int igraph_random_sample_alga(igraph_vector_t *res, igraph_integer_t l, igraph_integer_t h,
igraph_integer_t length) {
igraph_real_t N=h-l+1;
igraph_real_t n=length;
igraph_real_t top=N-n;
igraph_real_t Nreal=N;
igraph_real_t S=0;
igraph_real_t V, quot;
l=l-1;
while (n>=2) {
V=RNG_UNIF01();
S=1;
quot=top/Nreal;
while (quot>V) {
S+=1;
top=-1.0+top;
Nreal=-1.0+Nreal;
quot=(quot*top)/Nreal;
}
l+=S;
igraph_vector_push_back(res, l); /* allocated */
Nreal=-1.0+Nreal; n=-1+n;
}
S=floor(round(Nreal)*RNG_UNIF01());
l+=S+1;
igraph_vector_push_back(res, l); /* allocated */
return 0;
}
int splicing_reassign_samples(const splicing_matrix_t *matches,
const splicing_vector_int_t *match_order,
const splicing_vector_t *psi,
int noiso, splicing_vector_int_t *result) {
int noreads = splicing_matrix_ncol(matches);
int i, w;
double *prev, *curr;
double rand, sumpsi;
int noValid;
int *order=VECTOR(*match_order);
splicing_vector_t cumsum;
splicing_vector_int_t validIso;
SPLICING_CHECK(splicing_vector_init(&cumsum, noiso));
SPLICING_FINALLY(splicing_vector_destroy, &cumsum);
SPLICING_CHECK(splicing_vector_int_init(&validIso, noiso));
SPLICING_FINALLY(splicing_vector_int_destroy, &validIso);
SPLICING_CHECK(splicing_vector_int_resize(result, noreads));
if (noreads == 0) { return 0; }
prev = curr = &MATRIX(*matches, 0, order[0]);
CUMSUM();
for (i=0; i<noreads; i++) {
curr = &MATRIX(*matches, 0, order[i]);
/* Maybe we need to update the cumulative sum */
if (memcmp(prev, curr, sizeof(double)*noiso) != 0) { CUMSUM(); }
if (noValid == 0) {
VECTOR(*result)[order[i]] = -1;
} else if (noValid == 1) {
VECTOR(*result)[order[i]] = VECTOR(validIso)[0];
} else if (noValid == 2) {
rand = RNG_UNIF01() * sumpsi;
w = (rand < VECTOR(cumsum)[0]) ? VECTOR(validIso)[0] :
VECTOR(validIso)[1];
VECTOR(*result)[order[i]] = w;
} else {
/* Draw */
rand = RNG_UNIF01() * sumpsi;
/* TODO: Binary search for interval, if many classes */
for (w=0; rand > VECTOR(cumsum)[w]; w++) ;
VECTOR(*result)[order[i]] = VECTOR(validIso)[w];
}
prev=curr;
}
splicing_vector_int_destroy(&validIso);
splicing_vector_destroy(&cumsum);
SPLICING_FINALLY_CLEAN(2);
return 0;
}
double igraph_exp_rand(void)
{
/* q[k-1] = sum(log(2)^k / k!) k=1,..,n, */
/* The highest n (here 8) is determined by q[n-1] = 1.0 */
/* within standard precision */
const double q[] =
{
0.6931471805599453,
0.9333736875190459,
0.9888777961838675,
0.9984959252914960,
0.9998292811061389,
0.9999833164100727,
0.9999985691438767,
0.9999998906925558,
0.9999999924734159,
0.9999999995283275,
0.9999999999728814,
0.9999999999985598,
0.9999999999999289,
0.9999999999999968,
0.9999999999999999,
1.0000000000000000
};
double a, u, ustar, umin;
int i;
a = 0.;
/* precaution if u = 0 is ever returned */
u = RNG_UNIF01();
while(u <= 0.0 || u >= 1.0) u = RNG_UNIF01();
for (;;) {
u += u;
if (u > 1.0)
break;
a += q[0];
}
u -= 1.;
if (u <= q[0])
return a + u;
i = 0;
ustar = RNG_UNIF01();
umin = ustar;
do {
ustar = RNG_UNIF01();
if (ustar < umin)
umin = ustar;
i++;
} while (u > q[i]);
return a + umin * q[0];
}
int splicing_drift_proposal(int mode,
const splicing_vector_t *psi,
const splicing_vector_t *alpha,
double sigma,
const splicing_vector_t *otherpsi,
const splicing_vector_t *otheralpha, int noiso,
splicing_vector_t *respsi,
splicing_vector_t *resalpha,
double *ressigma, double *resscore) {
switch (mode) {
case 0: /* init */
{
SPLICING_CHECK(splicing_vector_resize(respsi, noiso));
SPLICING_CHECK(splicing_vector_resize(resalpha, noiso-1));
if (noiso != 2) {
int i;
for (i=0; i<noiso; i++) {
VECTOR(*respsi)[i] = 1.0/noiso;
}
for (i=0; i<noiso-1; i++) {
VECTOR(*resalpha)[i] = 1.0/(noiso-1);
}
*ressigma = 0.05;
} else {
VECTOR(*respsi)[0] = RNG_UNIF01();
VECTOR(*respsi)[1] = 1 - VECTOR(*respsi)[0];
VECTOR(*resalpha)[0] = 0.0;
VECTOR(*resalpha)[1] = 0.0;
*ressigma = 0.05;
}
}
break;
case 1: /* propose */
{
int len=noiso-1;
double sumpsi=0.0;
SPLICING_CHECK(splicing_vector_reserve(respsi, len+1));
SPLICING_CHECK(splicing_mvrnorm(alpha, sigma, resalpha, len));
SPLICING_CHECK(splicing_logit_inv(resalpha, respsi, len));
sumpsi = splicing_vector_sum(respsi);
SPLICING_CHECK(splicing_vector_resize(respsi, len+1));
VECTOR(*respsi)[len] = 1-sumpsi;
}
break;
case 2: /* score */
SPLICING_CHECK(splicing_mvplogisnorm(psi, otheralpha, sigma, noiso-1,
resscore));
break;
}
return 0;
}
int igraph_dot_product_game(igraph_t *graph, const igraph_matrix_t *vecs,
igraph_bool_t directed) {
igraph_integer_t nrow=igraph_matrix_nrow(vecs);
igraph_integer_t ncol=igraph_matrix_ncol(vecs);
int i, j;
igraph_vector_t edges;
igraph_bool_t warned_neg=0, warned_big=0;
IGRAPH_VECTOR_INIT_FINALLY(&edges, 0);
RNG_BEGIN();
for (i = 0; i < ncol; i++) {
int from=directed ? 0 : i+1;
igraph_vector_t v1;
igraph_vector_view(&v1, &MATRIX(*vecs, 0, i), nrow);
for (j = from; j < ncol; j++) {
igraph_real_t prob;
igraph_vector_t v2;
if (i==j) { continue; }
igraph_vector_view(&v2, &MATRIX(*vecs, 0, j), nrow);
igraph_lapack_ddot(&v1, &v2, &prob);
if (prob < 0 && ! warned_neg) {
warned_neg=1;
IGRAPH_WARNING("Negative connection probability in "
"dot-product graph");
} else if (prob > 1 && ! warned_big) {
warned_big=1;
IGRAPH_WARNING("Greater than 1 connection probability in "
"dot-product graph");
IGRAPH_CHECK(igraph_vector_push_back(&edges, i));
IGRAPH_CHECK(igraph_vector_push_back(&edges, j));
} else if (RNG_UNIF01() < prob) {
IGRAPH_CHECK(igraph_vector_push_back(&edges, i));
IGRAPH_CHECK(igraph_vector_push_back(&edges, j));
}
}
}
RNG_END();
igraph_create(graph, &edges, ncol, directed);
igraph_vector_destroy(&edges);
IGRAPH_FINALLY_CLEAN(1);
return 0;
}
int igraph_sample_sphere_volume(igraph_integer_t dim, igraph_integer_t n,
igraph_real_t radius,
igraph_bool_t positive,
igraph_matrix_t *res) {
igraph_integer_t i, j;
/* Arguments are checked by the following call */
IGRAPH_CHECK(igraph_sample_sphere_surface(dim, n, radius, positive, res));
RNG_BEGIN();
for (i = 0; i < n; i++) {
igraph_real_t *col=&MATRIX(*res, 0, i);
igraph_real_t U=pow(RNG_UNIF01(), 1.0/dim);
for (j = 0; j < dim; j++) { col[j] *= U; }
}
RNG_END();
return 0;
}
double igraph_rbinom(double nin, double pp)
{
/* FIXME: These should become THREAD_specific globals : */
static double c, fm, npq, p1, p2, p3, p4, qn;
static double xl, xll, xlr, xm, xr;
static double psave = -1.0;
static int nsave = -1;
static int m;
double f, f1, f2, u, v, w, w2, x, x1, x2, z, z2;
double p, q, np, g, r, al, alv, amaxp, ffm, ynorm;
int i,ix,k, n;
if (!R_FINITE(nin)) ML_ERR_return_NAN;
n = floor(nin + 0.5);
if (n != nin) ML_ERR_return_NAN;
if (!R_FINITE(pp) ||
/* n=0, p=0, p=1 are not errors <TSL>*/
n < 0 || pp < 0. || pp > 1.) ML_ERR_return_NAN;
if (n == 0 || pp == 0.) return 0;
if (pp == 1.) return n;
p = fmin(pp, 1. - pp);
q = 1. - p;
np = n * p;
r = p / q;
g = r * (n + 1);
/* Setup, perform only when parameters change [using static (globals): */
/* FIXING: Want this thread safe
-- use as little (thread globals) as possible
*/
if (pp != psave || n != nsave) {
psave = pp;
nsave = n;
if (np < 30.0) {
/* inverse cdf logic for mean less than 30 */
qn = pow(q, (double) n);
goto L_np_small;
} else {
ffm = np + p;
m = ffm;
fm = m;
npq = np * q;
p1 = (int)(2.195 * sqrt(npq) - 4.6 * q) + 0.5;
xm = fm + 0.5;
xl = xm - p1;
xr = xm + p1;
c = 0.134 + 20.5 / (15.3 + fm);
al = (ffm - xl) / (ffm - xl * p);
xll = al * (1.0 + 0.5 * al);
al = (xr - ffm) / (xr * q);
xlr = al * (1.0 + 0.5 * al);
p2 = p1 * (1.0 + c + c);
p3 = p2 + c / xll;
p4 = p3 + c / xlr;
}
} else if (n == nsave) {
if (np < 30.0)
goto L_np_small;
}
/*-------------------------- np = n*p >= 30 : ------------------- */
repeat {
u = RNG_UNIF01() * p4;
v = RNG_UNIF01();
/* triangular region */
if (u <= p1) {
ix = xm - p1 * v + u;
goto finis;
}
/* parallelogram region */
if (u <= p2) {
x = xl + (u - p1) / c;
v = v * c + 1.0 - fabs(xm - x) / p1;
if (v > 1.0 || v <= 0.)
continue;
ix = x;
} else {
if (u > p3) { /* right tail */
ix = xr - log(v) / xlr;
if (ix > n)
continue;
v = v * (u - p3) * xlr;
} else {/* left tail */
ix = xl + log(v) / xll;
if (ix < 0)
continue;
v = v * (u - p2) * xll;
}
}
/* determine appropriate way to perform accept/reject test */
k = abs(ix - m);
if (k <= 20 || k >= npq / 2 - 1) {
/* explicit evaluation */
f = 1.0;
if (m < ix) {
for (i = m + 1; i <= ix; i++)
f *= (g / i - r);
} else if (m != ix) {
for (i = ix + 1; i <= m; i++)
f /= (g / i - r);
}
if (v <= f)
goto finis;
} else {
/* squeezing using upper and lower bounds on log(f(x)) */
amaxp = (k / npq) * ((k * (k / 3. + 0.625) + 0.1666666666666) / npq + 0.5);
ynorm = -k * k / (2.0 * npq);
alv = log(v);
if (alv < ynorm - amaxp)
goto finis;
if (alv <= ynorm + amaxp) {
/* stirling's formula to machine accuracy */
/* for the final acceptance/rejection test */
x1 = ix + 1;
f1 = fm + 1.0;
z = n + 1 - fm;
w = n - ix + 1.0;
z2 = z * z;
x2 = x1 * x1;
f2 = f1 * f1;
w2 = w * w;
if (alv <= xm * log(f1 / x1) + (n - m + 0.5) * log(z / w) + (ix - m) * log(w * p / (x1 * q)) + (13860.0 - (462.0 - (132.0 - (99.0 - 140.0 / f2) / f2) / f2) / f2) / f1 / 166320.0 + (13860.0 - (462.0 - (132.0 - (99.0 - 140.0 / z2) / z2) / z2) / z2) / z / 166320.0 + (13860.0 - (462.0 - (132.0 - (99.0 - 140.0 / x2) / x2) / x2) / x2) / x1 / 166320.0 + (13860.0 - (462.0 - (132.0 - (99.0 - 140.0 / w2) / w2) / w2) / w2) / w / 166320.)
goto finis;
}
}
}
L_np_small:
/*---------------------- np = n*p < 30 : ------------------------- */
repeat {
ix = 0;
f = qn;
u = RNG_UNIF01();
repeat {
if (u < f)
goto finis;
if (ix > 110)
break;
u -= f;
ix++;
f *= (g / ix - r);
}
}
finis:
if (psave > 0.5)
ix = n - ix;
return (double)ix;
}
double igraph_rpois(double mu)
{
/* Factorial Table (0:9)! */
const double fact[10] =
{
1., 1., 2., 6., 24., 120., 720., 5040., 40320., 362880.
};
/* These are static --- persistent between calls for same mu : */
static int l, m;
static double b1, b2, c, c0, c1, c2, c3;
static double pp[36], p0, p, q, s, d, omega;
static double big_l;/* integer "w/o overflow" */
static double muprev = 0., muprev2 = 0.;/*, muold = 0.*/
/* Local Vars [initialize some for -Wall]: */
double del, difmuk= 0., E= 0., fk= 0., fx, fy, g, px, py, t, u= 0., v, x;
double pois = -1.;
int k, kflag, big_mu, new_big_mu = FALSE;
if (!R_FINITE(mu))
ML_ERR_return_NAN;
if (mu <= 0.)
return 0.;
big_mu = mu >= 10.;
if(big_mu)
new_big_mu = FALSE;
if (!(big_mu && mu == muprev)) {/* maybe compute new persistent par.s */
if (big_mu) {
new_big_mu = TRUE;
/* Case A. (recalculation of s,d,l because mu has changed):
* The poisson probabilities pk exceed the discrete normal
* probabilities fk whenever k >= m(mu).
*/
muprev = mu;
s = sqrt(mu);
d = 6. * mu * mu;
big_l = floor(mu - 1.1484);
/* = an upper bound to m(mu) for all mu >= 10.*/
}
else { /* Small mu ( < 10) -- not using normal approx. */
/* Case B. (start new table and calculate p0 if necessary) */
/*muprev = 0.;-* such that next time, mu != muprev ..*/
if (mu != muprev) {
muprev = mu;
m = imax2(1, (int) mu);
l = 0; /* pp[] is already ok up to pp[l] */
q = p0 = p = exp(-mu);
}
repeat {
/* Step U. uniform sample for inversion method */
u = RNG_UNIF01();
if (u <= p0)
return 0.;
/* Step T. table comparison until the end pp[l] of the
pp-table of cumulative poisson probabilities
(0.458 > ~= pp[9](= 0.45792971447) for mu=10 ) */
if (l != 0) {
for (k = (u <= 0.458) ? 1 : imin2(l, m); k <= l; k++)
if (u <= pp[k])
return (double)k;
if (l == 35) /* u > pp[35] */
continue;
}
/* Step C. creation of new poisson
probabilities p[l..] and their cumulatives q =: pp[k] */
l++;
for (k = l; k <= 35; k++) {
p *= mu / k;
q += p;
pp[k] = q;
if (u <= q) {
l = k;
return (double)k;
}
}
l = 35;
} /* end(repeat) */
}/* mu < 10 */
} /* end {initialize persistent vars} */
/* Only if mu >= 10 : ----------------------- */
/* Step N. normal sample */
g = mu + s * igraph_norm_rand();/* norm_rand() ~ N(0,1), standard normal */
if (g >= 0.) {
pois = floor(g);
/* Step I. immediate acceptance if pois is large enough */
if (pois >= big_l)
return pois;
/* Step S. squeeze acceptance */
fk = pois;
difmuk = mu - fk;
u = RNG_UNIF01(); /* ~ U(0,1) - sample */
if (d * u >= difmuk * difmuk * difmuk)
return pois;
}
/* Step P. preparations for steps Q and H.
(recalculations of parameters if necessary) */
if (new_big_mu || mu != muprev2) {
/* Careful! muprev2 is not always == muprev
because one might have exited in step I or S
*/
muprev2 = mu;
omega = M_1_SQRT_2PI / s;
/* The quantities b1, b2, c3, c2, c1, c0 are for the Hermite
* approximations to the discrete normal probabilities fk. */
b1 = one_24 / mu;
b2 = 0.3 * b1 * b1;
c3 = one_7 * b1 * b2;
c2 = b2 - 15. * c3;
c1 = b1 - 6. * b2 + 45. * c3;
c0 = 1. - b1 + 3. * b2 - 15. * c3;
c = 0.1069 / mu; /* guarantees majorization by the 'hat'-function. */
}
if (g >= 0.) {
/* 'Subroutine' F is called (kflag=0 for correct return) */
kflag = 0;
goto Step_F;
}
repeat {
/* Step E. Exponential Sample */
E = igraph_exp_rand(); /* ~ Exp(1) (standard exponential) */
/* sample t from the laplace 'hat'
(if t <= -0.6744 then pk < fk for all mu >= 10.) */
u = 2 * RNG_UNIF01() - 1.;
t = 1.8 + fsign(E, u);
if (t > -0.6744) {
pois = floor(mu + s * t);
fk = pois;
difmuk = mu - fk;
/* 'subroutine' F is called (kflag=1 for correct return) */
kflag = 1;
Step_F: /* 'subroutine' F : calculation of px,py,fx,fy. */
if (pois < 10) { /* use factorials from table fact[] */
px = -mu;
py = pow(mu, pois) / fact[(int)pois];
}
else {
/* Case pois >= 10 uses polynomial approximation
a0-a7 for accuracy when advisable */
del = one_12 / fk;
del = del * (1. - 4.8 * del * del);
v = difmuk / fk;
if (fabs(v) <= 0.25)
px = fk * v * v * (((((((a7 * v + a6) * v + a5) * v + a4) *
v + a3) * v + a2) * v + a1) * v + a0)
- del;
else /* |v| > 1/4 */
px = fk * log(1. + v) - difmuk - del;
py = M_1_SQRT_2PI / sqrt(fk);
}
x = (0.5 - difmuk) / s;
x *= x;/* x^2 */
fx = -0.5 * x;
fy = omega * (((c3 * x + c2) * x + c1) * x + c0);
if (kflag > 0) {
/* Step H. Hat acceptance (E is repeated on rejection) */
if (c * fabs(u) <= py * exp(px + E) - fy * exp(fx + E))
break;
} else
/* Step Q. Quotient acceptance (rare case) */
if (fy - u * fy <= py * exp(px - fx))
break;
}/* t > -.67.. */
}
return pois;
}
int igraph_random_sample(igraph_vector_t *res, igraph_integer_t l, igraph_integer_t h,
igraph_integer_t length) {
igraph_real_t N=h-l+1;
igraph_real_t n=length;
int retval;
igraph_real_t nreal=length;
igraph_real_t ninv=1.0/nreal;
igraph_real_t Nreal=N;
igraph_real_t Vprime;
igraph_real_t qu1=-n+1+N;
igraph_real_t qu1real=-nreal+1.0+Nreal;
igraph_real_t negalphainv=-13;
igraph_real_t threshold=-negalphainv*n;
igraph_real_t S;
igraph_vector_clear(res);
IGRAPH_CHECK(igraph_vector_reserve(res, length));
RNG_BEGIN();
Vprime=exp(log(RNG_UNIF01())*ninv);
while (n>1 && threshold < N) {
igraph_real_t X, U;
igraph_real_t limit, t;
igraph_real_t negSreal, y1, y2, top, bottom;
igraph_real_t nmin1inv=1.0/(-1.0+nreal);
while (1) {
while(1) {
X=Nreal*(-Vprime+1.0);
S=floor(X);
if (S==0) { S=1; }
if (S <qu1) { break; }
Vprime = exp(log(RNG_UNIF01())*ninv);
}
U=RNG_UNIF01();
negSreal=-S;
y1=exp(log(U*Nreal/qu1real)*nmin1inv);
Vprime=y1*(-X/Nreal+1.0)*(qu1real/(negSreal+qu1real));
if (Vprime <= 1.0) { break; }
y2=1.0;
top=-1.0+Nreal;
if (-1+n > S) {
bottom=-nreal+Nreal;
limit=-S+N;
} else {
bottom=-1.0+negSreal+Nreal;
limit=qu1;
}
for (t=-1+N; t>=limit; t--) {
y2=(y2*top)/bottom;
top=-1.0+top;
bottom=-1.0+bottom;
}
if (Nreal/(-X+Nreal) >= y1*exp(log(y2)*nmin1inv)) {
Vprime=exp(log(RNG_UNIF01())*nmin1inv);
break;
}
Vprime=exp(log(RNG_UNIF01())*ninv);
}
l+=S;
igraph_vector_push_back(res, l); /* allocated */
N=-S+(-1+N); Nreal=negSreal+(-1.0+Nreal);
n=-1+n; nreal=-1.0+nreal; ninv=nmin1inv;
qu1=-S+qu1; qu1real=negSreal+qu1real;
threshold=threshold+negalphainv;
}
if (n>1) {
retval=igraph_random_sample_alga(res, l, h, n);
} else {
retval=0;
S=floor(N*Vprime);
l+=S;
igraph_vector_push_back(res, l); /* allocated */
}
RNG_END();
return retval;
}
int splicing_miso_trinity(const splicing_matrix_t *match_matrix,
const splicing_vector_int_t *isolen,
int readLength, int noIterations, int noBurnIn,
int noLag, const splicing_vector_t *hyperp,
splicing_matrix_t *samples,
splicing_vector_t *logLik,
splicing_matrix_t *class_templates,
splicing_vector_t *class_counts,
splicing_vector_int_t *assignment,
splicing_miso_rundata_t *rundata) {
double acceptP, cJS, pJS, sigma;
int noiso = splicing_matrix_nrow(match_matrix);
int noReads = splicing_matrix_ncol(match_matrix);
splicing_vector_int_t *myass=assignment, vass;
splicing_vector_t vpsi, vpsiNew, valpha, valphaNew,
*psi=&vpsi, *psiNew=&vpsiNew, *alpha=&valpha, *alphaNew=&valphaNew;
int noSamples = (noIterations - noBurnIn + 1) / noLag;
int i, m, lagCounter=0, noS=0;
splicing_vector_int_t match_order;
splicing_vector_int_t effisolen;
splicing_vector_t isoscores;
if ( (class_templates ? 1 : 0) + (class_counts ? 1 : 0) == 1) {
SPLICING_ERROR("Only one of `class_templates' and `class_counts' is "
"given", SPLICING_EINVAL);
}
rundata->noIso=noiso;
rundata->noIters=noIterations;
rundata->noBurnIn=noBurnIn;
rundata->noLag=noLag;
rundata->noAccepted = rundata->noRejected = 0;
if (assignment) {
SPLICING_CHECK(splicing_vector_int_resize(myass, noReads));
splicing_vector_int_null(myass);
} else {
myass=&vass;
SPLICING_CHECK(splicing_vector_int_init(myass, noReads));
SPLICING_FINALLY(splicing_vector_int_destroy, myass);
}
SPLICING_CHECK(splicing_vector_init(&vpsi, noiso));
SPLICING_FINALLY(splicing_vector_destroy, &vpsi);
SPLICING_CHECK(splicing_vector_init(&vpsiNew, noiso));
SPLICING_FINALLY(splicing_vector_destroy, &vpsiNew);
SPLICING_CHECK(splicing_vector_init(&valpha, noiso-1));
SPLICING_FINALLY(splicing_vector_destroy, &valpha);
SPLICING_CHECK(splicing_vector_init(&valphaNew, noiso-1));
SPLICING_FINALLY(splicing_vector_destroy, &valphaNew);
SPLICING_CHECK(splicing_vector_int_init(&match_order, noReads));
SPLICING_FINALLY(splicing_vector_int_destroy, &match_order);
SPLICING_CHECK(splicing_order_matches(match_matrix, &match_order));
if (class_templates && class_counts) {
SPLICING_CHECK(splicing_i_miso_classes(match_matrix, &match_order,
class_templates, class_counts,
/*bin_class_templates=*/ 0,
/*bin_class_counts=*/ 0));
}
SPLICING_CHECK(splicing_vector_int_init(&effisolen, noiso));
SPLICING_FINALLY(splicing_vector_int_destroy, &effisolen);
SPLICING_CHECK(splicing_vector_init(&isoscores, noiso));
SPLICING_FINALLY(splicing_vector_destroy, &isoscores);
for (i=0; i<noiso; i++) {
int l=VECTOR(*isolen)[i]-readLength+1;
VECTOR(effisolen)[i] = l > 0 ? l : 0;
VECTOR(isoscores)[i] = -log((double) l);
}
SPLICING_CHECK(splicing_matrix_resize(samples, noiso, noSamples));
SPLICING_CHECK(splicing_vector_resize(logLik, noSamples));
/* Initialize Psi(0) randomly */
SPLICING_CHECK(splicing_drift_proposal(/* mode= */ 0, 0, 0, 0, 0, 0,
noiso, psi, alpha, &sigma, 0));
SPLICING_CHECK(splicing_drift_proposal(/* mode= */ 1, psi, alpha, sigma,
0, 0, noiso, psi, alpha, 0, 0));
/* Initialize assignments of reads */
SPLICING_CHECK(splicing_reassign_samples(match_matrix, &match_order, psi,
noiso, myass));
/* foreach Iteration m=1, ..., M do */
for (m=0; m < noIterations; m++) {
SPLICING_CHECK(splicing_drift_proposal(/* mode= */ 1, psi, alpha, sigma,
0, 0, noiso, psiNew, alphaNew, 0,
0));
SPLICING_CHECK(splicing_metropolis_hastings_ratio(myass, noReads, psiNew,
alphaNew, psi, alpha,
sigma, noiso,
&effisolen, hyperp,
&isoscores,
m > 0 ? 1 : 0,
&acceptP, &cJS, &pJS));
if (acceptP >= 1 || RNG_UNIF01() < acceptP) {
splicing_vector_t *tmp;
tmp=psi; psi=psiNew; psiNew=tmp;
tmp=alpha; alpha=alphaNew; alphaNew=tmp;
cJS = pJS;
rundata->noAccepted ++;
} else {
rundata->noRejected ++;
}
if (m >= noBurnIn) {
if (lagCounter == noLag - 1) {
memcpy(&MATRIX(*samples, 0, noS), VECTOR(*psi),
noiso * sizeof(double));
VECTOR(*logLik)[noS] = cJS;
noS++;
lagCounter = 0;
} else {
lagCounter ++;
}
}
SPLICING_CHECK(splicing_reassign_samples(match_matrix, &match_order,
psi, noiso, myass));
} /* for m < noIterations */
splicing_vector_destroy(&isoscores);
splicing_vector_int_destroy(&effisolen);
splicing_vector_int_destroy(&match_order);
splicing_vector_destroy(&valphaNew);
splicing_vector_destroy(&valpha);
splicing_vector_destroy(&vpsiNew);
splicing_vector_destroy(&vpsi);
SPLICING_FINALLY_CLEAN(7);
if (!assignment) {
splicing_vector_int_destroy(myass);
SPLICING_FINALLY_CLEAN(1);
}
return 0;
}
int splicing_simulate_reads(const splicing_gff_t *gff, int gene,
const splicing_vector_t *expression,
int noreads, int readLength,
splicing_vector_int_t *isoform,
splicing_vector_int_t *position,
splicing_strvector_t *cigar,
splicing_vector_t *sample_prob) {
size_t i, p, noiso, goodiso=0, nogenes;
splicing_vector_int_t effisolen;
splicing_vector_t sampleprob;
double rand, sumpsi=0.0;
splicing_vector_int_t exstart, exend, exidx;
SPLICING_CHECK(splicing_gff_nogenes(gff, &nogenes));
if (gene < 0 || gene >= nogenes) {
SPLICING_ERROR("Invalid gene id", SPLICING_EINVAL);
}
/* TODO: more error checks */
SPLICING_CHECK(splicing_gff_noiso_one(gff, gene, &noiso));
SPLICING_CHECK(splicing_vector_int_init(&effisolen, noiso));
SPLICING_FINALLY(splicing_vector_int_destroy, &effisolen);
SPLICING_CHECK(splicing_vector_init(&sampleprob, noiso));
SPLICING_FINALLY(splicing_vector_destroy, &sampleprob);
SPLICING_CHECK(splicing_vector_int_resize(isoform, noreads));
SPLICING_CHECK(splicing_gff_isolength_one(gff, gene, &effisolen));
for (i=0; i<noiso; i++) {
int l=VECTOR(effisolen)[i]-readLength+1;
VECTOR(effisolen)[i] = l > 0 ? l : 0;
VECTOR(sampleprob)[i] = VECTOR(*expression)[i] * VECTOR(effisolen)[i];
if (VECTOR(sampleprob)[i] != 0) { goodiso++; }
sumpsi += VECTOR(sampleprob)[i];
}
if (goodiso==0) {
SPLICING_ERROR("No isoform is possible", SPLICING_FAILURE);
}
if (sample_prob) {
SPLICING_CHECK(splicing_vector_update(sample_prob, &sampleprob));
}
for (i=1; i<noiso; i++) {
VECTOR(sampleprob)[i] += VECTOR(sampleprob)[i-1];
}
for (i=0; i<noreads; i++) {
int w;
if (noiso==1) {
w=0;
} else if (noiso==2) {
rand = RNG_UNIF01() * sumpsi;
w = (rand < VECTOR(sampleprob)[0]) ? 0 : 1;
} else {
rand = RNG_UNIF01() * sumpsi;
for (w=0; rand > VECTOR(sampleprob)[w]; w++) ;
}
VECTOR(*isoform)[i]=w;
}
splicing_vector_destroy(&sampleprob);
SPLICING_FINALLY_CLEAN(1);
/* OK, we have the isoforms, now we need the read positions,
these are uniformly sampled from the individual isoforms. */
SPLICING_CHECK(splicing_vector_int_resize(position, noreads));
SPLICING_CHECK(splicing_vector_int_init(&exstart, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exstart);
SPLICING_CHECK(splicing_vector_int_init(&exend, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exend);
SPLICING_CHECK(splicing_vector_int_init(&exidx, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exidx);
SPLICING_CHECK(splicing_gff_exon_start_end(gff, &exstart, &exend, &exidx,
gene));
/* Positions in isoform coordinates first */
for (i=0; i<noreads; i++) {
int iso=VECTOR(*isoform)[i];
int len=VECTOR(effisolen)[iso];
VECTOR(*position)[i]=RNG_INTEGER(1, len);
}
/* Translate isoform coordinates to genomic coordintes */
/* TODO: some of this is already calculated */
SPLICING_CHECK(splicing_iso_to_genomic(gff, gene, isoform, /*converter=*/ 0,
position));
/* CIGAR strings */
splicing_strvector_clear(cigar);
SPLICING_CHECK(splicing_strvector_reserve(cigar, noreads));
for (i=0; i<noreads; i++) {
char tmp[1000], *tmp2=tmp;
int iso=VECTOR(*isoform)[i];
size_t rs=VECTOR(*position)[i];
int ex=0;
int rl=readLength;
for (ex=VECTOR(exidx)[iso]; VECTOR(exend)[ex] < rs; ex++) ;
while (VECTOR(exend)[ex] < rs+rl-1) {
tmp2 += snprintf(tmp2, sizeof(tmp)/sizeof(char)-(tmp2-tmp)-1, "%iM%iN",
(int) (VECTOR(exend)[ex]-rs+1),
(int) (VECTOR(exstart)[ex+1]-VECTOR(exend)[ex]-1));
if (tmp2 >= tmp + sizeof(tmp)/sizeof(char)) {
SPLICING_ERROR("CIGAR string too long", SPLICING_EINVAL);
}
rl -= (VECTOR(exend)[ex] - rs + 1);
rs = VECTOR(exstart)[ex+1];
ex++;
}
tmp2 += snprintf(tmp2, sizeof(tmp)/sizeof(char)-(tmp2-tmp)-1, "%iM", rl);
if (tmp2 >= tmp + sizeof(tmp)/sizeof(char)) {
SPLICING_ERROR("CIGAR string too long", SPLICING_EINVAL); }
SPLICING_CHECK(splicing_strvector_append(cigar, tmp));
}
splicing_vector_int_destroy(&exidx);
splicing_vector_int_destroy(&exend);
splicing_vector_int_destroy(&exstart);
splicing_vector_int_destroy(&effisolen);
SPLICING_FINALLY_CLEAN(4);
return 0;
}
int splicing_simulate_paired_reads(const splicing_gff_t *gff, int gene,
const splicing_vector_t *expression,
int noreads, int readLength,
const splicing_vector_t *fragmentProb,
int fragmentStart, double normalMean,
double normalVar, double numDevs,
splicing_vector_int_t *isoform,
splicing_vector_int_t *position,
splicing_strvector_t *cigar,
splicing_vector_t *sampleprob) {
size_t i, j, noiso, il, nogenes;
splicing_vector_t *mysampleprob=sampleprob, vsampleprob;
splicing_vector_t px, cpx;
double sumpx, sumpsi=0.0;
splicing_vector_int_t isolen;
int goodiso=0;
splicing_vector_int_t exstart, exend, exidx;
splicing_vector_t *myfragmentProb=(splicing_vector_t*) fragmentProb,
vfragmentProb;
int fs, fl;
SPLICING_CHECK(splicing_gff_nogenes(gff, &nogenes));
if (gene < 0 || gene >= nogenes) {
SPLICING_ERROR("Invalid gene id", SPLICING_EINVAL);
}
/* TODO: more error checks */
if (!fragmentProb) {
myfragmentProb=&vfragmentProb;
SPLICING_CHECK(splicing_vector_init(&vfragmentProb, 0));
SPLICING_FINALLY(splicing_vector_destroy, &vfragmentProb);
SPLICING_CHECK(splicing_normal_fragment(normalMean, normalVar, numDevs,
readLength, myfragmentProb,
&fragmentStart));
splicing_vector_scale(myfragmentProb,
1.0/splicing_vector_sum(myfragmentProb));
}
il=splicing_vector_size(myfragmentProb);
fs=fragmentStart;
fl=fragmentStart+il-1;
SPLICING_CHECK(splicing_gff_noiso_one(gff, gene, &noiso));
if ( fabs(splicing_vector_sum(myfragmentProb) - 1.0) > 1e-10 ) {
SPLICING_ERROR("Fragment length distribution does not sum up to 1",
SPLICING_EINVAL);
}
SPLICING_CHECK(splicing_vector_int_init(&isolen, noiso));
SPLICING_FINALLY(splicing_vector_int_destroy, &isolen);
SPLICING_CHECK(splicing_gff_isolength_one(gff, gene, &isolen));
SPLICING_CHECK(splicing_vector_copy(&px, myfragmentProb));
SPLICING_FINALLY(splicing_vector_destroy, &px);
SPLICING_CHECK(splicing_vector_init(&cpx, il));
SPLICING_FINALLY(splicing_vector_destroy, &cpx);
if (!sampleprob) {
mysampleprob=&vsampleprob;
SPLICING_CHECK(splicing_vector_init(mysampleprob, noiso));
SPLICING_FINALLY(splicing_vector_destroy, mysampleprob);
} else {
SPLICING_CHECK(splicing_vector_resize(mysampleprob, noiso));
}
for (sumpx=VECTOR(px)[0], i=1; i<il; i++) {
VECTOR(px)[i] += VECTOR(px)[i-1];
sumpx += VECTOR(px)[i];
}
VECTOR(cpx)[0] = VECTOR(px)[0];
for (i=1; i<il; i++) {
VECTOR(cpx)[i] = VECTOR(cpx)[i-1] + VECTOR(px)[i];
}
for (i=0; i<noiso; i++) {
int ilen=VECTOR(isolen)[i];
int r1= ilen >= fl ? ilen - fl + 1 : 0;
int r2= ilen >= fs ? (ilen >= fl ? fl - fs : ilen - fs + 1) : 0;
/* int r3= fs - 1; */
double sp=0.0;
if (r1 > 0) { sp += r1; }
if (r2 > 0) { sp += VECTOR(cpx)[r2-1]; }
VECTOR(*mysampleprob)[i] = sp * VECTOR(*expression)[i];
if (VECTOR(*mysampleprob)[i] != 0) { goodiso += 1; }
sumpsi += VECTOR(*mysampleprob)[i];
}
if (goodiso == 0) {
SPLICING_ERROR("No isoform is possible", SPLICING_FAILURE);
}
for (i=1; i<noiso; i++) {
VECTOR(*mysampleprob)[i] += VECTOR(*mysampleprob)[i-1];
}
SPLICING_CHECK(splicing_vector_int_resize(isoform, noreads*2));
for (i=0; i<2*noreads; i+=2) {
int w;
double rand;
if (noiso==1) {
w=0;
} else if (noiso==2) {
rand = RNG_UNIF01() * sumpsi;
w = (rand < VECTOR(*mysampleprob)[0]) ? 0 : 1;
} else {
rand = RNG_UNIF01() * sumpsi;
for (w=0; rand > VECTOR(*mysampleprob)[w]; w++) ;
}
VECTOR(*isoform)[i]=VECTOR(*isoform)[i+1]=w;
}
if (!sampleprob) {
splicing_vector_destroy(mysampleprob);
SPLICING_FINALLY_CLEAN(1);
} else {
for (i=noiso-1; i>0; i--) {
VECTOR(*mysampleprob)[i] -= VECTOR(*mysampleprob)[i-1];
}
}
/* We have the isoforms, now get the read positions. */
SPLICING_CHECK(splicing_vector_int_resize(position, noreads*2));
SPLICING_CHECK(splicing_vector_int_init(&exstart, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exstart);
SPLICING_CHECK(splicing_vector_int_init(&exend, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exend);
SPLICING_CHECK(splicing_vector_int_init(&exidx, 0));
SPLICING_FINALLY(splicing_vector_int_destroy, &exidx);
SPLICING_CHECK(splicing_gff_exon_start_end(gff, &exstart, &exend, &exidx,
gene));
/* Positions in isoform coordinates first.
These are sampled based on the fragment length distribution. */
for (i=0, j=0; i<noreads; i++) {
int iso=VECTOR(*isoform)[2*i];
int ilen=VECTOR(isolen)[iso];
int r1= ilen >= fl ? ilen - fl + 1 : 0;
int r2= ilen >= fs ? (ilen >= fl ? fl - fs : ilen - fs + 1) : 0;
/* int r3= fs - 1; */
int pos, fragment;
double sp=0.0;
if (r1 > 0) { sp += r1; }
if (r2 > 0) { sp += VECTOR(cpx)[r2-1]; }
double rand=RNG_UNIF(0, sp);
if (rand < r1) {
pos = ceil(rand);
} else {
int w;
rand -= r1;
for (w=0; VECTOR(cpx)[w] < rand; w++) ;
pos = r1 + r2 - w;
}
if (pos <= r1) {
rand=RNG_UNIF(0, 1.0);
} else {
rand=RNG_UNIF(0, VECTOR(px)[r1+r2-pos]);
}
for (fragment=0; VECTOR(px)[fragment] < rand; fragment++) ;
fragment += fragmentStart;
VECTOR(*position)[j++] = pos;
VECTOR(*position)[j++] = pos+fragment-readLength;
}
/* Translate positions to genomic coordinates */
/* TODO: some of this is already calculated */
SPLICING_CHECK(splicing_iso_to_genomic(gff, gene, isoform, /*converter=*/ 0,
position));
/* CIGAR strings */
splicing_strvector_clear(cigar);
SPLICING_CHECK(splicing_strvector_reserve(cigar, 2*noreads));
for (j=0; j<2*noreads; j++) {
char tmp[1000], *tmp2=tmp;
int iso=VECTOR(*isoform)[j];
size_t rs=VECTOR(*position)[j];
int ex=0;
int rl=readLength;
for (ex=VECTOR(exidx)[iso]; VECTOR(exend)[ex] < rs; ex++) ;
while (rs + rl - 1 > VECTOR(exend)[ex]) {
tmp2 += snprintf(tmp2, sizeof(tmp)/sizeof(char)-(tmp2-tmp)-1, "%iM%iN",
(int) (VECTOR(exend)[ex]-rs+1),
(int) (VECTOR(exstart)[ex+1]-VECTOR(exend)[ex]-1));
if (tmp2 >= tmp + sizeof(tmp)/sizeof(char)) {
SPLICING_ERROR("CIGAR string too long", SPLICING_EINVAL);
}
rl -= (VECTOR(exend)[ex] - rs + 1);
rs = VECTOR(exstart)[ex+1];
ex++;
}
tmp2 += snprintf(tmp2, sizeof(tmp)/sizeof(char)-(tmp2-tmp)-1, "%iM", rl);
if (tmp2 >= tmp + sizeof(tmp)/sizeof(char)) {
SPLICING_ERROR("CIGAR string too long", SPLICING_EINVAL);
}
SPLICING_CHECK(splicing_strvector_append(cigar, tmp));
}
splicing_vector_int_destroy(&exidx);
splicing_vector_int_destroy(&exend);
splicing_vector_int_destroy(&exstart);
splicing_vector_destroy(&cpx);
splicing_vector_destroy(&px);
splicing_vector_int_destroy(&isolen);
SPLICING_FINALLY_CLEAN(6);
if (!fragmentProb) {
splicing_vector_destroy(myfragmentProb);
SPLICING_FINALLY_CLEAN(1);
}
return 0;
}
int igraph_layout_fruchterman_reingold_3d(const igraph_t *graph,
igraph_matrix_t *res,
igraph_bool_t use_seed,
igraph_integer_t niter,
igraph_real_t start_temp,
const igraph_vector_t *weight,
const igraph_vector_t *minx,
const igraph_vector_t *maxx,
const igraph_vector_t *miny,
const igraph_vector_t *maxy,
const igraph_vector_t *minz,
const igraph_vector_t *maxz) {
igraph_integer_t no_nodes=igraph_vcount(graph);
igraph_integer_t no_edges=igraph_ecount(graph);
igraph_integer_t i;
igraph_vector_float_t dispx, dispy, dispz;
igraph_real_t temp=start_temp;
igraph_real_t difftemp=start_temp / niter;
float width=sqrtf(no_nodes), height=width, depth=width;
igraph_bool_t conn=1;
float C;
if (niter < 0) {
IGRAPH_ERROR("Number of iterations must be non-negative in "
"Fruchterman-Reingold layout", IGRAPH_EINVAL);
}
if (use_seed && (igraph_matrix_nrow(res) != no_nodes ||
igraph_matrix_ncol(res) != 3)) {
IGRAPH_ERROR("Invalid start position matrix size in "
"Fruchterman-Reingold layout", IGRAPH_EINVAL);
}
if (weight && igraph_vector_size(weight) != igraph_ecount(graph)) {
IGRAPH_ERROR("Invalid weight vector length", IGRAPH_EINVAL);
}
if (minx && igraph_vector_size(minx) != no_nodes) {
IGRAPH_ERROR("Invalid minx vector length", IGRAPH_EINVAL);
}
if (maxx && igraph_vector_size(maxx) != no_nodes) {
IGRAPH_ERROR("Invalid maxx vector length", IGRAPH_EINVAL);
}
if (minx && maxx && !igraph_vector_all_le(minx, maxx)) {
IGRAPH_ERROR("minx must not be greater than maxx", IGRAPH_EINVAL);
}
if (miny && igraph_vector_size(miny) != no_nodes) {
IGRAPH_ERROR("Invalid miny vector length", IGRAPH_EINVAL);
}
if (maxy && igraph_vector_size(maxy) != no_nodes) {
IGRAPH_ERROR("Invalid maxy vector length", IGRAPH_EINVAL);
}
if (miny && maxy && !igraph_vector_all_le(miny, maxy)) {
IGRAPH_ERROR("miny must not be greater than maxy", IGRAPH_EINVAL);
}
if (minz && igraph_vector_size(minz) != no_nodes) {
IGRAPH_ERROR("Invalid minz vector length", IGRAPH_EINVAL);
}
if (maxz && igraph_vector_size(maxz) != no_nodes) {
IGRAPH_ERROR("Invalid maxz vector length", IGRAPH_EINVAL);
}
if (minz && maxz && !igraph_vector_all_le(minz, maxz)) {
IGRAPH_ERROR("minz must not be greater than maxz", IGRAPH_EINVAL);
}
igraph_is_connected(graph, &conn, IGRAPH_WEAK);
if (!conn) { C = no_nodes * sqrtf(no_nodes); }
RNG_BEGIN();
if (!use_seed) {
IGRAPH_CHECK(igraph_matrix_resize(res, no_nodes, 3));
for (i=0; i<no_nodes; i++) {
igraph_real_t x1=minx ? VECTOR(*minx)[i] : -width/2;
igraph_real_t x2=maxx ? VECTOR(*maxx)[i] : width/2;
igraph_real_t y1=miny ? VECTOR(*miny)[i] : -height/2;
igraph_real_t y2=maxy ? VECTOR(*maxy)[i] : height/2;
igraph_real_t z1=minz ? VECTOR(*minz)[i] : -depth/2;
igraph_real_t z2=maxz ? VECTOR(*maxz)[i] : depth/2;
MATRIX(*res, i, 0) = RNG_UNIF(x1, x2);
MATRIX(*res, i, 1) = RNG_UNIF(y1, y2);
MATRIX(*res, i, 2) = RNG_UNIF(z1, z2);
}
}
IGRAPH_CHECK(igraph_vector_float_init(&dispx, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispx);
IGRAPH_CHECK(igraph_vector_float_init(&dispy, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispy);
IGRAPH_CHECK(igraph_vector_float_init(&dispz, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispz);
for (i=0; i<niter; i++) {
igraph_integer_t v, u, e;
/* calculate repulsive forces, we have a special version
for unconnected graphs */
igraph_vector_float_null(&dispx);
igraph_vector_float_null(&dispy);
igraph_vector_float_null(&dispz);
if (conn) {
for (v=0; v<no_nodes; v++) {
for (u=v+1; u<no_nodes; u++) {
float dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
float dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
float dz=MATRIX(*res, v, 2) - MATRIX(*res, u, 2);
float dlen=dx * dx + dy * dy + dz * dz;
if (dlen == 0) {
dx = RNG_UNIF01() * 1e-9;
dy = RNG_UNIF01() * 1e-9;
dz = RNG_UNIF01() * 1e-9;
dlen = dx * dx + dy * dy + dz * dz;
}
VECTOR(dispx)[v] += dx/dlen;
VECTOR(dispy)[v] += dy/dlen;
VECTOR(dispz)[v] += dz/dlen;
VECTOR(dispx)[u] -= dx/dlen;
VECTOR(dispy)[u] -= dy/dlen;
VECTOR(dispz)[u] -= dz/dlen;
}
}
} else {
for (v=0; v<no_nodes; v++) {
for (u=v+1; u<no_nodes; u++) {
float dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
float dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
float dz=MATRIX(*res, v, 2) - MATRIX(*res, u, 2);
float dlen, rdlen;
dlen=dx * dx + dy * dy + dz * dz;
if (dlen == 0) {
dx = RNG_UNIF01() * 1e-9;
dy = RNG_UNIF01() * 1e-9;
dz = RNG_UNIF01() * 1e-9;
dlen = dx * dx + dy * dy + dz * dz;
}
rdlen=sqrt(dlen);
VECTOR(dispx)[v] += dx * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispy)[v] += dy * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispy)[v] += dz * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispx)[u] -= dx * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispy)[u] -= dy * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispz)[u] -= dz * (C-dlen * rdlen) / (dlen*C);
}
}
}
/* calculate attractive forces */
for (e=0; e<no_edges; e++) {
/* each edges is an ordered pair of vertices v and u */
igraph_integer_t v=IGRAPH_FROM(graph, e);
igraph_integer_t u=IGRAPH_TO(graph, e);
igraph_real_t dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
igraph_real_t dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
igraph_real_t dz=MATRIX(*res, v, 2) - MATRIX(*res, u, 2);
igraph_real_t w=weight ? VECTOR(*weight)[e] : 1.0;
igraph_real_t dlen=sqrt(dx * dx + dy * dy + dz * dz) * w;
VECTOR(dispx)[v] -= (dx * dlen);
VECTOR(dispy)[v] -= (dy * dlen);
VECTOR(dispz)[v] -= (dz * dlen);
VECTOR(dispx)[u] += (dx * dlen);
VECTOR(dispy)[u] += (dy * dlen);
VECTOR(dispz)[u] += (dz * dlen);
}
/* limit max displacement to temperature t and prevent from
displacement outside frame */
for (v=0; v<no_nodes; v++) {
igraph_real_t dx=VECTOR(dispx)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t dy=VECTOR(dispy)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t dz=VECTOR(dispz)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t displen=sqrt(dx * dx + dy * dy + dz * dz);
igraph_real_t mx=fabs(dx) < temp ? dx : temp;
igraph_real_t my=fabs(dy) < temp ? dy : temp;
igraph_real_t mz=fabs(dz) < temp ? dz : temp;
if (displen > 0) {
MATRIX(*res, v, 0) += (dx / displen) * mx;
MATRIX(*res, v, 1) += (dy / displen) * my;
MATRIX(*res, v, 2) += (dz / displen) * mz;
}
if (minx && MATRIX(*res, v, 0) < VECTOR(*minx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*minx)[v];
}
if (maxx && MATRIX(*res, v, 0) > VECTOR(*maxx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*maxx)[v];
}
if (miny && MATRIX(*res, v, 1) < VECTOR(*miny)[v]) {
MATRIX(*res, v, 1) = VECTOR(*miny)[v];
}
if (maxy && MATRIX(*res, v, 1) > VECTOR(*maxy)[v]) {
MATRIX(*res, v, 1) = VECTOR(*maxy)[v];
}
if (minz && MATRIX(*res, v, 2) < VECTOR(*minz)[v]) {
MATRIX(*res, v, 2) = VECTOR(*minz)[v];
}
if (maxz && MATRIX(*res, v, 2) > VECTOR(*maxz)[v]) {
MATRIX(*res, v, 2) = VECTOR(*maxz)[v];
}
}
temp -= difftemp;
}
RNG_END();
igraph_vector_float_destroy(&dispx);
igraph_vector_float_destroy(&dispy);
igraph_vector_float_destroy(&dispz);
IGRAPH_FINALLY_CLEAN(3);
return 0;
}
int igraph_layout_i_fr(const igraph_t *graph,
igraph_matrix_t *res,
igraph_bool_t use_seed,
igraph_integer_t niter,
igraph_real_t start_temp,
const igraph_vector_t *weight,
const igraph_vector_t *minx,
const igraph_vector_t *maxx,
const igraph_vector_t *miny,
const igraph_vector_t *maxy) {
igraph_integer_t no_nodes=igraph_vcount(graph);
igraph_integer_t no_edges=igraph_ecount(graph);
igraph_integer_t i;
igraph_vector_float_t dispx, dispy;
igraph_real_t temp=start_temp;
igraph_real_t difftemp=start_temp / niter;
float width=sqrtf(no_nodes), height=width;
igraph_bool_t conn=1;
float C;
igraph_is_connected(graph, &conn, IGRAPH_WEAK);
if (!conn) { C = no_nodes * sqrtf(no_nodes); }
RNG_BEGIN();
if (!use_seed) {
IGRAPH_CHECK(igraph_matrix_resize(res, no_nodes, 2));
for (i=0; i<no_nodes; i++) {
igraph_real_t x1=minx ? VECTOR(*minx)[i] : -width/2;
igraph_real_t x2=maxx ? VECTOR(*maxx)[i] : width/2;
igraph_real_t y1=miny ? VECTOR(*miny)[i] : -height/2;
igraph_real_t y2=maxy ? VECTOR(*maxy)[i] : height/2;
if (!igraph_finite(x1)) { x1 = -sqrt(no_nodes)/2; }
if (!igraph_finite(x2)) { x2 = sqrt(no_nodes)/2; }
if (!igraph_finite(y1)) { y1 = -sqrt(no_nodes)/2; }
if (!igraph_finite(y2)) { y2 = sqrt(no_nodes)/2; }
MATRIX(*res, i, 0) = RNG_UNIF(x1, x2);
MATRIX(*res, i, 1) = RNG_UNIF(y1, y2);
}
}
IGRAPH_CHECK(igraph_vector_float_init(&dispx, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispx);
IGRAPH_CHECK(igraph_vector_float_init(&dispy, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispy);
for (i=0; i<niter; i++) {
igraph_integer_t v, u, e;
/* calculate repulsive forces, we have a special version
for unconnected graphs */
igraph_vector_float_null(&dispx);
igraph_vector_float_null(&dispy);
if (conn) {
for (v=0; v<no_nodes; v++) {
for (u=v+1; u<no_nodes; u++) {
float dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
float dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
float dlen=dx * dx + dy * dy;
if (dlen == 0) {
dx = RNG_UNIF01() * 1e-9;
dy = RNG_UNIF01() * 1e-9;
dlen = dx * dx + dy * dy;
}
VECTOR(dispx)[v] += dx/dlen;
VECTOR(dispy)[v] += dy/dlen;
VECTOR(dispx)[u] -= dx/dlen;
VECTOR(dispy)[u] -= dy/dlen;
}
}
} else {
for (v=0; v<no_nodes; v++) {
for (u=v+1; u<no_nodes; u++) {
float dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
float dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
float dlen, rdlen;
dlen=dx * dx + dy * dy;
if (dlen == 0) {
dx = RNG_UNIF(0, 1e-6);
dy = RNG_UNIF(0, 1e-6);
dlen = dx * dx + dy * dy;
}
rdlen=sqrt(dlen);
VECTOR(dispx)[v] += dx * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispy)[v] += dy * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispx)[u] -= dx * (C-dlen * rdlen) / (dlen*C);
VECTOR(dispy)[u] -= dy * (C-dlen * rdlen) / (dlen*C);
}
}
}
/* calculate attractive forces */
for (e=0; e<no_edges; e++) {
/* each edges is an ordered pair of vertices v and u */
igraph_integer_t v=IGRAPH_FROM(graph, e);
igraph_integer_t u=IGRAPH_TO(graph, e);
igraph_real_t dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
igraph_real_t dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
igraph_real_t w=weight ? VECTOR(*weight)[e] : 1.0;
igraph_real_t dlen=sqrt(dx * dx + dy * dy) * w;
VECTOR(dispx)[v] -= (dx * dlen);
VECTOR(dispy)[v] -= (dy * dlen);
VECTOR(dispx)[u] += (dx * dlen);
VECTOR(dispy)[u] += (dy * dlen);
}
/* limit max displacement to temperature t and prevent from
displacement outside frame */
for (v=0; v<no_nodes; v++) {
igraph_real_t dx=VECTOR(dispx)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t dy=VECTOR(dispy)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t displen=sqrt(dx * dx + dy * dy);
igraph_real_t mx=fabs(dx) < temp ? dx : temp;
igraph_real_t my=fabs(dy) < temp ? dy : temp;
if (displen > 0) {
MATRIX(*res, v, 0) += (dx / displen) * mx;
MATRIX(*res, v, 1) += (dy / displen) * my;
}
if (minx && MATRIX(*res, v, 0) < VECTOR(*minx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*minx)[v];
}
if (maxx && MATRIX(*res, v, 0) > VECTOR(*maxx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*maxx)[v];
}
if (miny && MATRIX(*res, v, 1) < VECTOR(*miny)[v]) {
MATRIX(*res, v, 1) = VECTOR(*miny)[v];
}
if (maxy && MATRIX(*res, v, 1) > VECTOR(*maxy)[v]) {
MATRIX(*res, v, 1) = VECTOR(*maxy)[v];
}
}
temp -= difftemp;
}
RNG_END();
igraph_vector_float_destroy(&dispx);
igraph_vector_float_destroy(&dispy);
IGRAPH_FINALLY_CLEAN(2);
return 0;
}
int igraph_layout_i_grid_fr(const igraph_t *graph,
igraph_matrix_t *res, igraph_bool_t use_seed,
igraph_integer_t niter, igraph_real_t start_temp,
const igraph_vector_t *weight, const igraph_vector_t *minx,
const igraph_vector_t *maxx, const igraph_vector_t *miny,
const igraph_vector_t *maxy) {
igraph_integer_t no_nodes=igraph_vcount(graph);
igraph_integer_t no_edges=igraph_ecount(graph);
float width=sqrtf(no_nodes), height=width;
igraph_2dgrid_t grid;
igraph_vector_float_t dispx, dispy;
igraph_real_t temp=start_temp;
igraph_real_t difftemp=start_temp / niter;
igraph_2dgrid_iterator_t vidit;
igraph_integer_t i;
const float cellsize=2.0;
RNG_BEGIN();
if (!use_seed) {
IGRAPH_CHECK(igraph_matrix_resize(res, no_nodes, 2));
for (i=0; i<no_nodes; i++) {
igraph_real_t x1=minx ? VECTOR(*minx)[i] : -width/2;
igraph_real_t x2=maxx ? VECTOR(*maxx)[i] : width/2;
igraph_real_t y1=miny ? VECTOR(*miny)[i] : -height/2;
igraph_real_t y2=maxy ? VECTOR(*maxy)[i] : height/2;
if (!igraph_finite(x1)) { x1 = -sqrt(no_nodes)/2; }
if (!igraph_finite(x2)) { x2 = sqrt(no_nodes)/2; }
if (!igraph_finite(y1)) { y1 = -sqrt(no_nodes)/2; }
if (!igraph_finite(y2)) { y2 = sqrt(no_nodes)/2; }
MATRIX(*res, i, 0) = RNG_UNIF(x1, x2);
MATRIX(*res, i, 1) = RNG_UNIF(y1, y2);
}
}
/* make grid */
IGRAPH_CHECK(igraph_2dgrid_init(&grid, res, -width/2, width/2, cellsize,
-height/2, height/2, cellsize));
IGRAPH_FINALLY(igraph_2dgrid_destroy, &grid);
/* place vertices on grid */
for (i=0; i<no_nodes; i++) {
igraph_2dgrid_add2(&grid, i);
}
IGRAPH_CHECK(igraph_vector_float_init(&dispx, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispx);
IGRAPH_CHECK(igraph_vector_float_init(&dispy, no_nodes));
IGRAPH_FINALLY(igraph_vector_float_destroy, &dispy);
for (i=0; i<niter; i++) {
igraph_integer_t v, u, e;
igraph_vector_float_null(&dispx);
igraph_vector_float_null(&dispy);
/* repulsion */
igraph_2dgrid_reset(&grid, &vidit);
while ( (v=igraph_2dgrid_next(&grid, &vidit)-1) != -1) {
while ( (u=igraph_2dgrid_next_nei(&grid, &vidit)-1) != -1) {
float dx=MATRIX(*res, v, 0)-MATRIX(*res, u, 0);
float dy=MATRIX(*res, v, 1)-MATRIX(*res, u, 1);
float dlen=dx * dx + dy * dy;
if (dlen < cellsize * cellsize) {
VECTOR(dispx)[v] += dx/dlen;
VECTOR(dispy)[v] += dy/dlen;
VECTOR(dispx)[u] -= dx/dlen;
VECTOR(dispy)[u] -= dy/dlen;
}
}
}
/* attraction */
for (e=0; e<no_edges; e++) {
igraph_integer_t v=IGRAPH_FROM(graph, e);
igraph_integer_t u=IGRAPH_TO(graph, e);
igraph_real_t dx=MATRIX(*res, v, 0) - MATRIX(*res, u, 0);
igraph_real_t dy=MATRIX(*res, v, 1) - MATRIX(*res, u, 1);
igraph_real_t w=weight ? VECTOR(*weight)[e] : 1.0;
igraph_real_t dlen=sqrt(dx * dx + dy * dy) * w;
VECTOR(dispx)[v] -= (dx * dlen);
VECTOR(dispy)[v] -= (dy * dlen);
VECTOR(dispx)[u] += (dx * dlen);
VECTOR(dispy)[u] += (dy * dlen);
}
/* update */
for (v=0; v<no_nodes; v++) {
igraph_real_t dx=VECTOR(dispx)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t dy=VECTOR(dispy)[v] + RNG_UNIF01() * 1e-9;
igraph_real_t displen=sqrt(dx * dx + dy * dy);
igraph_real_t mx=fabs(dx) < temp ? dx : temp;
igraph_real_t my=fabs(dy) < temp ? dy : temp;
if (displen > 0) {
MATRIX(*res, v, 0) += (dx / displen) * mx;
MATRIX(*res, v, 1) += (dy / displen) * my;
}
if (minx && MATRIX(*res, v, 0) < VECTOR(*minx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*minx)[v];
}
if (maxx && MATRIX(*res, v, 0) > VECTOR(*maxx)[v]) {
MATRIX(*res, v, 0) = VECTOR(*maxx)[v];
}
if (miny && MATRIX(*res, v, 1) < VECTOR(*miny)[v]) {
MATRIX(*res, v, 1) = VECTOR(*miny)[v];
}
if (maxy && MATRIX(*res, v, 1) > VECTOR(*maxy)[v]) {
MATRIX(*res, v, 1) = VECTOR(*maxy)[v];
}
}
temp -= difftemp;
}
igraph_vector_float_destroy(&dispx);
igraph_vector_float_destroy(&dispy);
igraph_2dgrid_destroy(&grid);
IGRAPH_FINALLY_CLEAN(3);
return 0;
}