr")==0) {
    printf("Synthesizing t with dof=%d as ratio of z/sqrt(chi2)\n",dendof);
    rfs = RFspecInit(seed,NULL);
    // numerator
    rfs->name = strcpyalloc("gaussian");
    rfs->params[0] = 0; // mean
    rfs->params[1] = 1; // std
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri,rfs,NULL);
    // denominator
    rfs->name = strcpyalloc("chi2");
    rfs->params[0] = dendof;
    mri2 = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri2,rfs,NULL);
    fMRIsqrt(mri2,mri2); // sqrt of chi2
    mri = MRIdivide(mri,mri2,mri);
    MRIscalarMul(mri, mri, sqrt(dendof)) ;
    MRIfree(&mri2);
  } else if (strcmp(pdfname,"F")==0) {
    printf("Synthesizing F with num=%d den=%d\n",numdof,dendof);
    rfs = RFspecInit(seed,NULL);
    rfs->name = strcpyalloc("F");
    rfs->params[0] = numdof;
    rfs->params[1] = dendof;
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri,rfs,NULL);
  } else if (strcmp(pdfname,"Fr")==0) {
    printf("Synthesizing F with num=%d den=%d as ratio of two chi2\n",
           numdof,dendof);
    rfs = RFspecInit(seed,NULL);
    rfs->name = strcpyalloc("chi2");
    // numerator
    rfs->params[0] = numdof;
    mri = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri,rfs,NULL);
    // denominator
    rfs->params[0] = dendof;
    mri2 = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    RFsynth(mri2,rfs,NULL);
    mri = MRIdivide(mri,mri2,mri);
    MRIscalarMul(mri, mri, (double)dendof/numdof) ;
    MRIfree(&mri2);
  } else if (strcmp(pdfname,"voxcrs")==0) {
    // three frames. 1st=col, 2nd=row, 3rd=slice
    printf("Filling with vox CRS\n");
    mri = MRIconst(dim[0], dim[1], dim[2], 3, 0, NULL);
    for(c=0; c < mri->width; c ++){
      for(r=0; r < mri->height; r ++){
        for(s=0; s < mri->depth; s ++){
          MRIsetVoxVal(mri,c,r,s,0,c);
          MRIsetVoxVal(mri,c,r,s,1,r);
          MRIsetVoxVal(mri,c,r,s,2,s);
        }
      }
    }
  } else if (strcmp(pdfname,"boundingbox")==0) {
    printf("Setting bounding box \n");
    if(mritemp == NULL)
      mritemp = MRIconst(dim[0], dim[1], dim[2], dim[3], 0, NULL);
    mri = MRIsetBoundingBox(mritemp,&boundingbox,ValueA,ValueB);
    if(!mri) exit(1);
  } 
  else if (strcmp(pdfname,"checker")==0) {
    printf("Checker \n");
    mri=MRIchecker(mritemp,NULL);
    if(!mri) exit(1);
  } 
  else if (strcmp(pdfname,"sliceno")==0) {
    printf("SliceNo \n");
    if(mritemp == NULL){
      printf("ERROR: need --temp with sliceno\n");
      exit(1);
    }
    mri=MRIsliceNo(mritemp,NULL);
    if(!mri) exit(1);
  } 
  else if (strcmp(pdfname,"indexno")==0) {
    printf("IndexNo \n");
    if(mritemp == NULL){
      printf("ERROR: need --temp with indexno\n");
      exit(1);
    }
    mri=MRIindexNo(mritemp,NULL);
    if(!mri) exit(1);
  } 
  else if (strcmp(pdfname,"crs")==0) {
    printf("CRS \n");
    if(mritemp == NULL){
      printf("ERROR: need --temp with crs\n");
      exit(1);
    }
    mri=MRIcrs(mritemp,NULL);
    if(!mri) exit(1);
  } 
  else {
    printf("ERROR: pdf %s unrecognized, must be gaussian, uniform,\n"
	   "const, delta, checker\n", pdfname);
    exit(1);
  }
  if (tempid != NULL) {
    MRIcopyHeader(mritemp,mri);
    mri->type = MRI_FLOAT;
    // Override
    if(nframes > 0) mri->nframes = nframes;
    if(TR > 0) mri->tr = TR;
  } else {
    if(mri == NULL) {
      usage_exit();
    }
    mri->xsize = res[0];
    mri->ysize = res[1];
    mri->zsize = res[2];
    mri->tr    = res[3];
    mri->x_r = cdircos[0];
    mri->x_a = cdircos[1];
    mri->x_s = cdircos[2];
    mri->y_r = rdircos[0];
    mri->y_a = rdircos[1];
    mri->y_s = rdircos[2];
    mri->z_r = sdircos[0];
    mri->z_a = sdircos[1];
    mri->z_s = sdircos[2];
    if(!usep0){
      mri->c_r = cras[0];
      mri->c_a = cras[1];
      mri->c_s = cras[2];
    } 
    else MRIp0ToCRAS(mri, p0[0], p0[1], p0[2]);
  }

  if (gstd > 0) {
    if(!UseFFT){
      printf("Smoothing\n");
      MRIgaussianSmooth(mri, gstd, gmnnorm, mri); /* gmnnorm = 1 = normalize */
    }
    else {
      printf("Smoothing with FFT \n");
      mri2 = MRIcopy(mri,NULL);
      mri = MRI_fft_gaussian(mri2, mri,
                             gstd, gmnnorm); /* gmnnorm = 1 = normalize */
    }
    if (rescale) {
      printf("Rescaling\n");
      if (strcmp(pdfname,"z")==0)     RFrescale(mri,rfs,NULL,mri);
      if (strcmp(pdfname,"chi2")==0)  RFrescale(mri,rfs,NULL,mri);
      if (strcmp(pdfname,"t")==0)     RFrescale(mri,rfs,NULL,mri);
      if (strcmp(pdfname,"tr")==0)    RFrescale(mri,rfs,NULL,mri);
      if (strcmp(pdfname,"F")==0)     RFrescale(mri,rfs,NULL,mri);
      if (strcmp(pdfname,"Fr")==0)    RFrescale(mri,rfs,NULL,mri);
    }
  }

  if(DoHSC){
    // This multiplies each frame by a random number
    // between HSCMin HSCMax to simulate heteroscedastisity
    printf("Applying HSC %lf %lf\n",HSCMin,HSCMax);
    for(f=0; f < mri->nframes; f++){
      rval = (HSCMax-HSCMin)*drand48() + HSCMin;
      if(debug) printf("%3d %lf\n",f,rval);
      for(c=0; c < mri->width; c ++){
	for(r=0; r < mri->height; r ++){
	  for(s=0; s < mri->depth; s ++){
	    val = MRIgetVoxVal(mri,c,r,s,f);
	    MRIsetVoxVal(mri,c,r,s,f,rval*val);
	  }
        }
      }
    }
  }

  if(AddOffset) {
    printf("Adding offset\n");
    offset = MRIread(tempid);
    if(offset == NULL) exit(1);
    if(OffsetFrame == -1) OffsetFrame = nint(offset->nframes/2);
    printf("Offset frame %d\n",OffsetFrame);
    mritmp = fMRIframe(offset, OffsetFrame, NULL);
    if(mritmp == NULL) exit(1);
    MRIfree(&offset);
    offset = mritmp;
    fMRIaddOffset(mri, offset, NULL, mri);
  }

  if(SpikeTP > 0){
    printf("Spiking time point %d\n",SpikeTP);
    for(c=0; c < mri->width; c ++){
      for(r=0; r < mri->height; r ++){
        for(s=0; s < mri->depth; s ++){
          MRIsetVoxVal(mri,c,r,s,SpikeTP,1e9);
        }
      }
    }
  }

  if(DoAbs){
    printf("Computing absolute value\n");
    MRIabs(mri,mri);
  }

  if(!NoOutput){
    printf("Saving\n");
    if(!DoCurv)  MRIwriteAnyFormat(mri,volid,volfmt,-1,NULL);
    else {
      printf("Saving in curv format\n");
      MRIScopyMRI(surf, mri, 0, "curv");
      MRISwriteCurvature(surf,volid);
    }
  }

  if(sum2file){
    val = MRIsum2All(mri);
    fp = fopen(sum2file,"w");
    if(fp == NULL){
      printf("ERROR: opening %s\n",sum2file);
      exit(1);
    }
    printf("sum2all: %20.10lf\n",val);
    printf("vrf: %20.10lf\n",1/val);
    fprintf(fp,"%20.10lf\n",val);
  }

  return(0);
}